Dietary agents in cancer prevention: Flavonoids and isoflavonoids

Pharmacology and Therapeutics

Volumn 90, Issue 2-3, 2001, Pages 157-177

  Birt, Diane F ^a   Hendrich, Suzanne ^a   Wang, Weiqun ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

Bioavailability; Cancer; Epidemiology; Flavones; Isoflavones; Mechanisms

Indexed keywords

ALPHA TOCOPHEROL; APIGENIN; ASCORBIC ACID; BAICALIN; BETA CAROTENE; DAIDZEIN; DIOSMIN; ENZYME; FLAVANOL DERIVATIVE; FLAVANONE; FLAVONE DERIVATIVE; FLAVONOID; FLAVONOL; GALANGIN; GENISTEIN; GLYCOSIDE; HESPERETIN; HESPERIDIN; ISOFLAVONE DERIVATIVE; ISOFLAVONOID; KAEMPFEROL; LUTEOLIN; MYRICETIN; NARINGENIN; QUERCETIN; RUTOSIDE; SULINDAC; UNINDEXED DRUG; XANTHOPHYLL;

ANTIOXIDANT ACTIVITY; APOPTOSIS; CANCER; CANCER CONTROL; CANCER EPIDEMIOLOGY; CANCER PREVENTION; CARCINOGENESIS; CLINICAL TRIAL; DETOXIFICATION; DIET; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG MECHANISM; DRUG STRUCTURE; ESTROGEN ACTIVITY; HUMAN; HYDROPHOBICITY; IMMUNE SYSTEM; IMMUNOREGULATION; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SOYBEAN;

EID: 0034807826     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(01)00137-1     Document Type: Review

References (195)

