Phosphorylation of the mitotic regulator protein Hec1 by Nek2 kinase is essential for faithful chromosome segregation

Journal of Biological Chemistry

Volumn 277, Issue 51, 2002, Pages 49408-49416

  Chen, Yumay ^a   Riley, Daniel J ^a   Zheng, Lei ^a   Chen, Phang Lang ^a   Lee, Wen Hwa ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; GENETIC ENGINEERING; GROWTH KINETICS; PROTEINS; YEAST;

PHOSPHORYLATION;

BIOCHEMISTRY;

ALANINE; AMINO ACID; GLUTAMINE; NEK2 KINASE; PHOSPHOTRANSFERASE; PROTEIN HEC1; REGULATOR PROTEIN; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CELL CYCLE G2 PHASE; CELL GROWTH; CELL LINE; CHROMOSOME SEGREGATION; ERROR; GENE MUTATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LETHALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TEMPERATURE SENSITIVITY; YEAST CELL;

ALANINE; AMINO ACID SEQUENCE; AMINO ACIDS; BLOTTING, WESTERN; CELL CYCLE; CHROMOSOME SEGREGATION; DNA, COMPLEMENTARY; ESCHERICHIA COLI; G2 PHASE; GENOTYPE; GLUTATHIONE TRANSFERASE; HUMANS; MITOSIS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SERINE; TEMPERATURE; TIME FACTORS; TUMOR CELLS, CULTURED;

ASPERGILLUS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0347579850     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207069200     Document Type: Article

References (37)

1. Chen, Y., Riley, D. J., Chen, P.-L., and Lee, W.-H. (1997) Mol. Cell. Biol. 17, 6049-6056
2. Zheng, L., Chen, Y., Riley, D. J., Chen, P.-L., and Lee, W.-H. (2000) Mol. Cell. Biol. 20, 3529-3537
3. Zheng, L., Chen, Y., and Lee, W.-H. (1999) Mol. Cell. Biol. 19, 5417-5428
4. Hyland, K. M., Kingsbury, J., Koshland, D., and Hieter, P. (1999) J. Cell Biol. 145, 15-28
5. Chen, Y., Sharp, Z. D., and Lee, W.-H. (1997) J. Biol. Chem. 272, 24081-24087
6. Wigge, P. A., Jensen, O. N., Holmes, S., Soues, S., Mann, M., and Kilmartin, J. V. (1998) J. Cell Biol. 141, 967-977
7. Osmani, S. A., Pu, R. T., and Morris, N. R. (1988) Cell 53, 237-244
8. Osmani, S. A., Engle, D. B., Doonan, J. H., and Morris, N. R. (1988) Cell 52, 241-251
9. Osmani, S. A., May, G. S., and Morris, N. R. (1987) J. Cell Biol. 104, 1495-1504
10. Oakley, B. R., and Morris, N. R. (1983) J. Cell Biol. 96, 1155-1158
11. Chen, A., Yanai, A., Arama, E., Kilfin, G., and Motro, B. (1999) Gene (Amst.) 234, 127-137
12. Holland, P. M., Milne, A., Garka, K., Johnson, R. S., Willis, C., Sims, J. E., Rauch, C. T., Bird, T. A., and Virca, G. D. (2002) J. Biol. Chem. 277, 16229-16240
13. Kandli, M., Feige, E., Chen, A., Kilfin, G., and Motro, B. (2000) Genomics 68, 187-196
14. Letwin, K., Mizzen, L., Motro, B., Ben-David, Y., Bernstein, A., and Pawson, T. (1992) EMBO J. 11, 3521-3531
15. Li, M. Z., Yu, L., Liu, Q., Chu, J. Y., and Zhao, S. Y. (1999) Cytogenet. Cell Genet. 87, 271-272
16. Lu, K. P., and Hunter, T. (1995) Cell 81, 413-424
17. Schultz, S. J., Fry, A. M., Sutterlin, C., Ried, T., and Nigg, E. A. (1994) Cell Growth Differ. 5, 625-635
18. Tanaka, K., and Nigg, E, A. (1999) J. Biol. Chem. 274, 13491-13497
19. Schultz, S. J., and Nigg, E. A. (1993) Cell Growth Differ. 4, 821-830
20. Fry, A. M., Schultz, S. J., Bartek, J., and Nigg, E. A. (1995) J. Biol. Chem. 270, 12899-12905
21. Fry, A. M., Meraldi, P., and Nigg, E. A. (1998) EMBO J. 17, 470-481
22. Kim, Y. H. (2001) J. Arthroplasty 16, 730-739
23. Barton, A. B., Davies, C. J., Hutchison, C. A. D., and Kaback, D. B. (1992) Gene (Amst.) 117, 137-140
24. Jones, D. G., and Rosamond, J. (1990) Gene (Amst.) 90, 87-92
25. Schweitzer, B., and Philippsen, P. (1992) Mol. Gen. Genet. 234, 164-167
26. Chen, Y., Farmer, A. A., Chen, C.-F., Jones, D. C., Chen, P.-L., and Lee, W.-H. (1996) Cancer Res. 56, 3168-3172
27. Chen, P.-L., Scully, P., Shew, J.-Y., Wang, J. Y., and Lee, W.-H. (1989) Cell 58, 1193-1198
28. Koshland, D., and Hieter, P. (1987) Methods Enzymol. 155, 351-372
29. Studier, F. W., and Moffatt, B. A. (1986) J. Mol. Biol. 189, 113-130
30. Smith, G. E., Summers, M. D., and Fraser, M. J. (1983) Mol. Cell. Biol. 3, 2156-2165
31. Boyle, W. J., Van Der Geer, P., and Hunter, T. (1991) Methods Enzymol. 201, 110-152
32. Songyang, Z., Lu, K. P., Kwon, Y. T., Tsai, L. H., Filhol, O., Cochet, C., Brickey, D. A., Soderling, T. R., Bartleson, C., Graves, D. J., DeMaggio, A. J., Hoekstra, M. F., Blenis, J., Hunter, T., and Cantley, L. C. (1996) Mol. Cell. Biol. 16, 6486-6493
33. Fry, A. M., Mayor, T., Meraldi, P., Stierhof, Y. D., Tanaka, K., and Nigg, E. A. (1998) J. Cell Biol. 141, 1563-1574
34. Shirayama, M., Zachariae, W., Ciosk, R., and Nasmyth, K. (1998) EMBO J. 17, 1336-1349
35. Charles, J. F., Jaspersen, S. L., Tinker-Kulberg, R. L., Hwang, L., Szidon, A., and Morgan, D. O. (1998) Curr. Biol. 8, 497-507
36. Cheng, L., Hunke, L., and Hardy, C. F. J. (1998) Mol. Cell. Biol. 18, 7360-7370
37. Kunkel, T. A. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 488-492