-
1
-
-
9644291539
-
IL-12 and IL-23: master regulators of innate and adaptive immunity
-
Langrish CL, McKenzie BS, Wilson NJ, et al. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 2004; 202: 96-105.
-
(2004)
Immunol Rev
, vol.202
, pp. 96-105
-
-
Langrish, C.L.1
McKenzie, B.S.2
Wilson, N.J.3
-
2
-
-
0035827347
-
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
-
Mullen AC, High FA, Hutchins AS, et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 2001; 292: 1907-10.
-
(2001)
Science
, vol.292
, pp. 1907-1910
-
-
Mullen, A.C.1
High, F.A.2
Hutchins, A.S.3
-
3
-
-
0034056441
-
Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice
-
Hans W, Scholmerich J, Gross V, Falk W. Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice. Eur Cytokine Netw 2000; 11: 67-74.
-
(2000)
Eur Cytokine Netw
, vol.11
, pp. 67-74
-
-
Hans, W.1
Scholmerich, J.2
Gross, V.3
Falk, W.4
-
4
-
-
0031066597
-
G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines
-
Hornquist CE, Lu X, Rogers-FaniPMet al. G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol 1997; 158: 1068-77.
-
(1997)
J Immunol
, vol.158
, pp. 1068-1077
-
-
Hornquist, C.E.1
Lu, X.2
Rogers-Fani, P.M.3
-
5
-
-
0031568001
-
Induction and prevention of colonic inflammation in IL-2-deficient mice
-
Ehrhardt RO, Ludviksson BR, Gray B, et al. Induction and prevention of colonic inflammation in IL-2-deficient mice. J Immunol 1997; 158: 566-73.
-
(1997)
J Immunol
, vol.158
, pp. 566-573
-
-
Ehrhardt, R.O.1
Ludviksson, B.R.2
Gray, B.3
-
6
-
-
0037121941
-
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumornecrosis factor-induced Crohn's-like inflammatory bowel disease
-
Kontoyiannis D, Boulougouris G,ManoloukosMet al. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumornecrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 2002; 196: 1563-74.
-
(2002)
J Exp Med
, vol.196
, pp. 1563-1574
-
-
Kontoyiannis, D.1
Boulougouris, G.2
Manoloukos, M.3
-
7
-
-
0036142235
-
Distinct inflammatory mechanisms mediate early versus late colitis in mice
-
Spencer DM, Veldman GM, Banerjee S, et al. Distinct inflammatory mechanisms mediate early versus late colitis in mice. Gastroenterology 2002; 122: 94-105.
-
(2002)
Gastroenterology
, vol.122
, pp. 94-105
-
-
Spencer, D.M.1
Veldman, G.M.2
Banerjee, S.3
-
8
-
-
0032425062
-
Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism
-
Kullberg MC, Ward JM, Gorelick PL, et al. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun 1998; 66: 5157-66.
-
(1998)
Infect Immun
, vol.66
, pp. 5157-5166
-
-
Kullberg, M.C.1
Ward, J.M.2
Gorelick, P.L.3
-
9
-
-
0032550312
-
T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells
-
Simpson SJ, Shah S, ComiskeyMet al. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 1998; 187: 1225-34.
-
(1998)
J Exp Med
, vol.187
, pp. 1225-1234
-
-
Simpson, S.J.1
Shah, S.2
Comiskey, M.3
-
10
-
-
15844396183
-
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
-
Thierfelder WE, van Deursen JM, Yamamoto K, et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996; 382: 171-4.
-
(1996)
Nature
, vol.382
, pp. 171-174
-
-
Thierfelder, W.E.1
van Deursen, J.M.2
Yamamoto, K.3
-
11
-
-
9644257195
-
Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4
-
Watford WT, Hissong BD, Bream JH, et al. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev 2004; 202: 139-56.
-
(2004)
Immunol Rev
, vol.202
, pp. 139-156
-
-
Watford, W.T.1
Hissong, B.D.2
Bream, J.H.3
-
12
-
-
0030995575
-
Interleukin-12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
-
Monteleone G, Biancone L, Marasco R, et al. Interleukin-12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997; 112: 1169-78.
