Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway

Molecular Medicine Reports

Volumn 8, Issue 4, 2013, Pages 967-972

  Yu, Zhang ^a,b   Yong, Li Bao ^a   Yin, Wu ^b   Chun, Lei Yu ^a,b   Yan, Xin Huang ^a   Ying, Sun ^a   Li, Hua Zheng ^a   Yu, Xin Li ^a,b  

^a NORTHEAST NORMAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Alantolactone; Apoptosis; Colorectal cancer; Nature compounds

Indexed keywords

ACETYLCYSTEINE; ALANTOLACTONE; CASPASE 3; CASPASE 9; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CASP3 PROTEIN, HUMAN; CASP9 PROTEIN, HUMAN; LACTONE; SESQUITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG EXPOSURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN INDUCTION; WESTERN BLOTTING; DRUG EFFECTS; DRUG SCREENING; METABOLISM; TUMOR CELL LINE;

INULA HELENIUM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LACTONES; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SESQUITERPENES, EUDESMANE;

EID: 84883397220     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2013.1640     Document Type: Article

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