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Volumn 59, Issue 17, 1999, Pages 4375-4382

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; DNA DEPENDENT PROTEIN KINASE; RADIOSENSITIZING AGENT;

EID: 0033199892     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (964)

References (53)
  • 1
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine, A. J. p53, the cellular gatekeeper for growth and division. Cell, 88: 323-331, 1997.
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 2
    • 0031717905 scopus 로고    scopus 로고
    • Tumor-suppressor p53: Implications for tumor development and prognosis
    • Kirsch, D. G., and Kastan, M. B. Tumor-suppressor p53: implications for tumor development and prognosis. J. Clin. Oncol., 16: 3158-3168, 1998.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 3158-3168
    • Kirsch, D.G.1    Kastan, M.B.2
  • 3
    • 0032192140 scopus 로고    scopus 로고
    • The complexity of p53 modulation: Emerging patterns from divergent signals
    • Giaccia, A. J., and Kastan, M. B. The complexity of p53 modulation: emerging patterns from divergent signals. Genes Dev., 12: 2973-2983, 1998.
    • (1998) Genes Dev. , vol.12 , pp. 2973-2983
    • Giaccia, A.J.1    Kastan, M.B.2
  • 4
    • 0032475878 scopus 로고    scopus 로고
    • Signaling to p53: Breaking the MDM2-p53 circuit
    • Prives, C. Signaling to p53: breaking the MDM2-p53 circuit. Cell, 95: 5-8, 1998.
    • (1998) Cell , vol.95 , pp. 5-8
    • Prives, C.1
  • 5
    • 0028800996 scopus 로고
    • PIK-related kinases: DNA repair, recombination and cell cycle checkpoints
    • Washington DC
    • Keith, C. T., and Schreiber, S. L. PIK-related kinases: DNA repair, recombination and cell cycle checkpoints. Science (Washington DC), 270: 50-51, 1995.
    • (1995) Science , vol.270 , pp. 50-51
    • Keith, C.T.1    Schreiber, S.L.2
  • 6
    • 0030977349 scopus 로고    scopus 로고
    • Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family
    • Hoekstra, M. F. Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family. Curr. Opin. Genet. Dev., 7: 170-175, 1997.
    • (1997) Curr. Opin. Genet. Dev. , vol.7 , pp. 170-175
    • Hoekstra, M.F.1
  • 7
    • 0030910037 scopus 로고    scopus 로고
    • p53 and ATM: Cell cycle, cell death and cancer
    • Morgan, S. E., and Kastan, M. B. p53 and ATM: cell cycle, cell death and cancer. Found. Cancer Res., 71: 1-25, 1997.
    • (1997) Found. Cancer Res. , vol.71 , pp. 1-25
    • Morgan, S.E.1    Kastan, M.B.2
  • 8
    • 0031663617 scopus 로고    scopus 로고
    • ATM: From gene to function
    • Rotman, G., and Shiloh, Y. ATM: from gene to function. Hum. Mol. Genet., 7: 1555-1563, 1998.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1555-1563
    • Rotman, G.1    Shiloh, Y.2
  • 9
    • 0029899035 scopus 로고    scopus 로고
    • The ATM gene and the radiobiology of ataxia-telangiectasia
    • Jorgensen, T. J., and Shiloh, Y. The ATM gene and the radiobiology of ataxia-telangiectasia. Int. J. Radiat. Biol., 69: 527-537, 1996.
    • (1996) Int. J. Radiat. Biol. , vol.69 , pp. 527-537
    • Jorgensen, T.J.1    Shiloh, Y.2
  • 10
    • 0030933152 scopus 로고    scopus 로고
    • The genetic defect in ataxia-telangiectasia
    • Lavin, M. F., and Shiloh, Y. The genetic defect in ataxia-telangiectasia. Annu. Rev. Immunol., 15: 177-202, 1997.
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 177-202
    • Lavin, M.F.1    Shiloh, Y.2
  • 15
    • 0030867582 scopus 로고    scopus 로고
    • Conservation of the chk1 checkpoint pathway in mammals: Linkage of DNA damage to cdk regulation through Cdc25
    • Washington DC
    • Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwinica-Worms, H., and Elledge, S. J. Conservation of the chk1 checkpoint pathway in mammals: linkage of DNA damage to cdk regulation through Cdc25. Science (Washington DC), 277: 1497-1501, 1997.
    • (1997) Science , vol.277 , pp. 1497-1501
    • Sanchez, Y.1    Wong, C.2    Thoma, R.S.3    Richman, R.4    Wu, Z.5    Piwinica-Worms, H.6    Elledge, S.J.7
  • 16
    • 0030611095 scopus 로고    scopus 로고
    • Mitotic and G2 checkpoint control: Regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216
    • Washington DC
    • Peng, C-Y., Graves, P. R., Thoma, R. S., Wu, Z., Shaw, A. S., and Piwnica-Worms, H. Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science (Washington DC), 277: 1501-1505, 1997.