-
(1997)
Gastroenterology
, vol.112
, pp. 1169-1178
-
-
Monteleone, G.1
Biancone, L.2
Marasco, R.3
-
13
-
-
8344284998
-
Anti-interleukin-12 antibody for active Crohn's disease
-
Mannon PJ, Fuss IJ,Mayer L, et al. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 2004; 351: 2069-79.
-
(2004)
N Engl J Med
, vol.351
, pp. 2069-2079
-
-
Mannon, P.J.1
Fuss, I.J.2
Mayer, L.3
-
14
-
-
53049091561
-
A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patientswith moderate-to-severeCrohn's disease
-
Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patientswith moderate-to-severeCrohn's disease. Gastroenterology 2008; 135: 1130-41.
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
-
15
-
-
47249089097
-
IL-1, IL-18 and IL-33 families of cytokines
-
Arend WP, Palmer G, Gabay C. IL-1, IL-18 and IL-33 families of cytokines. Immunol Rev 2008; 223: 20-38.
-
(2008)
Immunol Rev
, vol.223
, pp. 20-38
-
-
Arend, W.P.1
Palmer, G.2
Gabay, C.3
-
16
-
-
0032193770
-
IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells and B cells: synergism with IL-18 for IFN-gamma production
-
Yoshimoto T, Takeda K, Tanaka T, et al. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells and B cells: synergism with IL-18 for IFN-gamma production. J Immunol 1998; 161: 3400-7.
-
(1998)
J Immunol
, vol.161
, pp. 3400-3407
-
-
Yoshimoto, T.1
Takeda, K.2
Tanaka, T.3
-
18
-
-
0030933144
-
Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells
-
Yoshimoto T, Okamura H, Tagawa YI, et al. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells. Proc Natl Acad Sci USA 1997; 94: 3948-53.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 3948-3953
-
-
Yoshimoto, T.1
Okamura, H.2
Tagawa, Y.I.3
-
19
-
-
0036135586
-
Treatment of T celldependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA
-
Wirtz S, Becker C, Blumberg R, et al. Treatment of T celldependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA. J Immunol 2002; 168: 411-20.
-
(2002)
J Immunol
, vol.168
, pp. 411-420
-
-
Wirtz, S.1
Becker, C.2
Blumberg, R.3
-
20
-
-
0034800289
-
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease
-
Kanai T, Watanabe M, Okazawa A, et al. Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology 2001; 121: 875-88.
-
(2001)
Gastroenterology
, vol.121
, pp. 875-888
-
-
Kanai, T.1
Watanabe, M.2
Okazawa, A.3
-
21
-
-
0036103112
-
Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
-
Sivakumar PV, Westrich GM, Kanaly S, et al. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 2002; 50: 812-20.
-
(2002)
Gut
, vol.50
, pp. 812-820
-
-
Sivakumar, P.V.1
Westrich, G.M.2
Kanaly, S.3
-
22
-
-
0034653432
-
IFN-gamma-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12
-
Nakamura S, Otani T, Ijiri Y, et al. IFN-gamma-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12. J Immunol 2000; 164: 3330-6.
-
(2000)
J Immunol
, vol.164
, pp. 3330-3336
-
-
Nakamura, S.1
Otani, T.2
Ijiri, Y.3
-
23
-
-
0033152023
-
IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Cytokines and Chemokines in Mucosal Homeostasis 147 expression and localization in intestinal mucosal cells
-
Pizarro TT, Michie MH, Bentz M, et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Cytokines and Chemokines in Mucosal Homeostasis 147 expression and localization in intestinal mucosal cells. J Immunol 1999; 162: 6829-35.
-
(1999)
J Immunol
, vol.162
, pp. 6829-6835
-
-
Pizarro, T.T.1
Michie, M.H.2
Bentz, M.3
-
24
-
-
0033168120
-
Bioactive IL-18 expression is up-regulated in Crohn's disease
-
Monteleone G, Trapasso F, Parrello T, et al. Bioactive IL-18 expression is up-regulated in Crohn's disease. J Immunol 1999; 163: 143-7.
