메뉴 건너뛰기




Volumn 18, Issue 2, 2013, Pages 1418-1433

Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction

Author keywords

Apoptosis; Bladder cancer; Costunolide; Reactive oxygen species; T24 cells

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; COSTUNOLIDE; REACTIVE OXYGEN METABOLITE; SESQUITERPENE;

EID: 84874603246     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18021418     Document Type: Article
Times cited : (100)

References (60)
  • 1
    • 67349258581 scopus 로고    scopus 로고
    • The present and future burden of urinary bladder cancer in the world
    • Ploeg, M.; Aben, K.K.; Kiemeney, L.A. The present and future burden of urinary bladder cancer in the world. World J. Urol. 2009, 27, 289-293.
    • (2009) World J. Urol. , vol.27 , pp. 289-293
    • Ploeg, M.1    Aben, K.K.2    Kiemeney, L.A.3
  • 3
    • 33847349283 scopus 로고    scopus 로고
    • Reactive oxygen species: A breath of life or death?
    • DOI 10.1158/1078-0432.CCR-06-2082
    • Fruehauf, J.P.; Meyskens, F.L., Jr. Reactive oxygen species: A breath of life or death? Clin. Cancer Res. 2007, 13, 789-794. (Pubitemid 46340350)
    • (2007) Clinical Cancer Research , vol.13 , Issue.3 , pp. 789-794
    • Fruehauf, J.P.1    Meyskens Jr., F.L.2
  • 4
    • 33748165596 scopus 로고    scopus 로고
    • Reactive oxygen species in cancer cells: Live by the sword, die by the sword
    • DOI 10.1016/j.ccr.2006.08.015, PII S1535610806002558
    • Schumacker, P.T. Reactive oxygen species in cancer cells: Live by the sword, die by the sword. Cancer Cell 2006, 10, 175-176. (Pubitemid 44311072)
    • (2006) Cancer Cell , vol.10 , Issue.3 , pp. 175-176
    • Schumacker, P.T.1
  • 6
    • 0035885243 scopus 로고    scopus 로고
    • Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-κB
    • DOI 10.1016/S0006-2952(01)00714-6, PII S0006295201007146
    • Koch, E.; Klaas, C.A.; Rungeler, P.; Castro, V.; Mora, G.; Vichnewski, W.; Merfort, I. Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-kappaB. Biochem. Pharmacol. 2001, 62, 795-801. (Pubitemid 32816998)
    • (2001) Biochemical Pharmacology , vol.62 , Issue.6 , pp. 795-801
    • Koch, E.1    Klaas, C.A.2    Rungeler, P.3    Castro, V.4    Mora, G.5    Vichnewski, W.6    Merfort, I.7
  • 7
    • 0029019899 scopus 로고
    • Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones
    • Robles, M.; Aregullin, M.; West, J.; Rodriguez, E. Recent studies on the zoopharmacognosy, pharmacology and neurotoxicology of sesquiterpene lactones. Planta Med. 1995, 61, 199-203.
