-
1
-
-
33947574564
-
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: Modern target but ancient solution
-
Aggarwal BB, Sethi G, Ahn KS, Sandur SK, Pandey MK, Kunnumakkara AB, Sung B, Ichikawa H. 2006. Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: Modern target but ancient solution. Ann N Y Acad Sci 1091: 151-169.
-
(2006)
Ann N Y Acad Sci
, vol.1091
, pp. 151-169
-
-
Aggarwal, B.B.1
Sethi, G.2
Ahn, K.S.3
Sandur, S.K.4
Pandey, M.K.5
Kunnumakkara, A.B.6
Sung, B.7
Ichikawa, H.8
-
2
-
-
69149098253
-
Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship?
-
Aggarwal BB, Kunnumakkara AB, Harikumar KB, Gupta SR, Tharakan ST, Koca C, Dey S, Sung B. 2009. Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship? Ann N Y Acad Sci 1171: 59-76.
-
(2009)
Ann N Y Acad Sci
, vol.1171
, pp. 59-76
-
-
Aggarwal, B.B.1
Kunnumakkara, A.B.2
Harikumar, K.B.3
Gupta, S.R.4
Tharakan, S.T.5
Koca, C.6
Dey, S.7
Sung, B.8
-
3
-
-
33749321904
-
Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway
-
Ahn KS, Sethi G, Shishodia S, Sung B, Arbiser JL, Aggarwal BB. 2006. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. Mol Cancer Res 4: 621-633.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 621-633
-
-
Ahn, K.S.1
Sethi, G.2
Shishodia, S.3
Sung, B.4
Arbiser, J.L.5
Aggarwal, B.B.6
-
4
-
-
79956053386
-
Advanced hepatocellular carcinoma. Review of targeted molecular drugs
-
Alves RC, Alves D, Guz B, Matos C, Viana M, Harriz M, Terrabuio D, Kondo M, Gampel O, Polletti P. 2011. Advanced hepatocellular carcinoma. Review of targeted molecular drugs. Ann Hepatol 10: 21-27.
-
(2011)
Ann Hepatol
, vol.10
, pp. 21-27
-
-
Alves, R.C.1
Alves, D.2
Guz, B.3
Matos, C.4
Viana, M.5
Harriz, M.6
Terrabuio, D.7
Kondo, M.8
Gampel, O.9
Polletti, P.10
-
7
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg J, Darnell JE, Jr. 2000. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 19: 2468-2473.
-
(2000)
Oncogene
, vol.19
, pp. 2468-2473
-
-
Bromberg, J.1
Darnell Jr., J.E.2
-
8
-
-
58649100056
-
Inflammation and cancer: IL-6 and STAT3 complete the link
-
Bromberg J, Wang TC. 2009. Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 15: 79-80.
-
(2009)
Cancer Cell
, vol.15
, pp. 79-80
-
-
Bromberg, J.1
Wang, T.C.2
-
9
-
-
33645976174
-
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
-
Calvisi DF, Ladu S, Gorden A, Farina M, Conner EA, Lee JS, Factor VM, Thorgeirsson SS. 2006. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 130: 1117-1128.
-
(2006)
Gastroenterology
, vol.130
, pp. 1117-1128
-
-
Calvisi, D.F.1
Ladu, S.2
Gorden, A.3
Farina, M.4
Conner, E.A.5
Lee, J.S.6
Factor, V.M.7
Thorgeirsson, S.S.8
-
10
-
-
0031018486
-
Constitutive activation of JAK1 in Src-transformed cells
-
Campbell GS, Yu CL, Jove R, Carter-Su C. 1997. Constitutive activation of JAK1 in Src-transformed cells. J Biol Chem 272: 2591-2594.