-
(1999)
J Immunol
, vol.163
, pp. 143-147
-
-
Monteleone, G.1
Trapasso, F.2
Parrello, T.3
-
25
-
-
57249089060
-
The role of interferon gamma in regulation of CD4+ T-cells and its clinical implications
-
Chen J, Liu X. The role of interferon gamma in regulation of CD4+ T-cells and its clinical implications. Cell Immunol 2009; 254: 85-90.
-
(2009)
Cell Immunol
, vol.254
, pp. 85-90
-
-
Chen, J.1
Liu, X.2
-
26
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-69.
-
(2000)
Cell
, vol.100
, pp. 655-669
-
-
Szabo, S.J.1
Kim, S.T.2
Costa, G.L.3
-
27
-
-
0141519112
-
IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells
-
Hibbert L, Pflanz S, De Waal Malefyt R, Kastelein RA. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res 2003; 23: 513-22.
-
(2003)
J Interferon Cytokine Res
, vol.23
, pp. 513-522
-
-
Hibbert, L.1
Pflanz, S.2
De Waal Malefyt, R.3
Kastelein, R.A.4
-
28
-
-
12344269852
-
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
-
Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 2005; 307: 430-3.
-
(2005)
Science
, vol.307
, pp. 430-433
-
-
Hwang, E.S.1
Szabo, S.J.2
Schwartzberg, P.L.3
Glimcher, L.H.4
-
29
-
-
34848841804
-
Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient inWiskott-Aldrich syndrome protein
-
Nguyen DD, Maillard MH, Cotta-de-Almeida V, et al. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient inWiskott-Aldrich syndrome protein. Gastroenterology 2007; 133: 1188-97.
-
(2007)
Gastroenterology
, vol.133
, pp. 1188-1197
-
-
Nguyen, D.D.1
Maillard, M.H.2
Cotta-de-Almeida, V.3
-
30
-
-
0029975876
-
Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease
-
Mizoguchi A, Mizoguchi E, Chiba C, et al. Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease. J Exp Med 1996; 183: 847-56.
-
(1996)
J Exp Med
, vol.183
, pp. 847-856
-
-
Mizoguchi, A.1
Mizoguchi, E.2
Chiba, C.3
-
31
-
-
0031736096
-
Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines
-
Dieleman LA, Palmen MJ, Akol H, et al. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol 1998; 114: 385-91.
-
(1998)
Clin Exp Immunol
, vol.114
, pp. 385-391
-
-
Dieleman, L.A.1
Palmen, M.J.2
Akol, H.3
-
32
-
-
0028179230
-
Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
-
Powrie F, Correa-Oliveira R, Mauze S, Coffman RL. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994; 179: 589-600.
-
(1994)
J Exp Med
, vol.179
, pp. 589-600
-
-
Powrie, F.1
Correa-Oliveira, R.2
Mauze, S.3
Coffman, R.L.4
-
33
-
-
0029813545
-
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
-
BergDJ, DavidsonN, KuhnRet al. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 1996; 98: 1010-20.
-
(1996)
J Clin Invest
, vol.98
, pp. 1010-1020
-
-
Berg, D.J.1
Davidson, N.2
Kuhn, R.3
-
34
-
-
33747089041
-
Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
-
Uhlig HH, McKenzie BS,Hue S, et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 2006; 25: 309-18.
-
(2006)
Immunity
, vol.25
, pp. 309-318
-
-
Uhlig, H.H.1
McKenzie, B.S.2
Hue, S.3
-
35
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath MF, Fuss I, Kelsall BL, et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995; 182: 1281-90.
-
(1995)
J Exp Med
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
-
36
-
-
0032707491
-
In vitro activated CD4+ T cells from interferon-gamma (IFN-gamma)- deficient mice induce intestinal inflammation in immunodeficient hosts
-
Bregenholt S, Brimnes J, Nissen MH, Claesson MH. In vitro activated CD4+ T cells from interferon-gamma (IFN-gamma)- deficient mice induce intestinal inflammation in immunodeficient hosts. Clin Exp Immunol 1999; 118: 228-34.