    • (1995) Planta Med. , vol.61 , pp. 199-203
    • Robles, M.1    Aregullin, M.2    West, J.3    Rodriguez, E.4
  • 8
    • 0030445832 scopus 로고    scopus 로고
    • Syringin 4-O-β-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldii
    • DOI 10.1021/np960452i
    • Park, H.J.; Jung, W.T.; Basnet, P.; Kadota, S.; Namba, T. Syringin 4-O-beta-glucoside, a new phenylpropanoid glycoside, and costunolide, a nitric oxide synthase inhibitor, from the stem bark of Magnolia sieboldii. J. Nat. Prod. 1996, 59, 1128-1130. (Pubitemid 27026571)
    • (1996) Journal of Natural Products , vol.59 , Issue.12 , pp. 1128-1130
    • Park, H.-J.1    Jung, W.-T.2    Basnet, P.3    Kadota, S.4    Namba, T.5
  • 9
    • 0033987198 scopus 로고    scopus 로고
    • New sources and antifungal activity of sesquiterpene lactones
    • DOI 10.1016/S0367-326X(99)00122-7, PII S0367326X99001227
    • Barrero, A.F.; Oltra, J.E.; Alvarez, M.; Raslan, D.S.; Saude, D.A.; Akssira, M. New sources and antifungal activity of sesquiterpene lactones. Fitoterapia 2000, 71, 60-64. (Pubitemid 30012019)
    • (2000) Fitoterapia , vol.71 , Issue.1 , pp. 60-64
    • Barrero, A.F.1    Oltra, J.E.2    Alvarez, M.3    Raslan, D.S.4    Saude, D.A.5    Akssira, M.6
  • 10
    • 0034615908 scopus 로고    scopus 로고
    • Fungicidal activity of natural and synthetic sesquiterpene lactone analogs
    • DOI 10.1016/S0031-9422(00)00008-X, PII S003194220000008X
    • Wedge, D.E.; Galindo, J.C.; Macias, F.A. Fungicidal activity of natural and synthetic sesquiterpene lactone analogs. Phytochemistry 2000, 53, 747-757. (Pubitemid 30194183)
    • (2000) Phytochemistry , vol.53 , Issue.7 , pp. 747-757
    • Wedge, D.E.1    Galindo, J.C.G.2    Macias, F.A.3
  • 11
    • 0029073836 scopus 로고
    • Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells
    • Chen, H.C.; Chou, C.K.; Lee, S.D.; Wang, J.C.; Yeh, S.F. Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. Antiviral Res. 1995, 27, 99-109.
    • (1995) Antiviral Res. , vol.27 , pp. 99-109
    • Chen, H.C.1    Chou, C.K.2    Lee, S.D.3    Wang, J.C.4    Yeh, S.F.5
  • 13
    • 0035836074 scopus 로고    scopus 로고
    • Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1
    • DOI 10.1016/S0304-3835(00)00704-7, PII S0304383500007047
    • Fukuda, K.; Akao, S.; Ohno, Y.; Yamashita, K.; Fujiwara, H. Inhibition by costunolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1. Cancer Lett. 2001, 164, 7-13. (Pubitemid 32144984)
    • (2001) Cancer Letters , vol.164 , Issue.1 , pp. 7-13
    • Fukuda, K.1    Akao, S.2    Ohno, Y.3    Yamashita, K.4    Fujiwara, H.5
  • 14
    • 0035084149 scopus 로고    scopus 로고
    • A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting i kappa B phosphorylation
    • Koo, T.H.; Lee, J.H.; Park, Y.J.; Hong, Y.S.; Kim, H.S.; Kim, K.W.; Lee, J.J. A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation. Planta Med. 2001, 67, 103-107.
    • (2001) Planta Med. , vol.67 , pp. 103-107
    • Koo, T.H.1    Lee, J.H.2    Park, Y.J.3    Hong, Y.S.4    Kim, H.S.5    Kim, K.W.6    Lee, J.J.7
  • 16
    • 57349129039 scopus 로고    scopus 로고
    • Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds
    • Kim, S.H.; Danilenko, M.; Kim, T.S. Differential enhancement of leukaemia cell differentiation without elevation of intracellular calcium by plant-derived sesquiterpene lactone compounds. Br. J. Pharmcol. 2008, 155, 814-825.
    • (2008) Br. J. Pharmcol. , vol.155 , pp. 814-825
    • Kim, S.H.1    Danilenko, M.2    Kim, T.S.3
  • 17
    • 0037107596 scopus 로고    scopus 로고
    • 3-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone
    • DOI 10.1016/S0006-2952(02)01292-3, PII S0006295202012923
    • Kim, S.H.; Kang, S.N.; Kim, H.J.; Kim, T.S. Potentiation of 1,25-dihydroxyvitamin D(3)-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone. Biochem. Pharmacol. 2002, 64, 1233-1242. (Pubitemid 35257918)
    • (2002) Biochemical Pharmacology , vol.64 , Issue.8 , pp. 1233-1242
    • Kim, S.H.1    Kang, S.N.2    Kim, H.J.3    Kim, T.S.4
  • 18
    • 84863786716 scopus 로고    scopus 로고
    • Costunolide: A novel anti-cancer sesquiterpene lactone
    • Rasul, A.; Parveen, S.; Ma, T. Costunolide: A novel anti-cancer sesquiterpene lactone. Bangladesh J. Pharmacol. 2012, 7, 6-13.