1. Western diet and western diseases: Some hormonal and biochemical mechanisms and associations
2. Phytoestrogens: Epidemiology and a possible role in cancer protection
3. Effects of ellipticine, flavone, and 7,8-benzoflavone upon 7,12-dimethylbenz[a]anthracene, 7,14-dimethyl-dibenzo[a,h]anthracene and dibenzo[a,h]anthracene initiated skin tumors in mice
4. Plant-based diets and bone health: Nutritional implications
5. The role of the immune system in the pathogenesis of cancer
6. Antioxidant activities of isoflavones and their biological metabolites in a liposomal system
7. Absorption and excretion of conjugated flavonols, including quercetin-4′-O-β-glucoside and isorhamnetin-4′-O-β-glucoside by human volunteers after the consumption of onions
8. A specific breeding problem of sheep on subterranean clover pastures in western Australia
9. Increase of NAD(P)H:quinone reductase by dietary antioxidants: Possible role in protection against carcinogenesis and toxicity
10. Soybeans and cancer prevention: A complex food and a complex disease
11. Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol
12. Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid
13. Chemoprevention of cancer
14. Fruit, vegetables, and cancer prevention: A review of the epidemiological evidence
15. The minor flavonoids
16. Isoflavones inhibits intestinal epithelial cell proliferation and induce apoptosis in vitro
17. Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance
18. Short-term effects of phytoestrogen-rich diet on postmenopausal women
19. Dietary flavonoids, quercetin, luteolin and genistein, reduce oxidative DNA damage and lipid peroxidation and quench free radicals
20. Effect of ellagic acid and hydroxylated flavonoids on the tumorigenicity of benzo[a]pyrene and (±-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9-10- tetrahydrobenzo[a]pyrene on mouse skin and in the newborn mouse
21. The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents
22. Induction of differentiation and DNA strand breakage in human HL-60 and K-562 leukemia cells by genistein
23. Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships
24. Inhibition of N-methyl-N-nitrosourea-induced mammary tumors in rats by the soybean isoflavones
25. Genistein induces maturation of cultured human breast cancer cells and prevents tumor growth in nude mice
26. Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occurring in medical herbs
27. Phytoestrogens in clinical practice
28. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
29. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia
30. The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high-fat diet
31. Isoflavonoids
32. Chemopreventive potential of dietary bioflavonoids against 20-methylcholanthrene-induced tumorigenesis
33. Non-selective inhibition of mammalian protein kinases by flavinoids in vitro
34. DT diaphorase
35. Potential value of plants as sources of new antifertility agents II
36. Flavonoids, coumarins, and cinnamic acids as antioxidants in a micellar system. Structure-activity relationship
37. Genistein, a dietary-derived inhibitor of in vitro angiogenesis
38. Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis
39. Soy, its components, and cancer prevention: A review of the in vitro, animal, and human data
40. Inhibition of oxidation of low-density lipoprotein by phenolic substances in red wine
41. Factors which facilitate inactivation of quercetin mutagencity
42. Dietary genistein: Perinatal mammary cancer prevention, bioavailability and toxicity testing in the rat
43. Flavonoids and the inhibition of PKC and PI 3-kinase
44. Intake of specific carotenoids and flavonoids and the risk of lung cancer in women in Barcelona, Spain
45. Effect of structurally related flavones/isoflavones on hydrogen peroxide production and oxidative DNA damage in phorbol ester-stimulated HL-60 cells
46. Induction of NAD(P)H:quinone reductase in human peripheral blood lymphocytes
47. Urinary metabolites of flavonoids and hydroxycinnamic acids in humans after application of a crude extract from equisetum arvense
48. Metabolism of apigenin and related compounds in the rat; metabolite formation in vivo and by the intestinal microflora in vitro
49. Inhibition of mammary cancer by citrus flavonoids
50. General procedures and measurement of total phenolics
51. Phase I clinical and pharmacokinetic trial of flavone acetic acid
52. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
53. Isoflavones metabolism and bioavailability
54. Human bioavailability of soy bean isoflavones: Influences of diet, dose, time and gut microflora
55. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the NLD
56. Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices
57. Dietary flavonoids and cancer risk in the Zutphen elderly study
58. Flavonoid intake and long-term risk of coronary heart disease and cancer in the Seven Countries Study
59. Influence of protein tyrosine phosphorylation on the expression of the c-myc oncogene in cancer of the large bowel
60. Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells
61. Absorption, metabolism and health effects of dietary flavonoids in man
62. Bioavailability and health effects of dietary flavonols in man
63. Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
64. Bioavailability of the dietary antioxidant flavonol quercetin in man
65. The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
