Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction

BioMed Research International

Volumn 2013, Issue , 2013, Pages

  Khan, Muhammad ^a,b   Li, Ting ^a   Ahmad Khan, Muhammad Khalil ^b   Rasul, Azhar ^a   Nawaz, Faisal ^c   Sun, Meiyan ^a   Zheng, Yongchen ^a   Ma, Tonghui ^a  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^b UNIVERSITY OF THE PUNJAB   (Pakistan)

^c Jilin University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALANTOLACTONE; CASPASE 3; GLUTATHIONE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; LACTONE; SESQUITERPENE; STAT3 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE RESPONSE; GLIOBLASTOMA; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; LIVER TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ACETYLCYSTEINE; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; GLUTATHIONE; HEP G2 CELLS; HUMANS; LACTONES; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; REACTIVE OXYGEN SPECIES; SESQUITERPENES, EUDESMANE; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION;

EID: 84874634964     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2013/719858     Document Type: Article

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