-
(1997)
J Biol Chem
, vol.272
, pp. 2591-2594
-
-
Campbell, G.S.1
Yu, C.L.2
Jove, R.3
Carter-Su, C.4
-
11
-
-
0033551802
-
Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways
-
Chen RH, Chang MC, Su YH, Tsai YT, Kuo ML. 1999. Interleukin-6 inhibits transforming growth factor-beta-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways. J Biol Chem 274: 23013-23019.
-
(1999)
J Biol Chem
, vol.274
, pp. 23013-23019
-
-
Chen, R.H.1
Chang, M.C.2
Su, Y.H.3
Tsai, Y.T.4
Kuo, M.L.5
-
12
-
-
9244244137
-
Honokiol: A potent chemotherapy candidate for human colorectal carcinoma
-
Chen F, Wang T, Wu YF, Gu Y, Xu XL, Zheng S, Hu X. 2004. Honokiol: A potent chemotherapy candidate for human colorectal carcinoma. World J Gastroenterol 10: 3459-3463.
-
(2004)
World J Gastroenterol
, vol.10
, pp. 3459-3463
-
-
Chen, F.1
Wang, T.2
Wu, Y.F.3
Gu, Y.4
Xu, X.L.5
Zheng, S.6
Hu, X.7
-
13
-
-
77951080149
-
Chemopreventive effects of honokiol on UVB-induced skin cancer development
-
Chilampalli S, Zhang X, Fahmy H, Kaushik RS, Zeman D, Hildreth MB, Dwivedi C. 2010. Chemopreventive effects of honokiol on UVB-induced skin cancer development. Anticancer Res 30: 777-783.
-
(2010)
Anticancer Res
, vol.30
, pp. 777-783
-
-
Chilampalli, S.1
Zhang, X.2
Fahmy, H.3
Kaushik, R.S.4
Zeman, D.5
Hildreth, M.B.6
Dwivedi, C.7
-
14
-
-
77950788603
-
Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma
-
Cirstea D, Hideshima T, Rodig S, Santo L, Pozzi S, Vallet S, Ikeda H, Perrone G, Gorgun G, Patel K, Desai N, Sportelli P, Kapoor S, Vali S, Mukherjee S, Munshi NC, Anderson KC, Raje N. 2010. Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma. Mol Cancer Ther 9: 963-975.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 963-975
-
-
Cirstea, D.1
Hideshima, T.2
Rodig, S.3
Santo, L.4
Pozzi, S.5
Vallet, S.6
Ikeda, H.7
Perrone, G.8
Gorgun, G.9
Patel, K.10
Desai, N.11
Sportelli, P.12
Kapoor, S.13
Vali, S.14
Mukherjee, S.15
Munshi, N.C.16
Anderson, K.C.17
Raje, N.18
-
15
-
-
67651171652
-
Honokiol-mediated inhibition of PI3K/mTOR pathway: A potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function
-
Crane C, Panner A, Pieper RO, Arbiser J, Parsa AT. 2009. Honokiol-mediated inhibition of PI3K/mTOR pathway: A potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function. J Immunother 32: 585-592.
-
(2009)
J Immunother
, vol.32
, pp. 585-592
-
-
Crane, C.1
Panner, A.2
Pieper, R.O.3
Arbiser, J.4
Parsa, A.T.5
-
16
-
-
0030840464
-
STATs and gene regulation
-
Darnell JE, Jr. 1997. STATs and gene regulation. Science 277: 1630-1635.
-
(1997)
Science
, vol.277
, pp. 1630-1635
-
-
Darnell Jr., J.E.1
-
17
-
-
54049113056
-
Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2)
-
Deng J, Qian Y, Geng L, Chen J, Wang X, Xie H, Yan S, Jiang G, Zhou L, Zheng S. 2008. Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2). Liver Int 28: 1458-1464.
-
(2008)
Liver Int
, vol.28
, pp. 1458-1464
-
-
Deng, J.1
Qian, Y.2
Geng, L.3
Chen, J.4
Wang, X.5
Xie, H.6
Yan, S.7
Jiang, G.8
Zhou, L.9
Zheng, S.10
-
18
-
-
0035833541
-
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades
-
Digicaylioglu M, Lipton SA. 2001. Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412: 641-647.