66. Inhibitory effect of quercetin on the synthesis of a possibly cell-cycle-related 17-kDa protein, in human colon cancer cells
67. Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo
68. Diet and cancer of the stomach: A case-control study in China
69. Polyhydroxy flavonoid antioxidants for edible oils: Structural criteria for activity
70. Effects of dietary antioxidants on the immune function of middle-aged adults
71. Hydroxyl radical scavenging activity of flavonoids
72. Urinary isoflavonoid phytoestrogen and lignan excretion after consumption of fermented and unfermented soy products
73. Responses of experimental rat tumours and a mouse colon tumour to flavone acetic acid
74. Antimutagenicity of flavones and flavonols to heterocyclic amines by specific and strong inhibition of the cytochrome P450 1A family
75. Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro
76. Urinary isoflavonoid excretion in humans is dose dependent at low to moderate levels of soy-protein consumption
77. Antiproliferative activity of flavonoids on several cancer cell lines
78. Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats
79. Metabolites of dietary (soya) isoflavones in human urine
80. The evidence for soybean products as cancer preventive agents
81. Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans
82. Absorption and excretion of the soy isoflavone genistein in rats
83. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms
84. A review of the clinical effects of phytoestrogens
85. Studies on inhibitors of skin tumor promotion. XI. Inhibitory effects of flavonoids from Scutellaria baicalensis on Epstein-Barr virus activation and their anti-tumor-promoting activities
86. Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked
87. Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes
88. Reversion of the transformed phenotypes of v-H-ras NIH3T3 cells by flavonoids through attenuating the content of phosphotyrosine
89. Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells
90. Dietary flavonoid and cancer prevention: Evidence and potential mechanism
91. Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity
92. A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model
93. Neonatal genistein chemoprevents mammary cancer
94. Genistein alters the ontogeny of mammary gland development and protects against chemically-induced mammary cancer in rats
95. Genistein studies in rats: Potential for breast cancer prevention and reproductive and developmental toxicity
96. Urinary equol excretion with a soy challenge: Influence of habitual diet
97. Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids
98. Soybean isoflavone extract suppresses early but not later promotion of hepatocarcinogenesis by phenobarbital in female rat liver
99. Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavonoids
100. Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity
101. Induction of p21/WAF1 and G1 cell-cycle arrest by the chemopreventive agent apigenin
102. The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes
103. Plant phenolics
104. Soybean isoflavones reduce experimental metastasis in mice
105. Genistein-induced G2-M arrest, p21WAF1 upregulation, and apoptosis in a non-small-cell lung cancer cell line
106. Soy protein, isoflavones and cardiovascular disease risk
107. Quantitative structure-activity relationship analysis of phenolic antioxidants
108. Dietary immunomodulation: Beneficial effects on oncogenesis and tumor growth
109. Altered time course of urinary daidzein and genistein excretion during chronic soya diet in healthy male subjects
110. Altered kinetics and extent of urinary daidzein and genistein excretion in women during chronic soya exposure
111. Dietary soybean may be antiestrogenic in male mice
112. Chemoprevention of 4-nitraquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin
113. Methyl p-hydroxyphenyllactate - An inhibitor of cell growth and proliferation and an endogenous ligand for nuclear type-II binding sites
114. Genistein arrests cell cycle progression at G2-M
115. The role of soy in preventing and treating chronic disease
116. Effect of plant flavonoids on immune and inflammatory cell function
117. Effects of flavonoids on immune and inflammatory cell functions
118. Commonly occurring plant flavonoids have estrogenic activity
119. Estrogenic flavonoids: Structural requirements for biological activity
120. Antioxidant efficacy of phytoestrogens in chemical and biological model systems
121. Recent trends in research on intestinal flora
122. The significance of oestrogens in pasture plants in relation to animal production
123. An in vitro and in vivo study of antitumor effects of genistein on hormone refractory prostate cancer
124. Induction of rat hepatic and intestinal glutathione S-transferases and glutathione by dietary naturally occurring anticarcinogens
125. Inhibition of aflatoxin B1 carcinogenesis in rainbow trout by flavone and indole compounds
126. Effects of flavonoids and vitamin C on oxidative DNA damage to human lymphocytes
127. What accounts for the association of vegetables and fruits with lower incidence of cancers and coronary heart diseases
128. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
129. Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats
130. Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents
131. Metabolism of the isoflavones genistein and biochanin A in human breast cancer cell lines
132. Type II estrogen binding sites and antiproliferative activity of quercetin in human meningiomas
133. Flavonoids in the human diet
134. Flavonoids activate wild-type p53
135. Influence of isoflavones in soy protein isolates on development of induced prostate-related cancers in L-W rats
136. Vegetables, fruit and phytoestrogens as preventive agents
137. Effects of flavonoids on nonenzymatic lipid peroxidation: Structure-activity relationship
138. Wine, alcohol, platelets, and the French paradox for coronary heart disease
139. Flavonoids are scavengers of superoxide anion
140. The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells
141. Nonsteroidal estrogens of dietary origin: Possible roles in hormone-dependent disease
142. A prospective study of demographics, diet, and prostate cancer among men of Japanese ancestry in Hawaii
143. Intestinal uptake and biliary excretion of the isoflavone genistein in rats
144. Phenolic antioxidants
145. Steroid and phyto-estrogen binding to sheep uterine receptors in vitro
146. Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices
147. The effect of soy isoflavones on the development of intestinal neoplasia in ApcMin mouse
148. The natural tyrosine kinase inhibitor genistein produces cell cycle arrest and apoptosis in Jukat T-leukemia cells
149. Vegetables, fruit, and cancer. I. Epidemiology
150. Vegetables, fruit, and cancer. II. Mechanisms
151. Vegetables, fruit, and colon cancer in the Iowa women's health study
152. Mechanisms of induction of enzymes that protect against chemical carcinogenesis
153. Chemoprotection against cancer by phase 2 enzyme induction
154. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin
155. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination
156. A diet high in wheat fiber suppresses the bioavailability of isoflavones in a single meal fed to women
157. Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium
158. Antioxidant activity of flavonoids and reactivity with peroxy radical
159. Effects of genistein on the growth and cell cycle progression of normal human lymphocytes and human leukemic MOLT-4 and HL-60 cells
160. Naturally-occurring estrogens in plant foodstuffs - A review
161. Effect of dietary phytochemicals on cancer development
162. Isoflavone content of commercial soybean foods
163. Antioxidant property of dietary phenolic agents in a human LDL-oxidation ex vivo model: Interaction of protein binding activity
164. Induction of NAD(P)H:quinone reductase by vitamins A, E and C in Colo205 colon cancer cells
165. Dietary soy protein is associated with reduced intestinal mucosal polyamine concentration in male Wistar rats
166. Proliferative response of mammary glandular tissues to formononetin
167. Individual and combinatory effects of soy isoflavones on the in vitro potentiation of lymphocyte activation
168. Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells
169. Cell-cycle arrest at G2/M and growth inhibition by apigenin in human colon carcinoma cell lines
170. Pharmacokinetics of soybean isoflavones in plasma, urine and feces of men after injestion of 60 g baked soybean powder (Kinako)
171. Immunological enhancement by fat-soluble vitamins, minerals, and trace metals: A factor in cancer prevention
172. Inhibition of carcinogenesis by minor dietary constituents
173. Chemoprevention of cancer by naturally occurring and synthetic compounds
174. Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice
175. Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice
176. Induction of apoptosis by quercetin: Involvemnt of heat shock protein
177. Induction of apoptosis by quercetin: Involvement of heat shock protein
178. C-ring cleavage of flavonoids by human intestinal bacteria
179. The bioavailability of non-nutrient plant factors: Dietary flavonoids and phyto-estrogens
180. Soy intake and risk of breast cancer in Asians and Asian Americans
181. Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women
182. Bioavailability of soybean isoflavones depends upon gut microflora in women
183. Neither background diet choice nor type or soy food affect isoflavone bioavailability in women
184. Prooxidant activity of caffeic acid, dietary non-flavonoid phenolic acid, on Cu(2+)-induced low density lipoprotein oxidation
185. Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle
186. Soy and rye diets inhibit the development of Dunning R3327 prostatic adenocarcinoma in rats
187. Enhancement of immune function in mice fed high doses of soy daidzein
188. Daidzein and genistein glucuronides in vitro are weakly estrogenic and activate human natural killer cells in nutritionally relevant concentrations
189. Urinary disposition of the soybean isoflavones daidzein, genistein and glycitein differs among humans with moderate fecal isoflavone degradation activity
190. Urinary excretion of isoflavonoids and the risk of breast cancer
191. Inhibition of murine bladder tumorigenesis by soy isoflavones via alterations in the cell cycle, apoptosis, and angiogenesis
192. A flavonoid antioxidant, silymarin, inhibits activation of erbB1 signaling and induces cyclin-dependent kinase inhibitors, G1 arrest, and anticarcinogenic effects in human prostate carcinoma DU145 cells
193. Blood flow failure as a major determinant in the antitumor action of flavone acetic acid