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Volumn 35, Issue 1, 2003, Pages 25-31

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 2; DNA;

EID: 0041854279     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1232     Document Type: Article
Times cited : (735)

References (52)
  • 1
    • 0025885070 scopus 로고
    • Isolation of the human Cdk2 gene that encodes the cyclin A- and adenovirus EiA-associated p33 kinase
    • Tsai, L.-H., Harlow, E. & Meyerson, M. Isolation of the human Cdk2 gene that encodes the cyclin A- and adenovirus EiA-associated p33 kinase. Nature 353, 174-177 (1991).
    • (1991) Nature , vol.353 , pp. 174-177
    • Tsai, L.-H.1    Harlow, E.2    Meyerson, M.3
  • 2
    • 0025894942 scopus 로고
    • A new human p34 protein kinase, Cdk2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Egl
    • Elledge, S.J. & Spottswood, R. A new human p34 protein kinase, Cdk2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Egl. EMBO J. 10, 2653-2659 (1991).
    • (1991) EMBO J. , vol.10 , pp. 2653-2659
    • Elledge, S.J.1    Spottswood, R.2
  • 3
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C.J. Cancer cell cycles. Science 274, 1672-1677 (1996).
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 4
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg, A.S. & Weinberg, R.A. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol. Cell. Biol. 18, 753-761 (1998).
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 5
    • 0033783177 scopus 로고    scopus 로고
    • Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators
    • Morris, L., Allen, K.E. & La Thangue, N.B. Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators, Nat. Cell. Biol. 2, 232-239 (2000).
    • (2000) Nat. Cell. Biol. , vol.2 , pp. 232-239
    • Morris, L.1    Allen, K.E.2    La Thangue, N.B.3
  • 6
    • 0035911969 scopus 로고    scopus 로고
    • Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication
    • Furstenthal, L., Kaiser, B.K., Swanson, C. & Jackson, P.K. Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication. J. Cell Biol. 152, 1267-1278 (2001).
    • (2001) J. Cell Biol. , vol.152 , pp. 1267-1278
    • Furstenthal, L.1    Kaiser, B.K.2    Swanson, C.3    Jackson, P.K.4
  • 7
    • 0034665635 scopus 로고    scopus 로고
    • NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription
    • NPAT by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. Genes Dev. 14, 2298-2313 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2298-2313
    • Ma, T.1
  • 8
    • 0034665757 scopus 로고    scopus 로고
    • NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription
    • Zhao, J. et al. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 14, 2283-2297 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 2283-2297
    • Zhao, J.1
  • 9
    • 0034730321 scopus 로고    scopus 로고
    • Nucleophosmin/B23 is a target of Cdk2/Cyclin E in centrosome duplication
    • Okuda, M. et al. Nucleophosmin/B23 is a target of Cdk2/Cyclin E in centrosome duplication. Cell 103, 127-140 (2000).
    • (2000) Cell , vol.103 , pp. 127-140
    • Okuda, M.1
  • 10
    • 0035854383 scopus 로고    scopus 로고
    • The mouse Mps1p-like kinase regulates centrosome duplication
    • Fisk, H.A. & Winey, M. The mouse Mps1p-like kinase regulates centrosome duplication. Cell 106, 95-104 (2001).
    • (2001) Cell , vol.106 , pp. 95-104
    • Fisk, H.A.1    Winey, M.2
  • 11
    • 0030925231 scopus 로고    scopus 로고
    • Cyclin E-CDK2 is a regulator of p27Kip1
    • Sheaff, R. J. et al. Cyclin E-CDK2 is a regulator of p27Kip1. Genes Dev. 11, 1464-1478 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 1464-1478
    • Sheaff, R.J.1
  • 12
    • 0030847760 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27
    • Vlach, J., Hennecke, S. & Amati, B. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27. EMBO J. 16, 5334-5344 (1997).
    • (1997) EMBO J. , vol.16 , pp. 5334-5344
    • Vlach, J.1    Hennecke, S.2    Amati, B.3
  • 13
    • 0034004129 scopus 로고    scopus 로고
    • Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase
    • Zou, L. & Stillman, B. Assembly of a complex containing Cdc45p, replication protein A, and Mcm2p at replication origins controlled by S-phase cyclin-dependent kinases and Cdc7p-Dbf4p kinase. Mol. Cell. Biol. 20, 3086-3096 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3086-3096
    • Zou, L.1    Stillman, B.2
  • 14
    • 0035812709 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
    • Koepp, D.M. et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 294, 173-177 (2001).