-
(2001)
Nature
, vol.412
, pp. 641-647
-
-
Digicaylioglu, M.1
Lipton, S.A.2
-
19
-
-
0035136846
-
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
-
Epling-Burnette PK, Liu JH, Catlett-Falcone R, Turkson J, Oshiro M, Kothapalli R, Li Y, Wang JM, Yang-Yen HF, Karras J, Jove R, Loughran TP, Jr. 2001. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J Clin Invest 107: 351-362.
-
(2001)
J Clin Invest
, vol.107
, pp. 351-362
-
-
Epling-Burnette, P.K.1
Liu, J.H.2
Catlett-Falcone, R.3
Turkson, J.4
Oshiro, M.5
Kothapalli, R.6
Li, Y.7
Wang, J.M.8
Yang-Yen, H.F.9
Karras, J.10
Jove, R.11
Loughran Jr., T.P.12
-
20
-
-
64749084915
-
Honokiol, a multifunctional antiangiogenic and antitumor agent
-
Fried LE, Arbiser JL. 2009. Honokiol, a multifunctional antiangiogenic and antitumor agent. Antioxid Redox Signal 11: 1139-1148.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 1139-1148
-
-
Fried, L.E.1
Arbiser, J.L.2
-
21
-
-
34848906227
-
Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells
-
Fuke H, Shiraki K, Sugimoto K, Tanaka J, Beppu T, Yoneda K, Yamamoto N, Ito K, Masuya M, Takei Y. 2007. Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells. Biochem Biophys Res Commun 363: 738-744.
-
(2007)
Biochem Biophys Res Commun
, vol.363
, pp. 738-744
-
-
Fuke, H.1
Shiraki, K.2
Sugimoto, K.3
Tanaka, J.4
Beppu, T.5
Yoneda, K.6
Yamamoto, N.7
Ito, K.8
Masuya, M.9
Takei, Y.10
-
22
-
-
0035799531
-
Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells
-
Garcia R, Bowman TL, Niu G, Yu H, Minton S, Muro-Cacho CA, Cox CE, Falcone R, Fairclough R, Parsons S, Laudano A, Gazit A, Levitzki A, Kraker A, Jove R. 2001. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 20: 2499-2513.
-
(2001)
Oncogene
, vol.20
, pp. 2499-2513
-
-
Garcia, R.1
Bowman, T.L.2
Niu, G.3
Yu, H.4
Minton, S.5
Muro-Cacho, C.A.6
Cox, C.E.7
Falcone, R.8
Fairclough, R.9
Parsons, S.10
Laudano, A.11
Gazit, A.12
Levitzki, A.13
Kraker, A.14
Jove, R.15
-
23
-
-
48249084606
-
Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells
-
Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N, Brown HA, Bar-Sagi D, Foster DA, Arbiser JL. 2008. Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res 14: 4267-4274.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4267-4274
-
-
Garcia, A.1
Zheng, Y.2
Zhao, C.3
Toschi, A.4
Fan, J.5
Shraibman, N.6
Brown, H.A.7
Bar-Sagi, D.8
Foster, D.A.9
Arbiser, J.L.10
-
24
-
-
31544458469
-
Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells
-
Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee JH, Beam CA, Cheng J, Minton S, Muro-Cacho CA, Jove R. 2006. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res 12: 11-19.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 11-19
-
-
Gritsko, T.1
Williams, A.2
Turkson, J.3
Kaneko, S.4
Bowman, T.5
Huang, M.6
Nam, S.7
Eweis, I.8
Diaz, N.9
Sullivan, D.10
Yoder, S.11
Enkemann, S.12
Eschrich, S.13
Lee, J.H.14
Beam, C.A.15
Cheng, J.16
Minton, S.17
Muro-Cacho, C.A.18
Jove, R.19
-
25
-
-
77549083560
-
Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer
-
Grivennikov SI, Karin M. 2010. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev 21: 11-19.
