Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells

Radiation Oncology

Volumn 6, Issue 1, 2011, Pages

  Liu, Chia Yuan ^a,b   Chang, Hsun Shuo ^c   Chen, Ih Sheng ^c   Chen, Chih Jen ^b   Hsu, Ming Ling ^b   Fu, Shu Ling ^a   Chen, Yu Jen ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b MACKAY MEMORIAL HOSPITAL   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; CELL CYCLE PROTEIN; CHECKPOINT KINASE 2; COSTUNOLIDE; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; DNA; HISTONE H3; PROTEIN TYROSINE PHOSPHATASE; ANTINEOPLASTIC AGENT; HISTONE; PLANT EXTRACT; RADIOSENSITIZING AGENT; SESQUITERPENE;

ARTICLE; CANCER RADIOTHERAPY; CARCINOMA CELL; CELL ASSAY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CLINICAL ASSESSMENT; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG EFFECT; DRUG ISOLATION; FLOW CYTOMETRY; HISTOGRAM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IONIZING RADIATION; LIVER CELL; LIVER CELL CARCINOMA; METAPHASE; MITOSIS INDEX; MITOSIS INHIBITION; MITOSIS SPINDLE; MORPHOLOGY; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; SENSITIZATION; SURVIVAL; UPREGULATION; WESTERN BLOTTING; CELL CYCLE; CELL SURVIVAL; LIVER TUMOR; MAGNOLIACEAE; METABOLISM; MITOSIS; PHOSPHORYLATION; RADIATION DOSE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL SURVIVAL; DNA; HISTONES; HUMANS; LIVER NEOPLASMS; MAGNOLIACEAE; MITOSIS; PHOSPHORYLATION; PLANT EXTRACTS; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; SESQUITERPENES;

EID: 79957571352     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-6-56     Document Type: Article

References (27)

