-
1
-
-
41349099104
-
Cancer statistics
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics. CA Cancer J Clin 2008;58:71-96.
-
(2008)
CA Cancer J Clin
, vol.58
, pp. 71-96
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Murray, T.6
-
4
-
-
52449100639
-
Goniothalamus species: A source of drugs for the treatment of cancers and bacterial infections?
-
Wiart C. Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections? Evid Based Complement Alternat Med 2007;4:299-311.
-
(2007)
Evid Based Complement Alternat Med
, vol.4
, pp. 299-311
-
-
Wiart, C.1
-
5
-
-
0033003511
-
Food, nutrition, and the prevention of cancer: A global perspective. American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research
-
Glade MJ. Food, nutrition, and the prevention of cancer: a global perspective. American Institute for Cancer Research/World Cancer Research Fund, American Institute for Cancer Research. Nutrition 1999;15:523-6.
-
(1999)
Nutrition
, vol.15
, pp. 523-526
-
-
Glade, M.J.1
-
6
-
-
0037248328
-
Cancer prevention - The potential for diet to modulate molecular signalling
-
Manson MM. Cancer prevention -the potential for diet to modulate molecular signalling. Trends Mol Med 2003;9:11-8.
-
(2003)
Trends Mol Med
, vol.9
, pp. 11-18
-
-
Manson, M.M.1
-
7
-
-
84862751121
-
Plants as a source of therapeutic and health products
-
Christen P, Cuendet M. Plants as a source of therapeutic and health products. Chimia (Aarau) 2012;66:320-3.
-
(2012)
Chimia (Aarau)
, vol.66
, pp. 320-323
-
-
Christen, P.1
Cuendet, M.2
-
8
-
-
77955933845
-
Evasion of apoptosis as a cellular stress response in cancer
-
Fulda S. Evasion of apoptosis as a cellular stress response in cancer. Int J Cell Biol 2010;2010:370835.
-
(2010)
Int J Cell Biol
, vol.2010
, pp. 370835
-
-
Fulda, S.1
-
9
-
-
77249086129
-
Anticancer effects of Alpinia pricei Hayata roots
-
Hsu CL, Yu YS, Yen GC. Anticancer effects of Alpinia pricei Hayata roots. J Agric Food Chem 2010;58:2201-8.
-
(2010)
J Agric Food Chem
, vol.58
, pp. 2201-2208
-
-
Hsu, C.L.1
Yu, Y.S.2
Yen, G.C.3
-
10
-
-
68949122548
-
Antiproliferative effects of honey and of its polyphenols: A review
-
Jaganathan SK, Mandal M. Antiproliferative effects of honey and of its polyphenols: a review. J Biomed Biotechnol 2009;2009:830616.
-
(2009)
J Biomed Biotechnol
, vol.2009
, pp. 830616
-
-
Jaganathan, S.K.1
Mandal, M.2
-
11
-
-
66849095259
-
Perspectives for cancer prevention with natural compounds
-
Amin AR, Kucuk O, Khuri FR, Shin DM. Perspectives for cancer prevention with natural compounds. J Clin Oncol 2009;27:2712-25.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2712-2725
-
-
Amin, A.R.1
Kucuk, O.2
Khuri, F.R.3
Shin, D.M.4
-
12
-
-
23044490704
-
Plants as a source of anti-cancer agents
-
Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacol 2005;100:72-9.
-
(2005)
J Ethnopharmacol
, vol.100
, pp. 72-79
-
-
Cragg, G.M.1
Newman, D.J.2
-
13
-
-
34250308322
-
Apoptosis: A review of programmed cell death
-
Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol 2007;35:495-516.
-
(2007)
Toxicol Pathol
, vol.35
, pp. 495-516
-
-
Elmore, S.1
-
14
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 2005;4:206-20.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
15
-
-
0017136711
-
Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids)
-
Sporn MB, Dunlop NM, Newton DL, Smith JM. Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids). Fed Proc 1976;35:1332-8.
-
(1976)
Fed Proc
, vol.35
, pp. 1332-1338
-
-
Sporn, M.B.1
Dunlop, N.M.2
Newton, D.L.3
Smith, J.M.4
-
16
-
-
82255172414
-
Rediscovering natural products as a source of new drugs
-
Koehn FE, Carter GT. Rediscovering natural products as a source of new drugs. Discov Med 2005;5:159-64.
-
(2005)
Discov Med
, vol.5
, pp. 159-164
-
-
Koehn, F.E.1
Carter, G.T.2
-
17
-
-
23044464476
-
Ethnopharmacology and drug discovery
-
Patwardhan B. Ethnopharmacology and drug discovery. J Ethnopharmacol 2005;100:50-2.
-
(2005)
J Ethnopharmacol
, vol.100
, pp. 50-52
-
-
Patwardhan, B.1
-
18
-
-
67749089313
-
Bioactive styryllactones and alkaloid from flowers of Goniothalamus laoticus
-
Lekphrom R, Kanokmedhakul S, Kanokmedhakul K. Bioactive styryllactones and alkaloid from flowers of Goniothalamus laoticus. J Ethnopharmacol 2009;125:47-50.
-
(2009)
J Ethnopharmacol
, vol.125
, pp. 47-50
-
-
Lekphrom, R.1
Kanokmedhakul, S.2
Kanokmedhakul, K.3
-
19
-
-
0037169358
-
Apoptosis: A link between cancer genetics and chemotherapy
-
Johnstone RW, Ruefli AA, Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002;108:153-64.
-
(2002)
Cell
, vol.108
, pp. 153-164
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Lowe, S.W.3
-
20
-
-
0034616946
-
Apoptotic pathways: Paper wraps stone blunts scissors
-
Green DR. Apoptotic pathways: paper wraps stone blunts scissors. Cell 2000;102:1-4.
-
(2000)
Cell
, vol.102
, pp. 1-4
-
-
Green, D.R.1
-
21
-
-
0032575714
-
Death receptors: Signaling and modulation
-
Ashkenazi A, Dixit VM. Death receptors: signaling and modulation. Science 1998;281:1305-8.
-
(1998)
Science
, vol.281
, pp. 1305-1308
-
-
Ashkenazi, A.1
Dixit, V.M.2
-
22
-
-
0026701521
-
Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence
-
Block G, Patterson B, Subar A. Fruit, vegetables, and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 1992;18:1-29.
-
(1992)
Nutr Cancer
, vol.18
, pp. 1-29
-
-
Block, G.1
Patterson, B.2
Subar, A.3
-
24
-
-
0034641918
-
The biochemistry of apoptosis
-
Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-6.
-
(2000)
Nature
, vol.407
, pp. 770-776
-
-
Hengartner, M.O.1
-
25
-
-
0031800969
-
Ethnopharmacology of Mexican asteraceae (Compositae)
-
Heinrich M, Robles M, West JE, Ortiz de Montellano BR, Rodriguez E. Ethnopharmacology of Mexican asteraceae (Compositae). Annu Rev Pharmacol Toxicol 1998;38:539-65.
-
(1998)
Annu Rev Pharmacol Toxicol
, vol.38
, pp. 539-565
-
-
Heinrich, M.1
Robles, M.2
West, J.E.3
Ortiz De Montellano, B.R.4
Rodriguez, E.5
-
26
-
-
84865967712
-
Sesquiterpene lactones as drugs with multiple targets in cancer treatment: Focus on parthenolide
-
Kreuger MR, Grootjans S, Biavatti MW, Vandenabeele P, D'Herde K. Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide. Anticancer Drugs 2012;23:883-96.
-
(2012)
Anticancer Drugs
, vol.23
, pp. 883-896
-
-
Kreuger, M.R.1
Grootjans, S.2
Biavatti, M.W.3
Vandenabeele, P.4
D'Herde, K.5
-
27
-
-
4944255743
-
Post-translational modification of p53 in tumorigenesis
-
Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 2004;4:793-805.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 793-805
-
-
Bode, A.M.1
Dong, Z.2
-
28
-
-
0037026606
-
TheBrn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1)
-
Budram-Mahadeo V, Morris PJ, Latchman DS. TheBrn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). Oncogene 2002;21:6123-31.
-
(2002)
Oncogene
, vol.21
, pp. 6123-6131
-
-
Budram-Mahadeo, V.1
Morris, P.J.2
Latchman, D.S.3
-
29
-
-
0034628848
-
Cell cycle. Piecing together the p53 puzzle
-
Carr AM. Cell cycle. Piecing together the p53 puzzle. Science 2000;287:1765-6.
-
(2000)
Science
, vol.287
, pp. 1765-1766
-
-
Carr, A.M.1
-
30
-
-
62449278758
-
Targeting p53 for enhanced radio-and chemosensitivity
-
Lu C, El-Deiry WS. Targeting p53 for enhanced radio-and chemosensitivity. Apoptosis 2009;14:597-606.
-
(2009)
Apoptosis
, vol.14
, pp. 597-606
-
-
Lu, C.1
El-Deiry, W.S.2
-
32
-
-
0035974798
-
Achilles' heel of cancer?
-
Vogelstein B, Kinzler KW. Achilles' heel of cancer? Nature 2001;412:865-6.
-
(2001)
Nature
, vol.412
, pp. 865-866
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
33
-
-
79955606571
-
Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: Sensitivity of ovarian cancer cells to phyto-active chemicals
-
Chen S, Cooper M, Jones M, Madhuri TK, Wade J, Bachelor A, et al. Combined activity of oridonin and wogonin in advanced-stage ovarian cancer cells: sensitivity of ovarian cancer cells to phyto-active chemicals. Cell Biol Toxicol 2011;27:133-47.
-
(2011)
Cell Biol Toxicol
, vol.27
, pp. 133-147
-
-
Chen, S.1
Cooper, M.2
Jones, M.3
Madhuri, T.K.4
Wade, J.5
Bachelor, A.6
-
34
-
-
20344367543
-
The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage
-
Chen S, Gao J, Halicka HD, Huang X, Traganos F, Darzynkiewicz Z. The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage. Int J Oncol 2005;26:579-88.
-
(2005)
Int J Oncol
, vol.26
, pp. 579-588
-
-
Chen, S.1
Gao, J.2
Halicka, H.D.3
Huang, X.4
Traganos, F.5
Darzynkiewicz, Z.6
-
35
-
-
84860641820
-
Advances in the treatment of ovarian cancer: A potential role of antiinflammatory phytochemicals
-
Chen SS, Michael A, Butler-Manuel SA. Advances in the treatment of ovarian cancer: a potential role of antiinflammatory phytochemicals. Discov Med 2012;13:7-17.
-
(2012)
Discov Med
, vol.13
, pp. 7-17
-
-
Chen, S.S.1
Michael, A.2
Butler-Manuel, S.A.3
-
36
-
-
35848945708
-
Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity
-
Hahm ER, Singh SV. Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity. Mol Cancer Ther 2007;6:2686-95.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2686-2695
-
-
Hahm, E.R.1
Singh, S.V.2
-
37
-
-
80055054560
-
Honokiol radiosensitizes colorectal cancer cells: Enhanced activity in cells with mismatch repair defects
-
He Z, Subramaniam D, Ramalingam S, Dhar A, Postier RG, Umar S, et al. Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects. Am J Physiol Gastrointest Liver Physiol 2011;301:G929-37.
-
(2011)
Am J Physiol Gastrointest Liver Physiol
, vol.301
, pp. G929-G937
-
-
He, Z.1
Subramaniam, D.2
Ramalingam, S.3
Dhar, A.4
Postier, R.G.5
Umar, S.6
-
38
-
-
77951080149
-
Chemopreventive effects of honokiol on UVB-induced skin cancer development
-
Chilampalli S, Zhang X, Fahmy H, Kaushik RS, Zeman D, Hildreth MB, et al. Chemopreventive effects of honokiol on UVB-induced skin cancer development. Anticancer Res 2010;30:777-83.
-
(2010)
Anticancer Res
, vol.30
, pp. 777-783
-
-
Chilampalli, S.1
Zhang, X.2
Fahmy, H.3
Kaushik, R.S.4
Zeman, D.5
Hildreth, M.B.6
-
39
-
-
64749084915
-
Honokiol, a multifunctional antiangiogenic and antitumor agent
-
Fried LE, Arbiser JL. Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxid Redox Signal 2009;11:1139-48.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 1139-1148
-
-
Fried, L.E.1
Arbiser, J.L.2
-
40
-
-
39749131007
-
Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction
-
Hahm ER, Arlotti JA, Marynowski SW, Singh SV. Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction. Clin Cancer Res 2008;14:1248-57.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1248-1257
-
-
Hahm, E.R.1
Arlotti, J.A.2
Marynowski, S.W.3
Singh, S.V.4
-
41
-
-
4344633662
-
Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO
-
Wang T, Chen F, Chen Z, Wu YF, Xu XL, Zheng S, et al. Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. World J Gastroenterol 2004;10:2205-8.
-
(2004)
World J Gastroenterol
, vol.10
, pp. 2205-2208
-
-
Wang, T.1
Chen, F.2
Chen, Z.3
Wu, Y.F.4
Xu, X.L.5
Zheng, S.6
-
42
-
-
84879490397
-
Casticin induces human glioma cell death through apoptosis and mitotic arrest
-
Liu E, Kuang Y, He W, Xing X, Gu J. Casticin induces human glioma cell death through apoptosis and mitotic arrest. Cell Physiol Biochem 2013;31:805-14.