-
(2010)
Cytokine Growth Factor Rev
, vol.21
, pp. 11-19
-
-
Grivennikov, S.I.1
Karin, M.2
-
26
-
-
39749131007
-
Honokiol, a constituent of oriental medicinal herb Magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction
-
Hahm ER, Arlotti JA, Marynowski SW, Singh SV. 2008. Honokiol, a constituent of oriental medicinal herb Magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction. Clin Cancer Res 14: 1248-1257.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1248-1257
-
-
Hahm, E.R.1
Arlotti, J.A.2
Marynowski, S.W.3
Singh, S.V.4
-
27
-
-
33750632572
-
Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK-positive anaplastic large-cell lymphoma
-
Han Y, Amin H, Franko B, Frantz C, Shi X, Lai R. 2006. Loss of SHP1 enhances JAK3/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK-positive anaplastic large-cell lymphoma. Blood 108: 2796-2803.
-
(2006)
Blood
, vol.108
, pp. 2796-2803
-
-
Han, Y.1
Amin, H.2
Franko, B.3
Frantz, C.4
Shi, X.5
Lai, R.6
-
28
-
-
78650859531
-
NF-kappaB and STAT3-Key players in liver inflammation and cancer
-
He G, Karin M. 2011. NF-kappaB and STAT3-Key players in liver inflammation and cancer. Cell Res 21: 159-168.
-
(2011)
Cell Res
, vol.21
, pp. 159-168
-
-
He, G.1
Karin, M.2
-
29
-
-
50149089033
-
Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models
-
Hou W, Chen L, Yang G, Zhou H, Jiang Q, Zhong Z, Hu J, Chen X, Wang X, Yuan Y, Tang M, Wen J, Wei Y. 2008. Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models. Phytother Res 22: 1125-1132.
-
(2008)
Phytother Res
, vol.22
, pp. 1125-1132
-
-
Hou, W.1
Chen, L.2
Yang, G.3
Zhou, H.4
Jiang, Q.5
Zhong, Z.6
Hu, J.7
Chen, X.8
Wang, X.9
Yuan, Y.10
Tang, M.11
Wen, J.12
Wei, Y.13
-
30
-
-
0030046753
-
STATs: Signal transducers and activators of transcription
-
Ihle JN. 1996. STATs: Signal transducers and activators of transcription. Cell 84: 331-334.
-
(1996)
Cell
, vol.84
, pp. 331-334
-
-
Ihle, J.N.1
-
31
-
-
74049119820
-
Combination chemotherapy of doxorubicin and paclitaxel for hepatocellular carcinoma in vitro and in vivo
-
Jin C, Li H, He Y, He M, Bai L, Cao Y, Song W, Dou K. 2010. Combination chemotherapy of doxorubicin and paclitaxel for hepatocellular carcinoma in vitro and in vivo. J Cancer Res Clin Oncol 136: 267-274.
-
(2010)
J Cancer Res Clin Oncol
, vol.136
, pp. 267-274
-
-
Jin, C.1
Li, H.2
He, Y.3
He, M.4
Bai, L.5
Cao, Y.6
Song, W.7
Dou, K.8
-
32
-
-
80054024030
-
Celastrol inhibits proliferation and induces chemosensitization through downregulation of NF-kappaB and STAT3 regulated gene products in multiple myeloma cells
-
Kannaiyan R, Hay HS, Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Chng WJ, Sethi G. 2011. Celastrol inhibits proliferation and induces chemosensitization through downregulation of NF-kappaB and STAT3 regulated gene products in multiple myeloma cells. Br J Pharmacol
-
(2011)
Br J Pharmacol
-
-
Kannaiyan, R.1
Hay, H.S.2
Rajendran, P.3
Li, F.4
Shanmugam, M.K.5
Vali, S.6
Abbasi, T.7
Kapoor, S.8
Sharma, A.9
Kumar, A.P.10
Chng, W.J.11
Sethi, G.12
-
33
-
-
70350786544
-
Novel treatments for hepatocellular cancer
-
Kerr SH, Kerr DJ. 2009. Novel treatments for hepatocellular cancer. Cancer Lett 286: 114-120.
