The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore

Journal of Pharmacology and Experimental Therapeutics

Volumn 303, Issue 2, 2002, Pages 858-866

  Stevenson, Christopher S ^a,b,c,d   Capper, Elizabeth A ^a   Roshak, Amy K ^a,b   Marquez, Brian ^a,b   Eichman, Chris ^a,c   Jackson, Jeffrey R ^a   Mattern, Michael ^a,b   Gerwick, William H ^d   Jacobs, Robert S ^b   Marshall, Lisa A ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Respiratory Inflammation and Respiratory Pathogens ^*  (United States)

^c GLAXOSMITHKLINE   (United States)

^d OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN B; CYCLIN DEPENDENT KINASE 1; ENDOTHELIAL CELL GROWTH FACTOR; GLUTATHIONE TRANSFERASE; NATURAL PRODUCT; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SCYTONEMIN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYANOBACTERIUM; DOSE TIME EFFECT RELATION; DRUG ISOLATION; ENZYME ACTIVITY; FIBROBLAST CULTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; LEUKEMIA CELL LINE; MARINE ENVIRONMENT; PHARMACOPHORE; PRIORITY JOURNAL; T LYMPHOCYTE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIN B; ENZYME INHIBITORS; GLUTATHIONE TRANSFERASE; HUMANS; INDOLES; JURKAT CELLS; KINETICS; PHENOLS; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS;

EID: 0036827627     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.036350     Document Type: Article

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