    • (2001) Science , vol.294 , pp. 173-177
    • Koepp, D.M.1
  • 15
    • 0033556238 scopus 로고    scopus 로고
    • Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its sebcellular localization
    • Petersen, B.O., Lukas, J., Sorensen, C.S., Bartek, J. & Helin, K. Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its sebcellular localization. EMBO J. 2, 396-410 (1999).
    • (1999) EMBO J. , vol.2 , pp. 396-410
    • Petersen, B.O.1    Lukas, J.2    Sorensen, C.S.3    Bartek, J.4    Helin, K.5
  • 16
    • 0001616078 scopus 로고    scopus 로고
    • A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-cdk2 during cell cycle progression
    • Sorensen, C.S. et al. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-cdk2 during cell cycle progression. Mol. Cell. Biol. 21, 3692-3703 (2001)
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3692-3703
    • Sorensen, C.S.1
  • 17
    • 0033145516 scopus 로고    scopus 로고
    • Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A
    • Meraldi, P., Lukas, J., Fry, A.M., Bartek, J. & Nigg, E.A. Centrosome duplication in mammalian somatic cells requires E2F and Cdk2-cyclin A. Nat. Cell Biol. 1, 88-93 (1999).
    • (1999) Nat. Cell Biol. , vol.1 , pp. 88-93
    • Meraldi, P.1    Lukas, J.2    Fry, A.M.3    Bartek, J.4    Nigg, E.A.5
  • 18
    • 0026583746 scopus 로고
    • Cyclin A is required at two points in the human cell cycle
    • Pagano, M., Pepperkok, R., Verde, F., Ansorge, W. & Draetta, G. Cyclin A is required at two points in the human cell cycle. EMBO J. 11, 961-971 (1992)
    • (1992) EMBO J. , vol.11 , pp. 961-971
    • Pagano, M.1    Pepperkok, R.2    Verde, F.3    Ansorge, W.4    Draetta, G.5
  • 19
    • 0027298902 scopus 로고
    • The cdk2 kinase is required for the G1-to-S transition in mammalian cells
    • Tsai, L.H., Lees, E., Faha, B., Harlow, E. & Riabowol, K. The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene 8, 1593-1602 (1993).
    • (1993) Oncogene , vol.8 , pp. 1593-1602
    • Tsai, L.H.1    Lees, E.2    Faha, B.3    Harlow, E.4    Riabowol, K.5
  • 20
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • Van den Heuvel, S., & Harlow, E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262, 2050-2054 (1993).
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van den Heuvel, S.1    Harlow, E.2
  • 22
    • 0034745051 scopus 로고    scopus 로고
    • S and G2 phase roles for cdk2 revealed by inducible expression of a dominant-negative mutant in human cells
    • Hu, B., Mitra, J., van den Heuvel, S. & Enders, G.H. S and G2 phase roles for cdk2 revealed by inducible expression of a dominant-negative mutant in human cells. Mol. Cell. Biol. 21, 2755-2766 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 2755-2766
    • Hu, B.1    Mitra, J.2    Van den Heuvel, S.3    Enders, G.H.4
  • 23
    • 0041327168 scopus 로고    scopus 로고
    • Proliferation of cancer cells despite CDK2 inhibition
    • Tetsu, O. & McCormick, F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 3, 233-245 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 233-245
    • Tetsu, O.1    McCormick, F.2
  • 24
    • 0029566108 scopus 로고
    • A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
    • Schwenk, F., Baron, U. & Ralewsky, K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 23, 5080-5081 (1995).
    • (1995) Nucleic Acids Res. , vol.23 , pp. 5080-5081
    • Schwenk, F.1    Baron, U.2    Ralewsky, K.3
  • 25
    • 0030918714 scopus 로고    scopus 로고
    • Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases
    • Zarkowska, T. & Mittnacht, S. Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J. Biol. Chem. 272, 12738-12746 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 12738-12746
    • Zarkowska, T.1    Mittnacht, S.2
  • 26
    • 0034906982 scopus 로고    scopus 로고
    • Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I
    • Prieto, I. et al. Mammalian STAG3 is a cohesin specific to sister chromatid arms in meiosis I. Nat. Cell Biol. 3, 761-766 (2001).
    • (2001) Nat. Cell Biol. , vol.3 , pp. 761-766
    • Prieto, I.1
  • 27
    • 0027958447 scopus 로고
    • The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes
    • Lammers, J.H. et al. The gene encoding a major component of the lateral elements of synaptonemal complexes of the rat is related to X-linked lymphocyte-regulated genes. Mol. Cell. Biol. 14, 1137-1146 (1994).
