메뉴 건너뛰기




Volumn 15, Issue 9, 2010, Pages 6466-6474

Effects of eupatilin and jaceosidin on cytochrome P450 enzyme activities in human liver microsomes

Author keywords

Cytochrome P450 inhibition; Drug drug interaction; Eupatilin; Human liver microsomes; Jaceosidin

Indexed keywords

ANTIOXIDANT; CYP2C9 PROTEIN, HUMAN; CYTOCHROME P450; CYTOCHROME P450 1A2; EUPATILIN; FLAVONOID; HERBACEOUS AGENT; JACEOSIDIN; UNSPECIFIC MONOOXYGENASE;

EID: 77957320051     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules15096466     Document Type: Article
Times cited : (33)

References (31)
  • 6
    • 44149121406 scopus 로고    scopus 로고
    • Protective effect of eupatilin on indomethacininduced cell damage in cultured feline ileal smooth muscle cells: Involvement of HO-1 and ERK
    • Song, H. J.; Shin, C. Y.; Oh, T. Y.; Sohn, U. D. Protective effect of eupatilin on indomethacininduced cell damage in cultured feline ileal smooth muscle cells: involvement of HO-1 and ERK. J. Ethnopharmacol. 2008, 118, 94-101.
    • (2008) J. Ethnopharmacol. , vol.118 , pp. 94-101
    • Song, H.J.1    Shin, C.Y.2    Oh, T.Y.3    Sohn, U.D.4
  • 7
    • 59249100492 scopus 로고    scopus 로고
    • 5, 7-dihydroxy-3, 4, 6-trimethoxyflavone inhibits the inflammatory effects induced by Bactertlides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and IκBα and IκB kinase-γ in intestinal epithelial cell culture
    • Kim, J. M.; Lee, D. H.; Kim, J. S.; Lee, J. Y.; Park, H. G.; Kim, Y. J.; Oh, Y.-K.; Jung, H. C.; Kim, S. I. 5, 7-dihydroxy-3, 4, 6-trimethoxyflavone inhibits the inflammatory effects induced by Bactertlides fragilis enterotoxin via dissociating the complex of heat shock protein 90 and IκBα and IκB kinase-γ in intestinal epithelial cell culture. Clin. Exp. Immunol. 2008, 155, 541-551.
    • (2008) Clin. Exp. Immunol. , vol.155 , pp. 541-551
    • Kim, J.M.1    Lee, D.H.2    Kim, J.S.3    Lee, J.Y.4    Park, H.G.5    Kim, Y.J.6    Oh, Y.-K.7    Jung, H.C.8    Kim, S.I.9
  • 8
    • 69949107470 scopus 로고    scopus 로고
    • Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice
    • Min, S. W.; Kim, N. J.; Baek, N. I.; Kim, D. H. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps on carrageenan-induced inflammation in mice. J. Ethnopharmacol. 2009, 125, 497-500.
    • (2009) J. Ethnopharmacol. , vol.125 , pp. 497-500
    • Min, S.W.1    Kim, N.J.2    Baek, N.I.3    Kim, D.H.4
  • 9
    • 65249157982 scopus 로고    scopus 로고
    • Eupatilin with heme oxygenase-1-inducing ability protects cultured feline esophageal epithelial cells from cell damage caused by indomethacin
    • Song, H. J.; Shin, C. Y.; Oh, T. Y.; Min, Y. S.; Park, E. S.; Sohn, U. D. Eupatilin with heme oxygenase-1-inducing ability protects cultured feline esophageal epithelial cells from cell damage caused by indomethacin. Biol. Pharm. Bull. 2009, 32, 589-596.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 589-596
    • Song, H.J.1    Shin, C.Y.2    Oh, T.Y.3    Min, Y.S.4    Park, E.S.5    Sohn, U.D.6
  • 10
    • 28744452914 scopus 로고    scopus 로고
    • Eupatilin blocks mediator release via tyrosine kinase inhibition in activated guinea pig lung mast cells
    • Kim, J. Y.; Kwon, E. Y.; Lee, Y. S.; Kim, W. B.; Ro, J. Y. Eupatilin blocks mediator release via tyrosine kinase inhibition in activated guinea pig lung mast cells. J. Toxicol. Environ. Health Part A 2005, 68, 2063-2080.
    • (2005) J. Toxicol. Environ. Health Part A , vol.68 , pp. 2063-2080
    • Kim, J.Y.1    Kwon, E.Y.2    Lee, Y.S.3    Kim, W.B.4    Ro, J.Y.5
  • 11
    • 35848946821 scopus 로고    scopus 로고
    • Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity
