Honokiol inhibits HepG2 migration via down-regulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis www.proteomics-journal.com

Proteomics

Volumn 10, Issue 7, 2010, Pages 1474-1483

  Liang, Shufang ^a   Fu, Afu ^a   Zhang, Qiang ^a   Tang, Minghai ^a   Zhou, Jin ^a   Wei, Yuquan ^a   Chen, Lijuan ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Cell biology; Cell migration; Honokiol; Quantitative proteomics; Ras gtpaseactivating like protein; Stable isotope labeling by amino acids in cell culture

Indexed keywords

HONOKIOL; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; PROTEIN CDC42; RAC1 PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ADHESION; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BIPHENYL COMPOUNDS; CDC42 GTP-BINDING PROTEIN; CELL MOVEMENT; DOWN-REGULATION; HEP G2 CELLS; HISTOCYTOCHEMISTRY; HUMANS; ISOTOPE LABELING; LIGNANS; MICE; MICE, NUDE; PROTEOME; PROTEOMICS; RAC1 GTP-BINDING PROTEIN; RAS GTPASE-ACTIVATING PROTEINS; REPRODUCIBILITY OF RESULTS; STATISTICS, NONPARAMETRIC; TUMOR BURDEN;

MUS MUSCULUS;

EID: 77950658212     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200900649     Document Type: Article

References (31)