-
(2013)
Cell Physiol Biochem
, vol.31
, pp. 805-814
-
-
Liu, E.1
Kuang, Y.2
He, W.3
Xing, X.4
Gu, J.5
-
43
-
-
84876732672
-
Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells
-
Zhou Y, Peng Y, Mao QQ, Li X, Chen MW, Su J, et al. Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells. Asian Pac J Trop Med 2013;6:372-8.
-
(2013)
Asian Pac J Trop Med
, vol.6
, pp. 372-378
-
-
Zhou, Y.1
Peng, Y.2
Mao, Q.Q.3
Li, X.4
Chen, M.W.5
Su, J.6
-
44
-
-
84871463035
-
Vitexicarpin affects proliferation and apoptosis in mutated p53 breast cancer cell
-
Song YC, Zhang X, Lei GY, Dang CX. [Vitexicarpin affects proliferation and apoptosis in mutated p53 breast cancer cell]. Zhonghua Yi Xue Za Zhi 2010;90:703-7.
-
(2010)
Zhonghua Yi Xue Za Zhi
, vol.90
, pp. 703-707
-
-
Song, Y.C.1
Zhang, X.2
Lei, G.Y.3
Dang, C.X.4
-
45
-
-
39649125467
-
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
-
Guzman ML, Rossi RM, Neelakantan S, Li X, Corbett CA, Hassane DC, et al. An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood 2007;110:4427-35.
-
(2007)
Blood
, vol.110
, pp. 4427-4435
-
-
Guzman, M.L.1
Rossi, R.M.2
Neelakantan, S.3
Li, X.4
Corbett, C.A.5
Hassane, D.C.6
-
46
-
-
58149487765
-
TNFalpha-induced activation of NFkappaB protects against UV-induced apoptosis specifically in p53-proficient cells
-
Szoltysek K, Pietranek K, Kalinowska-Herok M, Pietrowska M, Kimmel M, Widlak P. TNFalpha-induced activation of NFkappaB protects against UV-induced apoptosis specifically in p53-proficient cells. Acta Biochim Pol 2008;55:741-8.
-
(2008)
Acta Biochim Pol
, vol.55
, pp. 741-748
-
-
Szoltysek, K.1
Pietranek, K.2
Kalinowska-Herok, M.3
Pietrowska, M.4
Kimmel, M.5
Widlak, P.6
-
47
-
-
66449097674
-
Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions
-
Gopal YN, Chanchorn E, Van Dyke MW. Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions. Mol Cancer Ther 2009;8:552-62.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 552-562
-
-
Gopal, Y.N.1
Chanchorn, E.2
Van Dyke, M.W.3
-
48
-
-
84885237554
-
In human retinoblastoma Y79 cells okadaic acid-parthenolide co-treatment induces synergistic apoptotic effects, with PTEN as a key player
-
Di Fiore R, Drago-Ferrante R, D'Anneo A, Augello G, Carlisi D, De Blasio A, et al. In human retinoblastoma Y79 cells okadaic acid-parthenolide co-treatment induces synergistic apoptotic effects, with PTEN as a key player. Cancer Biol Ther 2013;14:922-31.
-
(2013)
Cancer Biol Ther
, vol.14
, pp. 922-931
-
-
Di Fiore, R.1
Drago-Ferrante, R.2
D'Anneo, A.3
Augello, G.4
Carlisi, D.5
De Blasio, A.6
-
49
-
-
84874634964
-
Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction
-
Khan M, Li T, Ahmad Khan MK, Rasul A, Nawaz F, Sun M, et al. Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction. Biomed Res Int 2013;2013:719858.
-
(2013)
Biomed Res Int
, vol.2013
, pp. 719858
-
-
Khan, M.1
Li, T.2
Ahmad Khan, M.K.3
Rasul, A.4
Nawaz, F.5
Sun, M.6
-
50
-
-
84864144305
-
Alantolactone induces activation of apoptosis in human hepatoma cells
-
Lei JC, Yu JQ, Yin Y, Liu YW, Zou GL. Alantolactone induces activation of apoptosis in human hepatoma cells. Food Chem Toxicol 2012;50:3313-9.
-
(2012)
Food Chem Toxicol
, vol.50
, pp. 3313-3319
-
-
Lei, J.C.1
Yu, J.Q.2
Yin, Y.3
Liu, Y.W.4
Zou, G.L.5
-
51
-
-
84876936613
-
Alantolactone inhibits growth of K562/adriamycin cells by downregulating Bcr/Abl and P-glycoprotein expression
-
Yang C, Yang J, Sun M, Yan J, Meng X, Ma T. Alantolactone inhibits growth of K562/adriamycin cells by downregulating Bcr/Abl and P-glycoprotein expression. IUBMB Life 2013;65:435-44.
-
(2013)
IUBMB Life
, vol.65
, pp. 435-444
-
-
Yang, C.1
Yang, J.2
Sun, M.3
Yan, J.4
Meng, X.5
Ma, T.6
-
52
-
-
84888861862
-
Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone
-
Rasul A, Khan M, Ali M, Li J, Li X. Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone. ScientificWorldJournal 2013;2013:248532.
-
(2013)
ScientificWorldJournal
, vol.2013
, pp. 248532
-
-
Rasul, A.1
Khan, M.2
Ali, M.3
Li, J.4
Li, X.5
-
53
-
-
4544342570
-
Nuclear factor-kappaB: The enemy within
-
Aggarwal BB. Nuclear factor-kappaB: the enemy within. Cancer Cell 2004;6:203-8.
-
(2004)
Cancer Cell
, vol.6
, pp. 203-208
-
-
Aggarwal, B.B.1
-
54
-
-
0036020941
-
NF-kappaB as a therapeutic target in cancer
-
Orlowski RZ, Baldwin AS Jr. NF-kappaB as a therapeutic target in cancer. Trends Mol Med 2002;8:385-9.
-
(2002)
Trends Mol Med
, vol.8
, pp. 385-389
-
-
Orlowski, R.Z.1
Baldwin, A.S.2
-
55
-
-
58149202128
-
Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls
-
Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009;8:33-40.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 33-40
-
-
Baud, V.1
Karin, M.2
-
56
-
-
61849127839
-
The IkappaB kinase complex: Master regulator of NF-kappaB signaling
-
Solt LA, May MJ. The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol Res 2008;42:3-18.
-
(2008)
Immunol Res
, vol.42
, pp. 3-18
-
-
Solt, L.A.1
May, M.J.2
-
57
-
-
54949147176
-
New regulators of NF-kappaB in inflammation
-
Ghosh S, Hayden MS. New regulators of NF-kappaB in inflammation. Nat Rev Immunol 2008;8:837-48.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 837-848
-
-
Ghosh, S.1
Hayden, M.S.2
-
58
-
-
0036546501
-
NF-kappaB in cancer: From innocent bystander to major culprit
-
Karin M, Cao Y, Greten FR, Li ZW. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2002;2:301-10.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
Li, Z.W.4
-
59
-
-
34248141100
-
A cytokine-mediated link between innate immunity, inflammation, and cancer
-
Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 2007;117:1175-83.
-
(2007)
J Clin Invest
, vol.117
, pp. 1175-1183
-
-
Lin, W.W.1
Karin, M.2
-
60
-
-
33947724745
-
IKKalpha at the crossroads of inflammation and metastasis
-
Affara NI, Coussens LM. IKKalpha at the crossroads of inflammation and metastasis. Cell 2007;129:25-6.
-
(2007)
Cell
, vol.129
, pp. 25-26
-
-
Affara, N.I.1
Coussens, L.M.2
-
61
-
-
26444605834
-
IKK/NF-kappaB signaling: Balancing life and death - A new approach to cancer therapy
-
Luo JL, Kamata H, Karin M. IKK/NF-kappaB signaling: balancing life and death - a new approach to cancer therapy. J Clin Invest 2005;115:2625-32.
-
(2005)
J Clin Invest
, vol.115
, pp. 2625-2632
-
-
Luo, J.L.1
Kamata, H.2
Karin, M.3
-
62
-
-
33750495811
-
Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer
-
Biswas DK, Iglehart JD. Linkage between EGFR family receptors and nuclear factor kappaB (NF-kappaB) signaling in breast cancer. J Cell Physiol 2006;209:645-52.
-
(2006)
J Cell Physiol
, vol.209
, pp. 645-652
-
-
Biswas, D.K.1
Iglehart, J.D.2
-
63
-
-
77951191133
-
Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells
-
Tanabe K, Matsushima-Nishiwaki R, Yamaguchi S, Iida H, Dohi S, Kozawa O. Mechanisms of tumor necrosis factor-alpha-induced interleukin-6 synthesis in glioma cells. J Neuroinflammation 2010;7:16.
-
(2010)
J Neuroinflammation
, vol.7
, pp. 16
-
-
Tanabe, K.1
Matsushima-Nishiwaki, R.2
Yamaguchi, S.3
Iida, H.4
Dohi, S.5
Kozawa, O.6
-
64
-
-
0037474320
-
JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression
-
Legendre F, Dudhia J, Pujol JP, Bogdanowicz P. JAK/STAT but not ERK1/ERK2 pathway mediates interleukin (IL)-6/soluble IL-6R down-regulation of Type II collagen, aggrecan core, and link protein transcription in articular chondrocytes. Association with a down-regulation of SOX9 expression. J Biol Chem 2003;278:2903-12.
-
(2003)
J Biol Chem
, vol.278
, pp. 2903-2912
-
-
Legendre, F.1
Dudhia, J.2
Pujol, J.P.3
Bogdanowicz, P.4
-
65
-
-
84863619176
-
Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities
-
Mathema VB, Koh YS, Thakuri BC, Sillanpaa M. Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities. Inflammation 2012;35:560-5.
-
(2012)
Inflammation
, vol.35
, pp. 560-565
-
-
Mathema, V.B.1
Koh, Y.S.2
Thakuri, B.C.3
Sillanpaa, M.4
-
66
-
-
6044240634
-
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
-
Nakshatri H, Rice SE, Bhat-Nakshatri P. Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase. Oncogene 2004;23:7330-44.
-
(2004)
Oncogene
, vol.23
, pp. 7330-7344
-
-
Nakshatri, H.1
Rice, S.E.2
Bhat-Nakshatri, P.3
-
67
-
-
80053468944
-
Honokiol stimulates osteoblastogenesis by suppressing NF-kappaB activation
-
Yamaguchi M, Arbiser JL, Weitzmann MN. Honokiol stimulates osteoblastogenesis by suppressing NF-kappaB activation. Int J Mol Med 2011;28:1049-53.
-
(2011)
Int J Mol Med
, vol.28
, pp. 1049-1053
-
-
Yamaguchi, M.1
Arbiser, J.L.2
Weitzmann, M.N.3
-
68
-
-
84901014302
-
Honokiol suppresses TNF-alpha-induced migration and matrix metalloproteinase expression by blocking NF-kappaB activation via the ERK signaling pathway in rat aortic smooth muscle cells
-
Zhu X, Wang Z, Hu C, Li Z, Hu J. Honokiol suppresses TNF-alpha-induced migration and matrix metalloproteinase expression by blocking NF-kappaB activation via the ERK signaling pathway in rat aortic smooth muscle cells. Acta Histochem 2014;116:588-95.
-
(2014)
Acta Histochem
, vol.116
, pp. 588-595
-
-
Zhu, X.1
Wang, Z.2
Hu, C.3
Li, Z.4
Hu, J.5
-
69
-
-
84896552191
-
Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice
-
Butturini E, Di Paola R, Suzuki H, Paterniti I, Ahmad A, Mariotto S, et al. Costunolide and Dehydrocostuslactone, two natural sesquiterpene lactones, ameliorate the inflammatory process associated to experimental pleurisy in mice. Eur J Pharmacol 2014;730C:107-115.
-
(2014)
Eur J Pharmacol
, vol.730 C
, pp. 107-115
-
-
Butturini, E.1
Di Paola, R.2
Suzuki, H.3
Paterniti, I.4
Ahmad, A.5
Mariotto, S.6
-
70
-
-
79953768967
-
Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway
-
Kim JH, Yang YI, Lee KT, Park HJ, Choi JH. Costunolide induces apoptosis in human endometriotic cells through inhibition of the prosurvival Akt and nuclear factor kappa B signaling pathway. Biol Pharm Bull 2011;34:580-5.
-
(2011)
Biol Pharm Bull
, vol.34
, pp. 580-585
-
-
Kim, J.H.1
Yang, Y.I.2
Lee, K.T.3
Park, H.J.4
Choi, J.H.5
-
71
-
-
84883659465
-
Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-kappaB inhibition
-
Whipple RA, Vitolo MI, Boggs AE, Charpentier MS, Thompson K, Martin SS. Parthenolide and costunolide reduce microtentacles and tumor cell attachment by selectively targeting detyrosinated tubulin independent from NF-kappaB inhibition. Breast Cancer Res 2013;15:R83.
-
(2013)
Breast Cancer Res
, vol.15
, pp. R83
-
-
Whipple, R.A.1
Vitolo, M.I.2
Boggs, A.E.3
Charpentier, M.S.4
Thompson, K.5
Martin, S.S.6
-
72
-
-
84872811571
-
Magnolol attenuates neointima formation by inducing cell cycle arrest via inhibition of ERK1/2 and NF-kappaB activation in vascular smooth muscle cells
-
Karki R, Ho OM, Kim DW. Magnolol attenuates neointima formation by inducing cell cycle arrest via inhibition of ERK1/2 and NF-kappaB activation in vascular smooth muscle cells. Biochim Biophys Acta 2013;1830:2619-28.