-
(2009)
Cancer Lett
, vol.286
, pp. 114-120
-
-
Kerr, S.H.1
Kerr, D.J.2
-
34
-
-
21044435937
-
Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling
-
Lee J, Jung E, Park J, Jung K, Lee S, Hong S, Park E, Kim J, Park S, Park D. 2005. Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling. Planta Med 71: 338-343.
-
(2005)
Planta Med
, vol.71
, pp. 338-343
-
-
Lee, J.1
Jung, E.2
Park, J.3
Jung, K.4
Lee, S.5
Hong, S.6
Park, E.7
Kim, J.8
Park, S.9
Park, D.10
-
35
-
-
63249092765
-
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
-
Lee H, Herrmann A, Deng JH, Kujawski M, Niu G, Li Z, Forman S, Jove R, Pardoll DM, Yu H. 2009. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15: 283-293.
-
(2009)
Cancer Cell
, vol.15
, pp. 283-293
-
-
Lee, H.1
Herrmann, A.2
Deng, J.H.3
Kujawski, M.4
Niu, G.5
Li, Z.6
Forman, S.7
Jove, R.8
Pardoll, D.M.9
Yu, H.10
-
36
-
-
77951729083
-
Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors
-
Leeman-Neill RJ, Cai Q, Joyce SC, Thomas SM, Bhola NE, Neill DB, Arbiser JL, Grandis JR. 2010. Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors. Clin Cancer Res 16: 2571-2579.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2571-2579
-
-
Leeman-Neill, R.J.1
Cai, Q.2
Joyce, S.C.3
Thomas, S.M.4
Bhola, N.E.5
Neill, D.B.6
Arbiser, J.L.7
Grandis, J.R.8
-
37
-
-
33845771270
-
Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3
-
Li WC, Ye SL, Sun RX, Liu YK, Tang ZY, Kim Y, Karras JG, Zhang H. 2006. Inhibition of growth and metastasis of human hepatocellular carcinoma by antisense oligonucleotide targeting signal transducer and activator of transcription 3. Clin Cancer Res 12: 7140-7148.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7140-7148
-
-
Li, W.C.1
Ye, S.L.2
Sun, R.X.3
Liu, Y.K.4
Tang, Z.Y.5
Kim, Y.6
Karras, J.G.7
Zhang, H.8
-
38
-
-
77951908366
-
Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
-
Li F, Fernandez PP, Rajendran P, Hui KM, Sethi G. 2010. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett 292: 197-207.
-
(2010)
Cancer Lett
, vol.292
, pp. 197-207
-
-
Li, F.1
Fernandez, P.P.2
Rajendran, P.3
Hui, K.M.4
Sethi, G.5
-
40
-
-
0041881635
-
The anti-inflammatory effect of honokiol on neutrophils: Mechanisms in the inhibition of reactive oxygen species production
-
Liou KT, Shen YC, Chen CF, Tsao CM, Tsai SK. 2003. The anti-inflammatory effect of honokiol on neutrophils: Mechanisms in the inhibition of reactive oxygen species production. Eur J Pharmacol 475: 19-27.