1. Bacac, M., Stamenkovic, I., Metastatic cancer cell. Annu. Rev. Pathol: Mech. Dis. 2008, 3, 221-247.
2. Noritake, J., Watanabe, T., Sato, K., Wang, S., Kaibuchi, K., IQGAP1: a key regulator of adhesion and migration. J. Cell. Sci. 2005, 118, 2085-2092.
3. Mataraza, J. M., Briggs, M. W., Li, Z., Entwistle, A. et al., IQGAP1 promotes cell motility and invasion. J. Biol. Chem. 2003, 278, 41237-41245.
4. Benseñor, L. B., Kan, H.-M., Wang, N., Wallrabe, H. et al., IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly. J. Cell. Sci. 2007, 120, 658-669.
5. Yamaoka-Tojo, M., Tojo, T., Kim, H. W., Hilenski, L et al., IQGAP1 mediates VE-cadherin-based cell-cell contacts and VEGF signaling at adherence junctions linked to angiogenesis. Arterioscler. Thromb. Vase. Biol. 2006, 26, 1991-1997.
6. Ikeda, S., Yamaoka-Tojo, M., Hilenski, L., Patrushev, N. A. et al., IQGAP1 regulates reactive oxygen species-dependent endothelial cell migration through interacting with Nox2. Arterioscler. Thromb. Vase. Biol. 2005, 25, 2295-2300.
7. Yamaoka-Tojo, M., Ushio-Fukai, M., Hilenski, H., Dikalov, S. I. et al., IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species-dependent endothelial migration and proliferation. Circ. Res. 2004, 95, 276-283.
8. Hirano, T., Gotoh, M., Oka, K., Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life. Sci. 1994, 55, 1061-1069.
9. Wang, T., Chen, F., Chen, Z., Wu, F. Y. et al., Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO. World J. Gastroenterol. 2004, 10, 2205-2208.
10. Yang, S. E., Hsieh, M. T., Tsai, T. H., Hsu, S. L., Downmodulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells. Biochem. Pharmacol. 2002, 63, 1641-1651.
11. Bai, X., Cerimele, F., Ushio-Fukai, M., Wagas, M. et al., Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J. Biol. Chem. 2003, 278, 35501-35507.
12. Ishitsuka, K., Hideshima, T., Hamasaki, M., Raje, N. et al., Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis. Blood 2005, 106, 1794-1800.
13. Wen, J., Fu, A., Chen, L., Xie, X. et al., Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model. Int. J. Cancer. 2009, 124, 2709-2718.
14. Liang, S., Xu, Y., Shen, G., Zhao, X. et al., Gene expression and methylation status of 14-3-3 a in human renal carcinoma tissues. IUBMB Life 2008, 60, 534-540.
15. Ong, S.-E., Blagoev, B., Kratchmarova, I., Kristensen, D. B. et al., Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell. Proteomics 2002, 1, 376-386.
16. Everley, P. A., Krijgsveld, J., Zetter, B. R., Gygi, S. P., Quantitative cancer proteomics: stable isotope labeling with amino acids in cell culture (SILAC) as a tool for prostate cancer research. Mol. Cell. Proteomics 2004, 3, 729-735.
17. Chen, X., Sun, L., Yu, Y., Xue, Y., Yang, P., Amino acidcoded tagging approaches in quantitative proteomics. Exp. Rev. Proteomics 2007, 4, 25-37. (Pubitemid 46239470)
18. Zhou, J., Liang, S., Fang, L., Chen, L. et al., Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS: J. Integr. Biol. 2009, 13, 93-103.
19. Liu, Y., Chen, L., He, X., Fan, L. et al., Enhancement of therapeutic effectiveness by combining pegylated liposomal of honokiol and cisplatin in ovarian carcinoma. Int. J. Gynecol. Cancer 2008, 18, 652-659.
20. Fukata, M., Kuroda, S., Fujii, K., Nakamura, T. et al., Regulation of cross-linking of actin filament by IQGAP1, a target for Cdc42. J. Biol. Chem. 1997, 272, 29579-29583.
21. Kuroda, S., Fukata, M., Nakagawa, M., Fujii, K. et al., Role of IQGAP1, a target of the small GTPases Cdc42 and Rad, in regulation of E-cadherin-mediated cell-cell adhesion. Science 1998, 281, 832-835.
22. Ho, Y.-D., Joyal, J. L., Li, Z., Sacks, D. B., IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling. J. Biol. Chem. 1999, 274, 464-470. (Pubitemid 29035084)
23. Hart, M. J., Callow, M. G., Souza, B., Polakis, P., IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. EMBO J. 1996, 15, 2997-3005. (Pubitemid 26187748)
24. Kuroda, S., Fukata, M., Kobayashi, K., Nakafuku, M. et al., Identification of IQGAP as a putative target for the small GTPases,Cdc42 and Rad. J. Biol. Chem. 1996, 271, 23363-23367. (Pubitemid 26314782)
25. Swait-Mataraza, J. M., Li, Z., Sacks, D. B., IQGAP1 is a component of CDC42 signaling to the cytoskeleton. J. Biol. Chem. 2002, 277, 24753-24763. (Pubitemid 34952007)
26. Liang, S., Yu, Y., Yang, P., Gu, S. et al., Analysis of the protein complex associated with 14-3-3 epsilon by a deuterated-leucine labeling quantitative proteomics strategy. J. Chromatogr. B 2009, 877, 627-634.
27. Roy, M., Li, Z., Sacks, D. B., IQGAP1 binds ERK2 and modulates its activity. J. Biol. Chem. 2004, 279, 17329-17337. (Pubitemid 38560493)
28. Noritake, J., Fukata, M., Sato, K., Nakagawa, M. et al., Positive role of IQGAP1, an effector of rac1, in actin-mesh-work formation at sites of cell-cell contact. Mol. Biol. Cell. 2004, 15, 1065-1076. (Pubitemid 38324580)
29. Jadeski, L., Mataraza, J. M., Jeong, H.-W., Li, Z., Sacks, D. B., IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells. J. Biol. Chem. 2008, 283, 1008-1017.
30. Hou, W., Chen, L., Yang, G., Zhou, H. et al., Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models. Phytother. Res. 2008, 22, 1122-1132.
31. Luo, H., Zhong, Q., Chen, L., Qi, X. et al., Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer. J. Cancer Res. Clin. Oncol. 2008, 134, 937-945.