메뉴 건너뛰기




Volumn 41, Issue 1, 2013, Pages 177-196

Oridonin induces apoptosis, inhibits migration and invasion on highly-metastatic human breast cancer cells

Author keywords

Apoptosis; Breast Cancer; Invasion; Migration; Oridonin

Indexed keywords

ANTINEOPLASTIC AGENT; BETA1 INTEGRIN; CASPASE 8; FAS ANTIGEN; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; HISTONE H2AX; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ORIDONIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BAX; PROTEIN BCL 2;

EID: 84872977175     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500134     Document Type: Article
Times cited : (103)

References (56)
  • 1
    • 78650420222 scopus 로고    scopus 로고
    • Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicinresistant human breast cancer cells
    • Arafa-el, S.A., Q. Zhu, Z.I. Shah, G. Wani, B.M. Barakat, I. Racoma, M.A. El-Mahdy and A.A. Wani. Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicinresistant human breast cancer cells. Mutat. Res. 706: 28-35, 2011
    • (2011) Mutat. Res , vol.706 , pp. 28-35
    • Arafa-El, S.A.1    Zhu, Q.2    Shah, Z.I.3    Wani, G.4    Barakat, B.M.5    Racoma, I.6    El-Mahdy, M.A.7    Wani, A.A.8
  • 2
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers, A.F., A.C. Groom and I.C. MacDonald. Dissemination and growth of cancer cells in metastatic sites. Nat. Rev. Cancer 2: 563-572, 2002
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 3
    • 79952312969 scopus 로고    scopus 로고
    • Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9
    • Chen, P., N. Lu, Y. Ling, Y. Chen, H. Hui, Z. Lu, X. Song, Z. Li, Q. You and Q. Guo. Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9. Toxicology 282: 122-128, 2011
    • (2011) Toxicology , vol.282 , pp. 122-128
    • Chen, P.1    Lu, N.2    Ling, Y.3    Chen, Y.4    Hui, H.5    Lu, Z.6    Song, X.7    Li, Z.8    You, Q.9    Guo, Q.10
  • 4
    • 70349469564 scopus 로고    scopus 로고
    • Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells
    • Cheng, Y., F. Qiu, Y.C. Ye, S. Tashiro, S. Onodera and T. Ikejima. Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. Arch. Biochem. Biophys. 490: 70-75, 2009
    • (2009) Arch. Biochem. Biophys , vol.490 , pp. 70-75
    • Cheng, Y.1    Qiu, F.2    Ye, Y.C.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 5
    • 34248158083 scopus 로고    scopus 로고
    • Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells
    • Cui, Q., S. Tashiro, S. Onodera, M. Minami and T. Ikejima. Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol. Pharm. Bull. 30: 859-864, 2007a.
    • (2007) Biol. Pharm. Bull , vol.30 , pp. 859-864
    • Cui, Q.1    Tashiro, S.2    Onodera, S.3    Minami, M.4    Ikejima, T.5
  • 6
    • 34347385839 scopus 로고    scopus 로고
    • P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells
    • Cui, Q., J.H. Yu, J.N. Wu, S. Tashiro, S. Onodera, M. Minami and T. Ikejima. P53-mediated cell cycle arrest and apoptosis through a caspase-3- independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells. Acta. Pharmacol. Sin. 28: 1057-1066, 2007b.