-
(2003)
Eur J Pharmacol
, vol.475
, pp. 19-27
-
-
Liou, K.T.1
Shen, Y.C.2
Chen, C.F.3
Tsao, C.M.4
Tsai, S.K.5
-
41
-
-
77954881040
-
Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals
-
Liu SH, Shen CC, Yi YC, Tsai JJ, Wang CC, Chueh JT, Lin KL, Lee TC, Pan HC, Sheu ML. 2010. Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals. Br J Pharmacol 160: 1963-1972.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 1963-1972
-
-
Liu, S.H.1
Shen, C.C.2
Yi, Y.C.3
Tsai, J.J.4
Wang, C.C.5
Chueh, J.T.6
Lin, K.L.7
Lee, T.C.8
Pan, H.C.9
Sheu, M.L.10
-
42
-
-
79952294625
-
Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-kappaB and STAT3 pathways in head and neck cancer cells
-
Macha MA, Matta A, Chauhan SS, Siu KW, Ralhan R. 2011. Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-kappaB and STAT3 pathways in head and neck cancer cells. Carcinogenesis 32: 368-380.
-
(2011)
Carcinogenesis
, vol.32
, pp. 368-380
-
-
Macha, M.A.1
Matta, A.2
Chauhan, S.S.3
Siu, K.W.4
Ralhan, R.5
-
43
-
-
0025819962
-
Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle
-
Matsushime H, Roussel MF, Ashmun RA, Sherr CJ. 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701-713.
-
(1991)
Cell
, vol.65
, pp. 701-713
-
-
Matsushime, H.1
Roussel, M.F.2
Ashmun, R.A.3
Sherr, C.J.4
-
44
-
-
43049147317
-
Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway
-
Moran DM, Mattocks MA, Cahill PA, Koniaris LG, McKillop IH. 2008. Interleukin-6 mediates G(0)/G(1) growth arrest in hepatocellular carcinoma through a STAT 3-dependent pathway. J Surg Res 147: 23-33.
-
(2008)
J Surg Res
, vol.147
, pp. 23-33
-
-
Moran, D.M.1
Mattocks, M.A.2
Cahill, P.A.3
Koniaris, L.G.4
McKillop, I.H.5
-
45
-
-
42949160050
-
Natural products as leads to potential drugs: An old process or the new hope for drug discovery?
-
Newman DJ. 2008. Natural products as leads to potential drugs: An old process or the new hope for drug discovery? J Med Chem 51: 2589-2599.
-
(2008)
J Med Chem
, vol.51
, pp. 2589-2599
-
-
Newman, D.J.1
-
46
-
-
85047695527
-
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H. 2002. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 21: 2000-2008.
-
(2002)
Oncogene
, vol.21
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
Song, L.4
Haura, E.5
Turkson, J.6
Zhang, S.7
Wang, T.8
Sinibaldi, D.9
Coppola, D.10
Heller, R.11
Ellis, L.M.12
Karras, J.13
Bromberg, J.14
Pardoll, D.15
Jove, R.16
Yu, H.17
-
47
-
-
14944385553
-
Global cancer statistics, 2002
-
Parkin DM, Bray F, Ferlay J, Pisani P. 2005. Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108.
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 74-108
-
-
Parkin, D.M.1
Bray, F.2
Ferlay, J.3
Pisani, P.4
-
48
-
-
51049115354
-
The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis
-
Raja SM, Chen S, Yue P, Acker TM, Lefkove B, Arbiser JL, Khuri FR, Sun SY. 2008. The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. Mol Cancer Ther 7: 2212-2223.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2212-2223
-
-
Raja, S.M.1
Chen, S.2
Yue, P.3
Acker, T.M.4
Lefkove, B.5
Arbiser, J.L.6
Khuri, F.R.7
Sun, S.Y.8
-
49
-
-
79952724023
-
Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo
-
Rajendran P, Ong TH, Chen L, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Hui KM, Sethi G. 2011. Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo. Clin Cancer Res 17: 1425-1439.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 1425-1439
-
-
Rajendran, P.1
Ong, T.H.2
Chen, L.3
Li, F.4
Shanmugam, M.K.5
Vali, S.6
Abbasi, T.7
Kapoor, S.8
Sharma, A.9
Kumar, A.P.10
Hui, K.M.11
Sethi, G.12
-
50
-
-
55549120187
-
siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo
-
Raskopf E, Vogt A, Sauerbruch T, Schmitz V. 2008. siRNA targeting VEGF inhibits hepatocellular carcinoma growth and tumor angiogenesis in vivo. J Hepatol 49: 977-984.
