메뉴 건너뛰기




Volumn 32, Issue 7, 2011, Pages 1013-1024

Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MESOTHELIN; MESSENGER RNA; MYC PROTEIN; PROTEIN BCL 2; RECOMBINANT INTERLEUKIN 6; SMALL INTERFERING RNA; SOLUBLE INTERLEUKIN 6 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG; WEDELOLACTONE;

EID: 79960068710     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr075     Document Type: Article
Times cited : (88)

References (47)
  • 1
    • 3042621639 scopus 로고    scopus 로고
    • Mesothelin: a new target for immunotherapy
    • Hassan,R. et al. (2004) Mesothelin: a new target for immunotherapy. Clin. Cancer Res., 10, 3937-3942.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3937-3942
    • Hassan, R.1
  • 2
    • 39749173738 scopus 로고    scopus 로고
    • Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer
    • Li,M. et al. (2008) Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol. Cancer Ther., 7, 286-296.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 286-296
    • Li, M.1
  • 3
    • 56449108335 scopus 로고    scopus 로고
    • Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3
    • Bharadwaj,U. et al. (2008) Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. Mol. Cancer Res., 6, 1755-1765.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1755-1765
    • Bharadwaj, U.1
  • 4
    • 40349102093 scopus 로고    scopus 로고
    • Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells
    • Uehara,N. et al. (2008) Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells. Mol. Cancer Res., 6, 186-193.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 186-193
    • Uehara, N.1
  • 5
    • 33747493036 scopus 로고    scopus 로고
    • Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas
    • Adachi,Y. et al. (2006) Interleukin-6 induces both cell growth and VEGF production in malignant mesotheliomas. Int. J. Cancer., 119, 1303-1311.
    • (2006) Int. J. Cancer. , vol.119 , pp. 1303-1311
    • Adachi, Y.1
  • 6
    • 33746238953 scopus 로고    scopus 로고
    • Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion
    • Yeh,H.H. et al. (2006) Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion. Oncogene, 25, 4300-4309.
    • (2006) Oncogene , vol.25 , pp. 4300-4309
    • Yeh, H.H.1
  • 7
    • 34247849312 scopus 로고    scopus 로고
    • The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1
    • Cavarretta,I.T. et al. (2007) The antiapoptotic effect of IL-6 autocrine loop in a cellular model of advanced prostate cancer is mediated by Mcl-1. Oncogene, 26, 2822-2832.
    • (2007) Oncogene , vol.26 , pp. 2822-2832
    • Cavarretta, I.T.1
  • 8
    • 0035681366 scopus 로고    scopus 로고
    • IL-6 inhibits apoptosis and retains oxidative DNA lesions in human gastric cancer AGS cells through up-regulation of antiapoptotic gene mcl-1
    • Lin,M.T. et al. (2001) IL-6 inhibits apoptosis and retains oxidative DNA lesions in human gastric cancer AGS cells through up-regulation of antiapoptotic gene mcl-1. Carcinogenesis, 22, 1947-1953.
    • (2001) Carcinogenesis , vol.22 , pp. 1947-1953
    • Lin, M.T.1
  • 9
    • 27544476971 scopus 로고    scopus 로고
    • The role of IL-6 and STAT3 in inflammation and cancer
    • Hodge,D.R. et al. (2005) The role of IL-6 and STAT3 in inflammation and cancer. Eur. J. Cancer., 41, 2502-2512.
    • (2005) Eur. J. Cancer. , vol.41 , pp. 2502-2512
    • Hodge, D.R.1
  • 10
    • 33644586895 scopus 로고    scopus 로고
    • Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival
    • Bellone,G. et al. (2006) Cytokine expression profile in human pancreatic carcinoma cells and in surgical specimens: implications for survival. Cancer Immunol. Immunother., 55, 684-698.
    • (2006) Cancer Immunol. Immunother. , vol.55 , pp. 684-698
    • Bellone, G.1
  • 11
    • 0031606207 scopus 로고    scopus 로고
    • Elevated serum interleukin-6 levels in patients with pancreatic cancer
    • Okada,S. et al. (1998) Elevated serum interleukin-6 levels in patients with pancreatic cancer. Jpn. J. Clin. Oncol., 28, 12-15.
