메뉴 건너뛰기




Volumn 61, Issue 11, 2013, Pages 2811-2819

P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in Vivo

Author keywords

apoptosis; Magnolol; P27 Kip1; siRNA; U373

Indexed keywords

HYDROXYLATED BIPHENYLS; INDUCED APOPTOSIS; LOW CONCENTRATIONS; MAGNOLOL; P27/KIP1; SIGNALING PATHWAYS; SIRNA; U373;

EID: 84875469127     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf400542m     Document Type: Article
Times cited : (28)

References (32)
  • 2
    • 70349210557 scopus 로고    scopus 로고
    • Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1
    • Chen, L. C.; Liu, Y. C.; Liang, Y. C.; Ho, Y. S.; Lee, W. S. Magnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1 J. Agric. Food Chem. 2009, 57, 7331-7337
    • (2009) J. Agric. Food Chem. , vol.57 , pp. 7331-7337
    • Chen, L.C.1    Liu, Y.C.2    Liang, Y.C.3    Ho, Y.S.4    Lee, W.S.5
  • 3
    • 84861603289 scopus 로고    scopus 로고
    • Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells
    • Ruan, J.; Zhang, L.; Yan, L.; Liu, Y.; Yue, Z.; Chen, L.; Wang, A. Y.; Chen, W.; Zheng, S.; Wang, S.; Lu, Y. Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells Mol. Med. Rep. 2012, 6, 232-238
    • (2012) Mol. Med. Rep. , vol.6 , pp. 232-238
    • Ruan, J.1    Zhang, L.2    Yan, L.3    Liu, Y.4    Yue, Z.5    Chen, L.6    Wang, A.Y.7    Chen, W.8    Zheng, S.9    Wang, S.10    Lu, Y.11
  • 4
    • 34247191560 scopus 로고    scopus 로고
    • Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells
    • Hsu, Y. F.; Lee, T. S.; Lin, S. Y.; Hsu, S. P.; Juan, S. H.; Hsu, Y. H.; Zhong, W. B.; Lee, W. S. Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells Mol. Carcinog. 2007, 46, 275-283
    • (2007) Mol. Carcinog. , vol.46 , pp. 275-283
    • Hsu, Y.F.1    Lee, T.S.2    Lin, S.Y.3    Hsu, S.P.4    Juan, S.H.5    Hsu, Y.H.6    Zhong, W.B.7    Lee, W.S.8
  • 5
    • 0035168066 scopus 로고    scopus 로고
    • Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells
    • Lin, S. Y.; Chang, Y. T.; Liu, J. D.; Yu, C. H.; Ho, Y. S.; Lee, Y. H.; Lee, W. S. Molecular mechanisms of apoptosis induced by magnolol in colon and liver cancer cells Mol. Carcinog. 2001, 32, 73-83
    • (2001) Mol. Carcinog. , vol.32 , pp. 73-83
    • Lin, S.Y.1    Chang, Y.T.2    Liu, J.D.3    Yu, C.H.4    Ho, Y.S.5    Lee, Y.H.6    Lee, W.S.7
  • 6
    • 0035702912 scopus 로고    scopus 로고
    • Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis
    • Lin, S. Y.; Liu, J. D.; Chang, H. C.; Yeh, S. D.; Lin, C. H.; Lee, W. S. Magnolol suppresses proliferation of cultured human colon and liver cancer cells by inhibiting DNA synthesis and activating apoptosis J. Cell. Biochem. 2002, 84, 532-544
    • (2002) J. Cell. Biochem. , vol.84 , pp. 532-544
    • Lin, S.Y.1    Liu, J.D.2    Chang, H.C.3    Yeh, S.D.4    Lin, C.H.5    Lee, W.S.6
  • 7
    • 0037357959 scopus 로고    scopus 로고
    • Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation
    • Zhong, W. B.; Wang, C. Y.; Ho, K. J.; Lu, F. J.; Chang, T. C.; Lee, W. S. Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation Anticancer Drugs 2003, 14, 211-217
    • (2003) Anticancer Drugs , vol.14 , pp. 211-217
    • Zhong, W.B.1    Wang, C.Y.2    Ho, K.J.3    Lu, F.J.4    Chang, T.C.5    Lee, W.S.6
  • 8
    • 84864286543 scopus 로고    scopus 로고
    • Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats
    • Li, L. F.; Lu, J.; Li, X. M.; Xu, C. L.; Deng, J. M.; Qu, R.; Ma, S. P. Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats Phytother. Res. 2012, 26, 1189-1194
    • (2012) Phytother. Res. , vol.26 , pp. 1189-1194