-
(2008)
J Hepatol
, vol.49
, pp. 977-984
-
-
Raskopf, E.1
Vogt, A.2
Sauerbruch, T.3
Schmitz, V.4
-
51
-
-
77649184903
-
Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line
-
Roy KR, Reddy GV, Maitreyi L, Agarwal S, Achari C, Vali S, Reddanna P. 2010. Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line. Cancer Chemother Pharmacol 65: 903-911.
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, pp. 903-911
-
-
Roy, K.R.1
Reddy, G.V.2
Maitreyi, L.3
Agarwal, S.4
Achari, C.5
Vali, S.6
Reddanna, P.7
-
52
-
-
0037160057
-
Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain
-
Schreiner SJ, Schiavone AP, Smithgall TE. 2002. Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. J Biol Chem 277: 45680-45687.
-
(2002)
J Biol Chem
, vol.277
, pp. 45680-45687
-
-
Schreiner, S.J.1
Schiavone, A.P.2
Smithgall, T.E.3
-
53
-
-
77949879162
-
Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway
-
Seitz SJ, Schleithoff ES, Koch A, Schuster A, Teufel A, Staib F, Stremmel W, Melino G, Krammer PH, Schilling T, Muller M. 2010. Chemotherapy-induced apoptosis in hepatocellular carcinoma involves the p53 family and is mediated via the extrinsic and the intrinsic pathway. Int J Cancer 126: 2049-2066.
-
(2010)
Int J Cancer
, vol.126
, pp. 2049-2066
-
-
Seitz, S.J.1
Schleithoff, E.S.2
Koch, A.3
Schuster, A.4
Teufel, A.5
Staib, F.6
Stremmel, W.7
Melino, G.8
Krammer, P.H.9
Schilling, T.10
Muller, M.11
-
54
-
-
33947543744
-
Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells
-
Shigemura K, Arbiser JL, Sun SY, Zayzafoon M, Johnstone PA, Fujisawa M, Gotoh A, Weksler B, Zhau HE, Chung LW. 2007. Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells. Cancer 109: 1279-1289.
-
(2007)
Cancer
, vol.109
, pp. 1279-1289
-
-
Shigemura, K.1
Arbiser, J.L.2
Sun, S.Y.3
Zayzafoon, M.4
Johnstone, P.A.5
Fujisawa, M.6
Gotoh, A.7
Weksler, B.8
Zhau, H.E.9
Chung, L.W.10
-
55
-
-
0034047190
-
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages
-
Son HJ, Lee HJ, Yun-Choi HS, Ryu JH. 2000. Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages. Planta Med 66: 469-471.
-
(2000)
Planta Med
, vol.66
, pp. 469-471
-
-
Son, H.J.1
Lee, H.J.2
Yun-Choi, H.S.3
Ryu, J.H.4
-
56
-
-
40649087829
-
Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN
-
Sun X, Zhang J, Wang L, Tian Z. 2008. Growth inhibition of human hepatocellular carcinoma cells by blocking STAT3 activation with decoy-ODN. Cancer Lett 262: 201-213.
-
(2008)
Cancer Lett
, vol.262
, pp. 201-213
-
-
Sun, X.1
Zhang, J.2
Wang, L.3
Tian, Z.4
-
57
-
-
77953753016
-
Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells
-
Tan SM, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G. 2010. Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells. J Pharmacol Exp Ther 334: 285-293.
