Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

EMBO Journal

Volumn 17, Issue 1, 1998, Pages 159-169

  Cliby, William A ^a,c   Roberts, Christopher J ^a,d   Cimprich, Karlene A ^b,e   Stringer, Cheri M ^a   Lamb, John R ^a   Schreiber, Stuart L ^d   Friend, Stephen H ^a  

^a USA   (United States)

^b HARVARD UNIVERSITY   (United States)

^c MAYO CLINIC   (United States)

^d ROSETTA INPHARMATICS   (United States)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATR protein; Cell cycle checkpoint; DNA damage; Hyroxyurea; Ionizing radiation

Indexed keywords

CELL DNA; CISPLATIN; HYDROXYUREA; MESYLIC ACID METHYL ESTER; PHOSPHATIDYLINOSITOL KINASE;

ALLELE; ARTICLE; ATAXIA TELANGIECTASIA; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA SYNTHESIS; DRUG SENSITIVITY; FIBROBLAST; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRAVIOLET RADIATION;

CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TRANSFORMED; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; FIBROBLASTS; G2 PHASE; HUMANS; MITOSIS; PHENOTYPE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE;

EID: 0032472330     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.1.159     Document Type: Article

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