Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

EMBO Journal

Volumn 20, Issue 23, 2001, Pages 6637-6647

  Sotillo, Roco ^a,b   Dubus, Pierre ^c   Martn, Javier ^a,b   De La Cueva, Ernesto ^a,b   Ortega, Sagrario ^a,b   Malumbres, Marcos ^a,b   Barbacid, Mariano ^a,b  

^a Hospital Infantil Universitario Niño Jesús   (Spain)

^b CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^c UNIVERSITÉ DE BORDEAUX   (France)

Author keywords

Animal models; Cell cycle regulation; Cyclin dependent kinase; INK4 inhibitors; Tumor development

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 4 INHIBITOR; CYCLIN DEPENDENT KINASE INHIBITOR; MUTANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANGIOSARCOMA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; ENDOCRINE TUMOR; EXON; EXPERIMENTAL MOUSE; FIBROBLAST; GENE LOCUS; GENETIC RECOMBINATION; HOMOZYGOSITY; LATENT PERIOD; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; NONHUMAN; PENETRANCE; POINT MUTATION; PRIORITY JOURNAL;

3T3 CELLS; ALLELES; ANIMALS; BLOTTING, WESTERN; CELL CYCLE; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; EXONS; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENES, RAS; GENETIC PREDISPOSITION TO DISEASE; HOMOZYGOTE; HUMANS; LYMPHOMA; MALE; MELANOMA; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTATION; POINT MUTATION; PRECIPITIN TESTS; PROTEIN BIOSYNTHESIS; PROTO-ONCOGENE PROTEINS; RECOMBINATION, GENETIC; SARCOMA; SEX FACTORS; TERATOMA; TIME FACTORS; TRANSFORMATION, GENETIC; TUMOR SUPPRESSOR PROTEIN P14ARF; TUMOR SUPPRESSOR PROTEINS;

EID: 0035803395     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.23.6637     Document Type: Article

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