    • (2012) Bangladesh J. Pharmacol. , vol.7 , pp. 6-13
    • Rasul, A.1    Parveen, S.2    Ma, T.3
  • 19
    • 44349171180 scopus 로고    scopus 로고
    • Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells
    • DOI 10.1248/bpb.31.1024
    • Kanno, S.; Kitajima, Y.; Kakuta, M.; Osanai, Y.; Kurauchi, K.; Ujibe, M.; Ishikawa, M. Costunolide-induced apoptosis is caused by receptor-mediated pathway and inhibition of telomerase activity in NALM-6 cells. Biol. Pharm. Bull. 2008, 31, 1024-1028. (Pubitemid 351731990)
    • (2008) Biological and Pharmaceutical Bulletin , vol.31 , Issue.5 , pp. 1024-1028
    • Kanno, S.-I.1    Kitajima, Y.2    Kakuta, M.3    Osanai, Y.4    Kurauchi, K.5    Ujibe, M.6    Ishikawa, M.7
  • 20
    • 0028038184 scopus 로고
    • Chemopreventive effect of costunolide, a constituent of oriental medicine, on azoxymethane-induced intestinal carcinogenesis in rats
    • DOI 10.1016/0304-3835(94)90315-8
    • Mori, H.; Kawamori, T.; Tanaka, T.; Ohnishi, M.; Yamahara, J. Chemopreventive effect of costunolide, a constituent of oriental medicine, on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett. 1994, 83, 171-175. (Pubitemid 24253534)
    • (1994) Cancer Letters , vol.83 , Issue.1-2 , pp. 171-175
    • Mori, H.1    Kawamori, T.2    Tanaka, T.3    Ohnishi, M.4    Yamahara, J.5
  • 21
    • 0346024017 scopus 로고    scopus 로고
    • A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells
    • DOI 10.1016/j.cbi.2003.10.008
    • Bocca, C.; Gabriel, L.; Bozzo, F.; Miglietta, A. A sesquiterpene lactone, costunolide, interacts with microtubule protein and inhibits the growth of MCF-7 cells. Chem. Biol. Interact. 2004, 147, 79-86. (Pubitemid 38076851)
    • (2004) Chemico-Biological Interactions , vol.147 , Issue.1 , pp. 79-86
    • Bocca, C.1    Gabriel, L.2    Bozzo, F.3    Miglietta, A.4
  • 22
    • 23844486024 scopus 로고    scopus 로고
    • Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells
    • DOI 10.1016/j.canlet.2005.01.011, PII S0304383505000637
    • Choi, S.H.; Im, E.; Kang, H.K.; Lee, J.H.; Kwak, H.S.; Bae, Y.T.; Park, H.J.; Kim, N.D. Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett. 2005, 227, 153-162. (Pubitemid 41169928)
    • (2005) Cancer Letters , vol.227 , Issue.2 , pp. 153-162
    • Choi, S.-H.1    Im, E.2    Kang, H.K.3    Lee, J.-H.4    Kwak, H.-S.5    Bae, Y.-T.6    Park, H.-J.7    Kim, N.D.8
  • 24
    • 0029119740 scopus 로고
    • Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs)
    • Grana, X.; Reddy, E.P. Cell cycle control in mammalian cells: Role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 1995, 11, 211-219.
    • (1995) Oncogene , vol.11 , pp. 211-219
    • Grana, X.1    Reddy, E.P.2
  • 25
    • 0028927179 scopus 로고
    • P53, cell cycle control and apoptosis: Implications for cancer
    • Kastan, M.B.; Canman, C.E.; Leonard, C.J. P53, cell cycle control and apoptosis: implications for cancer. Cancer Metastasis Rev. 1995, 14, 3-15.