    • (2007) Acta. Pharmacol. Sin , vol.28 , pp. 1057-1066
    • Cui, Q.1    Yu, J.H.2    Wu, J.N.3    Tashiro, S.4    Onodera, S.5    Minami, M.6    Ikejima, T.7
  • 7
    • 44849117768 scopus 로고    scopus 로고
    • Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    • Dan, H.C., M.J. Cooper, P.C. Cogswell, J.A. Duncan, J.P. Ting and A.S. Baldwin. Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK Genes. Dev. 22: 1490-1500, 2008
    • (2008) Genes. Dev , vol.22 , pp. 1490-1500
    • Dan, H.C.1    Cooper, M.J.2    Cogswell, P.C.3    Duncan, J.A.4    Ting, J.P.5    Baldwin, A.S.6
  • 8
    • 72949119124 scopus 로고    scopus 로고
    • Integrins in cancer: Biological implications and therapeutic opportunities
    • Desgrosellier, J.S. and D.A. Cheresh. Integrins in cancer: Biological implications and therapeutic opportunities. Nat. Rev. Cancer 10: 9-22, 2010
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 9-22
    • Desgrosellier, J.S.1    Cheresh, D.A.2
  • 9
    • 33750475618 scopus 로고    scopus 로고
    • Current insights into the regulation of programmed cell death by NF-kappaB
    • Dutta, J., Y. Fan, N. Gupta, G. Fan and C. Gelinas. Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene 25: 6800-6816, 2006
    • (2006) Oncogene , vol.25 , pp. 6800-6816
    • Dutta, J.1    Fan, Y.2    Gupta, N.3    Fan, G.4    Gelinas, C.5
  • 10
    • 35148815554 scopus 로고    scopus 로고
    • Bim and the pro-survival Bcl-2 proteins: Opposites attract
    • Ewings, K.E., C.M. Wiggins and S.J. Cook. Bim and the pro-survival Bcl-2 proteins: Opposites attract, ERK repels. Cell Cycle 6: 2236-2240, 2007
    • (2007) ERK Repels. Cell Cycle , vol.6 , pp. 2236-2240
    • Ewings, K.E.1    Wiggins, C.M.2    Cook, S.J.3
  • 12
  • 13
    • 0017265719 scopus 로고
    • Antitumor activity of the Isodon diterpenoids: Structural requirements for the activity
    • Fujita, E., Y. Nagao, M. Node, K. Kaneko, S. Nakazawa and H. Kuroda. Antitumor activity of the Isodon diterpenoids: Structural requirements for the activity. Experientia 32: 203-206, 1976
    • (1976) Experientia , vol.32 , pp. 203-206
    • Fujita, E.1    Nagao, Y.2    Node, M.3    Kaneko, K.4    Nakazawa, S.5    Kuroda, H.6
  • 14
    • 70449394399 scopus 로고    scopus 로고
    • A traditional Chinese medicine formulation consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity
    • Gao, J.L., T.C. He, Y.B. Li and Y.T. Wang. A traditional Chinese medicine formulation consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity. Oncol. Rep 1077-1083, 2009a.
    • (2009) Oncol. Rep , pp. 1077-1083
    • Gao, J.L.1    He, T.C.2    Li, Y.B.3    Wang, Y.T.4
  • 15
    • 70350484962 scopus 로고    scopus 로고
    • Angiogenic pathway inhibition of Corydalis yanhusuo and berberine in human umbilical vein endothelial cells
    • Gao, J.L., J.M. Shi, S.M. Lee, Q.W. Zhang and Y.T. Wang. Angiogenic pathway inhibition of Corydalis yanhusuo and berberine in human umbilical vein endothelial cells. Oncol. Res. 17: 519-526, 2009b.
