Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer

Genes Chromosomes and Cancer

Volumn 29, Issue 3, 2000, Pages 213-218

  Gemma, Akihiko ^a   Seike, Masahiro ^a   Seike, Yoko ^a   Uematsu, Kazutsugu ^a   Hibino, Suguru ^a   Kurimoto, Futosi ^a   Yoshimura, Akinobu ^a   Shibuya, Masahiko ^a   Harris, Curtis C ^b   Kudoh, Shoji ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYTOSINE; DNA; GUANINE; NUCLEOTIDE; THYMINE;

AMINO ACID SUBSTITUTION; ARTICLE; CARCINOGENESIS; CODON; CONTROLLED STUDY; DNA SEQUENCE; EXON; GENE; GENE MUTATION; HUMAN; HUMAN CELL; LUNG CANCER; MITOSIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; SOMATIC MUTATION; TUMOR GROWTH;

ADENOCARCINOMA; AMINO ACID SUBSTITUTION; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SMALL CELL; GENES, CDC; HUMAN; LUNG NEOPLASMS; MITOSIS; MUTATION; MUTATION, MISSENSE; POINT MUTATION; POLYMORPHISM (GENETICS); PROTEIN KINASES; SUPPORT, NON-U.S. GOV'T;

EID: 0033800018     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/1098-2264(2000)9999:9999<::AID-GCC1027>3.0.CO;2-G     Document Type: Article

References (27)

1. Nuclear DNA content by cytofluorometry of stage I adenocarcinoma of the lung in relation to postoperative recurrence
2. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
3. Fluorescence cytophotometric measurement of nuclear DNA in adenocarcinoma of the lung: Relation of proliferative activity and DNA ploidy to prognosis
4. Mutations of mitotic checkpoint genes in human cancers
5. Characterization of MAD2B and other mitotic spindle checkpoint genes
6. The effect of tumor size and tumor cell DNA content on the survival of patients with stage I adenocarcinoma of the lung
7. Cell cycle checkpoints: Preventing an identity crisis
8. Abnormal centrosome amplification in the absence of p53
9. Significance of nuclear DNA content analysis in advanced lung cancer using transbronchial biopsy samples
10. Molecular analysis of the cyclin-dependent kinase inhibitor genes p15INK4B/MTS2, p16 INK4/MTS1, p18 and p19 in human cancer cell lines
11. FHIT mutations in human primary gastric cancer
12. hSmad5 gene, a human hSmad family member: Its full length cDNA, genomic structure, promoter region and mutation analysis in human tumors
13. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice
14. SMC-mediated chromosome mechanics: A conserved scheme from bacteria to vertebrates?
15. Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers
16. Genetic instability in colorectal cancers
17. Genetic instabilities in human cancers
18. The genetics of cell cycle checkpoints
19. At the heart of the budding yeast cell cycle
20. When checkpoints fail
21. The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase
22. Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics
23. Stability of p53 tumor suppressor gene mutations during the process of metastasis and during chemotherapy
24. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
25. The percentage of aneuploid cells is significantly correlated with survival in accurately staged patients with stage 1 resected squamous cell lung cancer and long term follow up
26. Mutation analysis of hBUB1 in aneuploid HNSCC and lung cancer cell lines