    • (1995) Cancer Metastasis Rev. , vol.14 , pp. 3-15
    • Kastan, M.B.1    Canman, C.E.2    Leonard, C.J.3
  • 26
    • 0033574614 scopus 로고    scopus 로고
    • Mechanisms of cyclin-dependent kinase regulation: Structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors
    • DOI 10.1006/jmbi.1999.2640
    • Pavletich, N.P. Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors. J. Mol. Biol. 1999, 287, 821-828. (Pubitemid 29188868)
    • (1999) Journal of Molecular Biology , vol.287 , Issue.5 , pp. 821-828
    • Pavletich, N.P.1
  • 27
    • 79953799722 scopus 로고    scopus 로고
    • Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer
    • Hsu, J.L.; Pan, S.L.; Ho, Y.F.; Hwang, T.L.; Kung, F.L.; Guh, J.H. Costunolide induces apoptosis through nuclear calcium2+ overload and DNA damage response in human prostate cancer. J. Urol. 2011, 185, 1967-1974.
    • (2011) J. Urol. , vol.185 , pp. 1967-1974
    • Hsu, J.L.1    Pan, S.L.2    Ho, Y.F.3    Hwang, T.L.4    Kung, F.L.5    Guh, J.H.6
  • 28
    • 84863808834 scopus 로고    scopus 로고
    • Costunolide a sesquiterpene lactone induces G2/M phase arrest and mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells
    • Rasul, A.; Yu, B.; Yang, L.; Arshad, M.; Khan, M.; Ma, T.; Yang, H. Costunolide, a sesquiterpene lactone induces G2/M phase arrest and mitochondria-mediated apoptosis in human gastric adenocarcinoma SGC-7901 cells. J. Med. Plant. Res. 2012, 6, 1191-1200.
    • (2012) J. Med. Plant. Res. , vol.6 , pp. 1191-1200
    • Rasul, A.1    Yu, B.2    Yang, L.3    Arshad, M.4    Khan, M.5    Ma, T.6    Yang, H.7
  • 29
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: From caspases to alternative mechanisms
    • DOI 10.1038/35085008
    • Leist, M.; Jaattela, M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell. Biol. 2001, 2, 589-598. (Pubitemid 33674010)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.8 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 30
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • DOI 10.1080/01926230701320337, PII 779478428
    • Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516. (Pubitemid 46911891)
    • (2007) Toxicologic Pathology , vol.35 , Issue.4 , pp. 495-516
    • Elmore, S.1
  • 31
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner, M.O. The biochemistry of apoptosis. Nature 2000, 407, 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 32
    • 33644832665 scopus 로고    scopus 로고
    • Defects of the apoptotic pathway as therapeutic target against cancer
    • DOI 10.1016/j.drup.2005.11.001, PII S1368764605000993
    • Mashima, T.; Tsuruo, T. Defects of the apoptotic pathway as therapeutic target against cancer. Drug Resist. Updat. 2005, 8, 339-343. (Pubitemid 43358057)
    • (2005) Drug Resistance Updates , vol.8 , Issue.6 , pp. 339-343
    • Mashima, T.1    Tsuruo, T.2
  • 33
    • 2442464889 scopus 로고    scopus 로고
    • Apoptosis defects and chemotherapy resistance: Molecular interaction maps and networks
    • DOI 10.1038/sj.onc.1207515
    • Pommier, Y.; Sordet, O.; Antony, S.; Hayward, R.L.; Kohn, K.W. Apoptosis defects and chemotherapy resistance: Molecular interaction maps and networks. Oncogene 2004, 23, 2934-2949. (Pubitemid 38638854)
    • (2004) Oncogene , vol.23 , pp. 2934-2949
    • Pommier, Y.1    Sordet, O.2    Antony, S.3    Hayward, R.L.4    Kohn, K.W.5
  • 34
    • 77955933845 scopus 로고    scopus 로고
    • Evasion of apoptosis as a cellular stress response in cancer
    • Fulda, S. Evasion of apoptosis as a cellular stress response in cancer. Int. J. Cell Biol. 2010, 2010, 370835.