    • (2009) Oncol. Res , vol.17 , pp. 519-526
    • Gao, J.L.1    Shi, J.M.2    Lee, S.M.3    Zhang, Q.W.4    Wang, Y.T.5
  • 16
    • 64549109015 scopus 로고    scopus 로고
    • Targeted therapy of human osteosarcoma with 17AAG or rapamycin: Characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways
    • Gazitt, Y., V. Kolaparthi, K. Moncada, C. Thomas and J. Freeman. Targeted therapy of human osteosarcoma with 17AAG or rapamycin: Characterization of induced apoptosis and inhibition of mTOR and Akt/MAPK/Wnt pathways. Int. J. Oncol. 34: 551-561, 2009
    • (2009) Int. J. Oncol , vol.34 , pp. 551-561
    • Gazitt, Y.1    Kolaparthi, V.2    Moncada, K.3    Thomas, C.4    Freeman, J.5
  • 17
    • 54549087863 scopus 로고    scopus 로고
    • Apoptosis: Stabbed in the BAX
    • Green, D.R. and J.E. Chipuk. Apoptosis: Stabbed in the BAX. Nature 455: 1047-1049, 2008
    • (2008) Nature , vol.455 , pp. 1047-1049
    • Green, D.R.1    Chipuk, J.E.2
  • 18
    • 3042815666 scopus 로고    scopus 로고
    • Antineoplastic effects of peroxisome proliferatoractivated receptor gamma agonists
    • Grommes, C., G.E. Landreth and M.T. Heneka. Antineoplastic effects of peroxisome proliferatoractivated receptor gamma agonists. Lancet. Oncol. 5: 419-429, 2004
    • (2004) Lancet. Oncol , vol.5 , pp. 419-429
    • Grommes, C.1    Landreth, G.E.2    Heneka, M.T.3
  • 19
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden, M.S. and S. Ghosh. Signaling to NF-kappaB. Genes. Dev. 18: 2195-2224, 2004
    • (2004) Genes. Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 20
    • 25844511169 scopus 로고    scopus 로고
    • Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the Chinese herb Rabdosia rubescens
    • Hsieh, T.C., E.K. Wijeratne, J.Y. Liang, A.L. Gunatilaka and J.M. Wu. Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the Chinese herb Rabdosia rubescens. Biochem. Biophys. Res. Commun. 337: 224-231, 2005
    • (2005) Biochem. Biophys. Res. Commun , vol.337 , pp. 224-231
    • Hsieh, T.C.1    Wijeratne, E.K.2    Liang, J.Y.3    Gunatilaka, A.L.4    Wu., J.M.5
  • 22
    • 50149087699 scopus 로고    scopus 로고
    • Reactive oxygen species mediate oridonininduced hepg2 apoptosis through p53 mapk, and mitochondrial signaling pathways
    • Huang, J., L. Wu, S. Tashiro, S. Onodera and T. Ikejima. Reactive oxygen species mediate oridonininduced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways J. Pharmacol. Sci. 107: 370-379, 2008
    • (2008) J. Pharmacol. Sci , vol.107 , pp. 370-379
    • Huang, J.1    Wu, L.2    Tashiro, S.3    Onodera, S.4    Ikejima, T.5
  • 23
    • 77953359873 scopus 로고    scopus 로고
    • Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways
    • Kang, N., J.H. Zhang, F. Qiu, S. Tashiro, S. Onodera and T. Ikejima. Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer Lett. 294: 147-158, 2010
    • (2010) Cancer Lett , vol.294 , pp. 147-158
    • Kang, N.1    Zhang, J.H.2    Qiu, F.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 24
    • 79952739732 scopus 로고    scopus 로고
    • PPARgamma ligands induce growth inhibition and apoptosis through p63 and p73 in human ovarian cancer cells
    • Kim, S., J.J. Lee and D.S. Heo. PPARgamma ligands induce growth inhibition and apoptosis through p63 and p73 in human ovarian cancer cells. Biochem. Biophys. Res. Commun. 406: 389-395, 2011a.
    • (2011) Biochem. Biophys. Res. Commun , vol.406 , pp. 389-395
    • Kim, S.1    Lee, J.J.2    Heo, D.S.3
  • 25
    • 79955469358 scopus 로고    scopus 로고
    • 5′-Nitro-indirubinoxime, an indirubin derivative, suppresses metastatic ability of human head and neck cancer cells through the inhibition of Integrin beta1/FAK/Akt signaling
    • Kim, S.A., S.M. Kwon, J.A. Kim, K.W. Kang, J.H. Yoon and S.G. Ahn. 5′-Nitro-indirubinoxime, an indirubin derivative, suppresses metastatic ability of human head and neck cancer cells through the inhibition of Integrin beta1/FAK/Akt signaling. Cancer Lett. 306: 197-204, 2011b.
    • (2011) Cancer Lett , vol.306 , pp. 197-204
    • Kim, S.A.1    Kwon, S.M.2    Kim, J.A.3    Kang, K.W.4    Yoon, J.H.5    Ahn, S.G.6
  • 26
    • 79957440231 scopus 로고    scopus 로고
    • Regulation of death receptor-induced apoptosis induced via CD95/FAS and other death receptors
    • Lavrik, I.N. Regulation of death receptor-induced apoptosis induced via CD95/FAS and other death receptors. Mol. Biol. 45: 173-179, 2011
    • (2011) Mol. Biol , vol.45 , pp. 173-179
    • Lavrik, I.N.1
  • 27
    • 79953029230 scopus 로고    scopus 로고
    • Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics
    • Li, C.Y., E.Q. Wang, Y. Cheng and J.K. Bao. Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics. Int. J. Biochem. Cell Biol 701-704, 2011a.
