Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex

Cell Death and Differentiation

Volumn 11, Issue 1, 2004, Pages 123-130

  Kobori, M ^a,b   Yang, Z ^a   Gong, D ^c   Heissmeyer, V ^d   Zhu, H ^a   Jung, Y K ^a   Gakidis, M Angelica M ^a   Rao, A ^d   Sekine, T ^e   Ikegami, F ^e   Yuan, C ^c   Yuan, J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^c SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^d CENTER FOR BLOOD RESEARCH   (United States)

^e CHIBA UNIVERSITY   (Japan)

Author keywords

Caspase 11; IKK; LPS; NF kB; Wedelolactone

Indexed keywords

11,12 DIHYDROXYCOUMESTAN; CASPASE 11; ECLIPTA PROSTRATA EXTRACT; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; WEDELOLACTONE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ECLIPTA; ENZYME INDUCTION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BIOLOGICAL MARKERS; CASPASES; CELLS, CULTURED; COUMARINS; ECLIPTA; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; ECLIPTA; ECLIPTA PROSTRATA;

EID: 1642433084     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401325     Document Type: Article

References (26)

1. Wang S, Miura M, Jung YK, Zhu H, Gagliardini V, Shi L, Greenberg AH and Yuan J (1996) Identification and characterization of Ich-3, a member of the interleukin-1β converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 271: 20580-20587
2. Wang S, Miura M, Jung YK, Zhu H, Li E and Yuan J (1998) Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92: 501-509
3. Kang SJ, Wang S, Hara H, Peterson EP, Namura S, Amin-Hanjani S, Huang Z, Srinivasan A, Tomaselli KJ, Thomberry NA, Moskowitz MA and Yuan J (2000) Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J. Cell Biol. 149: 613-622
4. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wei FY, Wong W, Kamen R and Seshadri T (1995) Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80: 401-411
5. Ghayur T, Banerjee S, Hugunin M, Butler D, Herzog L, Carter A, Quintal L, Sekut L, Talanian R, Paskind M, Wong W, Kamen R, Tracey D. and Allen H (1997) Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production. Nature 386: 619-623
6. Kang SJ, Wang S, Kuida K and Yuan J (2002) Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ. 9: 1115-1125
7. Hisahara S, Yuan J, Momoi T, Okano H and Miura M (2001) Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. J. Exp. Med. 193: 111-122
8. Lin XY, Choi MSK and Porter AG (2000) Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-γ. J. Biol. Chem. 275: 39920-39926
9. Wangner H, Geyer B, Kiso Y, Hikino H and Rao GS (1986) Coumestans as the main active principles of the liver drugs Eclipta alba and Wedelia calendulacea. Planta Med. 52: 370-374
10. Melo PA, Nascimento MC, Mois WB and Suarez-Kurtz G (1994) Inhibition of the mytotoxic and hemorrhagic activities of crotalid venoms by Eclipta prostrata (Asteraceae) extracts and constituents. Toxicon 32: 595-603
11. Baeuerle PA (1998) IκB-NF-κB structures: at the interface of inflammation control. Cell 95: 729-731
12. Li X, Massa PE, Hanidu A, Peet GW, Aro P, Savitt A, Mishe S, Li J and Marcu KB (2002) IKKα, IKKβ, and NEMO/IKKγ are each required for the NF-κB mediated inflammatory response program. J. Biol. Chem. 277: 45129-45140
13. Schauvliege R, Vanrobaeys J, Schotte P and Beyaert R (2002) Caspase-11 gene expression in response to lipopolysaccharide and interferon-γ requires nuclear factor-κB and signal transducer and activator of transcription (STAT) 1. J. Biol. Chem. 277: 41624-41630
14. Johnson C, Van Antwerp D and Hope TJ (1999) An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IκBα. EMBO J. 18: 6682-6693
15. Fisher C, Page S, Weber M, Eisele T, Neumeier D and Brand K (1999) Differential effects of lipopolysaccharide, and tumor necrosis factor on monocytic IκB kinase signalsome activation and IκB proteolysis. J. Biol. Chem. 274: 24625-24632
16. Chen LJ, Parent L and Maniatis T (1996) Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84: 853-862
17. Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M and Santoro MG (2000) Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature 403: 103-118
18. Scherer DC, Brockman JA, Chen Z, Maniatis T and Ballard DW (1995) Signal-induced degradation of IκBα requires site-specific ubiquitination. Proc. Natl. Acad. Sci. USA 92: 11259-11263
19. Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li JW, Young DB, Barbosa M, Mann M, Manning A and Rao A (1997) IKK-1 and IKK-2: cytokine-activated IκB kinase essential for NF-κB activation. Science 278: 860-866
20. O'Connel MA, Bennet BL, Mercurio F, Manning AM and Mackman N (1998) Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. J. Biol. Chem. 273: 30410-30414
21. Delhase M, Hayakawa M, Chen Y and Karin M (1999) Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science 284: 309-313
22. Kwok BH, Koh B, Ndubusi MI, Elofsson M and Crews CM (2001) The anti-inflammatory natural product parthenolide from the medicinal herb feverfew directly binds to and inhibits IκB kinase. Chem. Biol. 8: 759-766
23. Bowie AG and O'Neil LAJ (2000) Vitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kianse. J. Immunol. 165: 7180-7188
24. Li H, Zhu H, Xu CJ and Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501
25. Pandey G, Muralikrishna C and Bhalerao UT (1989) Mushroom tyrosinase catalysed synthesis of coumestans, benzofuran derivatives and related heterocyclic compounds. Tetrahedron 45: 6867-6874
26. Kwak YT, Guo J, Shen J and Gaynor RB (2000) Analysis of domains in the IKKα and IKKβ proteins that regulate their kinase activity. J. Biol. Chem. 275: 14752-14759