    • (2010) Int. J. Cell Biol. , vol.2010 , pp. 370835
    • Fulda, S.1
  • 35
    • 0042318707 scopus 로고    scopus 로고
    • Apoptosis-an introduction
    • Lawen, A. Apoptosis-an introduction. Bioessays 2003, 25, 888-896.
    • (2003) Bioessays , vol.25 , pp. 888-896
    • Lawen, A.1
  • 36
    • 0036463649 scopus 로고    scopus 로고
    • Apoptosis-based therapies
    • DOI 10.1038/nrd726
    • Reed, J.C. Apoptosis-based therapies. Nat. Rev. Drug Discov. 2002, 1, 111-121. (Pubitemid 41646518)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.2 , pp. 111-121
    • Reed, J.C.1
  • 37
    • 84868126155 scopus 로고    scopus 로고
    • Dracorhodin perchlorate inhibits PI3K/Akt and NF-kappaB activation, up-regulates the expression of p53, and enhances apoptosis
    • Rasul, A.; Ding, C.; Li, X.; Khan, M.; Yi, F.; Ali, M.; Ma, T. Dracorhodin perchlorate inhibits PI3K/Akt and NF-kappaB activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis 2012, 17, 1104-1119.
    • (2012) Apoptosis , vol.17 , pp. 1104-1119
    • Rasul, A.1    Ding, C.2    Li, X.3    Khan, M.4    Yi, F.5    Ali, M.6    Ma, T.7
  • 38
    • 84874598090 scopus 로고    scopus 로고
    • In vitro cytotoxic screening of 300 selected Chinese medicinal herbs against human gastric adenocarcinoma SGC-7901 cells
    • Rasul, A.; Ma, T. In vitro cytotoxic screening of 300 selected Chinese medicinal herbs against human gastric adenocarcinoma SGC-7901 cells. Afr. J. Pharm. Pharmacol. 2012, 6, 592-600.
    • (2012) Afr. J. Pharm. Pharmacol. , vol.6 , pp. 592-600
    • Rasul, A.1    Ma, T.2
  • 39
    • 84863337524 scopus 로고    scopus 로고
    • Magnolol a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways
    • Rasul, A.; Yu, B.; Khan, M.; Zhang, K.; Iqbal, F.; Ma, T.; Yang, H. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int. J. Oncol. 2012, 40, 1153-1161.
    • (2012) Int. J. Oncol. , vol.40 , pp. 1153-1161
    • Rasul, A.1    Yu, B.2    Khan, M.3    Zhang, K.4    Iqbal, F.5    Ma, T.6    Yang, H.7
  • 40
    • 84863252809 scopus 로고    scopus 로고
    • Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy
    • Rasul, A.; Yu, B.; Zhong, L.; Khan, M.; Yang, H.; Ma, T. Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. Oncol. Rep. 2012, 27, 1481-1487.
    • (2012) Oncol. Rep. , vol.27 , pp. 1481-1487
    • Rasul, A.1    Yu, B.2    Zhong, L.3    Khan, M.4    Yang, H.5    Ma, T.6
  • 42
    • 0035080282 scopus 로고    scopus 로고
    • Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release
    • Lee, M.G.; Lee, K.T.; Chi, S.G.; Park, J.H. Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. Biol. Pharm. Bull. 2001, 24, 303-306.
