메뉴 건너뛰기




Volumn 18, Issue 48, 2012, Pages 7166-7174

Oridonin induces apoptosis in gastric cancer through Apaf-1, cytochrome c and caspase-3 signaling pathway

Author keywords

Apaf 1 caspase 3 cytochrome C; Apoptosis; Gastric cancer; Oridonin; Proliferation

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CYTOCHROME C; LACTATE DEHYDROGENASE; ORIDONIN; PROTEIN BAX; PROTEIN BCL 2;

EID: 84884189755     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v18.i48.7166     Document Type: Article
Times cited : (56)

References (36)
  • 1
    • 22344438694 scopus 로고    scopus 로고
    • Epidemiology of gastric cancer in Japan
    • Inoue M, Tsugane S. Epidemiology of gastric cancer in Japan. Postgrad Med J 2005; 81: 419-424
    • (2005) Postgrad Med J , vol.81 , pp. 419-424
    • Inoue, M.1    Tsugane, S.2
  • 3
    • 24044520336 scopus 로고    scopus 로고
    • Adjuvant and neoadjuvant therapy for gastric cancer
    • Gonzalez RJ, Mansfield PF. Adjuvant and neoadjuvant therapy for gastric cancer. Surg Clin North Am 2005; 85: 1033-1051
    • (2005) Surg Clin North Am , vol.85 , pp. 1033-1051
    • Gonzalez, R.J.1    Mansfield, P.F.2
  • 4
    • 23344434285 scopus 로고    scopus 로고
    • Herbal medicine and cancer: An introductory overview
    • Treasure J. Herbal medicine and cancer: an introductory overview. Semin Oncol Nurs 2005; 21: 177-183
    • (2005) Semin Oncol Nurs , vol.21 , pp. 177-183
    • Treasure, J.1
  • 6
    • 37549009531 scopus 로고    scopus 로고
    • Oridonin induces apoptosis in gastric cancer nin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation
    • Cui Q, Tashiro S, Onodera S, Minami M, Ikejima T. Orido Sun KW et al. Oridonin induces apoptosis in gastric cancer nin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation. J Pharmacol Sci 2007; 105: 317-325
    • (2007) J Pharmacol Sci , vol.105 , pp. 317-325
    • Cui, Q.1    Tashiro, S.2    Onodera, S.3    Minami, M.4    Ikejima, T.5    Orido, S.K.W.6
  • 7
    • 36849090058 scopus 로고    scopus 로고
    • Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway
    • Li D, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin induces human epidermoid carcinoma A431 cell apoptosis through tyrosine kinase and mitochondrial pathway. J Asian Nat Prod Res 2008; 10: 77-87
    • (2008) J Asian Nat Prod Res , vol.10 , pp. 77-87
    • Li, D.1    Wu, L.J.2    Tashiro, S.3    Onodera, S.4    Ikejima, T.5
  • 8
    • 34147131374 scopus 로고    scopus 로고
    • Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8; 21) leukemia in vitro and in vivo
    • Zhou GB, Kang H, Wang L, Gao L, Liu P, Xie J, Zhang FX, Weng XQ, Shen ZX, Chen J, Gu LJ, Yan M, Zhang DE, Chen SJ, Wang ZY, Chen Z. Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8; 21) leukemia in vitro and in vivo. Blood 2007; 109: 3441-3450
    • (2007) Blood , vol.109 , pp. 3441-3450
    • Zhou, G.B.1    Kang, H.2    Wang, L.3    Gao, L.4    Liu, P.5    Xie, J.6    Zhang, F.X.7    Weng, X.Q.8    Shen, Z.X.9    Chen, J.10    Gu, L.J.11    Yan, M.12    Zhang, D.E.13    Chen, S.J.14    Wang, Z.Y.15    Chen, Z.16
  • 9
    • 77956301155 scopus 로고    scopus 로고
    • Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells
    • Wang H, Ye Y, Chui JH, Zhu GY, Li YW, Fong DW, Yu ZL. Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells. Oncol Rep 2010; 24: 647-651
    • (2010) Oncol Rep , vol.24 , pp. 647-651
    • Wang, H.1    Ye, Y.2    Chui, J.H.3    Zhu, G.Y.4    Li, Y.W.5    Fong, D.W.6    Yu, Z.L.7
  • 10
    • 56149088148 scopus 로고    scopus 로고
    • Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling
    • Wang HJ, Li D, Yang FY, Tashiro S, Onodera S, Ikejima T. Oridonin induces human melanoma A375-S2 cell death partially through inhibiting insulin-like growth factor 1 receptor signaling. J Asian Nat Prod Res 2008; 10: 787-798
    • (2008) J Asian Nat Prod Res , vol.10 , pp. 787-798
    • Wang, H.J.1    Li, D.2    Yang, F.Y.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 11
    • 34250847036 scopus 로고    scopus 로고
    • Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice
    • Zhu Y, Xie L, Chen G, Wang H, Zhang R. Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice. Pharmazie 2007; 62: 439-444
    • (2007) Pharmazie , vol.62 , pp. 439-444
    • Zhu, Y.1    Xie, L.2    Chen, G.3    Wang, H.4    Zhang, R.5
  • 12
    • 34347385839 scopus 로고    scopus 로고
    • P53-mediated cell cycle arrest and apoptosis through a caspase-3independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells
    • Cui Q, Yu JH, Wu JN, Tashiro S, Onodera S, Minami M, Ikejima T. P53-mediated cell cycle arrest and apoptosis through a caspase-3independent, but caspase-9-dependent pathway in oridonin-treated MCF-7 human breast cancer cells. Acta Pharmacol Sin 2007; 28: 1057-1066
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 1057-1066
    • Cui, Q.1    Yu, J.H.2    Wu, J.N.3    Tashiro, S.4    Onodera, S.5    Minami, M.6    Ikejima, T.7
  • 14
    • 77953359873 scopus 로고    scopus 로고
    • Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways
    • Kang N, Zhang JH, Qiu F, Tashiro S, Onodera S, Ikejima T. Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways. Cancer Lett 2010; 294: 147-158
    • (2010) Cancer Lett , vol.294 , pp. 147-158
    • Kang, N.1    Zhang, J.H.2    Qiu, F.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 15
    • 50149087699 scopus 로고    scopus 로고
    • Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways
    • Huang J, Wu L, Tashiro S, Onodera S, Ikejima T. Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. J Pharmacol Sci 2008; 107: 370-379
    • (2008) J Pharmacol Sci , vol.107 , pp. 370-379
    • Huang, J.1    Wu, L.2    Tashiro, S.3    Onodera, S.4    Ikejima, T.5
  • 17
    • 84856107017 scopus 로고    scopus 로고
    • Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells
    • Zang L, Xu Q, Ye Y, Li X, Liu Y, Tashiro S, Onodera S, Ikejima T. Autophagy enhanced phagocytosis of apoptotic cells by oridonin-treated human histocytic lymphoma U937 cells. Arch Biochem Biophys 2012; 518: 31-41
    • (2012) Arch Biochem Biophys , vol.518 , pp. 31-41
    • Zang, L.1    Xu, Q.2    Ye, Y.3    Li, X.4    Liu, Y.5    Tashiro, S.6    Onodera, S.7    Ikejima, T.8
  • 18
    • 79953029230 scopus 로고    scopus 로고
    • Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics
    • Li CY, Wang EQ, Cheng Y, Bao JK. Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics. Int J Biochem Cell Biol 2011; 43: 701-704
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 701-704
    • Li, C.Y.1    Wang, E.Q.2    Cheng, Y.3    Bao, J.K.4
  • 19
    • 34648812757 scopus 로고    scopus 로고
    • Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells
    • Li D, Cui Q, Chen SG, Wu LJ, Tashiro S, Onodera S, Ikejima T. Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells. J Pharmacol Sci 2007; 105: 22-33
    • (2007) J Pharmacol Sci , vol.105 , pp. 22-33
    • Li, D.1    Cui, Q.2    Chen, S.G.3    Wu, L.J.4    Tashiro, S.5    Onodera, S.6    Ikejima, T.7
  • 21
  • 22
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: Multiple pathways to apoptosis
    • Adams JM. Ways of dying: multiple pathways to apoptosis. Genes Dev 2003; 17: 2481-2495
    • (2003) Genes Dev , vol.17 , pp. 2481-2495
    • Adams, J.M.1
  • 23
    • 84870990121 scopus 로고    scopus 로고
    • The secrets of the Bcl-2 family
    • García-Sáez AJ. The secrets of the Bcl-2 family. Cell Deat Differ 2012; 19: 1733-1740
    • (2012) Cell Deat Differ , vol.19 , pp. 1733-1740
    • García-Sáez, A.J.1
  • 26
    • 34248158083 scopus 로고    scopus 로고
    • Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells
    • Cui Q, Tashiro S, Onodera S, Minami M, Ikejima T. Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol Pharm Bull 2007; 30: 859-864
    • (2007) Biol Pharm Bull , vol.30 , pp. 859-864
    • Cui, Q.1    Tashiro, S.2    Onodera, S.3    Minami, M.4    Ikejima, T.5
  • 27
    • 33646812928 scopus 로고    scopus 로고
    • Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells
    • Zhang JF, Liu JJ, Liu PQ, Lin DJ, Li XD, Chen GH. Oridonin inhibits cell growth by induction of apoptosis on human hepatocelluar carcinoma BEL-7402 cells. Hepatol Res 2006; 35: 104-110