    • (1997) Science , vol.277 , pp. 1501-1505
    • Peng, C.-Y.1    Graves, P.R.2    Thoma, R.S.3    Wu, Z.4    Shaw, A.S.5    Piwnica-Worms, H.6
  • 17
    • 0030768948 scopus 로고    scopus 로고
    • Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase
    • Washington DC
    • Furnari, B., Rhind, N., and Russell, P. Cdc25 mitotic inducer targeted by Chk1 DNA damage checkpoint kinase. Science (Washington DC), 277: 1495-1497, 1997.
    • (1997) Science , vol.277 , pp. 1495-1497
    • Furnari, B.1    Rhind, N.2    Russell, P.3
  • 18
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to the cell cycle regulation by the Chk2 protein kinase
    • Washington DC
    • Matsuoka, S., Huang, M., and Elledge, S. J. Linkage of ATM to the cell cycle regulation by the Chk2 protein kinase. Science (Washington DC), 282: 1893-1897, 1998.
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 19
    • 0029664616 scopus 로고    scopus 로고
    • rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint
    • Washington DC
    • Walworth, N. C., and Bernards, R. rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science (Washington DC), 271: 353-356, 1996.
    • (1996) Science , vol.271 , pp. 353-356
    • Walworth, N.C.1    Bernards, R.2
  • 20
    • 0030232710 scopus 로고    scopus 로고
    • The p53 gene as a modifier of intrinsic radiosensitivity: Implications for radiotherapy
    • Bristow, R. G., Benchimol, S., and Hill, R. P. The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy. Radiother. Oncol., 40: 197-223, 1996.
    • (1996) Radiother. Oncol. , vol.40 , pp. 197-223
    • Bristow, R.G.1    Benchimol, S.2    Hill, R.P.3
  • 21
    • 0030310066 scopus 로고    scopus 로고
    • DNA damage checkpoints: Implications for cancer therapy
    • O'Connor, P. M., and Fan, S. DNA damage checkpoints: implications for cancer therapy. Progr. Cell Cycle Res., 2: 165-173, 1996.
    • (1996) Progr. Cell Cycle Res. , vol.2 , pp. 165-173
    • O'Connor, P.M.1    Fan, S.2
  • 22
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert, T. A., Kiser, G. L., and Hartwell, L. H. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev., 8: 652-665, 1994.
    • (1994) Genes Dev. , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 27
  • 28
    • 0008158443 scopus 로고
    • Radiosensitivity in ataxia-telangiectasia: A new explanation
    • Painter, R. B., and Young, B. R. Radiosensitivity in ataxia-telangiectasia: a new explanation. Proc. Natl. Acad. Sci. USA, 77: 7315-7317, 1980.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 7315-7317
    • Painter, R.B.1    Young, B.R.2
  • 29
    • 0015116420 scopus 로고
    • The initial effect of X-radiation on thymidine incorporation into DNA in thymus cells
    • Myers, D. K. The initial effect of X-radiation on thymidine incorporation into DNA in thymus cells. Radiat. Res., 47: 731-740, 1971.
    • (1971) Radiat. Res. , pp. 731-740
    • Myers, D.K.1
  • 30
    • 0017701081 scopus 로고
    • The action of caffeine on X-irradiated HeLa cells. I. Delayed inhibition of DNA synthesis
    • Tolmach, L. J., Jones, R. W., and Busse, P. M. The action of caffeine on X-irradiated HeLa cells. I. Delayed inhibition of DNA synthesis. Radiat. Res., 71:653-665, 1977.
    • (1977) Radiat. Res. , vol.71 , pp. 653-665
    • Tolmach, L.J.1    Jones, R.W.2    Busse, P.M.3
  • 31
    • 0027417482 scopus 로고
    • Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events
    • Secrist, J. P., Burns, L. A., Karnitz, L., Koretzky, G. A., and Abraham, R. T. Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events. J. Biol. Chem., 268: 5886-5893, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 5886-5893
    • Secrist, J.P.1    Burns, L.A.2    Karnitz, L.3    Koretzky, G.A.4    Abraham, R.T.5
  • 33
    • 0030667702 scopus 로고    scopus 로고
    • DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
    • Shieh, S-Y., Ikeda, M., Taya, Y., and Prives, C. DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell, 91: 325-334, 1997.
