Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells

Acta Pharmacologica Sinica

Volumn 32, Issue 10, 2011, Pages 1266-1275

  Zhang, Ya Hong ^a,b   Wu, Ying Liang ^b   Tashiro, Shin Ichi ^c   Onodera, Satoshi ^c   Ikejima, Takashi ^b  

^a HENAN UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

apoptosis; autophagy; Bax; Bcl 2; caspase 3; caspase 8; HeLa cell; oridonin; reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 8; CATALASE; ORIDONIN; PROCASPASE 3; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER INHIBITION; CELL LEVEL; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; GROWTH INHIBITION; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PLASMA CONCENTRATION-TIME CURVE; PROTEIN EXPRESSION; STAINING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; AUTOPHAGY; CELL SURVIVAL; DITERPENES, KAURANE; FEMALE; HELA CELLS; HUMANS; RABDOSIA; REACTIVE OXYGEN SPECIES; UTERINE CERVICAL NEOPLASMS;

EID: 80053923208     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.92     Document Type: Article

References (37)

1. Lockshin RA, Zakeri Z. Apoptosis, autophagy, and more. Int J Biochem Cell Biol 2004; 36: 2405-19. (Pubitemid 39119755)
2. Gerl R, Vaux DL. Apoptosis in the development and treatment of cancer. Carcinogenesis 2005; 26: 263-70. (Pubitemid 40246548)
3. Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-6.
4. Levine B. Autophagy and cancer. Nature 2007; 446: 745-7.
5. Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of auto-phagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003; 63: 2103-8. (Pubitemid 36538613)
6. Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032-6. (Pubitemid 40052234)
7. Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-75. (Pubitemid 351317450)
8. Cui Q, Tashiro SI, Onodera S, Minami M, Ikejima T. Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells. Biol Pharm Bull 2007; 30: 859-64. (Pubitemid 46708626)
9. Pattingre S, Tassa A, Qu XP, Garuti R, Liang XH, Mizushima N. Bcl-2 anti apoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-39. (Pubitemid 41345209)
10. Wang ZH, Xu L, Duan ZL, Zeng LQ, Yan NH, Peng ZL. Beclin 1-mediated macroautophagy involves regulation of caspase-9 expres sion in cervical cancer HeLa cells. Gynecol Oncol 2007; 107: 107-13. (Pubitemid 47495947)
11. Crack PJ, Taylor JM. Reactive oxygen species and the modulation of stroke. Free Radic Biol Med 2005; 38: 1433-44. (Pubitemid 40693828)
12. Klamt F, Dal-Pizzol F, Conte da Frota MLJR, Walz R, Andrades ME, da Silva EG, et al. Imbalance of antioxidant defense in mice lacking cellular prion protein. Free Radic Biol Med 2001; 30: 1137-44. (Pubitemid 32441839)
13. Ermak G, Davies KJ. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol 2002; 38: 713-21. (Pubitemid 34158874)
14. Simbula G, Columbano A, Ledda-Columbano GM, Sanna L, Deidda M, Diana A, et al. Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells. Apoptosis 2007; 12: 113-23. (Pubitemid 46009508)
15. Reinecke F, Levanets O, Olivier Y, Louw R, Semete B, Grobler A, et al. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. Biochem J 2006; 395: 405-15.
16. Kang YH, Lee E, Choi MK, Ku JL, Kim SH, Park YG, et al. Role of reactive oxygen species in the induction of apoptosis by alpha-toco-pheryl succinate. Int J Cancer 2004; 112: 385-92. (Pubitemid 39390601)
17. Yang J, Wu JN, Tashiro S, Onodera S, Ikejima T. Critical roles of reactive oxygen species in mitochondrial permeability transition in mediating evodiamine-induced human melanoma A375-S2 cell apoptosis. Free Radic Res 2007; 41: 1099-108. (Pubitemid 47470847)
