-
1
-
-
0037073737
-
Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation
-
Ahn J, Prives C. 2002. Checkpoint kinase 2 (Chk2) monomers or dimers phosphorylate Cdc25C after DNA damage regardless of threonine 68 phosphorylation. J Biol Chem 277:48418-48426.
-
(2002)
J Biol Chem
, vol.277
, pp. 48418-48426
-
-
Ahn, J.1
Prives, C.2
-
2
-
-
0034326802
-
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
-
Ahn JY, Schwarz JK, Piwnica-Worms H, Canman CE. 2000. Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res 60:5934-5936.
-
(2000)
Cancer Res
, vol.60
, pp. 5934-5936
-
-
Ahn, J.Y.1
Schwarz, J.K.2
Piwnica-Worms, H.3
Canman, C.E.4
-
3
-
-
0037205422
-
Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain
-
Ahn JY, Li X, Davis HL, Canman CE. 2002. Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain. J Biol Chem 277:19389-19395.
-
(2002)
J Biol Chem
, vol.277
, pp. 19389-19395
-
-
Ahn, J.Y.1
Li, X.2
Davis, H.L.3
Canman, C.E.4
-
4
-
-
11144265895
-
Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway
-
Araya R, Hirai I, Meyerkord CL, Wang HG. 2005. Loss of RPA1 induces Chk2 phosphorylation through a caffeine-sensitive pathway. FEBS Lett 579:157-161.
-
(2005)
FEBS Lett
, vol.579
, pp. 157-161
-
-
Araya, R.1
Hirai, I.2
Meyerkord, C.L.3
Wang, H.G.4
-
5
-
-
0038418869
-
Chk1 and Chk2 kinases in checkpoint control and cancer
-
Bartek J, Lukas J. 2003. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3:421-429.
-
(2003)
Cancer Cell
, vol.3
, pp. 421-429
-
-
Bartek, J.1
Lukas, J.2
-
6
-
-
17244367849
-
DNA damage response as a candidate anticancer barrier in early human tumorigenesis
-
Bartkova J, Horejsi Z, Koed K, Kramer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J. 2005. DNA damage response as a candidate anticancer barrier in early human tumorigenesis. Nature 434:864-870.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
Kramer, A.4
Tort, F.5
Zieger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
Orntoft, T.11
Lukas, J.12
Bartek, J.13
-
7
-
-
0033601346
-
Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
-
Bell DW, Varley JM, Szydlo TE, Kang DH, Wahrer DC, Shannon KE, Lubratovich M, Verselis SJ, Isselbacher KJ, Fraumeni JF, Birch JM, Li FP, Garber JE, Haber DA. 1999. Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome. Science 286:2528-25231.
-
(1999)
Science
, vol.286
, pp. 2528-25231
-
-
Bell, D.W.1
Varley, J.M.2
Szydlo, T.E.3
Kang, D.H.4
Wahrer, D.C.5
Shannon, K.E.6
Lubratovich, M.7
Verselis, S.J.8
Isselbacher, K.J.9
Fraumeni, J.F.10
Birch, J.M.11
Li, F.P.12
Garber, J.E.13
Haber, D.A.14
-
9
-
-
0034142325
-
Chk2/ hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
-
Chehab NH, Malikzay A, Appel M, Halazonetis TD. 2000. Chk2/ hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 14:278-288.
-
(2000)
Genes Dev
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
10
-
-
8844220451
-
CHEK2 is a multiorgan cancer susceptibility gene
-
Cybulski C, Gorski B, Huzarski T, Masojc B, Mierzejewski M, Debinak T, Teodorczyk U, Byrski T, Gronwald J, Matyjasik J, Zlowocka E, Lenner M, Grabowska E, Nej K, Castaneda J, Medrek K, Szymanska A, Szymanska J, Kurzawski G, Suchy J, Oszurek O, Witek A, Narod SA, Lubinski J. 2004. CHEK2 is a multiorgan cancer susceptibility gene. Am J Hum Genet 75:1131-1135.