-
(1999)
Clin Exp Immunol
, vol.118
, pp. 228-234
-
-
Bregenholt, S.1
Brimnes, J.2
Nissen, M.H.3
Claesson, M.H.4
-
37
-
-
0025333699
-
Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
-
MacDonald TT, Hutchings P, Choy MY, et al. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol 1990; 81: 301-5.
-
(1990)
Clin Exp Immunol
, vol.81
, pp. 301-305
-
-
MacDonald, T.T.1
Hutchings, P.2
Choy, M.Y.3
-
38
-
-
0030209985
-
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease
-
Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996; 157: 1261-70.
-
(1996)
Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol
, vol.157
, pp. 1261-1270
-
-
Fuss, I.J.1
Neurath, M.2
Boirivant, M.3
-
39
-
-
0027441514
-
Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa
-
Breese E, Braegger CP, Corrigan CJ, et al. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993; 78: 127-31.
-
(1993)
Immunology
, vol.78
, pp. 127-131
-
-
Breese, E.1
Braegger, C.P.2
Corrigan, C.J.3
-
40
-
-
0028787818
-
Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease
-
Noguchi M, Hiwatashi N, Liu Z, Toyota T. Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease. J Gastroenterol 1995; 30 Suppl 8: 52-5.
-
(1995)
J Gastroenterol
, vol.30
, Issue.SUUPL 8
, pp. 52-55
-
-
Noguchi, M.1
Hiwatashi, N.2
Liu, Z.3
Toyota, T.4
-
41
-
-
0034164544
-
Interleukin-10 expression in intestine of Crohn disease
-
Akagi S,Hiyama E, Imamura Y, Takesue Y, et al. Interleukin-10 expression in intestine of Crohn disease. Int J MolMed 2000; 5: 389-95.
-
(2000)
Int J MolMed
, vol.5
, pp. 389-395
-
-
Akagi, S.1
Hiyama, E.2
Imamura, Y.3
Takesue, Y.4
-
42
-
-
0028576989
-
Interferon expression in Crohn's disease patients: increased interferon-gamma and -alpha mRNA in the intestinal lamina propria mononuclear cells
-
Fais S, Capobianchi MR, SilvestriMet al. Interferon expression in Crohn's disease patients: increased interferon-gamma and -alpha mRNA in the intestinal lamina propria mononuclear cells. J Interferon Res 1994; 14: 235-8.
-
(1994)
J Interferon Res
, vol.14
, pp. 235-238
-
-
Fais, S.1
Capobianchi, M.R.2
Silvestri, M.3
-
43
-
-
0028853750
-
The role of proinflammatory and immunoregulatory cytokines in the pathogenesis of ulcerative colitis
-
Murata Y, Ishiguro Y, Itoh J,, et al. The role of proinflammatory and immunoregulatory cytokines in the pathogenesis of ulcerative colitis. J Gastroenterol 1995; 30 Suppl 8: 56-60.
-
(1995)
J Gastroenterol
, vol.30
, Issue.SUUPL 8
, pp. 56-60
-
-
Murata, Y.1
Ishiguro, Y.2
Itoh, J.3
-
44
-
-
0031057872
-
Type 1 Thelper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
-
Parronchi P, Romagnani P, Annunziato F, et al. Type 1 Thelper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am J Pathol 1997; 150: 823-32.
-
(1997)
Am J Pathol
, vol.150
, pp. 823-832
-
-
Parronchi, P.1
Romagnani, P.2
Annunziato, F.3
-
45
-
-
18744425752
-
Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease
-
Desreumaux P, Brandt E, Gambiez L, et al. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Gastroenterology 1997; 113: 118-26.
-
(1997)
Gastroenterology
, vol.113
, pp. 118-126
-
-
Desreumaux, P.1
Brandt, E.2
Gambiez, L.3
-
46
-
-
0021907183
-
Molecular cloning of the complementary DNA for human tumor necrosis factor
-
Wang AM, Creasey AA, Ladner MB, et al. Molecular cloning of the complementary DNA for human tumor necrosis factor. Science 1985; 228: 149-54.