18. Kiffin R, Bandyopadhyay U, Cuervo AM. Oxidative stress and autophagy. Antioxid Redox Signal 2006; 8: 152-62. (Pubitemid 43324542)
19. Kaushik S, Cuervo AM. Autophagy as a cell-repair mechanism: activation of chaperone-mediated autophagy during oxidative stress. Mol Aspects Med 2006; 27: 444-54. (Pubitemid 44472625)
20. Osawa K, Yasuda H, Maruyama T, Morita H, Takeya K. Antibacteria trichorabdal diterpenes from Rabdosia trichocarpa. Phytochemistry 1994; 36: 1287-91. (Pubitemid 2118500)
21. Han QB, Li ML, Li SH, Mou YK, Lin ZW, Sun HD. Ent-kaurane diterpenoids from Isodon rubescens var lushanensis. Chem Pharm Bull 2003; 51: 790-3.
22. Zhang YH, Wu YL, Tashiro S, Onodera S, Ikejima T. Involvment of PKC signal pathway in oridonin-induced autophagy in HeLa cells: a pro tective mechanism against apoptosis. Biochem Biophys Res Commun 2009; 378: 273-8.
23. Wu JN, Huang J, Yang J, Tashiro S, Onodera S, Ikejima T. Caspase inhibi tion augmented oridonin-induced cell death in murine fibrosarcoma L929 by enhancing reactive oxygen species generation. J Pharmacol Sci 2008; 108: 32-9.
24. Huang J, Wu JN, Tashiro S, Onodera S, Ikejima T. Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. J Pharmacol Sci 2008; 107: 370-9.
25. Jarrett SG, Albon J, Boulton M. The contribution of DNA repair and anti oxidants in determining cell type-specific resistance to oxidative stress. Free Radic Res 2006; 40: 1155-65. (Pubitemid 44490156)
26. Li LH, Wu LJ, Zhou B, Wu Z, Tashiro S, Onodera S, et al. Silymarin prevents UV irradiation-induced A375-S2 cell apoptosis. Biol Pharm Bull 2004; 27: 1031-6. (Pubitemid 41701754)
27. Biederbick A, Kern HF, Elsasser HP. Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol 1995; 66: 3-14.
28. Yang ML, Huang TS, Lee Y, Lu FJ. Free radical scavenging properties of sulfinpyrazone. Free Radic Res 2002; 36: 685-93. (Pubitemid 34567342)
29. Venkataraman S, Wagner BA, Jiang X, Wang HP, Schafer FQ, Ritchie JM, et al. Overexpression of manganese superoxide dis mutase promotes the survival of prostate cancer cells exposed to hyper thermia. Free Radic Res 2004; 38: 1119-32. (Pubitemid 39504348)
30. Zhang YH, Wu YL, Cheng Y, Zhao ZK, Tashiro S, Onodera S, et al. Fasmediated autophagy requires JNK activation in HeLa cells. Biochem Bio phys Res Commun 2008; 377: 1205-10.
31. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, et al. The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy. Biochim Bio phys Acta 1998; 1366: 177-96. (Pubitemid 28467031)
32. Liu ZH, Lenardo MJ. Reactive oxygen species regulate autophagy through redox-sensitive proteases. Dev Cell 2007; 12: 484-5. (Pubitemid 46523650)
33. Wang W, Xiong W, Wan J, Sun X, Xu H, Yang X. The decrease of PAMAM dendrimer-induced cytotoxicity by PEGylation via attenuation of oxida tive stress. Nanotechnology 2009; 20: 105103.
34. Gao J, Zhu ZR, Ding HQ, Qian Z, Zhu L, Ke Y. Vulnerability of neurons with mitochondrial dysfunction to oxidative stress is associated with down-regulation of thioredoxin. Neurochem Int 2007; 50: 379-85. (Pubitemid 46110920)
35. Tsujimoto Y. Role of Bcl-2 family proteins in apoptosis: apoptosomes and mitochondrial. Genes Cell 1998; 3: 697-707. (Pubitemid 29038090)
36. Rosati E, Sabatini R, Ayroldi E, Tabilio A, Bartoli A, Bruscoli S, et al. Apoptosis of human primary B lymphocytes is inhibited by N-acetyl-L-cysteine. J Leukoc Biol 2004; 76: 152-61. (Pubitemid 38857182)
37. Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007; 26: 1749-60. (Pubitemid 46624042)