메뉴 건너뛰기




Volumn 8, Issue 8, 2002, Pages 385-389

NF-κB as a therapeutic target in cancer

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; BORTEZOMIB; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRINOTECAN; PACLITAXEL; PROTEASOME INHIBITOR; THALIDOMIDE; TRANSCRIPTION FACTOR; I KAPPA B;

EID: 0036020941     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4914(02)02375-4     Document Type: Review
Times cited : (549)

References (50)
  • 2
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Rel proteins: Evolutionarily conserved mediators of the immune response
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225-260
    • Ghosh, S.1
  • 3
    • 0035137882 scopus 로고    scopus 로고
    • Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB
    • (2001) J. Clin. Invest. , vol.107 , pp. 241-246
    • Baldwin, A.1
  • 6
    • 0033587084 scopus 로고    scopus 로고
    • Mutations in the IκBα gene in Hodgkin's disease suggest a tumor suppressor role for IκBα
    • (1999) Oncogene , vol.18 , pp. 3063-3070
    • Cabannes, E.1
  • 7
    • 0031126817 scopus 로고    scopus 로고
    • The role of Rel/NF-κB proteins in viral oncogenesis and the regulation of viral transcription
    • (1997) Semin. Cancer Biol. , vol.8 , pp. 121-129
    • Mosialos, G.1
  • 8
    • 0033623830 scopus 로고    scopus 로고
    • Role of the IκB kinase complex in oncogenic Ras and Raf-mediated transformation of rat liver epithelial cells
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5381-5391
    • Arsura, M.1
  • 9
    • 18844465632 scopus 로고    scopus 로고
    • Constitutive NF-κB/RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells
    • (1997) J. Clin. Invest. , vol.100 , pp. 2961-2969
    • Bargou, R.1
  • 10
    • 0031440245 scopus 로고    scopus 로고
    • Aberrant NF-κB/Rel expression and the pathogenesis of breast cancer
    • (1997) J. Clin. Invest. , vol.100 , pp. 2952-2960
    • Sovak, M.1
  • 11
    • 0034708132 scopus 로고    scopus 로고
    • Selective activation of NF-κB subunits in human breast cancer: Potential roles for NF-κB2/p52 and Bcl-3
    • (2000) Oncogene , vol.19 , pp. 1123-1131
    • Cogswell, P.1
  • 12
    • 0033565217 scopus 로고    scopus 로고
    • Expression of a dominant mutant IκBα in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo
    • (1999) Cancer Res. , vol.59 , pp. 3468-3474
    • Duffey, D.1
  • 14
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-κB in p53-mediated programmed cell death
    • (2000) Nature , vol.404 , pp. 892-897
    • Ryan, K.1
  • 15
    • 0003504049 scopus 로고    scopus 로고
    • Cyclo-oxygenase regulates angiogenesis induced by colon carcinoma cells
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1
  • 16
    • 0033623902 scopus 로고    scopus 로고
    • NF-κB activity correlates with growth, angiogenesis and metastasis of human melanoma cells in nude mice
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2573-2581
    • Huang, S.1
  • 17
    • 0034541196 scopus 로고    scopus 로고
    • Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by NF-κB
    • (2000) Cancer Res. , vol.60 , pp. 6557-6562
    • Andela, V.1
  • 18
    • 0035849720 scopus 로고    scopus 로고
    • Blockade of NF-κB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion and metastasis
    • (2001) Oncogene , vol.20 , pp. 4188-4197
    • Huang, S.1
  • 19
    • 0032983865 scopus 로고    scopus 로고
    • Mice deficient in TNFα are resistant to skin carcinogenesis
    • (1999) Nat. Med. , vol.5 , pp. 828-831
    • Moore, R.1
  • 20
    • 0034742512 scopus 로고    scopus 로고
    • IL-1α promotes NF-κB and AP-1-induced IL-8 expression, cell survival and proliferation in head and neck squamous cell carcinomas
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1812-1820
    • Wolf, J.1
  • 21
    • 0035958517 scopus 로고    scopus 로고
    • The role of TNFα in the pathophysiology of human multiple myeloma: Therapeutic applications
    • (2001) Oncogene , vol.20 , pp. 4519-4527
    • Hideshima, T.1
  • 22
    • 0034730251 scopus 로고    scopus 로고
    • NF-κB-induced loss of MyoD mRNA: Possible role in muscle decay and cachexia
    • (2000) Science , vol.289 , pp. 2363-2366
    • Guttridge, D.1
  • 24
    • 0033152760 scopus 로고    scopus 로고
    • Proteasome inhibitors: A novel class of potent and effective antitumor agents
    • (1999) Cancer Res. , vol.59 , pp. 2615-2622
    • Adams, J.1
  • 25
    • 0032189685 scopus 로고    scopus 로고
    • Tumor growth inhibition in a murine model of human Burkitt's lymphoma by a proteasome inhibitor
    • (1998) Cancer Res. , vol.58 , pp. 4342-4348
    • Orlowski, R.Z.1
  • 26
    • 0035866355 scopus 로고    scopus 로고
    • CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinomaA-549 in nude mice
    • (2001) Cancer Res. , vol.61 , pp. 1280-1284
    • Sun, J.1
  • 27
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of NF-κB, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1419-1428
    • Sunwoo, J.1
  • 29
    • 0034680928 scopus 로고    scopus 로고
    • Inhibition of NF-κB activation by arsenite through reaction with a critical cysteine in the activation loop of IKK
    • (2000) J. Biol. Chem. , vol.275 , pp. 36062-36066
    • Kapahi, P.1
  • 30
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-κB activity by thalidomide through suppression of IκB kinase activity
    • (2001) J. Biol. Chem. , vol.276 , pp. 22382-22387
    • Keifer, J.1
  • 33
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic NF-κB inhibition
    • (2001) Cancer Res. , vol.61 , pp. 3535-3540
    • Cusack, J.1
  • 35
    • 0034662496 scopus 로고    scopus 로고
    • NF-κB/IκB signaling pathways may contribute to the mediation of paclitaxel-induced apoptosis in solid tumor cells
    • (2000) Cancer Res. , vol.60 , pp. 4426-4432
    • Huang, Y.1
  • 36
    • 0033570955 scopus 로고    scopus 로고
    • Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: Remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients
    • (1999) Blood , vol.94 , pp. 3315-3324
    • Niu, C.1
  • 42
    • 0033954292 scopus 로고    scopus 로고
    • Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas
    • (2000) J. Clin. Oncol. , vol.18 , pp. 708-715
    • Fine, H.A.1
  • 43
    • 0034783270 scopus 로고    scopus 로고
    • A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in patients with androgen-independent prostate cancer
    • (2001) Clin. Cancer Res. , vol.7 , pp. 1888-1893
    • Figg, W.D.1
  • 44
    • 0034795178 scopus 로고    scopus 로고
    • A randomized phase II trial of docetaxel (taxotere) plus thalidomide in androgen-independent prostate cancer
    • (2001) Semin. Oncol. , vol.28 , pp. 62-66
    • Figg, W.D.1
  • 49
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-kappa B
    • (1996) Blood , vol.87 , pp. 1104-1112
    • Chauhan, D.1
  • 50
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • (2001) Cancer Res. , vol.61 , pp. 3071-3076
    • Hideshima, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.