-
(2004)
Am J Hum Genet
, vol.75
, pp. 1131-1135
-
-
Cybulski, C.1
Gorski, B.2
Huzarski, T.3
Masojc, B.4
Mierzejewski, M.5
Debinak, T.6
Teodorczyk, U.7
Byrski, T.8
Gronwald, J.9
Matyjasik, J.10
Zlowocka, E.11
Lenner, M.12
Grabowska, E.13
Nej, K.14
Castaneda, J.15
Medrek, K.16
Szymanska, A.17
Szymanska, J.18
Kurzawski, G.19
Suchy, J.20
Oszurek, O.21
Witek, A.22
Narod, S.A.23
Lubinski, J.24
more..
-
11
-
-
0037224465
-
Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array
-
Dong, Y, Zhang H, Hawthorn L, Ganther HE, Ip C. 2003. Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array. Cancer Res 63:52-59.
-
(2003)
Cancer Res
, vol.63
, pp. 52-59
-
-
Dong, Y.1
Zhang, H.2
Hawthorn, L.3
Ganther, H.E.4
Ip, C.5
-
12
-
-
0033638454
-
The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms
-
Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. 2000. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell 6:1169-1182.
-
(2000)
Mol Cell
, vol.6
, pp. 1169-1182
-
-
Durocher, D.1
Taylor, I.A.2
Sarbassova, D.3
Haire, L.F.4
Westcott, S.L.5
Jackson, S.P.6
Smerdon, S.J.7
Yaffe, M.B.8
-
13
-
-
0035817764
-
Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway
-
Falck J, Lukas C, Protopopova M, Lukas J, Selivanova G, Bartek J. 2001a. Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathway. Oncogene 20:5503-5510.
-
(2001)
Oncogene
, vol.20
, pp. 5503-5510
-
-
Falck, J.1
Lukas, C.2
Protopopova, M.3
Lukas, J.4
Selivanova, G.5
Bartek, J.6
-
14
-
-
0035848819
-
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. 2001b. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 410:842-847.
-
(2001)
Nature
, vol.410
, pp. 842-847
-
-
Falck, J.1
Mailand, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
15
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis VG, Vassiliou LV, Karakaidos P, Zacharatos P, Kotsinas A, Liloglou T, Venere M, Ditullio RA Jr, Kastrinakis NG, Levy B, Kletsas D, Yoneta A, Herlyn M, Kittas C, Halazonetis TD. 2005. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434:907-913.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
Ditullio Jr., R.A.8
Kastrinakis, N.G.9
Levy, B.10
Kletsas, D.11
Yoneta, A.12
Herlyn, M.13
Kittas, C.14
Halazonetis, T.D.15
-
16
-
-
0035126617
-
Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias
-
Hofmann WK, Miller CW, Tsukasaki K, Tavor S, Ikezoe T, Hoelzer D, Takeuchi S, Koeffler HP. 2001. Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias. Leuk Res 25:333-338.
-
(2001)
Leuk Res
, vol.25
, pp. 333-338
-
-
Hofmann, W.K.1
Miller, C.W.2
Tsukasaki, K.3
Tavor, S.4
Ikezoe, T.5
Hoelzer, D.6
Takeuchi, S.7
Koeffler, H.P.8
-
17
-
-
0034624718
-
Cds1-mediated phosphorylation of BRCA1 regulates the DNA damage response
-
Lee JS, Collins KM, Brown AL, Lee CH, Chung JH. 2000. hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Nature 404:201-204.
-
(2000)
Nature
, vol.404
, pp. 201-204
-
-
Lee, J.S.1
Collins, K.M.2
Brown, A.L.3
Ch, L.4
Chung, J.H.5
-
18
-
-
0035890407
-
Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome
-
Lee SB, Kim SH, Bell DW, Wahrer DC, Schiripo TA, Jorczak MM, Sgroi DC, Garber JE, Li FP, Nichols KE, Varley JM, Godwin AK, Shannon KM, Harlow E, Haber DA. 2001. Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome. Cancer Res 61:8062-8067.
