Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line

Acta Pharmacologica Sinica

Volumn 28, Issue 11, 2007, Pages 1819-1826

  Hu, Hong Zhen ^a   Yang, Yue Bo ^b   Xu, Xiang Dong ^b   Shen, Hong Wei ^b   Shu, Yi Min ^c   Ren, Zi ^d   Li, Xiao Mao ^b   Shen, Hui Ming ^b   Zeng, Hai Tao ^b  

^a WANNAN MEDICAL COLLEGE   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^d GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Akt; Apoptosis; Cervical carcinoma; Oridonin

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CASPASE INHIBITOR; CYTOCHROME C; DITERPENOID; GLYCOGEN SYNTHASE KINASE 3; HOE 33342; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; ORIDONIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR FOXO;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG DETERMINATION; DRUG EFFECT; DRUG ISOLATION; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; FRAGMENTATION REACTION; HELA CELL; HUMAN; HUMAN CELL; MONITORING; MORPHOLOGY; POLYMERIZATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SECRETION; RABDOSIA; RABDOSIA RUBESCENS; STAINING; TIME; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; CASPASES; COLLAGEN TYPE XI; CYTOCHROMES C; DITERPENES, KAURANE; DOWN-REGULATION; FEMALE; HELA CELLS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; UTERINE CERVICAL NEOPLASMS;

EID: 35648937054     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00667.x     Document Type: Article

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