-
(2010)
J Pharmacol Exp Ther
, vol.334
, pp. 285-293
-
-
Tan, S.M.1
Li, F.2
Rajendran, P.3
Kumar, A.P.4
Hui, K.M.5
Sethi, G.6
-
58
-
-
78149234280
-
Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: Development of topical formulation
-
Vaid M, Sharma SD, Katiyar SK. 2010. Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: Development of topical formulation. Carcinogenesis 31: 2004-2011.
-
(2010)
Carcinogenesis
, vol.31
, pp. 2004-2011
-
-
Vaid, M.1
Sharma, S.D.2
Katiyar, S.K.3
-
59
-
-
34447256138
-
Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest
-
Wolf I, O'Kelly J, Wakimoto N, Nguyen A, Amblard F, Karlan BY, Arbiser JL, Koeffler HP. 2007. Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest. Int J Oncol 30: 1529-1537.
-
(2007)
Int J Oncol
, vol.30
, pp. 1529-1537
-
-
Wolf, I.1
O'Kelly, J.2
Wakimoto, N.3
Nguyen, A.4
Amblard, F.5
Karlan, B.Y.6
Arbiser, J.L.7
Koeffler, H.P.8
-
60
-
-
0344154466
-
SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases
-
Wu C, Guan Q, Wang Y, Zhao ZJ, Zhou GW. 2003. SHP-1 suppresses cancer cell growth by promoting degradation of JAK kinases. J Cell Biochem 90: 1026-1037.
-
(2003)
J Cell Biochem
, vol.90
, pp. 1026-1037
-
-
Wu, C.1
Guan, Q.2
Wang, Y.3
Zhao, Z.J.4
Zhou, G.W.5
-
61
-
-
77950833182
-
Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3
-
Yang F, Brown C, Buettner R, Hedvat M, Starr R, Scuto A, Schroeder A, Jensen M, Jove R. 2010. Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3. Mol Cancer Ther 9: 953-962.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 953-962
-
-
Yang, F.1
Brown, C.2
Buettner, R.3
Hedvat, M.4
Starr, R.5
Scuto, A.6
Schroeder, A.7
Jensen, M.8
Jove, R.9
-
62
-
-
0029069540
-
Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein
-
Yu CL, Meyer DJ, Campbell GS, Larner AC, Carter-Su C, Schwartz J, Jove R. 1995. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269: 81-83.
-
(1995)
Science
, vol.269
, pp. 81-83
-
-
Yu, C.L.1
Meyer, D.J.2
Campbell, G.S.3
Larner, A.C.4
Carter-Su, C.5
Schwartz, J.6
Jove, R.7
-
63
-
-
0036797750
-
Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB
-
Yu Z, Zhang W, Kone BC. 2002. Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem J 367: 97-105.
-
(2002)
Biochem J
, vol.367
, pp. 97-105
-
-
Yu, Z.1
Zhang, W.2
Kone, B.C.3
-
64
-
-
70350500225
-
STATs in cancer inflammation and immunity: A leading role for STAT3
-
Yu H, Pardoll D, Jove R. 2009. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer 9: 798-809.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 798-809
-
-
Yu, H.1
Pardoll, D.2
Jove, R.3
-
65
-
-
64849111865
-
Targeting STAT3 in cancer: How successful are we?
-
Yue P, Turkson J. 2009. Targeting STAT3 in cancer: How successful are we? Expert Opin Investig Drugs 18: 45-56.
-
(2009)
Expert Opin Investig Drugs
, vol.18
, pp. 45-56
-
-
Yue, P.1
Turkson, J.2
-
66
-
-
0036134884
-
Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma
-
Zhang Q, Raghunath PN, Xue L, Majewski M, Carpentieri DF, Odum N, Morris S, Skorski T, Wasik MA. 2002. Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J Immunol 168: 466-474.
-
(2002)
J Immunol
, vol.168
, pp. 466-474
-
-
Zhang, Q.1
Raghunath, P.N.2
Xue, L.3
Majewski, M.4
Carpentieri, D.F.5
Odum, N.6
Morris, S.7
Skorski, T.8
Wasik, M.A.9
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