-
(2001)
Cancer Res
, vol.61
, pp. 8062-8067
-
-
Lee, S.B.1
Kim, S.H.2
Bell, D.W.3
Wahrer, D.C.4
Schiripo, T.A.5
Jorczak, M.M.6
Sgroi, D.C.7
Garber, J.E.8
Li, F.P.9
Nichols, K.E.10
Varley, J.M.11
Godwin, A.K.12
Shannon, K.M.13
Harlow, E.14
Haber, D.A.15
-
19
-
-
0036285705
-
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2
-
Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ. 2002. Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell 9:1045-1054.
-
(2002)
Mol Cell
, vol.9
, pp. 1045-1054
-
-
Li, J.1
Williams, B.L.2
Haire, L.F.3
Goldberg, M.4
Wilker, E.5
Durocher, D.6
Yaffe, M.B.7
Jackson, S.P.8
Smerdon, S.J.9
-
20
-
-
15744386741
-
Regulation of Chk2 by DNA-dependent protein kinase
-
Li J, Stern DF. 2005. Regulation of Chk2 by DNA-dependent protein kinase. J Biol Chem 280:12041-12050.
-
(2005)
J Biol Chem
, vol.280
, pp. 12041-12050
-
-
Li, J.1
Stern, D.F.2
-
21
-
-
0034641724
-
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
-
Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ. 2000. Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci USA 97:10389-10394.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10389-10394
-
-
Matsuoka, S.1
Rotman, G.2
Ogawa, A.3
Shiloh, Y.4
Tamai, K.5
Elledge, S.J.6
-
22
-
-
0035878816
-
Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer
-
Matsuoka S, Nakagawa T, Masuda A, Haruki N, Elledge SJ, Takahashi T. 2001. Reduced expression and impaired kinase activity of a Chk2 mutant identified in human lung cancer. Cancer Res 61:5362-5365.
-
(2001)
Cancer Res
, vol.61
, pp. 5362-5365
-
-
Matsuoka, S.1
Nakagawa, T.2
Masuda, A.3
Haruki, N.4
Elledge, S.J.5
Takahashi, T.6
-
23
-
-
16344381702
-
p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation
-
Ou YH, Chung PH, Sun TP, Shieh SY. 2005. p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation. Mol Biol Cell 16:1684-1695.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 1684-1695
-
-
Ou, Y.H.1
Chung, P.H.2
Sun, T.P.3
Shieh, S.Y.4
-
24
-
-
0037795780
-
Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation
-
Schwarz JK, Lovly CM, Piwnica-Worms H. 2003. Regulation of the Chk2 protein kinase by oligomerization-mediated cis- and trans-phosphorylation. Mol Cancer Res 1:598-609.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 598-609
-
-
Schwarz, J.K.1
Lovly, C.M.2
Piwnica-Worms, H.3
-
26
-
-
0032504069
-
Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
-
Sun Z, Hsiao J, Fay DS, Stern DF. 1998. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 281:272-274.
-
(1998)
Science
, vol.281
, pp. 272-274
-
-
Sun, Z.1
Hsiao, J.2
Fay, D.S.3
Stern, D.F.4
-
27
-
-
0034909673
-
Analysis of the CHK2 gene in lymphoid malignancies
-
Tavor S, Takeuchi S, Tsukasaki K, Miller CW, Hofmann WK, Ikezoe T, Said JW, Koeffler HP. 2001. Analysis of the CHK2 gene in lymphoid malignancies. Leuk Lymphoma 42:517-520.
-
(2001)
Leuk Lymphoma
, vol.42
, pp. 517-520
-
-
Tavor, S.1
Takeuchi, S.2
Tsukasaki, K.3
Miller, C.W.4
Hofmann, W.K.5
Ikezoe, T.6
Said, J.W.7
Koeffler, H.P.8
-
28
-
-
0033615647
-
Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53
-
Tominaga K, Morisaki H, Kaneko Y, Fujimoto A, Tanaka T, Ohtsubo M, Hirai M, Okayama H, Ikeda K, Nakanishi M. 1999. Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. J Biol Chem 274:31463-31467.