    • Lee, S. H.; Bae, E. A.; Park, E. K.; Shin, Y. W.; Baek, N. I.; Han, E. J.; Chung, H. G.; Kim, D. H. Inhibitory effect of eupatilin and jaceosidin isolated from Artemisia princeps in IgE-induced hypersensitivity. Int. Immunopharmacol. 2007, 7, 1678-1684.
    • (2007) Int. Immunopharmacol , vol.7 , pp. 1678-1684
    • Lee, S.H.1    Bae, E.A.2    Park, E.K.3    Shin, Y.W.4    Baek, N.I.5    Han, E.J.6    Chung, H.G.7    Kim, D.H.8
  • 12
    • 0033863808 scopus 로고    scopus 로고
    • Antimutagens in gaiyou (Artemisia argyi levl. et vant)
    • Nakasugi, T.; Nakashima, M.; Komai, K. Antimutagens in gaiyou (Artemisia argyi levl. et vant). J. Agric. Food Chem. 2000, 48, 3256-3266.
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 3256-3266
    • Nakasugi, T.1    Nakashima, M.2    Komai, K.3
  • 13
    • 0035922193 scopus 로고    scopus 로고
    • Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells
    • Seo, H. J.; Surh, Y. J. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells. Mutat. Res. 2001, 496, 191-198.
    • (2001) Mutat. Res. , vol.496 , pp. 191-198
    • Seo, H.J.1    Surh, Y.J.2
  • 14
    • 0036637111 scopus 로고    scopus 로고
    • Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis BRIQ. and consideration of structure-activity relationship
    • Nagao, T.; Abe, F.; Kinjo, J.; Okabe, H. Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis BRIQ. and consideration of structure-activity relationship. Biol. Pharm. Bull. 2002, 25, 875-879.
    • (2002) Biol. Pharm. Bull. , vol.25 , pp. 875-879
    • Nagao, T.1    Abe, F.2    Kinjo, J.3    Okabe, H.4
  • 16
    • 33644844954 scopus 로고    scopus 로고
    • Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells
    • Kim, M. J.; Kim, D. H.; Na, H. K.; Oh, T. Y.; Shin, C. Y.; Surh, Y. J. Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human gastric cancer (AGS) cells. J. Environ. Pathol. Toxicol. Oncol. 2005, 24, 261-269.
    • (2005) J. Environ. Pathol. Toxicol. Oncol. , vol.24 , pp. 261-269
    • Kim, M.J.1    Kim, D.H.2    Na, H.K.3    Oh, T.Y.4    Shin, C.Y.5    Surh, Y.J.6
  • 18
    • 34247853280 scopus 로고    scopus 로고
    • Jaceosidin induces apoptosis in rastransformed human breast epithelial cells through generation of reactive oxygen species
    • Kim, M. J.; Kim, D. H.; Lee, K. W.; Yoon, D. Y.; Surh, Y. J. Jaceosidin induces apoptosis in rastransformed human breast epithelial cells through generation of reactive oxygen species. Ann. N. Y Acad. Sci. 2007, 1095, 483-495.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1095 , pp. 483-495
    • Kim, M.J.1    Kim, D.H.2    Lee, K.W.3    Yoon, D.Y.4    Surh, Y.J.5
  • 19
    • 34247882676 scopus 로고    scopus 로고
    • Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbolester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells
    • Jeong, M. A.; Lee, K. W.; Yoon, D. Y.; Surh, Y. J. Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbolester-induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells. Ann. N. Y. Acad. Sci. 2007, 1095, 458-466.
    • (2007) Ann. N. Y. Acad. Sci. , vol.1095 , pp. 458-466
    • Jeong, M.A.1    Lee, K.W.2    Yoon, D.Y.3    Surh, Y.J.4
  • 20
    • 47149114341 scopus 로고    scopus 로고
    • 2-induced apoptotic cell death through inhibition of mitogen-activated protein kinases and nuclear factor-κB
    • 2-induced apoptotic cell death through inhibition of mitogen-activated protein kinases and nuclear factor-κB. Food Chem. Toxicol. 2008, 46, 2865-2870.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 2865-2870
    • Lee, S.1    Lee, M.2    Kim, S.H.3
  • 21
    • 56149094346 scopus 로고    scopus 로고
    • Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway
    • Lv, W.; Sheng, X.; Chen, T.; Xu, Q.; Xie, X. Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway. J. Biomed. Biotechnol. 2008, 394802.