    • (2011) Int. J. Biochem. Cell Biol
    • Li, C.Y.1    Wang, E.Q.2    Cheng, Y.3    Bao, J.K.4
  • 28
    • 0022589379 scopus 로고
    • Characteristics of the cytostatic effects of oridonin in vitro
    • Li, X.T., C. Lin and P.Y. Li. Characteristics of the cytostatic effects of oridonin in vitro. Acta Pharmacol. Sin. 7: 361-363, 1986
    • (1986) Acta Pharmacol. Sin , vol.7 , pp. 361-363
    • Li, X.T.1    Lin, C.2    Li., P.Y.3
  • 29
    • 79952489973 scopus 로고    scopus 로고
    • Protective antioxidative and antiapoptotic effects of 2-methoxy-6-acetyl-7-methyljuglone from Polygonum cuspidatum in PC12 cells
    • Li, Y.B., Z.Q. Lin, Z.J. Zhang, M.W. Wang, H. Zhang, Q.W. Zhang, S.M. Lee, Y.T. Wang and P.M. Hoi. Protective, antioxidative and antiapoptotic effects of 2-methoxy-6-acetyl-7-methyljuglone from Polygonum cuspidatum in PC12 cells. Planta Med. 77: 354-361, 2011b.
    • (2011) Planta Med , vol.77 , pp. 354-361
    • Li, Y.B.1    Lin, Z.Q.2    Zhang, Z.J.3    Wang, M.W.4    Zhang, H.5    Zhang, Q.W.6    Lee, S.M.7    Wang, Y.T.8    Hoi, P.M.9
  • 30
    • 60449106119 scopus 로고    scopus 로고
    • Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage
    • Liu, Z., Q. Liu, B. Xu, J. Wu, C. Guo, F. Zhu, Q. Yang, G. Gao, Y. Gong and C. Shao. Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat. Res. 662: 75-83, 2009
    • (2009) Mutat. Res , vol.662 , pp. 75-83
    • Liu, Z.1    Liu, Q.2    Xu, B.3    Wu, J.4    Guo, C.5    Zhu, F.6    Yang, Q.7    Gao, G.8    Gong, Y.9    Shao, C.10
  • 31
    • 50649083301 scopus 로고    scopus 로고
    • Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells
    • Lu, N., Y. Ling, Y. Gao, Y. Chen, R. Mu, Q. Qi, W. Liu, H. Zhang, H. Gu, S. Wang, Y. Yang and Q. Guo. Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells. Exp. Biol. Med (Maywood) 233: 1013-1020, 2008
    • (2008) Exp. Biol. Med (Maywood) , vol.233 , pp. 1013-1020
    • Lu, N.1    Ling, Y.2    Gao, Y.3    Chen, Y.4    Mu, R.5    Qi, Q.6    Liu, W.7    Zhang, H.8    Gu, H.9    Wang, S.10    Yang, Y.11    Guo, Q.12
  • 32
    • 77956520830 scopus 로고    scopus 로고
    • Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: An investigation of human green tea ingestion
    • Malhomme de la Roche, H., S. Seagrove, A. Mehta, P. Divekar, S. Campbell and A. Curnow Using natural dietary sources of antioxidants to protect against ultraviolet and visible radiation-induced DNA damage: An investigation of human green tea ingestion. J. Photochem Photobiol. B. 101: 169-173, 2010
    • (2010) J. Photochem Photobiol. B. , vol.101 , pp. 169-173
    • Malhomme De La Roche, H.1    Seagrove, S.2    Mehta, A.3    Divekar, P.4    Campbell, S.5    Curnow, A.6
  • 33
    • 15044350668 scopus 로고    scopus 로고
    • The expanding TOR signaling network
    • Martin, D.E. and M.N. Hall. The expanding TOR signaling network. Curr. Opin. Cell. Biol. 17: 158- 166, 2005
    • (2005) Curr. Opin. Cell. Biol , vol.17 , pp. 158-166
    • Martin, D.E.1    Hall, M.N.2
  • 36
    • 0842301044 scopus 로고    scopus 로고
    • Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells
    • Michael, M.S., M.Z. Badr and A.F. Badawi. Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells. Int. J. Mol. Med. 11: 733-736, 2003
    • (2003) Int. J. Mol. Med , vol.11 , pp. 733-736
    • Michael, M.S.1    Badr, M.Z.2    Badawi, A.F.3
  • 37