    • (2001) Biol. Pharm. Bull. , vol.24 , pp. 303-306
    • Lee, M.G.1    Lee, K.T.2    Chi, S.G.3    Park, J.H.4
  • 45
    • 0030982120 scopus 로고    scopus 로고
    • The role of reactive oxygen species in mitochondrial permeability transition
    • DOI 10.1023/A:1027335217774
    • Vercesi, A.E.; Kowaltowski, A.J.; Grijalba, M.T.; Meinicke, A.R.; Castilho, R.F. The role of reactive oxygen species in mitochondrial permeability transition. Biosci. Rep. 1997, 17, 43-52. (Pubitemid 27267591)
    • (1997) Bioscience Reports , vol.17 , Issue.1 , pp. 43-52
    • Vercesi, A.E.1    Kowaltowski, A.J.2    Grijalba, M.T.3    Meinicke, A.R.4    Castilho, R.F.5
  • 46
    • 0346123227 scopus 로고    scopus 로고
    • Adaptation of the dichlorofluorescein assay for detection of radiation-induced oxidative stress in cultured cells
    • DOI 10.1667/3099
    • Wan, X.S.; Zhou, Z.; Kennedy, A.R. Adaptation of the dichlorofluorescein assay for detection of radiation-induced oxidative stress in cultured cells. Radiat. Res. 2003, 160, 622-630. (Pubitemid 37521704)
    • (2003) Radiation Research , vol.160 , Issue.6 , pp. 622-630
    • Wan, X.S.1    Zhou, Z.2    Kennedy, A.R.3
  • 47
    • 77954071961 scopus 로고    scopus 로고
    • Induction of G (2)/M phase arrest and apoptosis by oridonin in human laryngeal carcinoma cells
    • Kang, N.; Zhang, J.H.; Qiu, F.; Chen, S.; Tashiro, S.; Onodera, S.; Ikejima, T. Induction of G(2)/M phase arrest and apoptosis by oridonin in human laryngeal carcinoma cells. J. Nat. Prod. 73, 1058-1063.
    • J. Nat. Prod. , vol.73 , pp. 1058-1063
    • Kang, N.1    Zhang, J.H.2    Qiu, F.3    Chen, S.4    Tashiro, S.5    Onodera, S.6    Ikejima, T.7
  • 48
    • 34548247761 scopus 로고    scopus 로고
    • Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
    • DOI 10.1016/j.bbcan.2007.07.001, PII S0304419X07000212
    • Buytaert, E.; Dewaele, M.; Agostinis, P. Molecular effectors of multiple cell death pathways initiated by photodynamic therapy. Biochim. Biophys. Acta 2007, 1776, 86-107. (Pubitemid 47332075)
    • (2007) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1776 , Issue.1 , pp. 86-107
    • Buytaert, E.1    Dewaele, M.2    Agostinis, P.3
  • 49
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • Wang, X. The expanding role of mitochondria in apoptosis. Genes Dev. 2001, 15, 2922-2933. (Pubitemid 33078942)
    • (2001) Genes and Development , vol.15 , Issue.22 , pp. 2922-2933
    • Wang, X.1
  • 50
    • 0033935921 scopus 로고    scopus 로고
    • Apoptosis in the vasculature: Mechanisms and functional importance
    • Mallat, Z.; Tedgui, A. Apoptosis in the vasculature: mechanisms and functional importance. Br. J. Pharmacol. 2000, 130, 947-962. (Pubitemid 30453528)
    • (2000) British Journal of Pharmacology , vol.130 , Issue.5 , pp. 947-962
    • Mallat, Z.1    Tedgui, A.2
  • 51
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • DOI 10.1038/sj.onc.1210220, PII 1210220
    • Adams, J.M.; Cory, S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007, 26, 1324-1337. (Pubitemid 46328466)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 52
    • 0242522206 scopus 로고    scopus 로고
    • Regulation of apoptosis by Bcl-2 family proteins
    • Burlacu, A. Regulation of apoptosis by Bcl-2 family proteins. J. Cell. Mol. Med. 2003, 7, 249-257. (Pubitemid 37372044)
    • (2003) Journal of Cellular and Molecular Medicine , vol.7 , Issue.3 , pp. 249-257
    • Burlacu, A.1
  • 53
    • 37549069901 scopus 로고    scopus 로고
    • BCL-2 family proteins: Critical checkpoints of apoptotic cell death
    • Danial, N.N. BCL-2 family proteins: Critical checkpoints of apoptotic cell death. Clin. Cancer Res. 2007, 13, 7254-7263.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 7254-7263
    • Danial, N.N.1
  • 54
    • 0035433438 scopus 로고    scopus 로고
    • Apoptosis- Inducing costunolide and a novel acyclic monoterpene from the stem bark of Magnolia sieboldii
    • Park, H.J.; Kwon, S.H.; Han, Y.N.; Choi, J.W.; Miyamoto, K.; Lee, S.H.; Lee, K.T. Apoptosis- Inducing costunolide and a novel acyclic monoterpene from the stem bark of Magnolia sieboldii. Arch. Pharm. Res. 2001, 24, 342-348.