-
(2013)
Biochim Biophys Acta
, vol.1830
, pp. 2619-2628
-
-
Karki, R.1
Ho, O.M.2
Kim, D.W.3
-
73
-
-
79251528574
-
Magnolol inhibits LPS-induced NF-kappaB/Rel activation by blocking p38 kinase in murine macrophages
-
Li MH, Kothandan G, Cho SJ, Huong PT, Nan YH, Lee KY, et al. Magnolol inhibits LPS-induced NF-kappaB/Rel activation by blocking p38 kinase in murine macrophages. Korean J Physiol Pharmacol 2010;14:353-8.
-
(2010)
Korean J Physiol Pharmacol
, vol.14
, pp. 353-358
-
-
Li, M.H.1
Kothandan, G.2
Cho, S.J.3
Huong, P.T.4
Nan, Y.H.5
Lee, K.Y.6
-
74
-
-
77649178970
-
Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition
-
Wang C, Li S, Wang MW. Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition. Toxicol In Vitro 2010;24:898-904.
-
(2010)
Toxicol in Vitro
, vol.24
, pp. 898-904
-
-
Wang, C.1
Li, S.2
Wang, M.W.3
-
75
-
-
40649127279
-
Nitric oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells
-
Yang J, Wu LJ, Tashiro S, Onodera S, Ikejima T. Nitric oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells. Free Radic Res 2008;42:1-11.
-
(2008)
Free Radic Res
, vol.42
, pp. 1-11
-
-
Yang, J.1
Wu, L.J.2
Tashiro, S.3
Onodera, S.4
Ikejima, T.5
-
76
-
-
84866339788
-
Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-kappaB-COX-2-IL-1beta pathway
-
Zang L, He H, Ye Y, Liu W, Fan S, Tashiro S, et al. Nitric oxide augments oridonin-induced efferocytosis by human histocytic lymphoma U937 cells via autophagy and the NF-kappaB-COX-2-IL-1beta pathway. Free Radic Res 2012;46:1207-19.
-
(2012)
Free Radic Res
, vol.46
, pp. 1207-1219
-
-
Zang, L.1
He, H.2
Ye, Y.3
Liu, W.4
Fan, S.5
Tashiro, S.6
-
77
-
-
84866990008
-
Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-kappaB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells
-
Chun J, Choi RJ, Khan S, Lee DS, Kim YC, Nam YJ, et al. Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-kappaB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells. Int Immunopharmacol 2012;14:375-83.
-
(2012)
Int Immunopharmacol
, vol.14
, pp. 375-383
-
-
Chun, J.1
Choi, R.J.2
Khan, S.3
Lee, D.S.4
Kim, Y.C.5
Nam, Y.J.6
-
78
-
-
84881476269
-
Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib through NF-kappaB inhibition and Bcr/Abl protein deletion
-
Wei W, Huang H, Zhao S, Liu W, Liu CX, Chen L, et al. Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib through NF-kappaB inhibition and Bcr/Abl protein deletion. Apoptosis 2013;18:1060-70.
-
(2013)
Apoptosis
, vol.18
, pp. 1060-1070
-
-
Wei, W.1
Huang, H.2
Zhao, S.3
Liu, W.4
Liu, C.X.5
Chen, L.6
-
79
-
-
84886638907
-
Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-kappaB activation and MCP-1 and TGF-beta1 expression in rat mesangial cells
-
Jia QQ, Wang JC, Long J, Zhao Y, Chen SJ, Zhai JD, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-kappaB activation and MCP-1 and TGF-beta1 expression in rat mesangial cells. Molecules 2013;18:13061-77.
-
(2013)
Molecules
, vol.18
, pp. 13061-13077
-
-
Jia, Q.Q.1
Wang, J.C.2
Long, J.3
Zhao, Y.4
Chen, S.J.5
Zhai, J.D.6
-
80
-
-
79960317874
-
Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelial cells via NF-kappaB inactivation
-
Koh DJ, Ahn HS, Chung HS, Lee H, Kim Y, Lee JY, et al. Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelial cells via NF-kappaB inactivation. J Ethnopharmacol 2011;136:399-405.
-
(2011)
J Ethnopharmacol
, vol.136
, pp. 399-405
-
-
Koh, D.J.1
Ahn, H.S.2
Chung, H.S.3
Lee, H.4
Kim, Y.5
Lee, J.Y.6
-
81
-
-
69249115789
-
Pseudolaric acid B suppresses T lymphocyte activation through inhibition of NF-kappaB signaling pathway and p38 phosphorylation
-
Li T, Wong VK, Yi XQ, Wong YF, Zhou H, Liu L. Pseudolaric acid B suppresses T lymphocyte activation through inhibition of NF-kappaB signaling pathway and p38 phosphorylation. J Cell Biochem 2009;108:87-95.
-
(2009)
J Cell Biochem
, vol.108
, pp. 87-95
-
-
Li, T.1
Wong, V.K.2
Yi, X.Q.3
Wong, Y.F.4
Zhou, H.5
Liu, L.6
-
82
-
-
35848946821
-
Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity
-
Lee SH, Bae EA, Park EK, Shin YW, Baek NI, Han EJ, et al. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity. Int Immunopharmacol 2007;7:1678-84.
-
(2007)
Int Immunopharmacol
, vol.7
, pp. 1678-1684
-
-
Lee, S.H.1
Bae, E.A.2
Park, E.K.3
Shin, Y.W.4
Baek, N.I.5
Han, E.J.6
-
83
-
-
40249109853
-
The IkappaB kinase - A bridge between inflammation and cancer
-
Karin M. The IkappaB kinase -a bridge between inflammation and cancer. Cell Res 2008;18:334-42.
-
(2008)
Cell Res
, vol.18
, pp. 334-342
-
-
Karin, M.1
-
84
-
-
84880885989
-
KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells
-
Xu Y, Fang F, Miriyala S, Crooks PA, Oberley TD, Chaiswing L, et al. KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells. Cancer Res 2013;73:4406-17.
-
(2013)
Cancer Res
, vol.73
, pp. 4406-4417
-
-
Xu, Y.1
Fang, F.2
Miriyala, S.3
Crooks, P.A.4
Oberley, T.D.5
Chaiswing, L.6
-
85
-
-
78649787888
-
Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells
-
Yun BR, Lee MJ, Kim JH, Kim IH, Yu GR, Kim DG. Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells. Exp Mol Med 2010;42:787-97.
-
(2010)
Exp Mol Med
, vol.42
, pp. 787-797
-
-
Yun, B.R.1
Lee, M.J.2
Kim, J.H.3
Kim, I.H.4
Yu, G.R.5
Kim, D.G.6
-
86
-
-
38349165342
-
Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages
-
Pae HO, Jeong GS, Kim HS, Woo WH, Rhew HY, Kim HS, et al. Costunolide inhibits production of tumor necrosis factor-alpha and interleukin-6 by inducing heme oxygenase-1 in RAW264.7 macrophages. Inflamm Res 2007;56:520-6.
-
(2007)
Inflamm Res
, vol.56
, pp. 520-526
-
-
Pae, H.O.1
Jeong, G.S.2
Kim, H.S.3
Woo, W.H.4
Rhew, H.Y.5
Kim, H.S.6
-
87
-
-
54149084936
-
Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
-
Du Y, Villeneuve NF, Wang XJ, Sun Z, Chen W, Li J, et al. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. Environ Health Perspect 2008;116:1154-61.
-
(2008)
Environ Health Perspect
, vol.116
, pp. 1154-1161
-
-
Du, Y.1
Villeneuve, N.F.2
Wang, X.J.3
Sun, Z.4
Chen, W.5
Li, J.6
-
88
-
-
70350519605
-
Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes
-
Seo JY, Park J, Kim HJ, Lee IA, Lim JS, Lim SS, et al. Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes. J Med Food 2009;12:1038-45.
-
(2009)
J Med Food
, vol.12
, pp. 1038-1045
-
-
Seo, J.Y.1
Park, J.2
Kim, H.J.3
Lee, I.A.4
Lim, J.S.5
Lim, S.S.6
-
89
-
-
57349129095
-
Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium
-
Seo JY, Lim SS, Kim JR, Lim JS, Ha YR, Lee IA, et al. Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium. Phytother Res 2008;22:1500-5.
-
(2008)
Phytother Res
, vol.22
, pp. 1500-1505
-
-
Seo, J.Y.1
Lim, S.S.2
Kim, J.R.3
Lim, J.S.4
Ha, Y.R.5
Lee, I.A.6
-
90
-
-
0033198793
-
Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis
-
Sano S, Itami S, Takeda K, Tarutani M, Yamaguchi Y, Miura H, et al. Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J 1999;18:4657-68.
-
(1999)
EMBO J
, vol.18
, pp. 4657-4668
-
-
Sano, S.1
Itami, S.2
Takeda, K.3
Tarutani, M.4
Yamaguchi, Y.5
Miura, H.6
-
91
-
-
0035966321
-
Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila
-
Silver DL, Montell DJ. Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell 2001;107:831-41.
-
(2001)
Cell
, vol.107
, pp. 831-841
-
-
Silver, D.L.1
Montell, D.J.2
-
92
-
-
0013689209
-
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth In vitro
-
Grandis JR, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth In vitro. J Clin Invest 1998;102:1385-92.
-
(1998)
J Clin Invest
, vol.102
, pp. 1385-1392
-
-
Grandis, J.R.1
Drenning, S.D.2
Chakraborty, A.3
Zhou, M.Y.4
Zeng, Q.5
Pitt, A.S.6
-
93
-
-
84865292443
-
Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice
-
Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, et al. Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice. PLoS ONE 2012;7:e43711.
-
(2012)
PLoS ONE
, vol.7
, pp. e43711
-
-
Liu, S.H.1
Wang, K.B.2
Lan, K.H.3
Lee, W.J.4
Pan, H.C.5
Wu, S.M.6
-
94
-
-
84877909949
-
Wedelolactone, a naturally occurring coumestan, enhances interferon-gamma signaling through inhibiting STAT1 protein dephosphorylation
-
Chen Z, Sun X, Shen S, Zhang H, Ma X, Liu J, et al. Wedelolactone, a naturally occurring coumestan, enhances interferon-gamma signaling through inhibiting STAT1 protein dephosphorylation. J Biol Chem 2013;288:14417-27.
-
(2013)
J Biol Chem
, vol.288
, pp. 14417-14427
-
-
Chen, Z.1
Sun, X.2
Shen, S.3
Zhang, H.4
Ma, X.5
Liu, J.6
-
95
-
-
0029943605
-
Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
-
Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA, Williams LT. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol 1996;16:4117-27.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4117-4127
-
-
Klippel, A.1
Reinhard, C.2
Kavanaugh, W.M.3
Apell, G.4
Escobedo, M.A.5
Williams, L.T.6
-
96
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
Kauffmann-Zeh A, Rodriguez-Viciana P, Ulrich E, Gilbert C, Coffer P, Downward J, et al. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 1997;385:544-8.
-
(1997)
Nature
, vol.385
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
-
97
-
-
34347383964
-
Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax
-
Han Z, Hong L, Han Y, Wu K, Han S, Shen H, et al. Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and Bax. J Exp Clin Cancer Res 2007;26:261-8.
-
(2007)
J Exp Clin Cancer Res
, vol.26
, pp. 261-268
-
-
Han, Z.1
Hong, L.2
Han, Y.3
Wu, K.4
Han, S.5
Shen, H.6
-
98
-
-
84885952969
-
Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways
-
Rasul A, Khan M, Yu B, Ali M, Bo YJ, Yang H, et al. Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways. Arch Pharm Res 2013;36:1262-9.
-
(2013)
Arch Pharm Res
, vol.36
, pp. 1262-1269
-
-
Rasul, A.1
Khan, M.2
Yu, B.3
Ali, M.4
Bo, Y.J.5
Yang, H.6
-
99
-
-
35648937054
-
Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line
-
Hu HZ, Yang YB, Xu XD, Shen HW, Shu YM, Ren Z, et al. Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line. Acta Pharmacol Sin 2007;28:1819-26.
-
(2007)
Acta Pharmacol Sin
, vol.28
, pp. 1819-1826
-
-
Hu, H.Z.1
Yang, Y.B.2
Xu, X.D.3
Shen, H.W.4
Shu, Y.M.5
Ren, Z.6
-
100
-
-
81255143133
-
Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway
-
Wei WT, Chen H, Wang ZH, Ni ZL, Liu HB, Tong HF, et al. Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway. Int J Biol Sci 2012;8:1-14.
-
(2012)
Int J Biol Sci
, vol.8
, pp. 1-14
-
-
Wei, W.T.1
Chen, H.2
Wang, Z.H.3
Ni, Z.L.4
Liu, H.B.5
Tong, H.F.6
-
101
-
-
84878896619
-
Magnolol protects against oxidative stress-mediated neural cell damage by modulating mitochondrial dysfunction and PI3K/Akt signaling
-
Dong L, Zhou S, Yang X, Chen Q, He Y, Huang W. Magnolol protects against oxidative stress-mediated neural cell damage by modulating mitochondrial dysfunction and PI3K/Akt signaling. J Mol Neurosci 2013;50:469-81.
