Cell cycle and biochemical effects of PD 0183812. A potent inhibitor of the cyclin D-dependent kinases CDK4 and CDK6

Journal of Biological Chemistry

Volumn 276, Issue 20, 2001, Pages 16617-16623

  Fry, David W ^a   Bedford, David C ^b   Harvey, Patricia H ^a   Fritsch, Alexandra ^c,d   Keller, Paul R ^a   Wu, Zhipei ^a   Dobrusin, Ellen ^a   Leopold, Wilbur R ^a   Fattaey, Ali ^d   Garrett, Michelle D ^b,d  

^a PFIZER INC   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c Cytokinetics Inc   (United States)

^d ONYX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOLOGICAL MEMBRANES; CELL CULTURE; ENZYME INHIBITION; GENETIC ENGINEERING; ONCOLOGY; TUMORS;

BIOCHEMICAL PATHWAYS; FLOW CYTOMETRY;

BIOCHEMISTRY;

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR; PD 0183812; PYRIDO[2,3 D]PYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG; CDK4 PROTEIN, HUMAN; CDK6 PROTEIN, HUMAN; CYCLIN D; CYCLIN DEPENDENT KINASE; CYCLINE; DNA; ENZYME INHIBITOR; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; PYRIDONE DERIVATIVE; RECOMBINANT PROTEIN; RETINOBLASTOMA PROTEIN;

ARTICLE; CANCER CELL; CELL CULTURE; CELL CYCLE; CELL GROWTH; CHEMICAL STRUCTURE; CYTOLYSIS; ENZYME INHIBITION; FLOW CYTOMETRY; GROWTH INHIBITION; PRIORITY JOURNAL; WESTERN BLOTTING; ANIMAL; ARMYWORM; BIOSYNTHESIS; BREAST TUMOR; CELL CYCLE G1 PHASE; CELL LINE; DNA REPLICATION; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENETIC TRANSFECTION; HUMAN; KINETICS; METABOLISM; PHOSPHORYLATION;

ANIMALS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA REPLICATION; DNA, NEOPLASM; ENZYME INHIBITORS; FEMALE; G1 PHASE; HUMANS; KINETICS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PYRIDONES; PYRIMIDINES; RECOMBINANT PROTEINS; RETINOBLASTOMA PROTEIN; SPODOPTERA; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035907260     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008867200     Document Type: Article

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