1. Liu CY, Chen YW, Cheng MJ, Lee SJ, Abd El-Razek MH, Chang WH, Chen YJ, Chen IS. Cytotoxic constituents from the root wood of formosan Michelia compressa. J Chil Chem Soc 2008, 53:1523-1524.
2. Pandey MM, Rastogi S, Rawat AK. Saussurea costus: botanical, chemical and pharmacological review of an ayurvedic medicinal plant. J Ethnopharmacol 2007, 110:379-390. 10.1016/j.jep.2006.12.033, 17306480.
3. Li A, Sun A, Liu R. Preparative isolation and purification of costunolide and dehydrocostuslactone from Aucklandia lappa Decne by high-speed counter-current chromatography. J Chromatogr A 2005, 1076:193-197. 10.1016/j.chroma.2005.04.042, 15974088.
4. De Marino S, Borbone N, Zollo F, Ianaro A, Di Meglio P, Iorizzi M. New sesquiterpene lactones from Laurus nobilis leaves as inhibitors of nitric oxide production. Planta Med 2005, 71:706-710. 10.1055/s-2005-864191, 16142632.
5. Koo TH, Lee JH, Park YJ, Hong YS, Kim HS, Kim KW, Lee JJ. A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation. Planta Med 2001, 67:103-107. 10.1055/s-2001-11503, 11301852.
6. Mondranondra IO, Che CT, Rimando AM, Vajrodaya S, Fong HH, Farnsworth NR. Sesquiterpene lactones and other constituents from a cytotoxic extract of Michelia floribunda. Pharm Res 1990, 7:1269-1272. 10.1023/A:1015937921880, 2095565.
7. Bocca C, Gabriel L, Bozzo F, Miglietta A. A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells. Chem Bio Interacti 2004, 147:79-86.
8. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J Clin 2009, 59:225-249. 10.3322/caac.20006, 19474385.
9. Hertl M, Cosimi AB. Liver transplantation for malignancy. Oncologist 2005, 10:269-281. 10.1634/theoncologist.10-4-269, 15821247.
10. Poon RT, Fan ST, Lo CM, Liu CL, Wong J. Intrahepatic recurrence after curative resection of hepatocellular carcinoma: long-term results of treatment and prognostic factors. Ann Surg 1999, 229:216-222. 10.1097/00000658-199902000-00009, 1191634, 10024103.
11. Yamamoto J, Kosuge T, Takayama T, Shimada K, Yamasaki S, Ozaki H, Yamaguchi N, Makuuchi M. Recurrence of hepatocellular carcinoma after surgery. Br J Surg 1996, 83:1219-1222. 10.1002/bjs.1800830913, 8983610.
12. Pelletier G, Roche A, Ink O, Anciaux ML, Derhy S, Rougier P, Lenoir C, Attali P, Etienne JP. A randomized trial of hepatic arterial chemoembolization in patients with unresectable hepatocellular carcinoma. J Hepatol 1990, 11:181-184. 10.1016/0168-8278(90)90110-D, 2174933.
13. Lau WY, Lai EC. The current role of radiofrequency ablation in the management of hepatocellular carcinoma: a systematic review. Ann Surg 2009, 249:20-25. 10.1097/SLA.0b013e31818eec29, 19106671.
14. Kwon JH, Bae SH, Kim JY, Choi BO, Jang HS, Jang JW, Choi JY, Yoon SK, Chung KW. Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancer. BMC Cancer 2010, 10:475. 10.1186/1471-2407-10-475, 2940809, 20813065.
15. Cheng AL, Kang YK, Chen Z, Tsao CJ, Qin S, Kim JS, Luo R, Feng J, Ye S, Yang TS, et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol 2009, 10:25-34. 10.1016/S1470-2045(08)70285-7, 19095497.
16. Seong J, Han KH, Park YN, Nam SH, Kim SH, Keum WS, Kim KS. Lethal hepatic injury by combined treatment of radiation plus chemotherapy in rats with thioacetamide-induced liver cirrhosis. Int J Radiat Oncol Biol Phys 2003, 57:282-288. 10.1016/S0360-3016(03)00540-6, 12909244.
17. Park HC, Seong J, Han KH, Chon CY, Moon YM, Suh CO. Dose-response relationship in local radiotherapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys 2002, 54:150-155.
18. Milross CG, Mason KA, Hunter NR, Terry NH, Patel N, Harada S, Jibu T, Seong J, Milas L. Enhanced radioresponse of paclitaxel-sensitive and -resistant tumours in vivo. Eur J Cancer 1997, 33:1299-1308. 10.1016/S0959-8049(97)00107-X, 9301459.
19. Choy H, Rodriguez FF, Koester S, Hilsenbeck S, Von Hoff DD. Investigation of taxol as a potential radiation sensitizer. Cancer 1993, 71:3774-3778. 10.1002/1097-0142(19930601)71:11<3774::AID-CNCR2820711147>3.0.CO;2-0, 8098270.
20. Liu X, Guo Y, Li Y, Jiang Y, Chubb S, Azuma A, Huang P, Matsuda A, Hittelman W, Plunkett W. Molecular basis for G2 arrest induced by 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine and consequences of checkpoint abrogation. Cancer Res 2005, 65:6874-6881. 10.1158/0008-5472.CAN-05-0288, 16061671.
21. Watson C, Miller DA, Chin-Sinex H, Losch A, Hughes W, Sweeney C, Mendonca MS. Suppression of NF-kappaB activity by parthenolide induces X-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer cells. Radiat Res 2009, 171:389-396. 10.1667/RR1394.1, 19397439.
22. Chen YJ, Liao HF, Tsai TH, Wang SY, Shiao MS. Caffeic acid phenethyl ester preferentially sensitizes CT26 colorectal adenocarcinoma to ionizing radiation without affecting bone marrow radioresponse. Int J Radiat Oncol Biol Phys 2005, 63:1252-1261. 10.1016/j.ijrobp.2005.08.001, 16253780.
23. Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 2004, 59:928-942. 10.1016/j.ijrobp.2004.03.005, 15234026.
24. Terasima T, Tolmach LJ. X-ray sensitivity and DNA synthesis in synchronous populations of HeLa cells. Science 1963, 140:490-492. 10.1126/science.140.3566.490, 13980636.
25. Sinclair WK. Cyclic x-ray responses in mammalian cells in vitro. Radiat Res 1968, 33:620-643. 10.2307/3572419, 4867897.
26. Sinclair WK, Morton RA. X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells. Radiat Res 1966, 29:450-474. 10.2307/3572025, 5924188.
27. Schmit TL, Ahmad N. Regulation of mitosis via mitotic kinases: new opportunities for cancer management. Mol Cancer Ther 2007, 6:1920-1931. 10.1158/1535-7163.MCT-06-0781, 17620424.