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman, D.J. and G.M. Cragg. Natural products as sources of new drugs over the last 25 years J. Nat. Prod. 70: 461-477, 2007
    • (2007) J. Nat. Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 38
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl, H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18: 6853- 6866, 1999
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 39
    • 79954667347 scopus 로고    scopus 로고
    • Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro
    • Pal, S., P.B. Pal, J. Das and P.C. Sil. Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro. Toxicology 283: 129-139, 2011
    • (2011) Toxicology , vol.283 , pp. 129-139
    • Pal, S.1    Pal, P.B.2    Das, J.3    Sil, P.C.4
  • 40
    • 77957578387 scopus 로고    scopus 로고
    • Inhibition of cancer cell invasion and metastasis by genistein
    • Pavese, J.M., R.L. Farmer and R.C. Bergan. Inhibition of cancer cell invasion and metastasis by genistein. Cancer Metastasis Rev. 29: 465-482, 2010
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 465-482
    • Pavese, J.M.1    Farmer, R.L.2    Bergan, R.C.3
  • 41
    • 81155135198 scopus 로고    scopus 로고
    • Anticancer activity of Nigella sativa (black seed) - A review
    • Randhawa, M.A. and M.S. Alghamdi. Anticancer activity of Nigella sativa (black seed) - a review Am. J. Chin. Med. 39: 1075-1091, 2011
    • (2011) Am. J. Chin. Med , vol.39 , pp. 1075-1091
    • Randhawa, M.A.1    Alghamdi, M.S.2
  • 42
    • 29144444040 scopus 로고    scopus 로고
    • The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells
    • Ren, K.K., H.Z. Wang, L.P. Xie, D.W. Chen, X. Liu, J. Sun, Y.C. Nie and R.Q. Zhang. The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells J. Ethnopharmacol. 103: 176-180, 2006
    • (2006) J. Ethnopharmacol , vol.103 , pp. 176-180
    • Ren, K.K.1    Wang, H.Z.2    Xie, L.P.3    Chen, D.W.4    Liu, X.5    Sun, J.6    Nie, Y.C.7    Zhang, R.Q.8
  • 43
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou, E.P., D.R. Pilch, A.H. Orr, V.S. Ivanova and W.M. Bonner. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273: 5858-5868, 1998
    • (1998) J. Biol. Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 45
    • 0023792919 scopus 로고
    • Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
    • Scudiero, D.A., R.H. Shoemaker, K.D. Paull, A. Monks, S. Tierney, T.H. Nofziger, M.J. Currens, D. Seniff and M.R. Boyd. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res. 48: 4827-4833, 1988
    • (1988) Cancer Res , vol.48 , pp. 4827-4833
    • Scudiero, D.A.1    Shoemaker, R.H.2    Paull, K.D.3    Monks, A.4    Tierney, S.5    Nofziger, T.H.6    Currens, M.J.7    Seniff, D.8    Boyd, M.R.9
  • 46
    • 67649849871 scopus 로고    scopus 로고
    • Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs
    • Shibue, T. and R.A. Weinberg. Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc. Natl. Acad. Sci. USA 106: 10290- 10295, 2009
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 10290-10295
    • Shibue, T.1    Weinberg, R.A.2
  • 48
    • 34347233468 scopus 로고    scopus 로고
    • Estrogen receptor alpha mediates breast cancer cell resistance to paclitaxel through inhibition of apoptotic cell death
    • Sui, M., Y. Huang, B.H. Park, N.E. Davidson and W. Fan. Estrogen receptor alpha mediates breast cancer cell resistance to paclitaxel through inhibition of apoptotic cell death. Cancer Res. 67: 5337-5344, 2007