-
(2013)
J Mol Neurosci
, vol.50
, pp. 469-481
-
-
Dong, L.1
Zhou, S.2
Yang, X.3
Chen, Q.4
He, Y.5
Huang, W.6
-
102
-
-
84863337524
-
Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways
-
Rasul A, Yu B, Khan M, Zhang K, Iqbal F, Ma T, et al. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol 2012;40:1153-61.
-
(2012)
Int J Oncol
, vol.40
, pp. 1153-1161
-
-
Rasul, A.1
Yu, B.2
Khan, M.3
Zhang, K.4
Iqbal, F.5
Ma, T.6
-
103
-
-
67651171652
-
Honokiol-mediated inhibition of PI3K/mTOR pathway: A potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function
-
Crane C, Panner A, Pieper RO, Arbiser J, Parsa AT. Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function. J Immunother 2009;32:585-92.
-
(2009)
J Immunother
, vol.32
, pp. 585-592
-
-
Crane, C.1
Panner, A.2
Pieper, R.O.3
Arbiser, J.4
Parsa, A.T.5
-
104
-
-
37849052257
-
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression
-
Kim BH, Cho JY. Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol Sin 2008;29:113-22.
-
(2008)
Acta Pharmacol Sin
, vol.29
, pp. 113-122
-
-
Kim, B.H.1
Cho, J.Y.2
-
105
-
-
79959471528
-
Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway
-
Shi Y, Bao YL, Wu Y, Yu CL, Huang YX, Sun Y, et al. Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway. J Biomol Screen 2011;16:525-35.
-
(2011)
J Biomol Screen
, vol.16
, pp. 525-535
-
-
Shi, Y.1
Bao, Y.L.2
Wu, Y.3
Yu, C.L.4
Huang, Y.X.5
Sun, Y.6
-
106
-
-
80054097504
-
Isoalantolactone protects against Staphylococcus aureus pneumonia
-
Qiu J, Luo M, Wang J, Dong J, Li H, Leng B, et al. Isoalantolactone protects against Staphylococcus aureus pneumonia. FEMS Microbiol Lett 2011;324:147-55.
-
(2011)
FEMS Microbiol Lett
, vol.324
, pp. 147-155
-
-
Qiu, J.1
Luo, M.2
Wang, J.3
Dong, J.4
Li, H.5
Leng, B.6
-
107
-
-
0036676714
-
Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones
-
Schmidt TJ, Brun R, Willuhn G, Khalid SA. Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones. Planta Med 2002;68:750-1.
-
(2002)
Planta Med
, vol.68
, pp. 750-751
-
-
Schmidt, T.J.1
Brun, R.2
Willuhn, G.3
Khalid, S.A.4
-
108
-
-
55949115327
-
Microbial transformation of alantolactone by Mucor polymorphosporus
-
Xin XL, Ma XC, Liu KX, Han J, Wang BR, Guo DA. Microbial transformation of alantolactone by Mucor polymorphosporus. J Asian Nat Prod Res 2008;10:933-7.
-
(2008)
J Asian Nat Prod Res
, vol.10
, pp. 933-937
-
-
Xin, X.L.1
Ma, X.C.2
Liu, K.X.3
Han, J.4
Wang, B.R.5
Guo, D.A.6
-
109
-
-
0034807826
-
Dietary agents in cancer prevention: Flavonoids and isoflavonoids
-
Birt DF, Hendrich S, Wang W. Dietary agents in cancer prevention: flavonoids and isoflavonoids. Pharmacol Ther 2001;90:157-77.
-
(2001)
Pharmacol Ther
, vol.90
, pp. 157-177
-
-
Birt, D.F.1
Hendrich, S.2
Wang, W.3
-
110
-
-
55849152355
-
Aging: ROS or TOR
-
Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008;7:3344-54.
-
(2008)
Cell Cycle
, vol.7
, pp. 3344-3354
-
-
Blagosklonny, M.V.1
-
111
-
-
0035080282
-
Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release
-
Lee MG, Lee KT, Chi SG, Park JH. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. Biol Pharm Bull 2001;24:303-6.
-
(2001)
Biol Pharm Bull
, vol.24
, pp. 303-306
-
-
Lee, M.G.1
Lee, K.T.2
Chi, S.G.3
Park, J.H.4
-
112
-
-
84874603246
-
Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction
-
Rasul A, Bao R, Malhi M, Zhao B, Tsuji I, Li J, et al. Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules 2013;18:1418-33.
-
(2013)
Molecules
, vol.18
, pp. 1418-1433
-
-
Rasul, A.1
Bao, R.2
Malhi, M.3
Zhao, B.4
Tsuji, I.5
Li, J.6
-
113
-
-
84900361938
-
Honokiol inhibits tumor necrosis factor-alpha-stimulated rat aortic smooth muscle cell proliferation via caspase-and mitochondrial-dependent apoptosis
-
Fan S, Li X, Lin J, Chen S, Shan J, Qi G. Honokiol inhibits tumor necrosis factor-alpha-stimulated rat aortic smooth muscle cell proliferation via caspase-and mitochondrial-dependent apoptosis. Inflammation 2014;37:17-26.
-
(2014)
Inflammation
, vol.37
, pp. 17-26
-
-
Fan, S.1
Li, X.2
Lin, J.3
Chen, S.4
Shan, J.5
Qi, G.6
-
114
-
-
84897814616
-
Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis
-
Wang X, Beitler JJ, Wang H, Lee MJ, Huang W, Koenig L, et al. Honokiol enhances paclitaxel efficacy in multi-drug resistant human cancer model through the induction of apoptosis. PLoS ONE 2014;9:e86369.
-
(2014)
PLoS ONE
, vol.9
, pp. e86369
-
-
Wang, X.1
Beitler, J.J.2
Wang, H.3
Lee, M.J.4
Huang, W.5
Koenig, L.6
-
115
-
-
84866006480
-
Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway
-
Park JB, Lee MS, Cha EY, Lee JS, Sul JY, Song IS, et al. Magnolol-induced apoptosis in HCT-116 colon cancer cells is associated with the AMP-activated protein kinase signaling pathway. Biol Pharm Bull 2012;35:1614-20.
-
(2012)
Biol Pharm Bull
, vol.35
, pp. 1614-1620
-
-
Park, J.B.1
Lee, M.S.2
Cha, E.Y.3
Lee, J.S.4
Sul, J.Y.5
Song, I.S.6
-
116
-
-
84884761324
-
Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway
-
Zhou Y, Bi Y, Yang C, Yang J, Jiang Y, Meng F, et al. Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway. Pharmazie 2013;68:755-62.
-
(2013)
Pharmazie
, vol.68
, pp. 755-762
-
-
Zhou, Y.1
Bi, Y.2
Yang, C.3
Yang, J.4
Jiang, Y.5
Meng, F.6
-
117
-
-
0028068186
-
Free radicals, antioxidants, and human disease: Curiosity, cause, or consequence?
-
Halliwell B. Free radicals, antioxidants, and human disease: curiosity, cause, or consequence? Lancet 1994;344:721-4.
-
(1994)
Lancet
, vol.344
, pp. 721-724
-
-
Halliwell, B.1
-
118
-
-
0031980388
-
Role of oxidative DNA damage in cancer initiation and promotion
-
Poulsen HE, Prieme H, Loft S. Role of oxidative DNA damage in cancer initiation and promotion. Eur J Cancer Prev 1998;7:9-16.
-
(1998)
Eur J Cancer Prev
, vol.7
, pp. 9-16
-
-
Poulsen, H.E.1
Prieme, H.2
Loft, S.3
-
119
-
-
84859853336
-
NADPH oxidases as regulators of tumor angiogenesis: Current and emerging concepts
-
Coso S, Harrison I, Harrison CB, Vinh A, Sobey CG, Drummond GR, et al. NADPH oxidases as regulators of tumor angiogenesis: current and emerging concepts. Antioxid Redox Signal 2012;16:1229-47.
-
(2012)
Antioxid Redox Signal
, vol.16
, pp. 1229-1247
-
-
Coso, S.1
Harrison, I.2
Harrison, C.B.3
Vinh, A.4
Sobey, C.G.5
Drummond, G.R.6
-
120
-
-
33646525680
-
Vascular NADPH oxidases as drug targets for novel antioxidant strategies
-
Guzik TJ, Harrison DG. Vascular NADPH oxidases as drug targets for novel antioxidant strategies. Drug Discov Today 2006;11:524-33.
-
(2006)
Drug Discov Today
, vol.11
, pp. 524-533
-
-
Guzik, T.J.1
Harrison, D.G.2
-
121
-
-
84907029402
-
Anti-oxidative effects of Rooibos tea (Aspalathus linearis) on immobilization-induced oxidative stress in rat brain
-
Hong IS, Lee HY, Kim HP. Anti-oxidative effects of Rooibos tea (Aspalathus linearis) on immobilization-induced oxidative stress in rat brain. PLoS ONE 2014;9:e87061.
-
(2014)
PLoS ONE
, vol.9
, pp. e87061
-
-
Hong, I.S.1
Lee, H.Y.2
Kim, H.P.3
-
122
-
-
84893826824
-
Natural compounds as modulators of NADPH oxidases
-
Maraldi T. Natural compounds as modulators of NADPH oxidases. Oxid Med Cell Longev 2013;2013:271602.
-
(2013)
Oxid Med Cell Longev
, vol.2013
, pp. 271602
-
-
Maraldi, T.1
-
123
-
-
4244006599
-
Signalling mechanisms and oxidative stress in apoptosis
-
Slater AF, Stefan C, Nobel I, van den Dobbelsteen DJ, Orrenius S. Signalling mechanisms and oxidative stress in apoptosis. Toxicol Lett 1995;82-83:149-53.
-
(1995)
Toxicol Lett
, vol.82-83
, pp. 149-153
-
-
Slater, A.F.1
Stefan, C.2
Nobel, I.3
Van Den Dobbelsteen, D.J.4
Orrenius, S.5
-
124
-
-
84863611585
-
Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells
-
Khan M, Ding C, Rasul A, Yi F, Li T, Gao H, et al. Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells. Int J Biol Sci 2012;8:533-47.
-
(2012)
Int J Biol Sci
, vol.8
, pp. 533-547
-
-
Khan, M.1
Ding, C.2
Rasul, A.3
Yi, F.4
Li, T.5
Gao, H.6
-
125
-
-
84865331826
-
Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction
-
Khan M, Yi F, Rasul A, Li T, Wang N, Gao H, et al. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life 2012;64:783-94.
-
(2012)
IUBMB Life
, vol.64
, pp. 783-794
-
-
Khan, M.1
Yi, F.2
Rasul, A.3
Li, T.4
Wang, N.5
Gao, H.6
-
126
-
-
77956172542
-
Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa
-
Pal HC, Sehar I, Bhushan S, Gupta BD, Saxena AK. Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa. Toxicol In Vitro 2010;24:1599-609.
-
(2010)
Toxicol in Vitro
, vol.24
, pp. 1599-1609
-
-
Pal, H.C.1
Sehar, I.2
Bhushan, S.3
Gupta, B.D.4
Saxena, A.K.5
-
127
-
-
0035902115
-
Proliferation, cell cycle and apoptosis in cancer
-
Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature 2001;411:342-8.
-
(2001)
Nature
, vol.411
, pp. 342-348
-
-
Evan, G.I.1
Vousden, K.H.2
-
128
-
-
0344513852
-
Mitochondrial generation of reactive oxygen species and its role in aerobic life
-
Inoue M, Sato EF, Nishikawa M, Park AM, Kira Y, Imada I, et al. Mitochondrial generation of reactive oxygen species and its role in aerobic life. Curr Med Chem 2003;10:2495-505.
-
(2003)
Curr Med Chem
, vol.10
, pp. 2495-2505
-
-
Inoue, M.1
Sato, E.F.2
Nishikawa, M.3
Park, A.M.4
Kira, Y.5
Imada, I.6
-
129
-
-
84872945822
-
Magnolia polyphenols attenuate oxidative andinflammatory responses in neurons and microglial cells
-
Chuang DY, Chan MH, Zong Y, Sheng W, He Y, Jiang JH, et al. Magnolia polyphenols attenuate oxidative andinflammatory responses in neurons and microglial cells. J Neuroinflammation 2013;10:15.
-
(2013)
J Neuroinflammation
, vol.10
, pp. 15
-
-
Chuang, D.Y.1
Chan, M.H.2
Zong, Y.3
Sheng, W.4
He, Y.5
Jiang, J.H.6
-
130
-
-
67349230885
-
Reactive oxygen species production and Bax/Bcl-2 regulation in honokiol-induced apoptosis in human hepatocellular carcinoma SMMC-7721 cells
-
Han LL, Xie LP, Li LH, Zhang XW, Zhang RQ, Wang HZ. Reactive oxygen species production and Bax/Bcl-2 regulation in honokiol-induced apoptosis in human hepatocellular carcinoma SMMC-7721 cells. Environ Toxicol Pharmacol 2009;28:97-103.
-
(2009)
Environ Toxicol Pharmacol
, vol.28
, pp. 97-103
-
-
Han, L.L.1
Xie, L.P.2
Li, L.H.3
Zhang, X.W.4
Zhang, R.Q.5
Wang, H.Z.6
-
131
-
-
34247853280
-
Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species
-
Kim MJ, Kim DH, Lee KW, Yoon DY, Surh YJ. Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species. Ann N Y Acad Sci 2007;1095:483-95.
