Sensitization of cancer cells to DNA damage-induced cell death by specific cell cycle G2 checkpoint abrogation

Cancer Research

Volumn 59, Issue 23, 1999, Pages 5887-5891

  Suganuma, Masashi ^a,b   Kawabe, Takumi ^a   Hori, Haruna ^a   Funabiki, Takahiko ^b   Okamoto, Takashi ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE;

ARTICLE; CANCER CELL; CANCER THERAPY; CELL CYCLE G2 PHASE; CELL CYCLE PHASE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SENSITIZATION;

AMINO ACID SEQUENCE; CDC25 PHOSPHATASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL SURVIVAL; DNA DAMAGE; G2 PHASE; GENE PRODUCTS, TAT; HIV-1; HUMANS; JURKAT CELLS; PEPTIDE FRAGMENTS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS;

EID: 0033406451     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
2. Kawabe, T., Muslin, A. J., and Korsmeyer, S. J. HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. Nature (Lond.), 385: 454-458, 1997.
3. Hartwell, L. H., and Kastan, M. B. Cell cycle control and cancer. Science (Washington DC), 266: 1821-1828, 1994.
4. Yao, S. L., Akhtar, A. J., McKenna, K. A., Bedi, G. C., Sidransky, D., Mabry, M., Ravi, R., Collector, M. I., Jones, R. J., Sharkis, S. J., Fuchs, E. J., and Bedi, A. Selective radiosensitization of p53-deficient cells by caffeine-mediated activation of p34cdc2 kinase. Nat. Med., 2: 1140-1143, 1996.
5. Wang, Q., Fan, S., Eastman, A., Worland, P. J., Sausville, E. A., and O'Connor, P. M. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J. Natl. Cancer. Inst., 88: 956-965, 1996.
6. Traganos, F., Kapuscinski, J., Gong, J., Ardelt, B., Darzynkiewicz, R. J., and Darzynkiewicz, Z. Caffeine prevents apoptosis and cell cycle effects induced by camptothecin or topotecan in HL-60 cells. Cancer Res., 53: 4613-4618, 1993.
7. Timsori, J. Caffeine. Mutat. Res., 47, 1-52, 1977.
8. Enoch, T., and Nurse, P. Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication. Cell, 60: 665-673, 1990.
9. Dunphy, W. G., and Kumagai, A. The cdc25 protein contains an intrinsic phosphatase activity. Cell, 67: 189-196, 1991.
10. Walworth, N., Davey, S., and Beach, D. Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2. Nature (Lond.), 363: 368-371, 1993.
11. Walworth, N. C., Bernards, R. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science (Washington DC), 271: 353-356, 1996.
12. Paulovich, A. G., and Hartwell, L. H. A checkpoint regulates the rate of progression through S phase in S. cerivisiae in response to DNA damage. Cell, 82: 841-847, 1995.
13. Boddy, M. N., Furnar, B., Mondesert, O., and Russell, P. Replication checkpoint enforced by kinases Cds1 and Chk1. Science (Washington DC), 280: 909-912, 1998.
14. Fumari, B., Rhind, N., and Russell, P. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science (Washington DC), 277: 1495-1497, 1997.
15. Zeng, Y., Forbes, K. C., Wu, Z., Moreno. S., Piwnica-Worms, H., and Enoch, T. Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1. Nature (Lond.), 395: 507-510, 1998.
16. Lopez-Girona, A., Furnari, B., Mondesert, O., and Russell, P. Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein. Nature (Lond.), 597: 172-175, 1999.
17. Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., and Elledge, S. J. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science (Washington DC), 277: 1497-1501, 1997.
18. Kaneko, Y., Watanabe, N., Morisaki, H., Akita, H., Fujimoto, A., Tominaga, K., Terasawa, M., Tachibana, A., Ikeda, K., and Nakanishi, M. Cell cycle-dependent and ATM-independent expression of human Chk1 kinase. Oncogene, 18: 3673-3681, 1999.
19. Matsuoka, S., Huang, M., and Elledge, S. J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science (Washington DC), 282: 1893-1897, 1998.
20. Peng, C. Y., Graves, P. R., Thoma, R. S., Wu. Z., Shaw, A. S., and Piwnica-Worms, H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science (Washington DC), 277: 1501-1505, 1997.
21. Peng, C. Y., Graves, P. R., Ogg, S., Thoma, R. S., Byrnes, M. J., Wu, Z., Stephenson, M. T., and Piwnica-Worms, H. C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding. Cell Growth Differ., 9: 197-208, 1998.
22. Ono, T., Kawabe, T., Sonta, S., and Okamoto, T. Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. Cytogenet. Cell Genet., 79: 101-102, 1997.
23. r 78,000 marker in chemically induced transplantable carcinomas and primary carcinoma of human pancreas. Cancer Res., 48: 2265-2272, 1988.
24. Nagahara, H., Vocero-Akbani, A. M., Snyder, E. L., Ho, A., Latham, D. G., Lissy, N. A., Becker-Hapak, M., Ezhevsky, S. A., and Dowdy, S. F. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration. Nat. Med., 4: 1449-1452, 1998.
25. Scudiero, D. A., Shoemaker, R. H., Paull, K. D., Monks, A., Tierney, S., Nofziger, T. H., Currens, M. J., Seniff, D., and Boyd, M. R. Evaluation of a soluble tetrazolium/ formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res., 48: 4827-4833, 1988.