Suppression of NF-κB activity by parthenolide induces x-ray sensitivity through inhibition of split-dose repair in TP53 null prostate cancer Cells

Radiation Research

Volumn 171, Issue 4, 2009, Pages 389-396

  Watson, Christopher ^a   Miller, Douglas A ^a   Chin Sinex, Helen ^a   Losch, Adam ^a   Hughes, William ^a   Sweeney, Christopher ^a,b   Mendonca, Marc S ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PARTHENOLIDE; PROTEIN P53; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; NONSTEROID ANTIINFLAMMATORY AGENT; SESQUITERPENE; TP53 PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA;

ARTICLE; CANCER CELL; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL POPULATION; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIVITY; BIOLOGICAL MODEL; CELL CYCLE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; RADIATION RESPONSE; TUMOR CELL LINE; X RAY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL CYCLE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; MALE; MODELS, BIOLOGICAL; NF-KAPPA B; PROSTATIC NEOPLASMS; RADIATION TOLERANCE; RNA, SMALL INTERFERING; SESQUITERPENES; TRANSCRIPTION FACTOR RELA; TUMOR SUPPRESSOR PROTEIN P53; X-RAYS;

EID: 66149088525     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1394.1     Document Type: Article

References (30)

1. P. M. Bork, M. L. Schmitz, M. Kuhnt, C. Escher and M. Heinrich, Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-κB. FEBS Lett. 402, 85-90 (1997).
2. S. P. Hehner, M. Heinrich, P. M. Bork, M. Vogt, F. Ratter, V. Lehmann, K. Schulze-Osthoff, W. Droge and M. L. Schmitz, Sesquiterpene lactones specifically inhibit activation of NF-κB by preventing the degradation of IκB-α and IκB-β. J. Biol. Chem. 273, 1288-1297 (1998).
3. H. Nakshatri, P. Bhat-Nakshatri, D. A. Martin, R. J. Goulet, Jr. and G. W. Sledge, Jr., Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol. Cell. Biol. 17, 3629-3639 (1997).
4. M. Karin, Y. Cao, F. R. Greten and Z. W. Li, NF-κB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2, 301-310 (2002).
5. A. Arlt, A. Gehrz, S. Muerkoster, J. Vorndamm, M. L. Kruse, U. R. Folsch and H. Schafer, Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 22, 3243-3251 (2003).
6. C. Sweeney, L. Li, R. Shanmugam, P. Bhat-Nakshatri, V. Jayaprakasan, L. A. Baldridge, T. Gardner, M. Smith, H. Nakshatri and L. Cheng, Nuclear factor-κB is constitutively activated in prostate cancer in vitro and is overexpressed in prostatic intraepithelial neoplasia and adenocarcinoma of the prostate. Clin. Cancer Res. 10, 5501-5507 (2004).
7. H. J. Kim, N. Hawke and A. S. Baldwin, NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ. 13, 738-747 (2006).
8. T. Criswell, K. Leskov, S. Miyamoto, G. Luo and D. A. Boothman, Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene 22, 5813-5827 (2003).
9. M. Jung and A. Dritschilo, NF-κB signaling pathway as a target for human tumor radiosensitization. Semin. Radiat. Oncol. 11, 346-351 (2001).
10. Y. Habraken and J. Piette, NF-κB activation by double-strand breaks. Biochem. Pharmacol. 72, 1132-1141 (2006).
11. S. P. Hehner, T. G. Hofmann, W. Droge and M. L. Schmitz, The antiinflammatory sesquiterpene lactone parthenolide inhibits NF-κB by targeting the IκB kinase complex. J. Immunol. 163, 5617-5623 (1999).
12. S. Nozaki, G. W. Sledge, Jr. and H. Nakshatri, Repression of GADD153/CHOP by NF-κB: a possible cellular defense against endoplasmic reticulum stress-induced cell death. Oncogene 20, 2178-2185 (2001).
13. J. Wen, K. R. You, S. Y. Lee, C. H. Song and D. G. Kim, Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide. J. Biol. Chem. 277, 38954-38964 (2002).