-
(2007)
Ann N Y Acad Sci
, vol.1095
, pp. 483-495
-
-
Kim, M.J.1
Kim, D.H.2
Lee, K.W.3
Yoon, D.Y.4
Surh, Y.J.5
-
132
-
-
80053168978
-
Induction of apoptosis by casticin in cervical cancer cells through reactive oxygen species-mediated mitochondrial signaling pathways
-
Chen D, Cao J, Tian L, Liu F, Sheng X. Induction of apoptosis by casticin in cervical cancer cells through reactive oxygen species-mediated mitochondrial signaling pathways. Oncol Rep 2011;26:1287-94.
-
(2011)
Oncol Rep
, vol.26
, pp. 1287-1294
-
-
Chen, D.1
Cao, J.2
Tian, L.3
Liu, F.4
Sheng, X.5
-
133
-
-
84860467558
-
Induction of apoptosis by casticin in cervical cancer cells: Reactive oxygen species-dependent sustained activation of Jun N-terminal kinase
-
Zeng F, Tian L, Liu F, Cao J, Quan M, Sheng X. Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase. Acta Biochim Biophys Sin 2012;44:442-9.
-
(2012)
Acta Biochim Biophys Sin
, vol.44
, pp. 442-449
-
-
Zeng, F.1
Tian, L.2
Liu, F.3
Cao, J.4
Quan, M.5
Sheng, X.6
-
134
-
-
84865122055
-
Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells
-
Lee CS, Kim YJ, Lee SA, Myung SC, Kim W. Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells. Basic Clin Pharmacol Toxicol 2012;111:173-81.
-
(2012)
Basic Clin Pharmacol Toxicol
, vol.111
, pp. 173-181
-
-
Lee, C.S.1
Kim, Y.J.2
Lee, S.A.3
Myung, S.C.4
Kim, W.5
-
135
-
-
81155123109
-
Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species
-
Yang YI, Kim JH, Lee KT, Choi JH. Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species. Gynecol Oncol 2011;123:588-96.
-
(2011)
Gynecol Oncol
, vol.123
, pp. 588-596
-
-
Yang, Y.I.1
Kim, J.H.2
Lee, K.T.3
Choi, J.H.4
-
136
-
-
84883181330
-
Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells
-
Rasul A, Di J, Millimouno FM, Malhi M, Tsuji I, Ali M, et al. Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells. Molecules 2013;18:9382-96.
-
(2013)
Molecules
, vol.18
, pp. 9382-9396
-
-
Rasul, A.1
Di, J.2
Millimouno, F.M.3
Malhi, M.4
Tsuji, I.5
Ali, M.6
-
137
-
-
84883397220
-
Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway
-
Zhang Y, Bao YL,Wu Y, Yu CL, Huang YX, Sun Y, et al. Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. Mol Med Rep 2013;8:967-72.
-
(2013)
Mol Med Rep
, vol.8
, pp. 967-972
-
-
Zhang, Y.1
Bao, Y.L.2
Wu, Y.3
Yu, C.L.4
Huang, Y.X.5
Sun, Y.6
-
138
-
-
84873435725
-
Reactive oxygen species H2O2 and ∗OH, but not O2∗(-) promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells
-
Zang L, He H, Xu Q, Yu Y, Zheng N, Liu W, et al. Reactive oxygen species H2O2 and ∗OH, but not O2∗(-) promote oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells. Int Immunopharmacol 2013;15:414-23.
-
(2013)
Int Immunopharmacol
, vol.15
, pp. 414-423
-
-
Zang, L.1
He, H.2
Xu, Q.3
Yu, Y.4
Zheng, N.5
Liu, W.6
-
139
-
-
80053923208
-
Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells
-
Zhang YH, Wu YL, Tashiro S, Onodera S, Ikejima T. Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells. Acta Pharmacol Sin 2011;32:1266-75.
-
(2011)
Acta Pharmacol Sin
, vol.32
, pp. 1266-1275
-
-
Zhang, Y.H.1
Wu, Y.L.2
Tashiro, S.3
Onodera, S.4
Ikejima, T.5
-
140
-
-
84877297444
-
Pseudolaric acid B-induced autophagy contributes to senescence via enhancement of ROS generation and mitochondrial dysfunction in murine fibrosarcoma L929 cells
-
Qi M, Fan S, Yao G, Li Z, Zhou H, Tashiro S, et al. Pseudolaric acid B-induced autophagy contributes to senescence via enhancement of ROS generation and mitochondrial dysfunction in murine fibrosarcoma L929 cells. J Pharmacol Sci 2013;121:200-11.
-
(2013)
J Pharmacol Sci
, vol.121
, pp. 200-211
-
-
Qi, M.1
Fan, S.2
Yao, G.3
Li, Z.4
Zhou, H.5
Tashiro, S.6
-
141
-
-
84862797757
-
Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells
-
Zhao D, Lin F, Wu X, Zhao Q, Zhao B, Lin P, et al. Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells. Toxicol In Vitro 2012;26:595-602.
-
(2012)
Toxicol in Vitro
, vol.26
, pp. 595-602
-
-
Zhao, D.1
Lin, F.2
Wu, X.3
Zhao, Q.4
Zhao, B.5
Lin, P.6
-
142
-
-
34748824207
-
Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis
-
Yang J, Wu LJ, Tashino S, Onodera S, Ikejima T. Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis. Free Radic Res 2007;41:1099-108.
-
(2007)
Free Radic Res
, vol.41
, pp. 1099-1108
-
-
Yang, J.1
Wu, L.J.2
Tashino, S.3
Onodera, S.4
Ikejima, T.5
-
143
-
-
46649120102
-
Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells
-
Yang J, Wu LJ, Tashino S, Onodera S, Ikejima T. Reactive oxygen species and nitric oxide regulate mitochondria-dependent apoptosis and autophagy in evodiamine-treated human cervix carcinoma HeLa cells. Free Radic Res 2008;42:492-504.
-
(2008)
Free Radic Res
, vol.42
, pp. 492-504
-
-
Yang, J.1
Wu, L.J.2
Tashino, S.3
Onodera, S.4
Ikejima, T.5
-
144
-
-
0029874458
-
Checkpoints in the life-cycle of Cassiopea spp.: Control of metagenesis and metamorphosis in a tropical jellyfish
-
Hofmann DK, Fitt WK, Fleck J. Checkpoints in the life-cycle of Cassiopea spp.: control of metagenesis and metamorphosis in a tropical jellyfish. Int J Dev Biol 1996;40:331-8.
-
(1996)
Int J Dev Biol
, vol.40
, pp. 331-338
-
-
Hofmann, D.K.1
Fitt, W.K.2
Fleck, J.3
-
145
-
-
84894531752
-
AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in theDNAdamage response pathway
-
Sanli T, Steinberg GR, Singh G, Tsakiridis T. AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in theDNAdamage response pathway. Cancer Biol Ther 2014;15:156-69.
-
(2014)
Cancer Biol Ther
, vol.15
, pp. 156-169
-
-
Sanli, T.1
Steinberg, G.R.2
Singh, G.3
Tsakiridis, T.4
-
146
-
-
84861003268
-
GADD45 proteins: Central players in tumorigenesis
-
Tamura RE, de Vasconcellos JF, Sarkar D, Libermann TA, Fisher PB, Zerbini LF. GADD45 proteins: central players in tumorigenesis. Curr Mol Med 2012;12:634-51.
-
(2012)
Curr Mol Med
, vol.12
, pp. 634-651
-
-
Tamura, R.E.1
De Vasconcellos, J.F.2
Sarkar, D.3
Libermann, T.A.4
Fisher, P.B.5
Zerbini, L.F.6
-
147
-
-
0042318707
-
Apoptosis-an introduction
-
Lawen A. Apoptosis-an introduction. Bioessays 2003;25:888-96.
-
(2003)
Bioessays
, vol.25
, pp. 888-896
-
-
Lawen, A.1
-
148
-
-
0036463649
-
Apoptosis-based therapies
-
Reed JC. Apoptosis-based therapies. Nat Rev Drug Discov 2002;1:111-21.
-
(2002)
Nat Rev Drug Discov
, vol.1
, pp. 111-121
-
-
Reed, J.C.1
-
149
-
-
68849116745
-
Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo
-
Idris AI, Libouban H, Nyangoga H, Landao-Bassonga E, Chappard D, Ralston SH. Pharmacologic inhibitors of IkappaB kinase suppress growth and migration of mammary carcinosarcoma cells in vitro and prevent osteolytic bone metastasis in vivo. Mol Cancer Ther 2009;8:2339-47.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 2339-2347
-
-
Idris, A.I.1
Libouban, H.2
Nyangoga, H.3
Landao-Bassonga, E.4
Chappard, D.5
Ralston, S.H.6
-
150
-
-
3543018495
-
Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer
-
Curry EA III, Murry DJ, Yoder C, Fife K, Armstrong V, Nakshatri H, et al. Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer. Invest New Drugs 2004;22:299-305.
-
(2004)
Invest New Drugs
, vol.22
, pp. 299-305
-
-
Curry, E.A.1
Murry, D.J.2
Yoder, C.3
Fife, K.4
Armstrong, V.5
Nakshatri, H.6
-
151
-
-
84883551479
-
Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity
-
Sen S, Hassane DC, Corbett C, Becker MW, Jordan CT, Guzman ML. Novel mTOR inhibitory activity of ciclopirox enhances parthenolide antileukemia activity. Exp Hematol 2013;41:799-807 e4.
-
(2013)
Exp Hematol
, vol.41
-
-
Sen, S.1
Hassane, D.C.2
Corbett, C.3
Becker, M.W.4
Jordan, C.T.5
Guzman, M.L.6
-
152
-
-
79959648566
-
Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells
-
Arora S, Bhardwaj A, Srivastava SK, Singh S, McClellan S, Wang B, et al. Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells. PLoS ONE 2011;6:e21573.
-
(2011)
PLoS ONE
, vol.6
, pp. e21573
-
-
Arora, S.1
Bhardwaj, A.2
Srivastava, S.K.3
Singh, S.4
McClellan, S.5
Wang, B.6
-
153
-
-
84870161284
-
Honokiol: A novel natural agent for cancer prevention and therapy
-
Arora S, Singh S, Piazza GA, Contreras CM, Panyam J, Singh AP. Honokiol: a novel natural agent for cancer prevention and therapy. Curr Mol Med 2012;12:1244-52.
-
(2012)
Curr Mol Med
, vol.12
, pp. 1244-1252
-
-
Arora, S.1
Singh, S.2
Piazza, G.A.3
Contreras, C.M.4
Panyam, J.5
Singh, A.P.6
-
154
-
-
84875469127
-
P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo
-
Chen LC, Lee WS. P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in vivo. J Agric Food Chem 2013;61:2811-9.
-
(2013)
J Agric Food Chem
, vol.61
, pp. 2811-2819
-
-
Chen, L.C.1
Lee, W.S.2
-
155
-
-
84875701146
-
Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1alpha/VEGF signaling pathway in human bladder cancer cells
-
Chen MC, Lee CF, Huang WH, Chou TC. Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1alpha/VEGF signaling pathway in human bladder cancer cells. Biochem Pharmacol 2013;85:1278-87.
-
(2013)
Biochem Pharmacol
, vol.85
, pp. 1278-1287
-
-
Chen, M.C.1
Lee, C.F.2
Huang, W.H.3
Chou, T.C.4
-
156
-
-
79953772398
-
Honokiol: A promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells
-
Chen XR, Lu R, Dan HX, Liao G, Zhou M, Li XY, et al. Honokiol: a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells. Int J Oral Sci 2011;3:34-42.
-
(2011)
Int J Oral Sci
, vol.3
, pp. 34-42
-
-
Chen, X.R.1
Lu, R.2
Dan, H.X.3
Liao, G.4
Zhou, M.5
Li, X.Y.6
-
157
-
-
49149119432
-
Honokiol is a potent scavenger of superoxide and peroxyl radicals
-
Dikalov S, Losik T, Arbiser JL. Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem Pharmacol 2008;76:589-96.
-
(2008)
Biochem Pharmacol
, vol.76
, pp. 589-596
-
-
Dikalov, S.1
Losik, T.2
Arbiser, J.L.3
-
158
-
-
73849136351
-
Honokiol nanoparticles in thermosensitive hydrogel: Therapeutic effects on malignant pleural effusion
-
Fang F, Gong C, Qian Z, Zhang X, Gou M, You C, et al. Honokiol nanoparticles in thermosensitive hydrogel: therapeutic effects on malignant pleural effusion. ACS Nano 2009;3:4080-8.
-
(2009)
ACS Nano
, vol.3
, pp. 4080-4088
-
-
Fang, F.1
Gong, C.2
Qian, Z.3
Zhang, X.4
Gou, M.5
You, C.6
-
159
-
-
84873637453
-
Screening active antibreast cancer compounds from Cortex Magnolia officinalis by 2D LCMS
-
Hou X, Yuan X, Zhang B, Wang S, Chen Q. Screening active antibreast cancer compounds from Cortex Magnolia officinalis by 2D LCMS. J Sep Sci 2013;36:706-12.