    • (1998) Jpn. J. Clin. Oncol. , vol.28 , pp. 12-15
    • Okada, S.1
  • 12
    • 35948977339 scopus 로고    scopus 로고
    • Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth
    • Lang,S.A. et al. (2007) Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth. Clin. Cancer Res., 13, 6459-6468.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 6459-6468
    • Lang, S.A.1
  • 13
    • 0032813345 scopus 로고    scopus 로고
    • Growth factors and cytokines in pancreatic carcinogenesis
    • Friess,H. et al. (1999) Growth factors and cytokines in pancreatic carcinogenesis. Ann. N. Y. Acad. Sci., 880, 110-121.
    • (1999) Ann. N. Y. Acad. Sci. , vol.880 , pp. 110-121
    • Friess, H.1
  • 14
    • 0035153882 scopus 로고    scopus 로고
    • Interleukin-6 inhibits radiation induced apoptosis in pancreatic cancer cells
    • Miyamoto,Y. et al. (2001) Interleukin-6 inhibits radiation induced apoptosis in pancreatic cancer cells. Anticancer Res., 21, 2449-2456.
    • (2001) Anticancer Res. , vol.21 , pp. 2449-2456
    • Miyamoto, Y.1
  • 15
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens,L.M. et al. (2002) Inflammation and cancer. Nature, 420, 860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1
  • 16
    • 40649109728 scopus 로고    scopus 로고
    • The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer
    • Naugler,W.E. et al. (2008) The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer. Trends Mol. Med., 14, 109-119.
    • (2008) Trends Mol. Med. , vol.14 , pp. 109-119
    • Naugler, W.E.1
  • 17
    • 58649101347 scopus 로고    scopus 로고
    • gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath,J. et al. (2009) gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell, 15, 91-102.
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1
  • 18
    • 58649100056 scopus 로고    scopus 로고
    • Inflammation and cancer: IL-6 and STAT3 complete the link
    • Bromberg,J. et al. (2009) Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell, 15, 79-80.
    • (2009) Cancer Cell , vol.15 , pp. 79-80
    • Bromberg, J.1
  • 19
    • 0030160486 scopus 로고    scopus 로고
    • Interleukin 6 is an autocrine growth factor for normal human pleural mesothelial cells
    • Fujino,S. et al. (1996) Interleukin 6 is an autocrine growth factor for normal human pleural mesothelial cells. Am. J. Respir. Cell Mol. Biol., 14, 508-515.
    • (1996) Am. J. Respir. Cell Mol. Biol. , vol.14 , pp. 508-515
    • Fujino, S.1
  • 20
    • 79952755847 scopus 로고    scopus 로고
    • Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice
    • Zhang,D. et al. (2011) Deficiency of the Erc/mesothelin gene ameliorates renal carcinogenesis in Tsc2 knockout mice. Cancer Sci., 102, 720-727.
    • (2011) Cancer Sci. , vol.102 , pp. 720-727
    • Zhang, D.1
  • 21
    • 34347230533 scopus 로고    scopus 로고
    • Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation
    • Bharadwaj,U. et al. (2007) Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation. Cancer Res., 67, 5479-5488.
    • (2007) Cancer Res. , vol.67 , pp. 5479-5488
    • Bharadwaj, U.1
  • 22
    • 10044261013 scopus 로고    scopus 로고
    • Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis
    • Ebrahimi,B. et al. (2004) Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. Cancer, 101, 2727-2736.
    • (2004) Cancer , vol.101 , pp. 2727-2736
    • Ebrahimi, B.1
  • 23
    • 33750497844 scopus 로고    scopus 로고
    • Inflammation and cancer: how hot is the link?
    • Aggarwal,B.B. et al. (2006) Inflammation and cancer: how hot is the link? Biochem. Pharmacol., 72, 1605-1621.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1605-1621
    • Aggarwal, B.B.1
  • 24
    • 4043176334 scopus 로고    scopus 로고
    • IL-6 as an intracrine growth factor for renal carcinoma cell lines
    • Alberti,L. et al. (2004) IL-6 as an intracrine growth factor for renal carcinoma cell lines. Int. J. Cancer., 111, 653-661.