    • (2007) Cancer Res , vol.67 , pp. 5337-5344
    • Sui, M.1    Huang, Y.2    Park, B.H.3    Davidson, N.E.4    Fan, W.5
  • 49
    • 42349114775 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells
    • Sun, H., I.M. Berquin, R.T. Owens, J.T. O'Flaherty and I.J. Edwards. Peroxisome proliferatoractivated receptor gamma-mediated up-regulation of syndecan-1 by n-3 fatty acids promotes apoptosis of human breast cancer cells. Cancer Res. 68: 2912-2919, 2008
    • (2008) Cancer Res , vol.68 , pp. 2912-2919
    • Sun, H.1    Berquin, I.M.2    Owens, R.T.3    O'Flaherty, J.T.4    Edwards, I.J.5
  • 50
    • 77956301155 scopus 로고    scopus 로고
    • Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells
    • Wang, H., Y. Ye, J.H. Chui, G.Y. Zhu, Y.W. Li, D.W. Fong and Z.L. Yu. Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells Oncol. Rep. 24: 647-651, 2010
    • (2010) Oncol. Rep. , vol.24 , pp. 647-651
    • Wang, H.1    Ye, Y.2    Chui, J.H.3    Zhu, G.Y.4    Li, Y.W.5    Fong, D.W.6    Yu, Z.L.7
  • 51
    • 84860727944 scopus 로고    scopus 로고
    • Emodin loaded solid lipid nanoparticles: Preparation, characterization and antitumor activity studies
    • Wang, S., T. Chen, R. Chen, Y. Hu, M. Chen and Y. Wang. Emodin loaded solid lipid nanoparticles: preparation, characterization and antitumor activity studies. Int. J. Pharm. 430: 238-246, 2012
    • (2012) Int. J. Pharm , vol.430 , pp. 238-246
    • Wang, S.1    Chen, T.2    Chen, R.3    Hu, Y.4    Chen, M.5    Wang, Y.6
  • 52
    • 78751493724 scopus 로고    scopus 로고
    • Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities
    • Xu, Z., X. Chen, Z. Zhong, L. Chen and Y. Wang. Ganoderma lucidum polysaccharides: Immunomodulation and potential anti-tumor activities. Am. J. Chin. Med. 39: 15-27, 2011
    • (2011) Am. J. Chin. Med , vol.39 , pp. 15-27
    • Xu, Z.1    Chen, X.2    Zhong, Z.3    Chen, L.4    Wang, Y.5
  • 53
    • 69849112209 scopus 로고    scopus 로고
    • NF-kappaB facilitates oridonininduced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway
    • Zhang, Y., Y. Wu, D. Wu, S. Tashiro, S. Onodera and T. Ikejima. NF-kappaB facilitates oridonininduced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway. Arch Biochem. Biophys. 489: 25-33, 2009
    • (2009) Arch Biochem. Biophys , vol.489 , pp. 25-33
    • Zhang, Y.1    Wu, Y.2    Wu, D.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 54
    • 80052038761 scopus 로고    scopus 로고
    • Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis
    • Zhong, Z., X. Chen, W. Tan, Z. Xu, K. Zhou, T. Wu, L. Cui and Y. Wang. Germacrone inhibits the proliferation of breast cancer cell lines by inducing cell cycle arrest and promoting apoptosis Eur. J. Pharmacol. 667: 50-55, 2011
    • (2011) Eur. J. Pharmacol , vol.667 , pp. 50-55
    • Zhong, Z.1    Chen, X.2    Tan, W.3    Xu, Z.4    Zhou, K.5    Wu, T.6    Cui, L.7    Wang, Y.8
  • 56
    • 34247360358 scopus 로고    scopus 로고
    • Back to the future of oridonin: Again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo
    • Zhou, G.B., S.J. Chen, Z.Y. Wang and Z. Chen. Back to the future of oridonin: Again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo. Cell Res. 17: 274-276, 2007
    • (2007) Cell Res , vol.17 , pp. 274-276
    • Zhou, G.B.1    Chen, S.J.2    Wang, Z.Y.3    Chen, Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.