    • (2006) Hepatol Res , vol.35 , pp. 104-110
    • Zhang, J.F.1    Liu, J.J.2    Liu, P.Q.3    Lin, D.J.4    Li, X.D.5    Chen, G.H.6
  • 28
    • 2442530659 scopus 로고    scopus 로고
    • Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2/Bax and activating caspase-3/ICAD pathway
    • Zhang CL, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2/Bax and activating caspase-3/ICAD pathway. Acta Pharmacol Sin 2004; 25: 691-698
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 691-698
    • Zhang, C.L.1    Wu, L.J.2    Tashiro, S.3    Onodera, S.4    Ikejima, T.5
  • 30
    • 52949092696 scopus 로고    scopus 로고
    • Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation
    • Wu JN, Huang J, Yang J, Tashiro S, Onodera S, Ikejima T. Caspase inhibition augmented oridonin-induced cell death in murine fibrosarcoma l929 by enhancing reactive oxygen species generation. J Pharmacol Sci 2008; 108: 32-39
    • (2008) J Pharmacol Sci , vol.108 , pp. 32-39
    • Wu, J.N.1    Huang, J.2    Yang, J.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 31
    • 80052754693 scopus 로고    scopus 로고
    • Oridonininduced apoptosis in SW620 human colorectal adenocarcinoma cells
    • Ji Z, Tang Q, Zhang J, Yang Y, Liu Y, Pan Y. Oridonininduced apoptosis in SW620 human colorectal adenocarcinoma cells. Oncol Lett 2011; 2: 1303-1307
    • (2011) Oncol Lett , vol.2 , pp. 1303-1307
    • Ji, Z.1    Tang, Q.2    Zhang, J.3    Yang, Y.4    Liu, Y.5    Pan, Y.6
  • 32
    • 84864720584 scopus 로고    scopus 로고
    • Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway
    • Ye YC, Wang HJ, Xu L, Liu WW, Liu BB, Tashiro S, Onodera S, Ikejima T. Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway. Acta Pharmacol Sin 2012; 33: 1055-1061
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1055-1061
    • Ye, Y.C.1    Wang, H.J.2    Xu, L.3    Liu, W.W.4    Liu, B.B.5    Tashiro, S.6    Onodera, S.7    Ikejima, T.8
  • 33
    • 84863811994 scopus 로고    scopus 로고
    • Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells
    • Li X, Li X, Wang J, Ye Z, Li JC. Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci 2012; 8: 901-912
    • (2012) Int J Biol Sci , vol.8 , pp. 901-912
    • Li, X.1    Li, X.2    Wang, J.3    Ye, Z.4    Li, J.C.5
  • 34
    • 84863265308 scopus 로고    scopus 로고
    • Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells
    • Gao FH, Liu F, Wei W, Liu LB, Xu MH, Guo ZY, Li W, Jiang B, Wu YL. Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. Int J Mol Med 2012; 29: 649-655
    • (2012) Int J Mol Med , vol.29 , pp. 649-655
    • Gao, F.H.1    Liu, F.2    Wei, W.3    Liu, L.B.4    Xu, M.H.5    Guo, Z.Y.6    Li, W.7    Jiang, B.8    Wu, Y.L.9
  • 35
    • 84863553710 scopus 로고    scopus 로고
    • Interruption of hepatocyte growth factor signaling augmented oridonin-induced death in human non-small cell lung cancer A549 cells via c-met-nuclear factor-κB-cyclooxygenase-2 and c-Met-Bcl-2-caspase-3 pathways
    • Liu Y, Shi QF, Qi M, Tashiro S, Onodera S, Ikejima T. Interruption of hepatocyte growth factor signaling augmented oridonin-induced death in human non-small cell lung cancer A549 cells via c-met-nuclear factor-κB-cyclooxygenase-2 and c-Met-Bcl-2-caspase-3 pathways. Biol Pharm Bull 2012; 35: 1150-1158
    • (2012) Biol Pharm Bull , vol.35 , pp. 1150-1158
    • Liu, Y.1    Shi, Q.F.2    Qi, M.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 36
    • 18044371471 scopus 로고    scopus 로고
    • Oridonin induces a caspase-independent but mitochondria and MAPK-dependent cell death in the murine fibrosarcoma cell line L929
    • Zhang CL, Wu LJ, Tashiro S, Onodera S, Ikejima T. Oridonin induces a caspase-independent but mitochondria and MAPK-dependent cell death in the murine fibrosarcoma cell line L929. Biol Pharm Bull 2004; 27: 1527-1531
    • (2004) Biol Pharm Bull , vol.27 , pp. 1527-1531
    • Zhang, C.L.1    Wu, L.J.2    Tashiro, S.3    Onodera, S.4    Ikejima, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.