Magnolol protects against oxidative stress-mediated neural cell damage by modulating mitochondrial dysfunction and PI3K/Akt signaling

Journal of Molecular Neuroscience

Volumn 50, Issue 3, 2013, Pages 469-481

  Dong, Liqun ^a,b   Zhou, Shu ^b   Yang, Xiaohua ^b   Chen, Qianming ^c   He, Yang ^a   Huang, Wen ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Magnolol; Neuroprotection; Oxidative stress; Reactive oxygen species

Indexed keywords

MAGNOLOL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; NERVE CELL LESION; NEUROBLASTOMA CELL; OXIDATIVE STRESS;

ACROLEIN; APOPTOSIS; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; LIGNANS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT;

MAGNOLIA OFFICINALIS;

EID: 84878896619     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-013-9964-0     Document Type: Article

References (43)

1. Adams JD, Klaidman LK (1993) Acrolein-induced oxygen radical formation. Free Radic Biol Med 15:187-193
2. Akagi M, Tada T, Shirono A, Fukuyama Y, Nakade K, Zhai H, Yasui Y, Akagi R (2004) Neuroprotective effect of magnolol in the hippocampus of senescence-accelerated mice (SAMP1). Int Congr Ser 1260:405-408
3. Ansari MA, Joshi G, Huang Q, Opii WO, Abdul HM, Sultana R, Butterfield DA (2006) In vivo administration of D609 leads to protection of subsequently isolated gerbil brain mitochondria subjected to in vitro oxidative stress induced by amyloid beta-peptide and other oxidative stressors: relevance to Alzheimer's disease and other oxidative stress-related neurodegenerative disorders. Free Radic Biol Med 41:1694-1703
4. 2 in vascular smooth muscle cells: potential involvement in vascular disease. Int J Mol Med 11:229-234
5. Borchers MT, Carty MP, Leikauf GD (1999) Regulation of human airway mucins by acrolein and inflammatory mediators. Am J Physiol 276:549-555
6. Bowen PE, Borthakur G (2004) Postprandial lipid oxidation and cardiovascular disease risk. Curr Atheroscler Rep 6:477-484
7. Canas N, Valero T, Villarroya M, Montell E, Verges J, Garcia AG, Lopez MG (2007) Chondroitin sulfate protects SH-SY5Y cells from oxidative stress by inducing heme oxygenase-1 via phosphatidylinositol 3-kinase/Akt. J Pharmacol Exp Ther 323:946-953
8. Chang CP, Hsu YC, Lin MT (2003) Magnolol protects against cerebral ischaemic injury of rat heatstroke. Clin Exp Pharmacol Physiol 30:387-392
9. Chauhan V, Chauhan A (2006) Oxidative stress in Alzheimer's disease. Pathophysiology 13:195-208
10. Fujita M, Itokawa H, Sashida Y (1972) Honokiol, a new phenolic compound isolated from the bark of Magnolia obovata Thunb. Chem Pharm Bull 20:212-213
11. Gunter TE, Pfeiffer DR (1990) Mechanisms by which mitochondria transport calcium. Am J Physiol 258:C755-C786
12. Hagen S, Clinton SB, Ruhi A, Jeremy PES, Roger FD, Catherine RE, Enrique C (2003) c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J 372:359-369
13. Haibo L, Jianmei G, Xixiang Y, ShuPeng W, Jianchun L (2007) Protective effect of magnolol on TBHP-induced injury in H460 cells partially via a p53 dependent mechanism. Arch Pharm Res (Seoul) 30:850-857
14. 2-induced injury through the PDK1/Akt pathway. Neurosci Lett 450:45-50
15. Jin Y, Kim K, Kim Y, Ha Y, Kim H, Yun U, Bae K, Kim Y, Kang S, Seo H, Lee J, Chang K (2008) Anti-apoptotic effect of magnolol in myocardial ischemia and reperfusion injury requires extracellular signal-regulated kinase1/2 pathways in rat in vivo. Exp Biol Med 233:1280-1288
16. 2 or 2,2-azobis-(2-amidinopropane) dihydrochloride by the glutathione mimetic tricyclodecan-9-yl-xanthogenate. Free Radic Biol Med 38:1023-1031
17. Kehrer JP, Biswal SS (2000) The molecular effects of acrolein. Toxicol Sci 57:6-15
18. Kutuk O, Basaga H (2007) Apoptosis signaling by 4-hydroxynonenal: a role for JNK-c-Jun/AP-1 pathway. Redox Rep 12:30-34