-
(2013)
J Sep Sci
, vol.36
, pp. 706-712
-
-
Hou, X.1
Yuan, X.2
Zhang, B.3
Wang, S.4
Chen, Q.5
-
160
-
-
79953799722
-
Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer
-
Hsu JL, Pan SL, Ho YF, Hwang TL, Kung FL, Guh JH. Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer. J Urol 2011;185:1967-74.
-
(2011)
J Urol
, vol.185
, pp. 1967-1974
-
-
Hsu, J.L.1
Pan, S.L.2
Ho, Y.F.3
Hwang, T.L.4
Kung, F.L.5
Guh, J.H.6
-
161
-
-
84863968745
-
Wnt/beta-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells
-
Kang YJ, Park HJ, Chung HJ, Min HY, Park EJ, Lee MA, et al. Wnt/beta-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells. Mol Pharmacol 2012;82:168-77.
-
(2012)
Mol Pharmacol
, vol.82
, pp. 168-177
-
-
Kang, Y.J.1
Park, H.J.2
Chung, H.J.3
Min, H.Y.4
Park, E.J.5
Lee, M.A.6
-
162
-
-
84867700942
-
Metabolism studies of casticin in rats using HPLC-ESI-MS(n)
-
Ling Y, Zhu J, Fan M, Wu B, Qin L, Huang C. Metabolism studies of casticin in rats using HPLC-ESI-MS(n). Biomed Chromatogr 2012;26:1502-8.
-
(2012)
Biomed Chromatogr
, vol.26
, pp. 1502-1508
-
-
Ling, Y.1
Zhu, J.2
Fan, M.3
Wu, B.4
Qin, L.5
Huang, C.6
-
163
-
-
67649394233
-
Casticin induces leukemic cell death through apoptosis and mitotic catastrophe
-
Shen JK, Du HP, Yang M, Wang YG, Jin J. Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Ann Hematol 2009;88:743-52.
-
(2009)
Ann Hematol
, vol.88
, pp. 743-752
-
-
Shen, J.K.1
Du, H.P.2
Yang, M.3
Wang, Y.G.4
Jin, J.5
-
164
-
-
80955151280
-
Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells
-
Yang J, Yang Y, Tian L, Sheng XF, Liu F, Cao JG. Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells. World J Gastroenterol 2011;17:4298-307.
-
(2011)
World J Gastroenterol
, vol.17
, pp. 4298-4307
-
-
Yang, J.1
Yang, Y.2
Tian, L.3
Sheng, X.F.4
Liu, F.5
Cao, J.G.6
-
165
-
-
78649919250
-
Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro
-
Ye Q, Zhang QY, Zheng CJ, Wang Y, Qin LP. Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro. Acta Pharmacol Sin 2010;31:1564-8.
-
(2010)
Acta Pharmacol Sin
, vol.31
, pp. 1564-1568
-
-
Ye, Q.1
Zhang, Q.Y.2
Zheng, C.J.3
Wang, Y.4
Qin, L.P.5
-
166
-
-
84866524759
-
Honokiol exerts an anticancer effect in T98G human glioblastoma cells through the induction of apoptosis and the regulation of adhesion molecules
-
Jeong JJ, Lee JH, Chang KC, Kim HJ. Honokiol exerts an anticancer effect in T98G human glioblastoma cells through the induction of apoptosis and the regulation of adhesion molecules. Int J Oncol 2012;41:1358-64.
-
(2012)
Int J Oncol
, vol.41
, pp. 1358-1364
-
-
Jeong, J.J.1
Lee, J.H.2
Chang, K.C.3
Kim, H.J.4
-
167
-
-
70349312538
-
Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery
-
Li X, Guo Q, Zheng X, Kong X, Shi S, Chen L, et al. Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery. Drug Deliv 2009;16:160-6.
-
(2009)
Drug Deliv
, vol.16
, pp. 160-166
-
-
Li, X.1
Guo, Q.2
Zheng, X.3
Kong, X.4
Shi, S.5
Chen, L.6
-
168
-
-
49649114129
-
Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells
-
Li Z, Liu Y, Zhao X, Pan X, Yin R, Huang C, et al. Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells. Eur J Obstet Gynecol Reprod Biol 2008;140:95-102.
-
(2008)
Eur J Obstet Gynecol Reprod Biol
, vol.140
, pp. 95-102
-
-
Li, Z.1
Liu, Y.2
Zhao, X.3
Pan, X.4
Yin, R.5
Huang, C.6
-
169
-
-
77950658212
-
Honokiol inhibits HepG2 migration via down-regulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis
-
Liang S, Fu A, Zhang Q, Tang M, Zhou J, Wei Y, et al. Honokiol inhibits HepG2 migration via down-regulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis. Proteomics 2010;10:1474-83.
-
(2010)
Proteomics
, vol.10
, pp. 1474-1483
-
-
Liang, S.1
Fu, A.2
Zhang, Q.3
Tang, M.4
Zhou, J.5
Wei, Y.6
-
170
-
-
48749104995
-
Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer
-
Liu H, Zang C, Emde A, Planas-Silva MD, Rosche M, Kuhnl A, et al. Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer. Eur J Pharmacol 2008;591:43-51.
-
(2008)
Eur J Pharmacol
, vol.591
, pp. 43-51
-
-
Liu, H.1
Zang, C.2
Emde, A.3
Planas-Silva, M.D.4
Rosche, M.5
Kuhnl, A.6
-
171
-
-
77954881040
-
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals
-
Liu SH, Shen CC, Yi YC, Tsai JJ, Wang CC, Chueh JT, et al. Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. Br J Pharmacol 2010;160:1963-72.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1963-1972
-
-
Liu, S.H.1
Shen, C.C.2
Yi, Y.C.3
Tsai, J.J.4
Wang, C.C.5
Chueh, J.T.6
-
172
-
-
80051552550
-
Honokiol produces anti-neoplastic effects on melanoma cells in vitro
-
Mannal PW, Schneider J, Tangada A, McDonald D, McFadden DW. Honokiol produces anti-neoplastic effects on melanoma cells in vitro. J Surg Oncol 2011;104:260-4.
-
(2011)
J Surg Oncol
, vol.104
, pp. 260-264
-
-
Mannal, P.W.1
Schneider, J.2
Tangada, A.3
McDonald, D.4
McFadden, D.W.5
-
173
-
-
84862907992
-
Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1
-
Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, et al. Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1. J Cell Physiol 2012;227:2184-95.
-
(2012)
J Cell Physiol
, vol.227
, pp. 2184-2195
-
-
Rajendran, P.1
Li, F.2
Shanmugam, M.K.3
Vali, S.4
Abbasi, T.5
Kapoor, S.6
-
174
-
-
79952012897
-
Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2
-
Singh T, Katiyar SK. Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2. Int J Oncol 2011;38:769-76.
-
(2011)
Int J Oncol
, vol.38
, pp. 769-776
-
-
Singh, T.1
Katiyar, S.K.2
-
175
-
-
84873621298
-
Honokiol synergizes chemotherapy drugs in multidrug resistant breast cancer cells via enhanced apoptosis and additional programmed necrotic death
-
Tian W, Deng Y, Li L, He H, Sun J, Xu D. Honokiol synergizes chemotherapy drugs in multidrug resistant breast cancer cells via enhanced apoptosis and additional programmed necrotic death. Int J Oncol 2013;42:721-32.
-
(2013)
Int J Oncol
, vol.42
, pp. 721-732
-
-
Tian, W.1
Deng, Y.2
Li, L.3
He, H.4
Sun, J.5
Xu, D.6
-
176
-
-
84868273888
-
Honokiol, a multifunctional tumor cell death inducer
-
Tian W, Xu D, Deng YC. Honokiol, a multifunctional tumor cell death inducer. Pharmazie 2012;67:811-6.
-
(2012)
Pharmazie
, vol.67
, pp. 811-816
-
-
Tian, W.1
Xu, D.2
Deng, Y.C.3
-
177
-
-
78149234280
-
Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: Development of topical formulation
-
Vaid M, Sharma SD, Katiyar SK. Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation. Carcinogenesis 2010;31:2004-11.
-
(2010)
Carcinogenesis
, vol.31
, pp. 2004-2011
-
-
Vaid, M.1
Sharma, S.D.2
Katiyar, S.K.3
-
178
-
-
78651268098
-
Honokiol: An effective inhibitor of high-glucose-induced upregulation of inflammatory cytokine production in human renal mesangial cells
-
Wu JP, Zhang W, Wu F, Zhao Y, Cheng LF, Xie JJ, et al. Honokiol: an effective inhibitor of high-glucose-induced upregulation of inflammatory cytokine production in human renal mesangial cells. Inflamm Res 2010;59:1073-9.
-
(2010)
Inflamm Res
, vol.59
, pp. 1073-1079
-
-
Wu, J.P.1
Zhang, W.2
Wu, F.3
Zhao, Y.4
Cheng, L.F.5
Xie, J.J.6
-
179
-
-
77957320051
-
Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes
-
Ji HY, Kim SY, Kim DK, Jeong JH, Lee HS. Effects of eupatilin and jaceosidin on cytochrome p450 enzyme activities in human liver microsomes. Molecules 2010;15:6466-75.
-
(2010)
Molecules
, vol.15
, pp. 6466-6475
-
-
Ji, H.Y.1
Kim, S.Y.2
Kim, D.K.3
Jeong, J.H.4
Lee, H.S.5
-
180
-
-
84873563211
-
Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation
-
Lee JG, Kim JH, Ahn JH, Lee KT, Baek NI, Choi JH. Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation. Food Chem Toxicol 2013;55:214-21.
-
(2013)
Food Chem Toxicol
, vol.55
, pp. 214-221
-
-
Lee, J.G.1
Kim, J.H.2
Ahn, J.H.3
Lee, K.T.4
Baek, N.I.5
Choi, J.H.6
-
181
-
-
56149094346
-
Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway
-
Lv W, Sheng X, Chen T, Xu Q, Xie X. Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. J Biomed Biotechnol 2008;2008:394802.
-
(2008)
J Biomed Biotechnol
, vol.2008
, pp. 394802
-
-
Lv, W.1
Sheng, X.2
Chen, T.3
Xu, Q.4
Xie, X.5
-
182
-
-
70349949009
-
Costunolide-induced apoptosis in human leukemia cells: Involvement of c-jun N-terminal kinase activation
-
Choi JH, Lee KT. Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation. Biol Pharm Bull 2009;32:1803-8.
-
(2009)
Biol Pharm Bull
, vol.32
, pp. 1803-1808
-
-
Choi, J.H.1
Lee, K.T.2
-
183
-
-
84857909839
-
Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231
-
Choi YK, Seo HS, Choi HS, Kim SR, Shin YC, Ko SG. Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231. Mol Cell Biochem 2012;363:119-28.
-
(2012)
Mol Cell Biochem
, vol.363
, pp. 119-128
-
-
Choi, Y.K.1
Seo, H.S.2
Choi, H.S.3
Kim, S.R.4
Shin, Y.C.5
Ko, S.G.6
-
184
-
-
57349129039
-
Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds
-
Kim SH, Danilenko M, Kim TS. Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds. Br J Pharmacol 2008;155:814-25.
-
(2008)
Br J Pharmacol
, vol.155
, pp. 814-825
-
-
Kim, S.H.1
Danilenko, M.2
Kim, T.S.3
-
185
-
-
80052278228
-
Inhibitory effects of costunolide isolated from laurus nobilis on IgE-induced degranulation of mast cell-like RBL-2H3 cells and the growth of Y16 pro-B cells
-
Jun 14. [Epub ahead of print]
-
Kim TJ, Nam KW, Kim B, Lee SJ, Oh KB, Kim KH, et al. Inhibitory effects of costunolide isolated from laurus nobilis on IgE-induced degranulation of mast cell-like RBL-2H3 cells and the growth of Y16 pro-B cells. Phytother Res 2011 Jun 14. [Epub ahead of print].
-
(2011)
Phytother Res
-
-
Kim, T.J.1
Nam, K.W.2
Kim, B.3
Lee, S.J.4
Oh, K.B.5
Kim, K.H.6
-
186
-
-
79957571352
-
Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells
-
Liu CY, Chang HS, Chen IS, Chen CJ, Hsu ML, Fu SL, et al. Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells. Radiat Oncol 2011;6:56.
-
(2011)
Radiat Oncol
, vol.6
, pp. 56
-
-
Liu, C.Y.1
Chang, H.S.2
Chen, I.S.3
Chen, C.J.4
Hsu, M.L.5
Fu, S.L.6
-
187
-
-
80052218554
-
Parthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells in vitro
-
Cheng G, Xie L. Parthenolide induces apoptosis and cell cycle arrest of human 5637 bladder cancer cells in vitro. Molecules 2011;16:6758-68.
-
(2011)
Molecules
, vol.16
, pp. 6758-6768
-
-
Cheng, G.1
Xie, L.2
-
188
-
-
84873426890
-
Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres
-
Czyz M, Koprowska K, Sztiller-Sikorska M. Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres. Cancer Biol Ther 2013;14:135-45.