    • (2001) Arch. Pharm. Res. , vol.24 , pp. 342-348
    • Park, H.J.1    Kwon, S.H.2    Han, Y.N.3    Choi, J.W.4    Miyamoto, K.5    Lee, S.H.6    Lee, K.T.7
  • 55
    • 0030931876 scopus 로고    scopus 로고
    • Caspases: The executioners of apoptosis
    • Cohen, G.M. Caspases: The executioners of apoptosis. Biochem. J. 1997, 326, 1-16. (Pubitemid 27386911)
    • (1997) Biochemical Journal , vol.326 , Issue.1 , pp. 1-16
    • Cohen, G.M.1
  • 56
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: Multiple pathways to apoptosis
    • DOI 10.1101/gad.1126903
    • Adams, J.M. Ways of dying: Multiple pathways to apoptosis. Genes Dev. 2003, 17, 2481-2495. (Pubitemid 37271417)
    • (2003) Genes and Development , vol.17 , Issue.20 , pp. 2481-2495
    • Adams, J.M.1
  • 58
    • 79959339899 scopus 로고    scopus 로고
    • Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells
    • Shawi, A.A.; Rasul, A.; Khan, M.; Iqbal, F.; Ma, T. Eupatilin: A flavonoid compound isolated from the artemisia plant, induces apoptosis and G2/M phase cell cycle arrest in human melanoma A375 cells. Afr. J. Pharm. Pharmacol. 2011, 5, 582-588.
    • (2011) Afr. J. Pharm. Pharmacol. , vol.5 , pp. 582-588
    • Shawi, A.A.1    Rasul, A.2    Khan, M.3    Iqbal, F.4    Ma, T.5
  • 59
    • 84863229144 scopus 로고    scopus 로고
    • Xanthoxyletin a coumarin induces s phase arrest and apoptosis in human gastric adenocarcinoma sgc-7901 cells
    • Rasul, A.; Khan, M.; Yu, B.; Ma, T.; Yang, H. Xanthoxyletin, a Coumarin Induces S Phase Arrest and Apoptosis in Human Gastric Adenocarcinoma SGC-7901 Cells. Asian Pac. J. Cancer Prev. 2011, 12, 1219-1223.
    • (2011) Asian Pac. J. Cancer Prev. , vol.12 , pp. 1219-1223
    • Rasul, A.1    Khan, M.2    Yu, B.3    Ma, T.4    Yang, H.5
  • 60
    • 84863238350 scopus 로고    scopus 로고
    • Induction of mitochondriamediated apoptosis in human gastric adenocarcinoma SGC-7901 cells by kuraridin and Norkurarinone isolated from Sophora flavescens
    • Rasul, A.; Yu, B.; Yang, L.F.; Ali, M.; Khan, M.; Ma, T.; Yang, H. Induction of mitochondriamediated apoptosis in human gastric adenocarcinoma SGC-7901 cells by kuraridin and Norkurarinone isolated from Sophora flavescens. Asian Pac. J. Cancer Prev. 2011, 12, 2499-2504.
    • (2011) Asian Pac. J. Cancer Prev. , vol.12 , pp. 2499-2504
    • Rasul, A.1    Yu, B.2    Yang, L.F.3    Ali, M.4    Khan, M.5    Ma, T.6    Yang, H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.