19. Lewitt PA (2000) New drugs for the treatment of Parkinson's disease. Pharmacotherapy 20:26S-32S
20. Li Z, Pan-Pan Y, Xia-Jing T, Zhang Y-D (2009) Protective effect of magnolol against hydrogen peroxide-induced oxidative stress in human lens epithelial cells. Am J Chin Med 37:785-796
21. Lin MH, Chao HT, Hong CY (1995) Magnolol protects human sperm motility against lipid peroxidation: a sperm head fixation method. Syst Biol Reprod Med 34:151-156
22. Liou JY, Chen YL, Loh SH, Chen PY, Hong CY, Chen J, Cheng TH, Liu JC (2009) Magnolol depresses urotensin-II-induced cell proliferation in rat cardiac fibroblasts. Clin Exp Pharmacol Physiol 36:711-716
23. Liu-Snyder P, McNally H, Shi R, Borgens RB (2006) Acrolein-mediated mechanisms of neuronal death. J Neurosci Res 84:209-218
24. Lo Y-C, Teng C-M, Chen C-F, Chen C-C, Hong C-Y (1994) Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation. Biochem Pharmacol 47:549-553
25. Long C, Lei L, Jun Y, Yan L, Shile H (2009) Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. Int J Biochem Cell Biol 41:1284-1295
26. Lovell MA, Xie C, Markesbery WR (2001) Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures. Neurobiol Aging 22:187-194
27. Luo J, Robinson JP, Shi R (2005) Acrolein-induced cell death in PC12 cells: role of mitochondria-mediated oxidative stress. Neurochem Int 47:449-457
28. Maiese K, Chong Z, Shang Y (2007) "Sly as a FOXO": new paths with Forkhead signaling in the brain. Curr Neurovasc Res 4:295-302
29. Marco T, Maria P, Dirk-Jan S, Harold G, Nicolas A, Antoon J, Rainer B, Henk F (2007) Cigarette smoke irreversibly modifies glutathione in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 293:L1156-L1162
30. Mohmmad AH, Butterfield DA (2007) Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-l-carnitine and α-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. Free Radic Biol Med 42:371-384
31. Nobuaki M, Kazuki T, Miho T, Touma K, Kaori N, Kana Y, Hideaki T, Kenichi T, Hideki O, Yuki K, Yumiko Y, Nobuyuki F, Yoshiyasu F, Masaaki A (2009) Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice. Brain Res 1305:108-117
32. Park CH, Kim MR, Han JM, Jeong TS, Sok DE (2009) Lysophosphatidylcholine exhibits selective cytotoxicity, accompanied by ROS formation, in RAW 264.7 macrophages. Lipids Health Dis 44:425-435
33. Perkinton M, Wood G, Crossthwaite A, Williams R (2002) Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2). Akt/PKB and CREB in striatal neurones. J Neurochem 80:239-254
34. Pocernich CB, Butterfield DA (2003) Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease. Neurotoxicol Res 5:515-520
35. Pocernich CB, Cardin AL, Racine CL, Lauderback CM, Butterfield DA (2001) Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease. Neurochem Int 39:141-149
36. Pugazhenthi S, Phansalkar K, Audesirk G, West A, Cabell L (2006) Differential regulation of c-Jun and CREB by acrolein and 4-hydroxynonenal. Free Radic Biol Med 40:21-34
37. Rajagopalan S, Kurz S, Munzel T, Tarpey M, Freeman BA, Griendling KK, Harrison DG (1996) Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. J Clin Invest 97:1916-1923
38. Ramassamy C (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur J Pharmacol 545:51-64
39. Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 106:207-212
40. Tsai TH, Chou CJ, Chen CF (1996) Pharmacokinetics and brain distribution of magnolol in the rat after intravenous bolus injection. J Pharm Pharmacol 48:57-59
41. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44-84
42. Yi-Rong C, Anju S, Tse-Hua T (2001) Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate. Oncogene Res 20:367-374
43. Zhao DL, Zou LB, Lin S, Shi JG, Zhu HB (2007) Anti-apoptotic effect of esculin on dopamine-induced cytotoxicity in the human neuroblastoma SH-SY5Y cell line. Neuropharmacology 53:724-732