-
(2013)
Cancer Biol Ther
, vol.14
, pp. 135-145
-
-
Czyz, M.1
Koprowska, K.2
Sztiller-Sikorska, M.3
-
189
-
-
77953208098
-
Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells
-
Czyz M, Lesiak-Mieczkowska K, Koprowska K, Szulawska-Mroczek A, Wozniak M. Cell context-dependent activities of parthenolide in primary and metastatic melanoma cells. Br J Pharmacol 2010;160:1144-57.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1144-1157
-
-
Czyz, M.1
Lesiak-Mieczkowska, K.2
Koprowska, K.3
Szulawska-Mroczek, A.4
Wozniak, M.5
-
190
-
-
84865163278
-
Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma
-
Li Y, Zhang Y, Fu M, Yao Q, Zhuo H, Lu Q, et al. Parthenolide induces apoptosis and lytic cytotoxicity in Epstein-Barr virus-positive Burkitt lymphoma. Mol Med Rep 2012;6:477-82.
-
(2012)
Mol Med Rep
, vol.6
, pp. 477-482
-
-
Li, Y.1
Zhang, Y.2
Fu, M.3
Yao, Q.4
Zhuo, H.5
Lu, Q.6
-
191
-
-
77955288887
-
Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro
-
Liu JW, Cai MX, Xin Y, Wu QS, Ma J, Yang P, et al. Parthenolide induces proliferation inhibition and apoptosis of pancreatic cancer cells in vitro. J Exp Clin Cancer Res 2010;29:108.
-
(2010)
J Exp Clin Cancer Res
, vol.29
, pp. 108
-
-
Liu, J.W.1
Cai, M.X.2
Xin, Y.3
Wu, Q.S.4
Ma, J.5
Yang, P.6
-
192
-
-
84867002638
-
Involvement of Akt/NF-kappaB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo
-
Nakabayashi H, Shimizu K. Involvement of Akt/NF-kappaB pathway in antitumor effects of parthenolide on glioblastoma cells in vitro and in vivo. BMC Cancer 2012;12:453.
-
(2012)
BMC Cancer
, vol.12
, pp. 453
-
-
Nakabayashi, H.1
Shimizu, K.2
-
193
-
-
79953212611
-
A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-kappaB and generating reactive oxygen species
-
Shanmugam R, Kusumanchi P, Appaiah H, Cheng L, Crooks P, Neelakantan S, et al. A water soluble parthenolide analog suppresses in vivo tumor growth of two tobacco-associated cancers, lung and bladder cancer, by targeting NF-kappaB and generating reactive oxygen species. Int J Cancer 2011;128:2481-94.
-
(2011)
Int J Cancer
, vol.128
, pp. 2481-2494
-
-
Shanmugam, R.1
Kusumanchi, P.2
Appaiah, H.3
Cheng, L.4
Crooks, P.5
Neelakantan, S.6
-
194
-
-
79951962599
-
Parthenolide, an NF-kappaB inhibitor, suppresses tumor growth and enhances response to chemotherapy in gastric cancer
-
Sohma I, Fujiwara Y, Sugita Y, Yoshioka A, Shirakawa M, Moon JH, et al. Parthenolide, an NF-kappaB inhibitor, suppresses tumor growth and enhances response to chemotherapy in gastric cancer. Cancer Genomics Proteomics 2011;8:39-47.
-
(2011)
Cancer Genomics Proteomics
, vol.8
, pp. 39-47
-
-
Sohma, I.1
Fujiwara, Y.2
Sugita, Y.3
Yoshioka, A.4
Shirakawa, M.5
Moon, J.H.6
-
195
-
-
77950855526
-
A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
-
Sun Y, St Clair DK, Xu Y, Crooks PA, St Clair WH. A NADPH oxidase-dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells. Cancer Res 2010;70:2880-90.
-
(2010)
Cancer Res
, vol.70
, pp. 2880-2890
-
-
Sun, Y.1
St Clair, D.K.2
Xu, Y.3
Crooks, P.A.4
St Clair, W.H.5
-
196
-
-
66149088525
-
Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer cells
-
Watson C, Miller DA, Chin-Sinex H, Losch A, Hughes W, Sweeney C, et al. Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer cells. Radiat Res 2009;171:389-96.
-
(2009)
Radiat Res
, vol.171
, pp. 389-396
-
-
Watson, C.1
Miller, D.A.2
Chin-Sinex, H.3
Losch, A.4
Hughes, W.5
Sweeney, C.6
-
197
-
-
84155188969
-
Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6) - A new compound with alpha-methylene-gamma-lactone motif - on two breast cancer cell lines
-
Wyrebska A, Gach K, Szemraj J, Szewczyk K, Hrabec E, Koszuk J, et al. Comparison of anti-invasive activity of parthenolide and 3-isopropyl-2-methyl-4-methyleneisoxazolidin-5-one (MZ-6) - a new compound with alpha-methylene-gamma-lactone motif - on two breast cancer cell lines. Chem Biol Drug Des 2012;79:112-20.
-
(2012)
Chem Biol Drug des
, vol.79
, pp. 112-120
-
-
Wyrebska, A.1
Gach, K.2
Szemraj, J.3
Szewczyk, K.4
Hrabec, E.5
Koszuk, J.6
-
198
-
-
84878363798
-
Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines
-
Wyrebska A, Szymanski J, Gach K, Piekielna J, Koszuk J, Janecki T, et al. Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines. Mol Biol Rep 2013;40:1655-63.
-
(2013)
Mol Biol Rep
, vol.40
, pp. 1655-1663
-
-
Wyrebska, A.1
Szymanski, J.2
Gach, K.3
Piekielna, J.4
Koszuk, J.5
Janecki, T.6
-
199
-
-
67651160513
-
Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo
-
Zhang D, Qiu L, Jin X, Guo Z, Guo C. Nuclear factor-kappaB inhibition by parthenolide potentiates the efficacy of Taxol in non-small cell lung cancer in vitro and in vivo. Mol Cancer Res 2009;7:1139-49.
-
(2009)
Mol Cancer Res
, vol.7
, pp. 1139-1149
-
-
Zhang, D.1
Qiu, L.2
Jin, X.3
Guo, Z.4
Guo, C.5
-
200
-
-
68149124202
-
Effect of parthenolide on proliferation and apoptosis in gastric cancer cell line SGC7901
-
Zhao LJ, Xu YH, Li Y. Effect of parthenolide on proliferation and apoptosis in gastric cancer cell line SGC7901. J Dig Dis 2009;10:172-80.
-
(2009)
J Dig Dis
, vol.10
, pp. 172-180
-
-
Zhao, L.J.1
Xu, Y.H.2
Li, Y.3
-
201
-
-
77957888236
-
Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11)
-
Zunino SJ, Storms DH, Ducore JM. Parthenolide treatment activates stress signaling proteins in high-risk acute lymphoblastic leukemia cells with chromosomal translocation t(4;11). Int J Oncol 2010;37:1307-13.
-
(2010)
Int J Oncol
, vol.37
, pp. 1307-1313
-
-
Zunino, S.J.1
Storms, D.H.2
Ducore, J.M.3
-
202
-
-
84863084635
-
Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-kappaB pathway in HT-29 cells
-
Feb 8. [Epub ahead of print]
-
Hou L, Xu B, Guo W, Ran FX, Liu JT, Yuan X, et al. Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-kappaB pathway in HT-29 cells. J Cancer Res Clin Oncol 2012 Feb 8. [Epub ahead of print].
-
(2012)
J Cancer Res Clin Oncol
-
-
Hou, L.1
Xu, B.2
Guo, W.3
Ran, F.X.4
Liu, J.T.5
Yuan, X.6
-
203
-
-
84863686689
-
Pseudolaric Acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells
-
Khan M, Zheng B, Yi F, Rasul A, Gu Z, Li T, et al. Pseudolaric Acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells. Evid Based Complement Alternat Med 2012;2012:957568.
-
(2012)
Evid Based Complement Alternat Med
, vol.2012
, pp. 957568
-
-
Khan, M.1
Zheng, B.2
Yi, F.3
Rasul, A.4
Gu, Z.5
Li, T.6
-
204
-
-
77955482084
-
Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B
-
Ma G, Chong L, Li XC, Khan IA, Walker LA, Khan SI. Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B. J Cancer Res Clin Oncol 2010;136:1333-40.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 1333-1340
-
-
Ma, G.1
Chong, L.2
Li, X.C.3
Khan, I.A.4
Walker, L.A.5
Khan, S.I.6
-
205
-
-
65249117412
-
Induction of G2/M arrest by pseudolaric acid B is mediated by activation of the ATM signaling pathway
-
Meng AG, Jiang LL. Induction of G2/M arrest by pseudolaric acid B is mediated by activation of the ATM signaling pathway. Acta Pharmacol Sin 2009;30:442-50.
-
(2009)
Acta Pharmacol Sin
, vol.30
, pp. 442-450
-
-
Meng, A.G.1
Jiang, L.L.2
-
206
-
-
60749106661
-
Pseudolaric acid B-induced apoptosis through p53-dependent pathway in human gastric carcinoma cells
-
Meng AG, Jiang LL. Pseudolaric acid B-induced apoptosis through p53-dependent pathway in human gastric carcinoma cells. J Asian Nat Prod Res 2009;11:142-52.
-
(2009)
J Asian Nat Prod Res
, vol.11
, pp. 142-152
-
-
Meng, A.G.1
Jiang, L.L.2
-
207
-
-
84860486010
-
Pseudolaric acidBinduces mitotic catastrophe followed by apoptotic cell death in murine fibrosarcoma L929 cells
-
Qi M, Yao G, Fan S, Cheng W, Tashiro S, Onodera S, et al. Pseudolaric acidBinduces mitotic catastrophe followed by apoptotic cell death in murine fibrosarcoma L929 cells. Eur J Pharmacol 2012;683:16-26.
-
(2012)
Eur J Pharmacol
, vol.683
, pp. 16-26
-
-
Qi, M.1
Yao, G.2
Fan, S.3
Cheng, W.4
Tashiro, S.5
Onodera, S.6
-
208
-
-
84864131939
-
Interaction of pseudolaric acid B with the colchicine site of tubulin
-
Sarkar T, Nguyen TL, Su ZW, Hao J, Bai R, Gussio R, et al. Interaction of pseudolaric acid B with the colchicine site of tubulin. Biochem Pharmacol 2012;84:444-50.
-
(2012)
Biochem Pharmacol
, vol.84
, pp. 444-450
-
-
Sarkar, T.1
Nguyen, T.L.2
Su, Z.W.3
Hao, J.4
Bai, R.5
Gussio, R.6
-
209
-
-
84878869733
-
Pseudolaric acid B induces caspase-dependent apoptosis and autophagic cell death in prostate cancer cells
-
Tong J, Yin S, Dong Y, Guo X, Fan L, Ye M, et al. Pseudolaric acid B induces caspase-dependent apoptosis and autophagic cell death in prostate cancer cells. Phytother Res 2012;27:885-91.
-
(2012)
Phytother Res
, vol.27
, pp. 885-891
-
-
Tong, J.1
Yin, S.2
Dong, Y.3
Guo, X.4
Fan, L.5
Ye, M.6
-
210
-
-
36649016901
-
Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF-7
-
Yu JH, Cui Q, Jiang YY, Yang W, Tashiro S, Onodera S, et al. Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF-7. Acta Pharmacol Sin 2007;28:1975-83.
-
(2007)
Acta Pharmacol Sin
, vol.28
, pp. 1975-1983
-
-
Yu, J.H.1
Cui, Q.2
Jiang, Y.Y.3
Yang, W.4
Tashiro, S.5
Onodera, S.6
-
211
-
-
84865044204
-
Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway
-
Bu HQ, Luo J, Chen H, Zhang JH, Li HH, Guo HC, et al. Oridonin enhances antitumor activity of gemcitabine in pancreatic cancer through MAPK-p38 signaling pathway. Int J Oncol 2012;41:949-58.
-
(2012)
Int J Oncol
, vol.41
, pp. 949-958
-
-
Bu, H.Q.1
Luo, J.2
Chen, H.3
Zhang, J.H.4
Li, H.H.5
Guo, H.C.6
-
212
-
-
84455163076
-
Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells
-
Chen G, Wang K, Yang BY, Tang B, Chen JX, Hua ZC. Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells. Int J Oncol 2012;40:139-47.
-
(2012)
Int J Oncol
, vol.40
, pp. 139-147
-
-
Chen, G.1
Wang, K.2
Yang, B.Y.3
Tang, B.4
Chen, J.X.5
Hua, Z.C.6
-
213
-
-
77649310828
-
Inhibitory effect of Oridonin injection on heterotransplanted gastric adenocarcinoma in nude mice and its mechanism
-
Chen JH, Wang SB, Li EM, Chen LM, Yuan SJ, Wang RL, et al. [Inhibitory effect of Oridonin injection on heterotransplanted gastric adenocarcinoma in nude mice and its mechanism]. Zhonghua Zhong Liu Za Zhi 2008;30:89-92.
-
(2008)
Zhonghua Zhong Liu Za Zhi
, vol.30
, pp. 89-92
-
-
Chen, J.H.1
Wang, S.B.2
Li, E.M.3
Chen, L.M.4
Yuan, S.J.5
Wang, R.L.6
-
214
-
-
65249128643
-
Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells
-
Cheng Y, Qiu F, Ikejima T. Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells. Autophagy 2009;5:430-1.
-
(2009)
Autophagy
, vol.5
, pp. 430-431
-
-
Cheng, Y.1
Qiu, F.2
Ikejima, T.3
-
215
-
-
70349469564
-
Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells
-
Cheng Y, Qiu F, Ye YC, Tashiro S, Onodera S, Ikejima T. Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. Arch Biochem Biophys 2009;490:70-5.
