Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells

Toxicology in Vitro

Volumn 26, Issue 4, 2012, Pages 595-602

  Zhao, Dandan ^a,b   Lin, Feng ^a   Wu, Xingde ^c   Zhao, Qinshi ^c   Zhao, Binjiahui ^a   Lin, Ping ^a   Zhang, Yanlong ^b   Yu, Xiaoguang ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY   (China)

^c KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

Apoptosis; Bcl 2 degradation; Hormone refractory prostate cancer; Proteasome; Pseudolaric acid B; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE 3; CASPASE 8; CASPASE 9; LACTATE DEHYDROGENASE; PROTEASOME; PROTEIN BCL 2; PSEUDOLARIC ACID B; REACTIVE OXYGEN METABOLITE; UBIQUITIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PROSTATE CANCER; PROTEIN DEGRADATION; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; CYTOSTATIC AGENTS; DITERPENES; DRUGS, CHINESE HERBAL; HUMANS; L-LACTATE DEHYDROGENASE; MALE; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 84862797757     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.02.004     Document Type: Article

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