Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

International Journal of Biochemistry and Cell Biology

Volumn 43, Issue 5, 2011, Pages 701-704

  Li, Chun Yang ^a   Wang, En Qin ^a   Cheng, Yan ^b   Bao, Jin Ku ^a  

^a SICHUAN UNIVERSITY   (China)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Anti neoplastic drug; Apoptosis; Autophagy; Cell cycle arrest; Oridonin

Indexed keywords

ORIDONIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL PROLIFERATION; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; HUMAN; NONHUMAN;

EID: 79953029230     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2011.01.020     Document Type: Short Survey

References (30)

1. P.H. Abelson Medicine from plants Science 247 1990 513 (Pubitemid 20073650)
2. S. Chen, J. Gao, H.D. Halicka, X. Huang, F. Traganos, and Z. Darzynkiewicz The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage Int J Oncol 26 2005 579 588
3. Y. Cheng, F. Qiu, and T. Ikejima Molecular mechanisms of oridonin-induced apoptosis and autophagy in murine fibrosarcoma L929 cells Autophagy 5 2009 430 431
4. Y. Cheng, F. Qiu, Y.C. Ye, Z.M. Guo, S. Tashiro, and S. Onodera Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells FEBS J 276 2009 1291 1306
5. 2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells Arch Biochem Biophys 490 2009 70 75
6. Q. Cui, S.I. Tashiro, S. Onodera, and T. Ikejima Augmentation of oridonin-induced apoptosis observed with reduced autophagy J Pharmacol Sci 101 2006 230 239 (Pubitemid 44114317)
7. Q. Cui, S. Tashiro, S. Onodera, M. Minami, and T. Ikejima Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells Biol Pharm Bull 30 2007 859 864 (Pubitemid 46708626)
8. Q. Cui, S.I. Tashiro, S. Onodera, M. Minami, and T. Ikejima Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and p38 regulation J Pharmacol Sci 105 2007 317 325
9. Q. Cui, J.H. Yu, J.N. Wu, S. Tashiro, S. Onodera, and M. Minami p53-mediated cell cycle arrest and apoptosis through a caspase-3-independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells Acta Pharmacol Sin 28 2007 1057 1066 (Pubitemid 47020485)
10. Y.F. Du, P.W. Liu, X.W. Shi, Y.R. Jin, Q. Wang, and X.W. Zhang A novel analysis method for diterpenoids in rat plasma by liquid chromatography- electrospray ionization mass spectrometry Anal Biochem 407 2010 111 119
11. E. Fujita, H. Katayama, and M. Shibuya Oridonin, a new diterpenoid from isodon. Species Chem Commun 1967 252
12. E. Fujita, Y. Nagao, M. Node, K. Kaneko, S. Nakazawa, and H. Kuroda Antitumor activity of the isodon diterpenoids: structural requirements for the activity Cell Mol Life Sci 32 1976 203 206
13. T. Fujita, S. Takao, and E. Fujita Biosynthesis of the diterpenes enmein and oridonin from ent-16-kaurene J Chem Soc Chem Commun 1973 434 435
14. F.H. Gao, Z.Y. Guo, M.H. Xu, and S.T. Wang Oridonin induces apoptosis and senescence of colorectal cancer SW1116 cells in vitro and in vivo J Shanghai Jiaotong Univ (Med Sci) 2010 30
15. H.Z. Hu, Y.B. Yang, X.D. Xu, H.W. Shen, Y.M. Shu, and Z. Ren Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line Acta Pharmacol Sin 28 2007 1819 1826 (Pubitemid 350029332)
16. S. Jin, J.N. Shen, J. Wang, G. Huang, and J.G. Zhou Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells Cancer Biol Ther 6 2007 261 268 (Pubitemid 46641633)
17. N. Kang, J.H. Zhang, F. Qiu, S. Tashiro, S. Onodera, and T. Ikejima Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways Cancer Lett 294 2010 147 158
18. D. Li, Q. Cui, S.G. Chen, L.J. Wu, S.I. Tashiro, and S. Onodera Inactivation of Ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in A431 cells J Pharmacol Sci 105 2007 22 33 (Pubitemid 47463521)
19. Y.Q. Liu, Z.Q. Mu, S. You, S. Tashiro, S. Onodera, and T. Ikejima Fas/FasL signaling allows extracelluar-signal regulated kinase to regulate cytochrome c release in oridonin-induced apoptotic U937 cells Biol Pharm Bull 29 2006 1873 1879 (Pubitemid 44338410)
20. H.Y. Lou, X.M. Zhang, L. Gao, F.F. Feng, J.Y. Wang, and X.B. Wei In vitro and in vivo antitumor activity of oridonin nanosuspension Int J Pharm 379 2009 181 186
21. Y.H. Mei, J. Xu, J.H. Zhao, N.P. Feng, Y. Liu, and L. Wei method for determination of oridonin in rabbits using isopsoralen as an internal standard and its application to pharmacokinetic studies for oridonin-loaded nanoparticles J Chromatogr B 869 2008 138 141
22. K.K. Ren, H.Z. Wang, L.P. Xie, D.W. Chen, X. Liu, and J. Sun The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells J Ethnopharmacol 103 2006 176 180 (Pubitemid 41796914)
23. J.Y. Xu, J.Y. Yang, Q. Ran, L. Wang, J. Liu, and Z.X. Wang Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates Bioorg Med Chem Lett 18 2008 4741 4744
24. C.L. Zhang, L.J. Wu, S. Tashiro, S. Onodera, and T. Ikejima Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome J Asian Nat Prod Res 6 2004 127 138 (Pubitemid 38173850)
25. C.L. Zhang, L.J. Wu, H.J. Zuo, S. Tashiro, S. Onodera, and T. Ikejima Cytochrome c release from oridonin-treated apoptotic A375-S2 cells is dependent on p53 and extracellular signal-regulated kinase activation J Pharmacol Sci 96 2004 155 163 (Pubitemid 39469606)
26. Y. Zhang, Y. Wu, D. Wu, S. Tashiro, S. Onodera, and T. Ikejima facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway Arch Biochem Biophys 489 2009 25 33
27. G.B. Zhou, S.J. Chen, Z.Y. Wang, and Z. Chen Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo Cell Res 17 2007 274 276 (Pubitemid 46639922)
28. G.B. Zhou, H. Kang, L. Wang, L. Gao, P. Liu, and J. Xie Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo Blood 109 2007 3441 3450 (Pubitemid 46572534)
29. T.C. Hsieh, E.K. Wijeratne, J.Y. Liang, A.L. Gunatilaka, and J.M. Wu Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens Biochem Biophys Res Commun. 337 2005 224 231 (Pubitemid 41393783)
30. Y. Zhu, L.P. Xie, G. Chen, H.Z. Wang, and R.Q. Zhang Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice Pharmazie 62 2007 439 444 (Pubitemid 46975266)