The biochemistry of apoptosis

Nature

Volumn 407, Issue 6805, 2000, Pages 770-776

  Hengartner, M O ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CELL PROTEIN; PROTEIN BCL 2;

APOPTOSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMAL; APOPTOSIS; CASPASES; HUMAN; MITOCHONDRIA;

EID: 0034641918     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35037710     Document Type: Review

References (75)

1. Cell death in development
2. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
3. Cell death: The significance of apoptosis
4. Human ICE/CED-3 protease nomenclature
5. Biochemical pathways of caspase activation during apoptosis
6. Identification of caspases and apoptosis in the simple metazoan Hydra
7. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
8. Caspases: Enemies within
9. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
10. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
11. Apoptotic DNA fragmentation
12. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
13. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
14. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
15. Lamin proteolysis facilitates nuclear events during apoptosis
16. Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis
17. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
18. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
19. Caspase structure, proteolylic substrates, and function during apoptotic cell death
20. An induced proximity model for caspase-8 activation
21. Essential role of CED-4 oligomerization in CED-3 activation and apoptosis
22. Caspase activation: The induced-proximity model
23. Caspase-9 and APAF-1 form an active holoenzyme
24. Caspase-9 can be activated without proteolytic processing
25. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
26. Apaf-1 a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
27. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
28. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
29. Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex
30. The modular nature of apoptotic signaling proteins
31. NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain
32. NMR structure and mutagenesis of the FADD (Mort1) death-effector domain
33. Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: A structural basis for specific adaptor/caspase interaction
34. Double identity for proteins of the Bcl-2 family
35. The Bcl-2 protein family: Arbiters of cell survival
36. The Bcl-2 protein family
37. Genetics of programmed cell death in C. elegans: Past, present and future
38. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
39. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
40. Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L)
41. BCL-2 family members and the mitochondria in apoptosis
42. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death
43. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
44. The mitochondrion in cell death control: Certainties and incognita
45. Two CD95 (APO-1/Fas) signaling pathways
46. Apoptosis inducing factor (A1F): A phylogenetically old, caspase-independent effector of cell death
47. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
48. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
49. Neuroprotection by the inhibition of apoptosis
50. ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis
51. Caspase knockouts: Matters of life and death
52. Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
53. An exegesis of IAPs: Salvation and surprises from BIR motifs
54. The central executioners of apoptosis: Caspases or mitochondria?
55. Mitochondria and apoptosis
56. An emerging blueprint for apoptosis in Drosophila
57. Apoptosis without caspases: An inefficient molecular guillotine?
58. Caspase-independent programmed cell death with necrotic morphology
59. Interdigital cell death can occur through a necrotic and caspase-independent pathway
60. Dismantling in cell death: Molecular mechanisms and relationship to caspase activation
61. Inhibition of death receptor signals by cellular FLIP
62. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
63. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
64. Movement of Bax from the cytosol to mitochondria during apoptosis
65. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
66. Escaping cell death: Survival proteins in cancer
67. Heat shock proteins as death determinants
68. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
69. Involvement of the bcl-2 gene in human follicular lymphoma
70. Solution structure of the proapoptotic molecule BID: A structural basis for apoptotic agonists and antagonists
71. Solution structure of BID, an intracellular amplifier of apoptotic signaling
72. Structure of Bcl-xL-Bak peptide complex: Recognition between regulators of apoptosis
73. BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
74. p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum
75. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1