-
(1985)
Science
, vol.228
, pp. 149-154
-
-
Wang, A.M.1
Creasey, A.A.2
Ladner, M.B.3
-
47
-
-
44749088915
-
Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models
-
Kruglov AA, Kuchmiy A, Grivennikov SI, et al. Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models. Cytokine Growth Factor Rev 2008; 19: 231-44.
-
(2008)
Cytokine Growth Factor Rev
, vol.19
, pp. 231-244
-
-
Kruglov, A.A.1
Kuchmiy, A.2
Grivennikov, S.I.3
-
48
-
-
0024405827
-
The biology of cachectin/TNF-a primary mediator of the host response
-
Beutler B, Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 1989; 7: 625-55.
-
(1989)
Annu Rev Immunol
, vol.7
, pp. 625-655
-
-
Beutler, B.1
Cerami, A.2
-
49
-
-
18944375672
-
Long-term exposure of the HT-29 human intestinal epithelial cell line to TNF causes sustained upregulation of the polymeric Ig receptor and proinflammatory genes through transcriptional and posttranscriptional mechanisms
-
Bruno ME, Kaetzel CS. Long-term exposure of the HT-29 human intestinal epithelial cell line to TNF causes sustained upregulation of the polymeric Ig receptor and proinflammatory genes through transcriptional and posttranscriptional mechanisms. J Immunol 2005; 174: 7278-84.
-
(2005)
J Immunol
, vol.174
, pp. 7278-7284
-
-
Bruno, M.E.1
Kaetzel, C.S.2
-
50
-
-
0041885346
-
Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide
-
Loncar MB, Al-azzeh ED, Sommer PS, et al. Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide. Gut 2003; 52: 1297-303.
-
(2003)
Gut
, vol.52
, pp. 1297-1303
-
-
Loncar, M.B.1
Al-azzeh, E.D.2
Sommer, P.S.3
-
51
-
-
0033103805
-
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
-
Kontoyiannis D, Pasparakis M, Pizarro TT, et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999; 10: 387-98.
-
(1999)
Immunity
, vol.10
, pp. 387-398
-
-
Kontoyiannis, D.1
Pasparakis, M.2
Pizarro, T.T.3
-
52
-
-
0035106502
-
Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
-
Kosiewicz MM, Nast CC, Krishnan A, et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest 2001; 107: 695-702.
-
(2001)
J Clin Invest
, vol.107
, pp. 695-702
-
-
Kosiewicz, M.M.1
Nast, C.C.2
Krishnan, A.3
-
53
-
-
0036896960
-
T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
-
Musch MW, Clarke LL, Mamah D, et al. T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J Clin Invest 2002; 110: 1739-47.
-
(2002)
J Clin Invest
, vol.110
, pp. 1739-1747
-
-
Musch, M.W.1
Clarke, L.L.2
Mamah, D.3
-
54
-
-
38649106435
-
TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality
-
Mizoguchi E, Hachiya Y, Kawada M, et al. TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality. Gastroenterology 2008; 134: 470-80.
-
(2008)
Gastroenterology
, vol.134
, pp. 470-480
-
-
Mizoguchi, E.1
Hachiya, Y.2
Kawada, M.3
-
55
-
-
0027451455
-
Enhanced secretion of tumour necrosis factor-alpha, IL-6 and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
-
Reinecker HC, Steffen M, Witthoeft T, et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6 and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993; 94: 174-81.
-
(1993)
Clin Exp Immunol
, vol.94
, pp. 174-181
-
-
Reinecker, H.C.1
Steffen, M.2
Witthoeft, T.3
-
56
-
-
0030842468
-
Quantitative PCR analysis of TNFalpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies
-
Dionne S, Hiscott J, D'Agata I, et al. Quantitative PCR analysis of TNFalpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies. Dig Dis Sci 1997; 42: 1557-66.
-
(1997)
Dig Dis Sci
, vol.42
, pp. 1557-1566
-
-
Dionne, S.1
Hiscott, J.2
D'Agata, I.3
-
57
-
-
0030954732
-
A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
-
Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997; 337: 1029-35.
-
(1997)
Crohn's Disease cA2 Study Group. N Engl J Med
, vol.337
, pp. 1029-1035
-
-
Targan, S.R.1
Hanauer, S.B.2
van Deventer, S.J.3
-
58
-
-
0033529049
-
Infliximab for the treatment of fistulas in patients with Crohn's disease
-
Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340: 1398-405.