-
(1999)
J Biol Chem
, vol.274
, pp. 31463-31467
-
-
Tominaga, K.1
Morisaki, H.2
Kaneko, Y.3
Fujimoto, A.4
Tanaka, T.5
Ohtsubo, M.6
Hirai, M.7
Okayama, H.8
Ikeda, K.9
Nakanishi, M.10
-
29
-
-
10644270921
-
p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2
-
Urist M, Tanaka T, Poyurovsky MV, Prives C. 2004. p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev 18:3041-3054.
-
(2004)
Genes Dev
, vol.18
, pp. 3041-3054
-
-
Urist, M.1
Tanaka, T.2
Poyurovsky, M.V.3
Prives, C.4
-
30
-
-
0035930536
-
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks
-
Ward IM, Wu X, Chen J. 2001. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J Biol Chem 276:47755-57758.
-
(2001)
J Biol Chem
, vol.276
, pp. 47755-57758
-
-
Ward, I.M.1
Wu, X.2
Chen, J.3
-
31
-
-
14844333117
-
TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on Thr68
-
Wei JH, Chou YF, Ou YH, Ye YS, Tyan SW, Sun TP, Shen CY, Shieh SY. 2004. TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on Thr68. J Biol Chem 280:7748-7757.
-
(2004)
J Biol Chem
, vol.280
, pp. 7748-7757
-
-
Wei, J.H.1
Chou, Y.F.2
Ou, Y.H.3
Ye, Y.S.4
Tyan, S.W.5
Sun, T.P.6
Shen, C.Y.7
Shieh, S.Y.8
-
32
-
-
0347262257
-
Identical short peptide sequences in unrelated proteins can have different conformations: A testing ground for theories of immune recognition
-
Wilson IA, Haft DH, Getzoff ED, Tainer JA, Lerner RA, Brenner S. 1985. Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. Proc Natl Acad Sci USA 82:5255-5259.
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 5255-5259
-
-
Wilson, I.A.1
Haft, D.H.2
Getzoff, E.D.3
Tainer, J.A.4
Lerner, R.A.5
Brenner, S.6
-
33
-
-
0035951809
-
Characterization of tumor-associated Chk2 mutations
-
Wu X, Webster SR, Chen J. 2001. Characterization of tumor-associated Chk2 mutations. J Biol Chem 276:2971-2974.
-
(2001)
J Biol Chem
, vol.276
, pp. 2971-2974
-
-
Wu, X.1
Webster, S.R.2
Chen, J.3
-
34
-
-
0141704306
-
Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis
-
Wu X, Chen J. 2003. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. J Biol Chem 278:36163-36168.
-
(2003)
J Biol Chem
, vol.278
, pp. 36163-36168
-
-
Wu, X.1
Chen, J.2
-
35
-
-
0036258583
-
Chk2 activation and phosphorylation-dependent oligomerization
-
Xu X, Tsvetkov LM, Stern DF. 2002. Chk2 activation and phosphorylation-dependent oligomerization. Mol Cell Biol 22:4419-4432.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4419-4432
-
-
Xu, X.1
Tsvetkov, L.M.2
Stern, D.F.3
-
36
-
-
0036847998
-
PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2
-
Yang S, Kuo C, Bisi JE, Kim MK. 2002. PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat Cell Biol 4:865-870.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 865-870
-
-
Yang, S.1
Kuo, C.2
Bisi, J.E.3
Kim, M.K.4
-
37
-
-
10944257464
-
Human cell senescence as a DNA damage response
-
Zglinicki T, Saretzki G, Ladhoff J, Fagagna F, Jackson SP. 2005. Human cell senescence as a DNA damage response. Mech Ageing Dev 126:111-117.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 111-117
-
-
Zglinicki, T.1
Saretzki, G.2
Ladhoff, J.3
Fagagna, F.4
Jackson, S.P.5
-
38
-
-
0034707047
-
The DNA damage response: Putting checkpoints in perspective
-
Zhou BB, Elledge SJ. 2000. The DNA damage response: putting checkpoints in perspective. Nature 408:433-439.
-
(2000)
Nature
, vol.408
, pp. 433-439
-
-
Zhou, B.B.1
Elledge, S.J.2
|