A pan-specific inhibitor of the polo-box domains of polo-like kinases arrests cancer cells in mitosis

ChemBioChem

Volumn 10, Issue 7, 2009, Pages 1145-1148

  Reindl, Wolfgang ^a   Yuan, Juping ^b   Krämer, Andrea ^b   Strebhardt, Klaus ^b   Berg, Thorsten ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

Enzymes; Inhibitors; Mitosis; Polo like kinases; Protein protein interactions

Indexed keywords

PHOSPHOTRANSFERASE INHIBITOR; POLO LIKE KINASE INHIBITOR; POLOXIPAN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; FUSED HETEROCYCLIC RINGS; ONCOPROTEIN; POLO LIKE KINASE 1; POLO-LIKE KINASE 1; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE;

ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; DRUG SPECIFICITY; ENZYME INHIBITION; FLUORESCENCE POLARIZATION; HELA CELL; HUMAN; HUMAN CELL; IC 50; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; CENTROSOME; CHEMISTRY; DRUG ANTAGONISM; MITOSIS; MOLECULAR LIBRARY; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CENTROSOME; HELA CELLS; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; MITOSIS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 67650472492     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900059     Document Type: Article

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