-
(1999)
N Engl J Med
, vol.340
, pp. 1398-1405
-
-
Present, D.H.1
Rutgeerts, P.2
Targan, S.3
-
59
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
-
Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541-9.
-
(2002)
Lancet
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
-
60
-
-
10744221312
-
Infliximab maintenance therapy for fistulizing Crohn's disease
-
Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 2004; 350: 876-85.
-
(2004)
N Engl J Med
, vol.350
, pp. 876-885
-
-
Sands, B.E.1
Anderson, F.H.2
Bernstein, C.N.3
-
61
-
-
28844473957
-
Infliximab for induction and maintenance therapy for ulcerative colitis
-
Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. NEngl J Med 2005; 353: 2462-76.
-
(2005)
NEngl J Med
, vol.353
, pp. 2462-2476
-
-
Rutgeerts, P.1
Sandborn, W.J.2
Feagan, B.G.3
-
62
-
-
32044451548
-
Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial.
-
Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 2006; 130: 323-33. quiz 591.
-
(2006)
Gastroenterology
, vol.130
, pp. 323-333
-
-
Hanauer, S.B.1
Sandborn, W.J.2
Rutgeerts, P.3
-
63
-
-
33846242958
-
Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial
-
Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 2007; 132: 52-65.
-
(2007)
Gastroenterology
, vol.132
, pp. 52-65
-
-
Colombel, J.F.1
Sandborn, W.J.2
Rutgeerts, P.3
-
64
-
-
34447515607
-
Maintenance therapy with certolizumab pegol for Crohn's disease
-
Schreiber S,Khaliq-KareemiM,Lawrance IC, et al. Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med 2007; 357: 239-50.
-
(2007)
N Engl J Med
, vol.357
, pp. 239-250
-
-
Schreiber, S.1
Khaliq-Kareemi, M.2
Lawrance, I.C.3
-
65
-
-
34447523749
-
Certolizumab pegol for the treatment of Crohn's disease
-
Sandborn WJ, Feagan BG, Stoinov S, et al. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med 2007; 357: 228-38.
-
(2007)
N Engl J Med
, vol.357
, pp. 228-238
-
-
Sandborn, W.J.1
Feagan, B.G.2
Stoinov, S.3
-
66
-
-
34248136340
-
Inflammatory bowel disease: clinical aspects and established and evolving therapies
-
Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 2007; 369: 1641-57.
-
(2007)
Lancet
, vol.369
, pp. 1641-1657
-
-
Baumgart, D.C.1
Sandborn, W.J.2
-
67
-
-
2442560241
-
Optimizing anti- TNF treatment in inflammatory bowel disease
-
Rutgeerts P, Van Assche G, Vermeire S. Optimizing anti- TNF treatment in inflammatory bowel disease. Gastroenterology 2004; 126: 1593-610.
-
(2004)
Gastroenterology
, vol.126
, pp. 1593-1610
-
-
Rutgeerts, P.1
Van Assche, G.2
Vermeire, S.3
-
68
-
-
41949097030
-
The biology of interleukin-2
-
Malek TR. The biology of interleukin-2. Annu Rev Immunol 2008; 26: 453-79.
-
(2008)
Annu Rev Immunol
, vol.26
, pp. 453-479
-
-
Malek, T.R.1
-
69
-
-
0027369395
-
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
-
Saddlack B, Merz H, Scholrle H, et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993; 75: 253-61.
-
(1993)
Cell
, vol.75
, pp. 253-261
-
-
Saddlack, B.1
Merz, H.2
Scholrle, H.3
-
70
-
-
0028784289
-
Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
-
Willerford DM, Chen J, Ferry JA, et al. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995; 3: 521-30.
-
(1995)
Immunity
, vol.3
, pp. 521-530
-
-
Willerford, D.M.1
Chen, J.2
Ferry, J.A.3
-
71
-
-
0029028363
-
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
-
Suzuki H, Kundig TM, Furlonger C, et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995; 268: 1472-6.