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1137-1146
    • Lammers, J.H.1
  • 28
    • 0027091588 scopus 로고
    • A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes
    • Meuwissen, R.L. et al. A coiled-coil related protein specific for synapsed regions of meiotic prophase chromosomes. EMBO J. 11, 5091-5100 (1992).
    • (1992) EMBO J. , vol.11 , pp. 5091-5100
    • Meuwissen, R.L.1
  • 29
    • 0030061451 scopus 로고    scopus 로고
    • Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity
    • Guadagno, T.M. & Newport, J.W. Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. Cell 84, 73-82 (1996).
    • (1996) Cell , vol.84 , pp. 73-82
    • Guadagno, T.M.1    Newport, J.W.2
  • 30
    • 0031771752 scopus 로고    scopus 로고
    • Cyclin A1 is required for meiosis in the male mouse
    • Liu, D. et al, Cyclin A1 is required for meiosis in the male mouse. Nat. Genet 20, 377-380 (1998).
    • (1998) Nat. Genet. , vol.20 , pp. 377-380
    • Liu, D.1
  • 31
    • 0031030730 scopus 로고    scopus 로고
    • Delayed early embryonic lethality following disruption of the murine cyclin A2 gene
    • Murphy, M. et al. Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat. Genet. 15, 83-86 (1997).
    • (1997) Nat. Genet. , vol.15 , pp. 83-86
    • Murphy, M.1
  • 32
    • 0041308632 scopus 로고    scopus 로고
    • Cyclin E function in the mouse
    • in the press
    • Geng, Y. et al Cyclin E function in the mouse. Cell (in the press).
    • Cell
    • Geng, Y.1
  • 33
    • 0141737069 scopus 로고    scopus 로고
    • Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells
    • in the press
    • Parisi, T. et al. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. (in the press).
    • EMBO J.
    • Parisi, T.1
  • 34
    • 0037131309 scopus 로고    scopus 로고
    • The oncogenic activity of Cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein
    • Geisen, C. & Moroy, T. The oncogenic activity of Cyclin E is not confined to Cdk2 activation alone but relies on several other, distinct functions of the protein. J. Biol. Chem. 277, 39909-39918 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 39909-39918
    • Geisen, C.1    Moroy, T.2
  • 35
    • 0034058708 scopus 로고    scopus 로고
    • A screen for modifiers of Cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2
    • Lane, M.E. et al. A screen for modifiers of Cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2. Genetics 155, 233-244 (2000).
    • (2000) Genetics , vol.155 , pp. 233-244
    • Lane, M.E.1
  • 36
    • 0037172662 scopus 로고    scopus 로고
    • The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor
    • Tunquist, B.J., Schwab, M.S., Chen, L.G. & Maller, J.L. The spindle checkpoint kinase bub1 and cyclin e/cdk2 both contribute to the establishment of meiotic metaphase arrest by cytostatic factor. Curr. Biol. 12, 1027-1033 (2002).
    • (2002) Curr. Biol. , vol.12 , pp. 1027-1033
    • Tunquist, B.J.1    Schwab, M.S.2    Chen, L.G.3    Maller, J.L.4
  • 37
    • 0035084060 scopus 로고    scopus 로고
    • Localization of two mammalian cyelin dependent kinases during mammalian meiosis
    • Ashley, T., Walpita, D. & de Rooij, D.G. Localization of two mammalian cyelin dependent kinases during mammalian meiosis. J. Cell Sci. 114, 685-693 (2001).
    • (2001) J. Cell Sci. , vol.114 , pp. 685-693
    • Ashley, T.1    Walpita, D.2    De Rooij, D.G.3
  • 38
    • 0037150670 scopus 로고    scopus 로고
    • Sex matters in meiosis
    • Hunt, P.A. & Hassold, T.J. Sex matters in meiosis. Science 296, 2181-2183 (2002).
    • (2002) Science , vol.296 , pp. 2181-2183
    • Hunt, P.A.1    Hassold, T.J.2
  • 39
    • 0036384175 scopus 로고    scopus 로고
    • Meiotic prophase abnormalities and metaphase cell death in MLH 1-deficient mouse spermatocytes: Insights into regulation of spermatogenic progress
    • Eaker, S., Cobb, J., Pyle, A. & Handel, M.A. Meiotic prophase abnormalities and metaphase cell death in MLH 1-deficient mouse spermatocytes: insights into regulation of spermatogenic progress. Dev. Biol. 249, 85-95 (2002).
