Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells

International Immunopharmacology

Volumn 14, Issue 4, 2012, Pages 375-383

  Chun, Jaemoo ^a   Choi, Ran Joo ^a   Khan, Salman ^a   Lee, Dong Sung ^b   Kim, Youn Chul ^b   Nam, Young Joo ^c   Lee, Dong Ung ^c   Kim, Yeong Shik ^a  

^a Seoul National University   (South Korea)

^b Wonkwang University   (South Korea)

^c Dongguk University   (South Korea)

Author keywords

Alantolactone; AP 1; Inflammation; Macrophage; MAPK; NF B

Indexed keywords

ALANTOLACTONE; CYCLOOXYGENASE 2; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE; PROSTAGLANDIN E2; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUCKLANDIA LAPPA; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME PHOSPHORYLATION; MEDICINAL PLANT; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLOOXYGENASE 2; DOWN-REGULATION; GENE EXPRESSION REGULATION; LACTONES; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR STRUCTURE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; NITRIC OXIDE SYNTHASE; SESQUITERPENES, EUDESMANE; TRANSCRIPTION FACTOR AP-1;

EID: 84866990008     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.08.011     Document Type: Article

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