Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction

IUBMB Life

Volumn 64, Issue 9, 2012, Pages 783-794

  Khan, Muhammad ^a   Yi, Fei ^a   Rasul, Azhar ^a   Li, Ting ^a   Wang, Nan ^a   Gao, Hongwen ^a   Gao, Rong ^a   Ma, Tonghui ^a  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

alantolactone; apoptosis; glioblastoma; GSH; ROS

Indexed keywords

ACETYLCYSTEINE; ALANTOLACTONE; CARDIOLIPIN; CASPASE 3; CASPASE 9; CATALASE; CYTOCHROME C; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROGOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SN 50; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG MECHANISM; GLIOBLASTOMA; HUMAN; HUMAN CELL; LIPID OXIDATION; LIVER TOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEPHROTOXICITY; NONHUMAN; TOXICITY TESTING; TREATMENT DURATION;

ACETYLCYSTEINE; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CARDIOLIPINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; GLIOBLASTOMA; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; KIDNEY; LACTONES; LIVER; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; NF-KAPPA B; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SESQUITERPENES, EUDESMANE; TISSUE DISTRIBUTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84865331826     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1068     Document Type: Article

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