    • Li, L.F.1    Lu, J.2    Li, X.M.3    Xu, C.L.4    Deng, J.M.5    Qu, R.6    Ma, S.P.7
  • 9
    • 0029871503 scopus 로고    scopus 로고
    • Pharmacokinetics and brain distribution of magnolol in the rat after intravenous bolus injection
    • Tsai, T. H.; Chou, C. J.; Chen, C. F. Pharmacokinetics and brain distribution of magnolol in the rat after intravenous bolus injection J. Pharm. Pharmacol. 1996, 48, 57-59
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 57-59
    • Tsai, T.H.1    Chou, C.J.2    Chen, C.F.3
  • 10
    • 23844434046 scopus 로고    scopus 로고
    • Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures
    • Lin, Y. R.; Chen, H. H.; Ko, C. H.; Chan, M. H. Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures Neuropharmacology 2005, 49, 542-550
    • (2005) Neuropharmacology , vol.49 , pp. 542-550
    • Lin, Y.R.1    Chen, H.H.2    Ko, C.H.3    Chan, M.H.4
  • 11
    • 80054024231 scopus 로고    scopus 로고
    • Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice
    • Chen, C. R.; Tan, R.; Qu, W. M.; Wu, Z.; Wang, Y.; Urade, Y.; Huang, Z. L. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice Br. J. Pharmacol. 2011, 164, 1534-1546
    • (2011) Br. J. Pharmacol. , vol.164 , pp. 1534-1546
    • Chen, C.R.1    Tan, R.2    Qu, W.M.3    Wu, Z.4    Wang, Y.5    Urade, Y.6    Huang, Z.L.7
  • 12
    • 0034572969 scopus 로고    scopus 로고
    • Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats
    • Hou, Y. C.; Chao, P. D.; Chen, S. Y. Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats Am. J. Chin. Med. 2000, 28, 379-384
    • (2000) Am. J. Chin. Med. , vol.28 , pp. 379-384
    • Hou, Y.C.1    Chao, P.D.2    Chen, S.Y.3
  • 13
    • 75249101732 scopus 로고    scopus 로고
    • Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors
    • Shih, Y. L.; Liu, H. C.; Chen, C. S.; Hsu, C. H.; Pan, M. H.; Chang, H. W.; Chang, C. H.; Chen, F. C.; Ho, C. T.; Yang, Y. Y.; Ho, Y. S. Combination treatment with luteolin and quercetin enhances antiproliferative effects in nicotine-treated MDA-MB-231 cells by down-regulating nicotinic acetylcholine receptors J. Agric. Food Chem. 2010, 58, 235-241
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 235-241
    • Shih, Y.L.1    Liu, H.C.2    Chen, C.S.3    Hsu, C.H.4    Pan, M.H.5    Chang, H.W.6    Chang, C.H.7    Chen, F.C.8    Ho, C.T.9    Yang, Y.Y.10    Ho, Y.S.11
  • 15
    • 0031903520 scopus 로고    scopus 로고
    • Induction of apoptosis in human tumour xenografts after oral administration of uracil and tegafur to nude mice bearing tumours
    • Oki, E.; Sakaguchi, Y.; Toh, Y.; Oda, S.; Maehara, Y.; Yamamoto, N.; Sugimachi, K. Induction of apoptosis in human tumour xenografts after oral administration of uracil and tegafur to nude mice bearing tumours Br. J. Cancer 1998, 78, 625-630
    • (1998) Br. J. Cancer , vol.78 , pp. 625-630
    • Oki, E.1    Sakaguchi, Y.2    Toh, Y.3    Oda, S.4    Maehara, Y.5    Yamamoto, N.6    Sugimachi, K.7
  • 16
    • 0035254988 scopus 로고    scopus 로고
    • Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells
    • Ho, Y. S.; Duh, J. S.; Jeng, J. H.; Wang, Y. J.; Liang, Y. C.; Lin, C. H.; Tseng, C. J.; Yu, C. F.; Chen, R. J.; Lin, J. K. Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cells Int. J. Cancer 2001, 91, 393-401
    • (2001) Int. J. Cancer , vol.91 , pp. 393-401
    • Ho, Y.S.1    Duh, J.S.2    Jeng, J.H.3    Wang, Y.J.4    Liang, Y.C.5    Lin, C.H.6    Tseng, C.J.7    Yu, C.F.8    Chen, R.J.9    Lin, J.K.10
  • 17
    • 37549018148 scopus 로고    scopus 로고