    • (2004) Int. J. Cancer. , vol.111 , pp. 653-661
    • Alberti, L.1
  • 25
    • 0032185816 scopus 로고    scopus 로고
    • Proliferation of human non-small-cell lung cancer cell lines: role of interleukin-6
    • Bihl,M. et al. (1998) Proliferation of human non-small-cell lung cancer cell lines: role of interleukin-6. Am. J. Respir. Cell Mol. Biol., 19, 606-612.
    • (1998) Am. J. Respir. Cell Mol. Biol. , vol.19 , pp. 606-612
    • Bihl, M.1
  • 26
    • 0028344845 scopus 로고
    • Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130
    • Nishimoto,N. et al. (1994) Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130. J. Exp. Med., 179, 1343-1347.
    • (1994) J. Exp. Med. , vol.179 , pp. 1343-1347
    • Nishimoto, N.1
  • 27
    • 0031014669 scopus 로고    scopus 로고
    • Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro
    • Okamoto,M. et al. (1997) Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro. Cancer Res., 57, 141-146.
    • (1997) Cancer Res. , vol.57 , pp. 141-146
    • Okamoto, M.1
  • 28
    • 34248341267 scopus 로고    scopus 로고
    • The IL-6/sIL-6R complex as a novel target for therapeutic approaches
    • Rose-John,S. et al. (2007) The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin. Ther. Targets., 11, 613-624.
    • (2007) Expert Opin. Ther. Targets. , vol.11 , pp. 613-624
    • Rose-John, S.1
  • 29
    • 63949085839 scopus 로고    scopus 로고
    • High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
    • Cheng,W.F. et al. (2009) High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma. Br. J. Cancer., 100, 1144-1153.
    • (2009) Br. J. Cancer. , vol.100 , pp. 1144-1153
    • Cheng, W.F.1
  • 30
    • 34547158244 scopus 로고    scopus 로고
    • Generation and characterization of an ascitogenic mesothelin-expressing tumor model
    • Cheng,W.F. et al. (2007) Generation and characterization of an ascitogenic mesothelin-expressing tumor model. Cancer, 110, 420-431.
    • (2007) Cancer , vol.110 , pp. 420-431
    • Cheng, W.F.1
  • 31
    • 63849290925 scopus 로고    scopus 로고
    • Fibrinogen induces cytokine and collagen production in pancreatic stellate cells
    • Masamune,A. et al. (2009) Fibrinogen induces cytokine and collagen production in pancreatic stellate cells. Gut, 58, 550-559.
    • (2009) Gut , vol.58 , pp. 550-559
    • Masamune, A.1
  • 32
    • 33846682591 scopus 로고    scopus 로고
    • The inflammatory cytokine tumor necrosis factoralpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells
    • Kulbe,H. et al. (2007) The inflammatory cytokine tumor necrosis factoralpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells. Cancer Res., 67, 585-592.
    • (2007) Cancer Res. , vol.67 , pp. 585-592
    • Kulbe, H.1
  • 33
    • 0028959739 scopus 로고
    • Peritoneal lavage fluids stimulate NIH3T3 fibroblast proliferation and contain increased tumour necrosis factor and IL-6 in experimental silica-induced rat peritonitis
    • Lee,H.G. et al. (1995) Peritoneal lavage fluids stimulate NIH3T3 fibroblast proliferation and contain increased tumour necrosis factor and IL-6 in experimental silica-induced rat peritonitis. Clin. Exp. Immunol., 100, 139-144.
    • (1995) Clin. Exp. Immunol. , vol.100 , pp. 139-144
    • Lee, H.G.1
  • 34
    • 0034026325 scopus 로고    scopus 로고
    • Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins
    • Althoff,K. et al. (2000) Shedding of interleukin-6 receptor and tumor necrosis factor alpha. Contribution of the stalk sequence to the cleavage pattern of transmembrane proteins. Eur. J. Biochem., 267, 2624-2631.
    • (2000) Eur. J. Biochem. , vol.267 , pp. 2624-2631
    • Althoff, K.1
  • 35
    • 0032976025 scopus 로고    scopus 로고
    • Generation and function of the soluble interleukin-6 receptor
    • Mullberg,J. et al. (1999) Generation and function of the soluble interleukin-6 receptor. Biochem. Soc. Trans., 27, 211-219.
    • (1999) Biochem. Soc. Trans. , vol.27 , pp. 211-219
    • Mullberg, J.1
  • 36
    • 0141866756 scopus 로고    scopus 로고
    • Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
    • Matthews,V. et al. (2003) Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J. Biol. Chem., 278, 38829-38839.