14. A. J. Garcia-Pineres, M. T. Lindenmeyer and I. Merfort, Role of cysteine residues of p65/NF-κB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential. Life Sci. 75, 841-856 (2004).
15. R. Shanmugam, V. Jayaprakasan, Y. Gokmen-Polar, S. Kelich, K. D. Miller, M. Yip-Schneider, L. Cheng, P. Bhat-Nakshatri, G. W. Sledge, Jr. and C. J. Sweeney, Restoring chemotherapy and hormone therapy sensitivity by parthenolide in a xenograft hormone refractory prostate cancer model. Prostate 66, 1498-1511 (2006).
16. M. V. Pilepich, K. Winter, C. A. Lawton, R. E. Krisch, H. B. Wolkov, B. Movsas, E. B. Hug, S. O. Asbell and D. Grignon, Androgen suppression adjuvant to definitive radiotherapy in prostate carcinoma - long-term results of phase III RTOG 85-31. Int. J. Radiat. Oncol. Biol. Phys. 61, 1285-1290 (2005).
17. M. S. Mendonca, H. Chin-Sinex, J. Gomez-Millan, N. Datzman, M. Hardacre, K. Comerford, H. Nakshatri, M. Nye, L. Benjamin and C. Sweeney, Parthenolide sensitizes cells to X-ray-induced cell killing through inhibition of NF-κB and split-dose repair. Radiat. Res. 168, 689-697 (2007).
18. Y. Sun, D. K. St. Clair, F. Fang, G. W. Warren, V. M. Rangnekar, P. A. Crooks and W. H. St. Clair, The radiosensitization effect of parthenolide in prostate cancer cells is mediated by nuclear factor-κB inhibition and enhanced by the presence of PTEN. Mol. Cancer Ther. 6, 2477-2486 (2007).
19. C. J. Sweeney, S. Mehrotra, M. R. Sadaria, S. Kumar, N. H. Shortle, Y. Roman, C. Sheridan, R. A. Campbell, D. J. Murry and H. Nakshatri, The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer. Mol. Cancer Ther. 4, 1004-1012 (2005).
20. N. H. Nam, Naturally occurring NF-κB inhibitors. Mini Rev. Med. Chem. 6, 945-951 (2006).
21. M. S. Mendonca, B. M. Mayhugh, B. McDowell, H. Chin-Sinex, M. L. Smith, J. R. Dynlacht, D. F. Spandau and D. A. Lewis, A radiation-induced acute apoptosis involving TP53 and BAX precedes the delayed apoptosis and neoplastic transformation of CGL1 human hybrid cells. Radiat. Res. 163, 614-622 (2005).
22. M. S. Mendonca, L. A. Desmond, T. M. Temples, D. L. Farrington and B. M. Mayhugh, Loss of chromosome 14 increases the radio-sensitivity of CGL1 human hybrid cells but lowers their susceptibility to radiation-induced neoplastic transformation. Mutagenesis 15, 187-193 (2000).
23. S. T. Palayoor, M. Y. Youmell, S. K. Calderwood, C. N. Coleman and B. D. Price, Constitutive activation of IκB kinase alpha and NF-κB in prostate cancer cells is inhibited by ibuprofen. Oncogene 18, 7389-7394 (1999).
24. S. Cory and J. M. Adams, The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656 (2002).
25. D. R. Green, Apoptotic pathways: the roads to ruin. Cell 94, 695-698 (1998).
26. D. R. Green and J. C. Reed, Mitochondria and apoptosis. Science 281, 1309-1312 (1998).
27. E. S. Johnson, N. P. Kadam, D. M. Hylands and P. J. Hylands, Efficacy of feverfew as prophylactic treatment of migraine. Br. Med. J. 291, 569-573 (1985).
28. N. M. Patel, S. Nozaki, N. H. Shortle, P. Bhat-Nakshatri, T. R. Newton, S. Rice, V. Gelfanov, S. H. Boswell, R. J. Goulet, Jr. and H. Nakshatri, Paclitaxel sensitivity of breast cancer cells with constitutively active NF-κB is enhanced by Iκ-Bα super-repressor and parthenolide. Oncogene 19, 4159-4169 (2000).
29. N. Magne, R. A. Toillon, V. Bottero, C. Didelot, P. V. Houtte, J. P. Gerard and J. F. Peyron, NF-κB modulation and ionizing radiation: mechanisms and future directions for cancer treatment. Cancer Lett. 231, 158-168 (2006).
30. J. Parada-Turska, R. Paduch, M. Majdan, M. Kandefer-Szerszen and W. Rzeski, Antiproliferative activity of parthenolide against three human cancer cell lines and human umbilical vein endothelial cells. Pharmacol. Rep. 59, 233-237 (2007).