Metabolism studies of casticin in rats using HPLC-ESI-MSn

Biomedical Chromatography

Volumn 26, Issue 12, 2012, Pages 1502-1508

  Ling, Yun ^a   Zhu, Jianyong ^b   Fan, Mingsong ^a   Wu, Bin ^a   Qin, Luping ^b,c   Huang, Chenggang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c Second Military University   (China)

Author keywords

Casticin; Metabolites; Rat

Indexed keywords

ALKYLATION; BIOCONVERSION; BIOMOLECULES; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PHYSIOLOGY; RATS;

ANTI-TUMORS; CASTICIN; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; HPLC-ESI MS; IMMUNOMODULATORY; IN-VIVO; LC-ESI-MS; LIQUID CHROMATOGRAPHY ELECTROSPRAY; PHARMACOLOGICAL ACTIVITY; SYSTEMATIC METHOD;

METABOLITES;

CASTICIN; DRUG METABOLITE; FLAVONOID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DEMETHYLATION; DRUG BLOOD LEVEL; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SULFATION; DRUG TISSUE LEVEL; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; METHYLATION; MOLECULAR WEIGHT; NONHUMAN; RAT; SINGLE DRUG DOSE;

RATTUS;

EID: 84867700942     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.2724     Document Type: Article

References (10)

1. Chen LY, Li ZX, Tang YH, Cui XL, Luo RH, Guo SS, Zheng YT and Huang CG. Isolation, identification and antiviral activities of metabolites of calycosin-7-O-β- d-glucopyranoside. Journal of Pharmaceutical and Biomedical Analysis 2011; 56: 382-389.
2. Haïdara K, Zamir L, Shi QW and Batist G. The flavonoid casticin has multiple mechanisms of tumor cytotoxicity action. Cancer Letters 2006; 242: 180-190.
3. Iwata H, Tsuchiya S, Ueno K, Nakamura T and Yano S. Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in mice. European Journal of Pharmacology 2008; 600: 130-132.
4. Liu HH, Wang K, Tang YH, Sun ZL, Jian LH, Li ZX, Wu B and Huang CG. Structure elucidation of in vivo and in vitro metabolites of mangiferin. Journal of Pharmaceutical and Biomedical Analysis 2011, 55: 1075-1082.
5. Mesaik MA, Azizuddin, Murad S, Khan KM, Tareen RB, Atta-ur-Rahman AA and Choudhary MI. Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. Phytotherapy Research 2009; 23: 1516-1520.
6. Peng ZH, Song W, Han FM, Chen HX, Zhu MM and Chen Y. Identification of metabolites of lobeline in the rat urine by liquid chromatography-tandem mass spectrometry. International Journal of Mass Spectrometry 2008; 269: 131-137.
7. Spohr TC, Stipursky J, Sasaki AC, Barbosa PR, Martins V, Benjamim CF, Roque NF, Costa SL and Gomes FC. Effects of the flavonoid casticin from brazilian croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes. Journal of Neuroscience Research 2010; 88: 530-541.
8. Xie J, Bai J, Sheng XF, Cao JG and Xie WY. Proliferation inhibition of human cervical cancer HeLa cells by casticin in vitro. Chinese-German Journal of Clinical Oncology 2011; 10: 47-50.
9. Ye Q, Zhang YQ, Zheng CJ, Wang Y and Qin LP. Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro. Acta Pharmacologica Sinica 2010; 31: 1564-1568.
10. n. Biomedical Chromatography 2008; 23: 219-221.