The anticancer effect of oridonin is mediated by fatty acid synthase suppression in human colorectal cancer cells

Journal of Gastroenterology

Volumn 48, Issue 2, 2013, Pages 182-192

  Kwan, Hiu Yee ^a   Yang, Zhijun ^a   Fong, Wang Fun ^a   Hu, Yong Mei ^a   Yu, Zhi Ling ^a   Hsiao, Wen Luan Wendy ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

Author keywords

Apoptosis; Colorectal cancer; Fatty acid synthase; Oridonin

Indexed keywords

ARACHIDONIC ACID; DOCOSAHEXAENOIC ACID; FATTY ACID SYNTHASE; INSULIN; MESSENGER RNA; OLEIC ACID; ORIDONIN; PALMITIC ACID; SMALL INTERFERING RNA; STEARIC ACID; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; ANTINEOPLASTIC AGENT; FAS ANTIGEN; FAS PROTEIN, HUMAN; KAURANE DERIVATIVE; RNA; SREBF1 PROTEIN, HUMAN; STEARIC ACID DERIVATIVE; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL; CELL VIABILITY ASSAY; COLORECTAL CANCER; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOWN REGULATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING; BIOSYNTHESIS; COLORECTAL TUMOR; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; GENE SILENCING; GENETICS; METABOLISM; METHODOLOGY; PATHOLOGY; TUMOR CELL CULTURE;

ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; COLORECTAL NEOPLASMS; DITERPENES, KAURANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; FATTY ACID SYNTHETASE COMPLEX; GENE KNOCKDOWN TECHNIQUES; HUMANS; NEOPLASM PROTEINS; PALMITIC ACID; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; RNA, NEOPLASM; RNA, SMALL INTERFERING; STEARIC ACIDS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TUMOR CELLS, CULTURED;

MLCS; MLOWN;

EID: 84880994584     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-012-0612-1     Document Type: Article

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