    • (1997) Cell , vol.91 , pp. 325-334
    • Shieh, S.-Y.1    Ikeda, M.2    Taya, Y.3    Prives, C.4
  • 34
    • 0032189483 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
    • Sarkaria, J. N., Tibbetts, R. S., Busby, E. C., Kennedy, A. P., Hill, D. E., and Abraham, R. T. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res., 58: 4375-4382, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 4375-4382
    • Sarkaria, J.N.1    Tibbetts, R.S.2    Busby, E.C.3    Kennedy, A.P.4    Hill, D.E.5    Abraham, R.T.6
  • 35
    • 0027849610 scopus 로고
    • Tamoxifen induced increase in the potential doubling time (Tpot) of MCF-7 xenografts as determined by bromodeoxyuridine labeling and flow cytometry
    • Sarkaria, J., Gibson, D., Jordan, V., Fowler, J., Lindstrom, M., and Mulcahy, R. Tamoxifen induced increase in the potential doubling time (Tpot) of MCF-7 xenografts as determined by bromodeoxyuridine labeling and flow cytometry. Cancer Res., 53: 4413-4417, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 4413-4417
    • Sarkaria, J.1    Gibson, D.2    Jordan, V.3    Fowler, J.4    Lindstrom, M.5    Mulcahy, R.6
  • 36
    • 0025282246 scopus 로고
    • Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity
    • Musk, S. R. R., and Steel, G. G. Override of the radiation-induced mitotic block in human tumour cells by methylxanthines and its relationship to the potentiation of cytotoxicity. Int. J. Radiat. Biol., 57: 1105-1112, 1990.
    • (1990) Int. J. Radiat. Biol. , vol.57 , pp. 1105-1112
    • Musk, S.R.R.1    Steel, G.G.2
  • 38
    • 0029829249 scopus 로고    scopus 로고
    • Defect in multiple cell cycle checkpoints in ataxia-telangiectasia post-irradiation
    • Beamish, H., Williams, R., Chen, P., and Lavin, M. F. Defect in multiple cell cycle checkpoints in ataxia-telangiectasia post-irradiation. J. Biol. Chem., 271: 20486-20493, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 20486-20493
    • Beamish, H.1    Williams, R.2    Chen, P.3    Lavin, M.F.4
  • 39
    • 0029952441 scopus 로고    scopus 로고
    • In vivo ubiquitination and proteasome-mediated degradation of p53
    • Maki, C. G., Huibregtse, J. M., and Howley, P. M. In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Res., 56: 2649-2654, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 2649-2654
    • Maki, C.G.1    Huibregtse, J.M.2    Howley, P.M.3
  • 40
    • 0031309798 scopus 로고    scopus 로고
    • Mammalian MAP kinase modules: How to transduce specific signals
    • Brunet, A., and Pouyssegur, J. Mammalian MAP kinase modules: how to transduce specific signals. Essays Biochem., 32: 1-16, 1997.
    • (1997) Essays Biochem. , vol.32 , pp. 1-16
    • Brunet, A.1    Pouyssegur, J.2
  • 41
    • 0032472330 scopus 로고    scopus 로고
    • Overexpression of a kinase-inactive ATR protein causes sensitivity to DMA-damaging agents and defects in cell cycle checkpoints
    • Cliby, W. A., Roberts, C. J., Cimprich, K. A., Stringer, C. M., Lamb, J. R., Schreiber, S. L., and Friend, S. H. Overexpression of a kinase-inactive ATR protein causes sensitivity to DMA-damaging agents and defects in cell cycle checkpoints. EMBO J., 17: 159-169, 1998.
    • (1998) EMBO J. , vol.17 , pp. 159-169
    • Cliby, W.A.1    Roberts, C.J.2    Cimprich, K.A.3    Stringer, C.M.4    Lamb, J.R.5    Schreiber, S.L.6    Friend, S.H.7
  • 43
    • 0030449425 scopus 로고    scopus 로고
    • p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine
    • DeFrank, J. S., Tang, W., and Powell, S. N. p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine. Cancer Res., 56: 5365-5368, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 5365-5368
    • DeFrank, J.S.1    Tang, W.2    Powell, S.N.3
  • 44
    • 0022259310 scopus 로고
    • The effect of caffeine on X-ray-induced mitotic delay in normal human and ataxia-telangiectasia fibroblasts
    • Zampetti-Bosseler, F., and Scott, D. The effect of caffeine on X-ray-induced mitotic delay in normal human and ataxia-telangiectasia fibroblasts. Mutat. Res., 143: 251-256, 1985.
    • (1985) Mutat. Res. , vol.143 , pp. 251-256
    • Zampetti-Bosseler, F.1    Scott, D.2
  • 45
    • 0021645927 scopus 로고
    • 2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells
    • 2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells. Hum. Genet., 67: 329-335, 1984.
    • (1984) Hum. Genet. , vol.67 , pp. 329-335
    • Hansson, K.1    Natarajan, A.T.2    Kihlman, B.A.3
  • 52
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman, T., Lengauer, C., Kinzler, K. W., and Vogelstein, B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature (Lond.), 381: 713-716, 1996.
    • (1996) Nature (Lond.) , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3    Vogelstein, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.