Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231

Molecular and Cellular Biochemistry

Volumn 363, Issue 1-2, 2012, Pages 119-128

  Choi, Youn Kyung ^a   Seo, Hye Sook ^a   Choi, Han Seok ^a   Choi, Hyeong Sim ^a   Kim, Soon Re ^a   Shin, Yong Cheol ^a   Ko, Seong Gyu ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Apoptosis; Breast cancer; Cell cycle; Costunolide; p21WAF1; ROS

Indexed keywords

CASPASE 3; CASPASE 8; COSTUNOLIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1; ESTROGEN RECEPTOR; FAS LIGAND; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL GROWTH; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME BINDING; ENZYME DEGRADATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; PROTEIN STABILITY;

ANTIGENS, CD95; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BREAST NEOPLASMS; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN B; CYCLIN B1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; RECEPTORS, ESTROGEN; SESQUITERPENES; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84857909839     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-1164-z     Document Type: Article

References (38)

1. Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LA, Schrag D, Jamison PM, Jemal A, Wu XC, Friedman C, Harlan L, Warren J, Anderson RN, Pickle LW (2005) Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 97:1407-1427 (Pubitemid 41520077)
2. Park S, Bae J, Nam BH, Yoo KY (2008) Aetiology of cancer in Asia. Asian Pac J Cancer Prev 9:371-380
3. Ziegler RG, Anderson WF, Gail MH (2008) Increasing breast cancer incidence in China: the numbers add up. J Natl Cancer Inst 100:1339-1341
4. Devasagayam TP, Tilak JC, Boloor KK, Sane KS, Ghaskadbi SS, Lele RD (2004) Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India 52:794-804 (Pubitemid 41279997)
5. Michieli P, Chedid M, Lin D, Pierce JH, Mercer WE, Givol D (1994) Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res 54:3391-3395 (Pubitemid 24225956)
6. Hetz CA, Torres V, Quest AF (2005) Beyond apoptosis: nonapoptotic cell death in physiology and disease. Biochem Cell Biol 83:579-588 (Pubitemid 41812835)
7. Konopleva M, Zhao S, Xie Z, Segall H, Younes A, Claxton DF, Estrov Z, Kornblau SM, Andreeff M (1999) Apoptosis. Molecules and mechanisms. Adv Exp Med Biol 457:217-236
8. Waring P, Mullbacher A (1999) Cell death induced by the Fas/Fas ligand pathway and its role in pathology. Immunol Cell Biol 77:312-317 (Pubitemid 29370101)
9. Martinou JC, Green DR (2001) Breaking the mitochondrial barrier. Natl Rev Mol Cell Biol 2:63-67
10. Wang X (2001) The expanding role of mitochondria in apoptosis. Genes Dev 15:2922-2933
11. Thornberry NA, Lazebnik Y (1998) Caspases: enemies within. Science 281:1312-1316 (Pubitemid 28406817)
12. Reed JC (1997) Cytochrome c: can't live with it-can't live without it. Cell 91:559-562
13. Gupta S (2003) Molecular signaling in death receptor and mitochondrial pathways of apoptosis (Review). Int J Oncol 22:15-20
14. Lopez-Saez JF, de la Torre C, Pincheira J, Gimenez-Martin G (1998) Cell proliferation and cancer. Histol Histopathol 13:1197-1214 (Pubitemid 28480375)
15. Cox LS, Lane DP (1995) Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. Bioessays 17:501-508
16. Nasmyth K (1996) Viewpoint: putting the cell cycle in order. Science 274:1643-1645
17. Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S (2004) Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 73:39-85 (Pubitemid 39050363)
18. Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB (2007) p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 11:175-189 (Pubitemid 46209849)
19. Bartek J, Lukas J (2003) Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 3:421-429 (Pubitemid 38340288)
20. Tyagi A, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R (2005) Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis 26:1978-1987 (Pubitemid 41631273)
21. Kuo PL, Hsu YL, Cho CY (2006) Plumbagin induces G2-M arrest and autophagy by inhibiting the AKT/mammalian target of rapamycin pathway in breast cancer cells. Mol Cancer Ther 5:3209-3221
22. Taylor WR, Stark GR (2001) Regulation of the G2/M transition by p53. Oncogene 20:1803-1815 (Pubitemid 32458690)
23. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP, Sedivy JM, Kinzler KW, Vogelstein B (1998) Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 282:1497-1501 (Pubitemid 28538613)
24. Smits VA, Klompmaker R, Vallenius T, Rijksen G, Makela TP, Medema RH (2000) p21 inhibits Thr161 phosphorylation of Cdc2 to enforce the G2 DNA damage checkpoint. J Biol Chem 275:30638-30643
25. Robinson A, Kumar TV, Sreedhar E, Naidu VG, Krishna SR, Babu KS, Srinivas PV, Rao JM (2008) A new sesquiterpene lactone from the roots of Saussurea lappa: structure-anticancer activity study. Bioorg Med Chem Lett 18:4015-4017
26. Matsuda H, Shimoda H, Uemura T, Yoshikawa M (1999) Preventive effect of sesquiterpenes from bay leaf on blood ethanol elevation in ethanol-loaded rat: structure requirement and suppression of gastric emptying. Bioorg Med Chem Lett 9:2647-2652 (Pubitemid 29468927)
27. Kassuya CA, Cremoneze A, Barros LF, Simas AS, Lapa Fda R, Mello-Silva R, Stefanello ME, Zampronio AR (2009) Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae). J Ethnopharmacol 124:369-376
28. Chen HC, Chou CK, Lee SD, Wang JC, Yeh SF (1995) Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. Antiviral Res 27:99-109
29. Wedge DE, Galindo JC, Macias FA (2000) Fungicidal activity of natural and synthetic sesquiterpene lactone analogs. Phytochemistry 53:747-757 (Pubitemid 30194183)
30. Choi JH, Lee KT (2009) Costunolide-induced apoptosis in human leukemia cells: involvement of c-jun N-terminal kinase activation. Biol Pharm Bull 32:1803-1808
31. Kanno S, Kitajima Y, Kakuta M, Osanai Y, Kurauchi K, Ujibe M, Ishikawa M (2008) Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells. Biol Pharm Bull 31:1024-1028 (Pubitemid 351731990)
32. Jeong SJ, Itokawa T, Shibuya M, Kuwano M, Ono M, Higuchi R, Miyamoto T (2002) Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway. Cancer Lett 187:129-133 (Pubitemid 35279341)
33. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776
34. Degterev A, Yuan J (2008) Expansion and evolution of cell death programmes. Natl Rev Mol Cell Biol 9:378-390 (Pubitemid 351574200)
35. Schulze-Osthoff K, Ferrari D, Los M, Wesselborg S, Peter ME (1998) Apoptosis signaling by death receptors. Eur J Biochem 254:439-459 (Pubitemid 28308094)
36. Micheau O, Tschopp J (2003) Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114:181-190 (Pubitemid 36936912)
37. Zou H, Li Y, Liu X, Wang X (1999) An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 274:11549-11556
38. De Souza CP, Ellem KA, Gabrielli BG (2000) Centrosomal and cytoplasmic Cdc2/cyclin B1 activation precedes nuclear mitotic events. Exp Cell Res 257:11-21 (Pubitemid 30324640)