    • (2002) Dev. Biol. , vol.249 , pp. 85-95
    • Eaker, S.1    Cobb, J.2    Pyle, A.3    Handel, M.A.4
  • 40
    • 0033634652 scopus 로고    scopus 로고
    • The mouse Spoll gene is required for meiotic chromosome synapsis
    • Romanienko, P.J. & Camerini-Otero, R.D. The mouse Spoll gene is required for meiotic chromosome synapsis. Mol Cell 6, 975-987 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 975-987
    • Romanienko, P.J.1    Camerini-Otero, R.D.2
  • 41
    • 0032039077 scopus 로고    scopus 로고
    • Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmcl, a germline-specific RecA homolog
    • Pittman, D.L. et al. Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmcl, a germline-specific RecA homolog. Mol. Cell 1, 697-705 (1998).
    • (1998) Mol. Cell , vol.1 , pp. 697-705
    • Pittman, D.L.1
  • 42
    • 0034192849 scopus 로고    scopus 로고
    • MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
    • Kneitz, B. et al. MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. Genes Dev. 14, 1085-1097 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1085-1097
    • Kneitz, B.1
  • 43
    • 0033105760 scopus 로고    scopus 로고
    • Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis
    • de Vries, S.S. et al. Mouse MutS-like protein Msh5 is required for proper chromosome synapsis in male and female meiosis. Genes Dev. 13, 523-531 (1999).
    • (1999) Genes Dev. , vol.13 , pp. 523-531
    • De Vries, S.S.1
  • 44
    • 0033975302 scopus 로고    scopus 로고
    • The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility
    • Yuan, L. et al. The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. Mol. Cell 5, 73-83 (2000).
    • (2000) Mol. Cell , vol.5 , pp. 73-83
    • Yuan, L.1
  • 45
    • 0029781869 scopus 로고    scopus 로고
    • Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing
    • Scherthan, H. et al. Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing. J. Cell Biol. 134, 1109-1125 (1996).
    • (1996) J. Cell Biol. , vol.134 , pp. 1109-1125
    • Scherthan, H.1
  • 46
    • 0035754080 scopus 로고    scopus 로고
    • To cycle or not to cycle a critical decision in cancer
    • Malumbres, M. & Barbacid, M. To cycle or not to cycle a critical decision in cancer. Nat. Rev. Cancer 1, 222-231 (2001).
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 222-231
    • Malumbres, M.1    Barbacid, M.2
  • 47
    • 0031675550 scopus 로고    scopus 로고
    • Drosophila engrailed car substitute for mouse Engrailedl function in mid-hindbrain, but not limb development
    • Hanks, M.C. et al. Drosophila engrailed car substitute for mouse Engrailedl function in mid-hindbrain, but not limb development. Development 125, 4521-4530 (1998).
    • (1998) Development , vol.125 , pp. 4521-4530
    • Hanks, M.C.1
  • 48
    • 0025780879 scopus 로고
    • Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
    • Tybulewicz, V.L., Crawford, C.E., Jackson, P.K., Bronson, R.T. & Mulligan, R.C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65, 1153-1163 (1991).
    • (1991) Cell , vol.65 , pp. 1153-1163
    • Tybulewicz, V.L.1    Crawford, C.E.2    Jackson, P.K.3    Bronson, R.T.4    Mulligan, R.C.5
  • 49
    • 0027321548 scopus 로고
    • Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
    • Nagy, A., Rossant, J., Nagy, R., Abromow-Newerly, W. & Roder, J.C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90, 8424-8428 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abromow-Newerly, W.4    Roder, J.C.5
  • 50
    • 0035803395 scopus 로고    scopus 로고
    • Wide spectrum of tumors in knock-in mice carrying a Cdk 4 protein insensitive to INK4 inhibitors
    • Sotillo, R. et al. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. EMBO J. 20, 6637-6647 (2001).
    • (2001) EMBO J. , vol.20 , pp. 6637-6647
    • Sotillo, R.1
  • 51
    • 0034600841 scopus 로고    scopus 로고
    • Limited overlapping roles of P15(INK4b) and P18 (INK4c) cell cycle inhibitors in proliferation and tumorigenesis
    • Latres, E. et al. Limited overlapping roles of P15(INK4b) and P18 (INK4c) cell cycle inhibitors in proliferation and tumorigenesis. EMBO J. 19, 3496-3506 (2000).
    • (2000) EMBO J. , vol.19 , pp. 3496-3506
    • Latres, E.1


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