-
(2009)
Arch Biochem Biophys
, vol.490
, pp. 70-75
-
-
Cheng, Y.1
Qiu, F.2
Ye, Y.C.3
Tashiro, S.4
Onodera, S.5
Ikejima, T.6
-
216
-
-
78049385776
-
Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc
-
Gao FH, Hu XH, Li W, Liu H, Zhang YJ, Guo ZY, et al. Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc. BMC Cancer 2010;10:610.
-
(2010)
BMC Cancer
, vol.10
, pp. 610
-
-
Gao, F.H.1
Hu, X.H.2
Li, W.3
Liu, H.4
Zhang, Y.J.5
Guo, Z.Y.6
-
217
-
-
84868348363
-
Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway
-
Guo Y, Shan Q, Gong Y, Lin J, Yang X, Zhou R. Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway. Cancer Biol Ther 2012;13:1244-54.
-
(2012)
Cancer Biol Ther
, vol.13
, pp. 1244-1254
-
-
Guo, Y.1
Shan, Q.2
Gong, Y.3
Lin, J.4
Yang, X.5
Zhou, R.6
-
218
-
-
84870266095
-
Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach
-
Harris ES, Cao S, Schoville SD, Dong C, Wang W, Jian Z, et al. Selection for high oridonin yield in the Chinese medicinal plant Isodon (Lamiaceae) using a combined phylogenetics and population genetics approach. PLoS ONE 2012;7:e50753.
-
(2012)
PLoS ONE
, vol.7
, pp. e50753
-
-
Harris, E.S.1
Cao, S.2
Schoville, S.D.3
Dong, C.4
Wang, W.5
Jian, Z.6
-
219
-
-
50149087699
-
Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways
-
Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. J Pharmacol Sci 2008;107:370-9.
-
(2008)
J Pharmacol Sci
, vol.107
, pp. 370-379
-
-
Huang, J.1
Wu, L.2
Tashiro, S.3
Onodera, S.4
Ikejima, T.5
-
220
-
-
84880994584
-
The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells
-
Kwan HY, Yang Z, Fong WF, Hu YM, Yu ZL, Hsiao WL. The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells. J Gastroenterol 2013;48:182-92.
-
(2013)
J Gastroenterol
, vol.48
, pp. 182-192
-
-
Kwan, H.Y.1
Yang, Z.2
Fong, W.F.3
Hu, Y.M.4
Yu, Z.L.5
Hsiao, W.L.6
-
221
-
-
79953029230
-
Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics
-
Li CY, Wang EQ, Cheng Y, Bao JK. Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics. Int J Biochem Cell Biol 2011;43:701-4.
-
(2011)
Int J Biochem Cell Biol
, vol.43
, pp. 701-704
-
-
Li, C.Y.1
Wang, E.Q.2
Cheng, Y.3
Bao, J.K.4
-
222
-
-
36849090058
-
Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway
-
Li D, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway. J Asian Nat Prod Res 2008;10:77-87.
-
(2008)
J Asian Nat Prod Res
, vol.10
, pp. 77-87
-
-
Li, D.1
Wu, L.J.2
Tashiro, S.3
Onodera, S.4
Ikejima, T.5
-
223
-
-
84863811994
-
Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells
-
Li X, Wang J, Ye Z, Li JC. Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci 2012;8:901-12.
-
(2012)
Int J Biol Sci
, vol.8
, pp. 901-912
-
-
Li, X.1
Wang, J.2
Ye, Z.3
Li, J.C.4
-
224
-
-
84868142361
-
Oridonin: Targeting programmed cell death pathways as an anti-tumour agent
-
Liu Z, Ouyang L, Peng H, Zhang WZ. Oridonin: targeting programmed cell death pathways as an anti-tumour agent. Cell Prolif 2012;45:499-507.
-
(2012)
Cell Prolif
, vol.45
, pp. 499-507
-
-
Liu, Z.1
Ouyang, L.2
Peng, H.3
Zhang, W.Z.4
-
225
-
-
79960422870
-
Oridonin nanosuspension enhances anti-tumor efficacy in SMMC-7721 cells and H22 tumor bearing mice
-
Lou H, Gao L, Wei X, Zhang Z, Zheng D, Zhang D, et al. Oridonin nanosuspension enhances anti-tumor efficacy in SMMC-7721 cells and H22 tumor bearing mice. Colloids Surf B Biointerfaces 2011;87:319-25.
-
(2011)
Colloids Surf B Biointerfaces
, vol.87
, pp. 319-325
-
-
Lou, H.1
Gao, L.2
Wei, X.3
Zhang, Z.4
Zheng, D.5
Zhang, D.6
-
226
-
-
84866772465
-
Oridonin nano-suspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line
-
Qi X, Zhang D, Xu X, Feng F, Ren G, Chu Q, et al. Oridonin nano-suspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line. Int J Nanomedicine 2012;7:1793-804.
-
(2012)
Int J Nanomedicine
, vol.7
, pp. 1793-1804
-
-
Qi, X.1
Zhang, D.2
Xu, X.3
Feng, F.4
Ren, G.5
Chu, Q.6
-
227
-
-
84884189755
-
Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway
-
Sun KW, Ma YY, Guan TP, Xia YJ, Shao CM, Chen LG, et al. Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway. World J Gastroenterol 2012;18:7166-74.
-
(2012)
World J Gastroenterol
, vol.18
, pp. 7166-7174
-
-
Sun, K.W.1
Ma, Y.Y.2
Guan, T.P.3
Xia, Y.J.4
Shao, C.M.5
Chen, L.G.6
-
228
-
-
84872977175
-
Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells
-
Wang S, Zhong Z, Wan J, Tan W, Wu G, Chen M, et al. Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells. Am J Chin Med 2013;41:177-96.
-
(2013)
Am J Chin Med
, vol.41
, pp. 177-196
-
-
Wang, S.1
Zhong, Z.2
Wan, J.3
Tan, W.4
Wu, G.5
Chen, M.6
-
229
-
-
84864841426
-
Redox state alters anti-cancer effects of wedelolactone
-
Benes P, Alexova P, Knopfova L, Spanova A, Smarda J. Redox state alters anti-cancer effects of wedelolactone. Environ Mol Mutagen 2012;53:515-24.
-
(2012)
Environ Mol Mutagen
, vol.53
, pp. 515-524
-
-
Benes, P.1
Alexova, P.2
Knopfova, L.3
Spanova, A.4
Smarda, J.5
-
230
-
-
79951852253
-
Inhibition of topoisomerase IIalpha: Novel function of wedelolactone
-
Benes P, Knopfova L, Trcka F, Nemajerova A, Pinheiro D, Soucek K, et al. Inhibition of topoisomerase IIalpha: novel function of wedelolactone. Cancer Lett 2011;303:29-38.
-
(2011)
Cancer Lett
, vol.303
, pp. 29-38
-
-
Benes, P.1
Knopfova, L.2
Trcka, F.3
Nemajerova, A.4
Pinheiro, D.5
Soucek, K.6
-
231
-
-
80052143814
-
Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappaB activation and IL-6/Mcl-1 overexpression
-
Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappaB activation and IL-6/Mcl-1 overexpression. Mol Cancer 2011;10:106.
-
(2011)
Mol Cancer
, vol.10
, pp. 106
-
-
Bharadwaj, U.1
Marin-Muller, C.2
Li, M.3
Chen, C.4
Yao, Q.5
-
232
-
-
79960068710
-
Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation
-
Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. Carcinogenesis 2011;32:1013-24.
-
(2011)
Carcinogenesis
, vol.32
, pp. 1013-1024
-
-
Bharadwaj, U.1
Marin-Muller, C.2
Li, M.3
Chen, C.4
Yao, Q.5
-
233
-
-
47049101962
-
Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation
-
Hammadi A, Billard C, Faussat AM, Kolb JP. Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation. Nitric Oxide 2008;19:138-45.
-
(2008)
Nitric Oxide
, vol.19
, pp. 138-145
-
-
Hammadi, A.1
Billard, C.2
Faussat, A.M.3
Kolb, J.P.4
-
234
-
-
1642433084
-
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex
-
Kobori M, Yang Z, Gong D, Heissmeyer V, Zhu H, Jung YK, et al. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. Cell Death Differ 2004;11:123-30.
-
(2004)
Cell Death Differ
, vol.11
, pp. 123-130
-
-
Kobori, M.1
Yang, Z.2
Gong, D.3
Heissmeyer, V.4
Zhu, H.5
Jung, Y.K.6
-
235
-
-
84866503308
-
Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells
-
Lim S, Jang HJ, Park EH, Kim JK, Kim JM, Kim EK, et al. Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells. J Cell Biochem 2012;113:3436-45.
-
(2012)
J Cell Biochem
, vol.113
, pp. 3436-3445
-
-
Lim, S.1
Jang, H.J.2
Park, E.H.3
Kim, J.K.4
Kim, J.M.5
Kim, E.K.6
-
236
-
-
65649146157
-
Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells
-
Tanabe K, Nishimura K, Dohi S, Kozawa O. Mechanisms of interleukin-1beta-induced GDNF release from rat glioma cells. Brain Res 2009;1274:11-20.
-
(2009)
Brain Res
, vol.1274
, pp. 11-20
-
-
Tanabe, K.1
Nishimura, K.2
Dohi, S.3
Kozawa, O.4
-
237
-
-
69949089790
-
Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice
-
Tsai CH, Lin FM, Yang YC, Lee MT, Cha TL, Wu GJ, et al. Herbal extract of Wedelia chinensis attenuates androgen receptor activity and orthotopic growth of prostate cancer in nude mice. Clin Cancer Res 2009;15:5435-44.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5435-5444
-
-
Tsai, C.H.1
Lin, F.M.2
Yang, Y.C.3
Lee, M.T.4
Cha, T.L.5
Wu, G.J.6
-
238
-
-
84860394995
-
Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes
-
Chao DC, Lin LJ, Hsiang CY, Li CC, Lo HY, Liang JA, et al. Evodiamine inhibits 12-O-tetradecanoylphorbol-13-acetate-induced activator protein 1 transactivation and cell transformation in human hepatocytes. Phytother Res 2011;25:1018-23.
-
(2011)
Phytother Res
, vol.25
, pp. 1018-1023
-
-
Chao, D.C.1
Lin, L.J.2
Hsiang, C.Y.3
Li, C.C.4
Lo, H.Y.5
Liang, J.A.6
-
239
-
-
77955474313
-
Antiproliferative effects of evodiamine on human thyroid cancer cell line ARO
-
Chen MC, Yu CH, Wang SW, Pu HF, Kan SF, Lin LC, et al. Antiproliferative effects of evodiamine on human thyroid cancer cell line ARO. J Cell Biochem 2010;110:1495-503.
-
(2010)
J Cell Biochem
, vol.110
, pp. 1495-1503
-
-
Chen, M.C.1
Yu, C.H.2
Wang, S.W.3
Pu, H.F.4
Kan, S.F.5
Lin, L.C.6
-
240
-
-
67249138744
-
Evodiamine: A novel anti-cancer alkaloid from Evodia rutaecarpa
-
Jiang J, Hu C. Evodiamine: a novel anti-cancer alkaloid from Evodia rutaecarpa. Molecules 2009;14:1852-9.
-
(2009)
Molecules
, vol.14
, pp. 1852-1859
-
-
Jiang, J.1
Hu, C.2
-
241
-
-
84862790283
-
Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells
-
Pan X, Hartley JM, Hartley JA, White KN, Wang Z, Bligh SW. Evodiamine, a dual catalytic inhibitor of type I and II topoisomerases, exhibits enhanced inhibition against camptothecin resistant cells. Phytomedicine 2012;19:618-24.
-
(2012)
Phytomedicine
, vol.19
, pp. 618-624
-
-
Pan, X.1
Hartley, J.M.2
Hartley, J.A.3
White, K.N.4
Wang, Z.5
Bligh, S.W.6
-
242
-
-
84863252809
-
Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy
-
Rasul A, Yu B, Zhong L, Khan M, Yang H, Ma T. Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. Oncol Rep 2012;27:1481-7.
-
(2012)
Oncol Rep
, vol.27
, pp. 1481-1487
-
-
Rasul, A.1
Yu, B.2
Zhong, L.3
Khan, M.4
Yang, H.5
Ma, T.6
-
243
-
-
84870364791
-
Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells
-
Yang J, Cai X, Lu W, Hu C, Xu X, Yu Q, et al. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells. Cancer Lett 2013;328:243-51.
-
(2013)
Cancer Lett
, vol.328
, pp. 243-251
-
-
Yang, J.1
Cai, X.2
Lu, W.3
Hu, C.4
Xu, X.5
Yu, Q.6
-
244
-
-
77955226921
-
Evodiamine induces caspase-dependent apoptosis and S phase arrest in human colon lovo cells
-
Zhang C, Fan X, Xu X, Yang X,Wang X, Liang HP. Evodiamine induces caspase-dependent apoptosis and S phase arrest in human colon lovo cells. Anticancer Drugs 2010;21:766-76.
-
(2010)
Anticancer Drugs
, vol.21
, pp. 766-776
-
-
Zhang, C.1
Fan, X.2
Xu, X.3
Yang, X.4
Wang, X.5
Liang, H.P.6
|