    • Use of a fluorescently labeled poly-caspase inhibitor for in vivo detection of apoptosis related to vascular-targeting agent arsenic trioxide for cancer therapy
    • Griffin, R. J.; Williams, B. W.; Bischof, J. C.; Olin, M.; Johnson, G. L.; Lee, B. W. Use of a fluorescently labeled poly-caspase inhibitor for in vivo detection of apoptosis related to vascular-targeting agent arsenic trioxide for cancer therapy Technol. Cancer Res. Treat. 2007, 6, 651-654
    • (2007) Technol. Cancer Res. Treat. , vol.6 , pp. 651-654
    • Griffin, R.J.1    Williams, B.W.2    Bischof, J.C.3    Olin, M.4    Johnson, G.L.5    Lee, B.W.6
  • 20
    • 0042836586 scopus 로고    scopus 로고
    • Quercetin elevates p27(Kip1) and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1
    • Beniston, R. G.; Campo, M. S. Quercetin elevates p27(Kip1) and arrests both primary and HPV16 E6/E7 transformed human keratinocytes in G1 Oncogene 2003, 22, 5504-5514
    • (2003) Oncogene , vol.22 , pp. 5504-5514
    • Beniston, R.G.1    Campo, M.S.2
  • 21
    • 0033584257 scopus 로고    scopus 로고
    • Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis
    • Philipp, J.; Vo, K.; Gurley, K. E.; Seidel, K.; Kemp, C. J. Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis Oncogene 1999, 18, 4689-4698
    • (1999) Oncogene , vol.18 , pp. 4689-4698
    • Philipp, J.1    Vo, K.2    Gurley, K.E.3    Seidel, K.4    Kemp, C.J.5
  • 27
    • 84875052438 scopus 로고    scopus 로고
    • Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-κB/p53 pathway mediated by folic acid receptor
    • Lin, S. Y.; Lee, W. R.; Su, Y. F.; Hsu, S. P.; Lin, H. C.; Ho, P. Y.; Hou, T. C.; Chou, Y. P.; Kuo, C. T.; Lee, W. S. Folic acid inhibits endothelial cell proliferation through activating the cSrc/ERK 2/NF-κB/p53 pathway mediated by folic acid receptor Angiogenesis 2012, 15, 671-683
    • (2012) Angiogenesis , vol.15 , pp. 671-683
    • Lin, S.Y.1    Lee, W.R.2    Su, Y.F.3    Hsu, S.P.4    Lin, H.C.5    Ho, P.Y.6    Hou, T.C.7    Chou, Y.P.8    Kuo, C.T.9    Lee, W.S.10
  • 28
    • 84872683508 scopus 로고    scopus 로고
    • Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP- signaling pathway
    • Hou, T. C.; Lin, J. J.; Wen, H. C.; Chen, L. C.; Hsu, S. P.; Lee, W. S. Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP- signaling pathway Biochem. Pharmacol. 2013, 85, 376-384
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 376-384
    • Hou, T.C.1    Lin, J.J.2    Wen, H.C.3    Chen, L.C.4    Hsu, S.P.5    Lee, W.S.6
  • 31
    • 59149098373 scopus 로고    scopus 로고
    • P21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer
    • Roy, S.; Gu, M.; Ramasamy, K.; Singh, R. P.; Agarwal, C.; Siriwardana, S.; Sclafani, R. A.; Agarwal, R. p21/Cip1 and p27/Kip1 Are essential molecular targets of inositol hexaphosphate for its antitumor efficacy against prostate cancer Cancer Res. 2009, 69, 1166-1173
    • (2009) Cancer Res. , vol.69 , pp. 1166-1173
    • Roy, S.1    Gu, M.2    Ramasamy, K.3    Singh, R.P.4    Agarwal, C.5    Siriwardana, S.6    Sclafani, R.A.7    Agarwal, R.8
  • 32
    • 39749093675 scopus 로고    scopus 로고
    • Curcumin sensitizes TRAIL-resistant xenografts: Molecular mechanisms of apoptosis, metastasis and angiogenesis
    • Shankar, S.; Ganapathy, S.; Chen, Q.; Srivastava, R. K. Curcumin sensitizes TRAIL-resistant xenografts: Molecular mechanisms of apoptosis, metastasis and angiogenesis Mol. Cancer 2008, 7, 16
    • (2008) Mol. Cancer , vol.7 , pp. 16
    • Shankar, S.1    Ganapathy, S.2    Chen, Q.3    Srivastava, R.K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.