    • (2003) J. Biol. Chem. , vol.278 , pp. 38829-38839
    • Matthews, V.1
  • 37
    • 0034880223 scopus 로고    scopus 로고
    • gp130-specific antisense oligonucleotides inhibit IL-6 signal inducing junB mRNA transcription in the human hepatoma cell line, HepG2
    • Varga,V.L. et al. (2001) gp130-specific antisense oligonucleotides inhibit IL-6 signal inducing junB mRNA transcription in the human hepatoma cell line, HepG2. Cell Biol. Int., 25, 835-840.
    • (2001) Cell Biol. Int. , vol.25 , pp. 835-840
    • Varga, V.L.1
  • 38
    • 58149291810 scopus 로고    scopus 로고
    • Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk
    • Amati,M. et al. (2008) Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk. Mutat. Res., 655, 52-58.
    • (2008) Mutat. Res. , vol.655 , pp. 52-58
    • Amati, M.1
  • 39
    • 0027298546 scopus 로고
    • Human peritoneal mesothelial cells synthesize interleukin-6: induction by IL-1 beta and TNF alpha
    • Topley,N. et al. (1993) Human peritoneal mesothelial cells synthesize interleukin-6: induction by IL-1 beta and TNF alpha. Kidney Int., 43, 226-233.
    • (1993) Kidney Int. , vol.43 , pp. 226-233
    • Topley, N.1
  • 40
    • 0029848801 scopus 로고    scopus 로고
    • Superinduction of IL-6 synthesis in human peritoneal mesothelial cells is related to the induction and stabilization of IL-6 mRNA
    • Witowski,J. et al. (1996) Superinduction of IL-6 synthesis in human peritoneal mesothelial cells is related to the induction and stabilization of IL-6 mRNA. Kidney Int., 50, 1212-1223.
    • (1996) Kidney Int. , vol.50 , pp. 1212-1223
    • Witowski, J.1
  • 41
    • 0026407120 scopus 로고
    • Studies on the interaction between interleukin 6 and human malignant nonhematopoietic cell lines
    • Serve,H. et al. (1991) Studies on the interaction between interleukin 6 and human malignant nonhematopoietic cell lines. Cancer Res., 51, 3862-3866.
    • (1991) Cancer Res. , vol.51 , pp. 3862-3866
    • Serve, H.1
  • 42
    • 33846813656 scopus 로고    scopus 로고
    • Expression profiling identifies microRNA signature in pancreatic cancer
    • Lee,E.J. et al. (2007) Expression profiling identifies microRNA signature in pancreatic cancer. Int. J. Cancer., 120, 1046-1054.
    • (2007) Int. J. Cancer. , vol.120 , pp. 1046-1054
    • Lee, E.J.1
  • 43
    • 44649101304 scopus 로고    scopus 로고
    • Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
    • Kuilman,T. et al. (2008) Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network. Cell, 133, 1019-1031.
    • (2008) Cell , vol.133 , pp. 1019-1031
    • Kuilman, T.1
  • 44
    • 58149473474 scopus 로고    scopus 로고
    • Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo
    • Galvez,A.S. et al. (2009) Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. Mol. Cell. Biol., 29, 104-115.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 104-115
    • Galvez, A.S.1
  • 45
    • 12144287282 scopus 로고    scopus 로고
    • A genetically defined model for human ovarian cancer
    • Liu,J. et al. (2004) A genetically defined model for human ovarian cancer. Cancer Res., 64, 1655-1663.
    • (2004) Cancer Res. , vol.64 , pp. 1655-1663
    • Liu, J.1
  • 46
    • 70449707106 scopus 로고    scopus 로고
    • An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas
    • Fukamachi,K. et al. (2009) An animal model of preclinical diagnosis of pancreatic ductal adenocarcinomas. Biochem. Biophys. Res. Commun., 390, 636-641.
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 636-641
    • Fukamachi, K.1
  • 47
    • 33645514605 scopus 로고    scopus 로고
    • Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgendependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
    • Wallner,L. et al. (2006) Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgendependent prostate cancer to an androgen-independent phenotype in orchiectomized mice. Cancer Res., 66, 3087-3095.
    • (2006) Cancer Res. , vol.66 , pp. 3087-3095
    • Wallner, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.