    • (2008) J. Biomed. Biotechnol. , pp. 394802
    • Lv, W.1    Sheng, X.2    Chen, T.3    Xu, Q.4    Xie, X.5
  • 22
    • 61849086790 scopus 로고    scopus 로고
    • Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells
    • Choi, E. J.; Oh, H. M.; Wee, H.; Choi, C. S.; Choi, S. C.; Kim, K. H.; Han, W. C.; Oh, T. Y.; Kim, S. H.; Jun, C. D. Eupatilin exhibits a novel anti-tumor activity through the induction of cell cycle arrest and differentiation of gastric carcinoma AGS cells. Differentiation 2009, 77, 412-423.
    • (2009) Differentiation , vol.77 , pp. 412-423
    • Choi, E.J.1    Oh, H.M.2    Wee, H.3    Choi, C.S.4    Choi, S.C.5    Kim, K.H.6    Han, W.C.7    Oh, T.Y.8    Kim, S.H.9    Jun, C.D.10
  • 24
    • 2342475138 scopus 로고    scopus 로고
    • Metabolism of eupatilin in rats using liquid chromatography/electrospray mass spectrometry
    • Ji, H. Y.; Lee, H. W.; Shim, H. J.; Kim, S. H.; Kim, W. B.; Lee, H. S. Metabolism of eupatilin in rats using liquid chromatography/electrospray mass spectrometry. Biomed. Chromatogr. 2004, 18, 173-177.
    • (2004) Biomed. Chromatogr. , vol.18 , pp. 173-177
    • Ji, H.Y.1    Lee, H.W.2    Shim, H.J.3    Kim, S.H.4    Kim, W.B.5    Lee, H.S.6
  • 25
    • 34547946590 scopus 로고    scopus 로고
    • In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes
    • Lee, H. S.; Ji, H. Y.; Park, E. J.; Kim, S. Y. In vitro metabolism of eupatilin by multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes. Xenobiotica 2007, 37, 803-817.
    • (2007) Xenobiotica , vol.37 , pp. 803-817
    • Lee, H.S.1    Ji, H.Y.2    Park, E.J.3    Kim, S.Y.4
  • 26
    • 0033987220 scopus 로고    scopus 로고
    • Medicinal herbs: Drugs or dietary supplements
    • Chang, J. Medicinal herbs: drugs or dietary supplements. Biochem. Pharmacol. 2000, 59, 211-219.
    • (2000) Biochem. Pharmacol. , vol.59 , pp. 211-219
    • Chang, J.1
  • 28
    • 70350023302 scopus 로고    scopus 로고
    • Drug-botanical interactions: A review of the laboratory, animal, and human data for 8 common botanicals
    • Shord, S. S.; Shah, K.; Lukose, A. Drug-botanical interactions: a review of the laboratory, animal, and human data for 8 common botanicals. Integr. Cancer Ther. 2009, 8, 208-227.
    • (2009) Integr. Cancer Ther. , vol.8 , pp. 208-227
    • Shord, S.S.1    Shah, K.2    Lukose, A.3
  • 29
    • 73349108767 scopus 로고    scopus 로고
    • Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2
    • Zhou, S. F.; Yang, L. P.; Zhou, Z. W.; Liu, Y. H.; Chan, E. Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2. APPS J. 2009, 11, 481-494.
    • (2009) APPS J. , vol.11 , pp. 481-494
    • Zhou, S.F.1    Yang, L.P.2    Zhou, Z.W.3    Liu, Y.H.4    Chan, E.5
  • 30
    • 77951447009 scopus 로고    scopus 로고
    • Structure, function and polymorphism and the clinical significance of human cytochrome P450 1A2
    • Zhou, S. F.; Wang, B.; Yang, L. P.; Liu, J. P. Structure, function and polymorphism and the clinical significance of human cytochrome P450 1A2. Drug Metab. Rev. 2010, 42, 268-354.
    • (2010) Drug Metab. Rev. , vol.42 , pp. 268-354
    • Zhou, S.F.1    Wang, B.2    Yang, L.P.3    Liu, J.P.4
  • 31
    • 70450245353 scopus 로고    scopus 로고
    • Substrate, inducers, inhibitors and structure-activity relationships of human cytochrome P450 2C9 and implications in drug development
    • Zhou, S. F.; Zhou, Z. W.; Yang, L. P.; Cai, J. P. Substrate, inducers, inhibitors and structure-activity relationships of human cytochrome P450 2C9 and implications in drug development. Curr. Med. Chem. 2009, 16, 3480-3675.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 3480-3675
    • Zhou, S.F.1    Zhou, Z.W.2    Yang, L.P.3    Cai, J.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.