Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability

Cancer Research

Volumn 61, Issue 21, 2001, Pages 7727-7730

  Menoyo, Anna ^a   Alazzouzi, Hafid ^a   Schwartz, Simo ^a   Espín, Eloi ^b   Armengol, Manel ^b   Yamamoto, Hiroyuki ^c  

^a Ctr d'Investigacions en B   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ATAXIA TELANGIECTASIA; CARCINOGENESIS; DNA DAMAGE; DNA REPAIR; FRAMESHIFT MUTATION; GENE MUTATION; HUMAN; HUMAN CELL; MICROSATELLITE INSTABILITY; PHENOTYPE; PRIORITY JOURNAL; STOMACH TUMOR;

CELL CYCLE PROTEINS; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; ENDODEOXYRIBONUCLEASES; FRAMESHIFT MUTATION; HUMANS; MICROSATELLITE REPEATS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHENOTYPE; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; STOMACH NEOPLASMS;

EID: 0035503171     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Cancer of the microsatellite mutator phenotype
2. ATM and ATR: Networking cellular responses to DNA damage
3. ATM: A mediator of multiple responses to genotoxic stress
4. 2/M DNA damage checkpoint
5. The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
6. Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCAI following deoxyribonucleic acid damage
7. BASC, a super complex of BRCAI-associated proteins involved in the recognition and repair of aberrant DNA structures
8. MEDI, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLHI
9. MLH3: A DNA mismatch repair gene associated with mammalian microsatellite instability
10. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
11. Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation
12. Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype
13. Frameshift somatic mutations in gastric cancer of the microsatellite mutator phenotype
14. Frameshift mutations at coding mononucleotide repeats of the hRAD50 gene in gastrointestinal carcinomas with microsatellite instability
15. ATR: Disruption leads to chromosomal fragmentation and early embryonic lethality
16. Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
17. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
18. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
19. Frameshift mutations in Fas, Apaf-l, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotype
20. The DNA repair gene MBD4(MEDI) is mutated in human carcinomas with microsatellite instability