-
(1995)
Science
, vol.268
, pp. 1472-1476
-
-
Suzuki, H.1
Kundig, T.M.2
Furlonger, C.3
-
72
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
73
-
-
15244354286
-
Regulatory T cell lineage specification by the forkhead transcription factor foxp3
-
Fontenot JD, Rasmussen JP, Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005; 22: 329-41.
-
(2005)
Immunity
, vol.22
, pp. 329-341
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Williams, L.M.3
-
75
-
-
2442637772
-
Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
-
Thornton AM, Donovan EE, Piccirillo CA, Shevach EM. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 2004; 172: 6519-23.
-
(2004)
J Immunol
, vol.172
, pp. 6519-6523
-
-
Thornton, A.M.1
Donovan, E.E.2
Piccirillo, C.A.3
Shevach, E.M.4
-
77
-
-
0031451918
-
Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation
-
Autenrieth IB, Bucheler N, Bohn E, et al. Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation. Gut 1997; 41: 793-800.
-
(1997)
Gut
, vol.41
, pp. 793-800
-
-
Autenrieth, I.B.1
Bucheler, N.2
Bohn, E.3
-
78
-
-
0031954425
-
Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice
-
MeijssenMA, Brandwein SL, Reinecker HC, et al. Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice. Am J Physiol 1998; 274: G472-9.
-
(1998)
Am J Physiol
, vol.274
-
-
Meijssen, M.A.1
Brandwein, S.L.2
Reinecker, H.C.3
-
79
-
-
0029156966
-
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2- deficient colitis
-
Simpson SJ, Mizoguchi E, Allen D, et al. Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2- deficient colitis. Eur J Immunol 1995; 25: 2618-25.
-
(1995)
Eur J Immunol
, vol.25
, pp. 2618-2625
-
-
Simpson, S.J.1
Mizoguchi, E.2
Allen, D.3
-
80
-
-
38649118188
-
Protein kinase C theta plays a fundamental role in different types of chronic colitis
-
Nagahama K, Ogawa A, Shirane K, et al. Protein kinase C theta plays a fundamental role in different types of chronic colitis. Gastroenterology 2008; 134: 459-69.
-
(2008)
Gastroenterology
, vol.134
, pp. 459-469
-
-
Nagahama, K.1
Ogawa, A.2
Shirane, K.3
-
81
-
-
0033000343
-
IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation
-
Schultz M, Tonkonogy SL, Sellon RK, et al. IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am J Physiol 1999; 276: G1461-72.
-
(1999)
Am J Physiol
, vol.276
-
-
Schultz, M.1
Tonkonogy, S.L.2
Sellon, R.K.3
-
82
-
-
33747114270
-
Role of toll-like receptors in spontaneous commensal-dependent colitis
-
Rakoff-Nahoum S, Hao L, Medzhitov R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 2006; 25: 319-29.
-
(2006)
Immunity
, vol.25
, pp. 319-329
-
-
Rakoff-Nahoum, S.1
Hao, L.2
Medzhitov, R.3
-
83
-
-
0026514203
-
Increased concentrations of interleukin 1 beta, interleukin-2 and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease
-
Brynskov J, Tvede N, Andersen CB, Vilien M. Increased concentrations of interleukin 1 beta, interleukin-2 and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease. Gut 1992; 33: 55-8.
-
(1992)
Gut
, vol.33
, pp. 55-58
-
-
Brynskov, J.1
Tvede, N.2
Andersen, C.B.3
Vilien, M.4
-
84
-
-
0026552488
-
Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis
-
Mullin GE, Lazenby AJ, HarrisML, et al. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992; 102: 1620-7.
-
(1992)
Gastroenterology
, vol.102
, pp. 1620-1627
-
-
Mullin, G.E.1
Lazenby, A.J.2
Harris, M.L.3
-
85
-
-
0029130042
-
Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
-
NiessnerM, Volk BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101: 428-35.
-
(1995)
Clin Exp Immunol
, vol.101
, pp. 428-435
-
-
Niessner, M.1
Volk, B.A.2
-
86
-
-
0027434948
-
Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis
-
Gurbindo C, Sabbah S, Menezes J, et al. Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis. J Pediatr Gastroenterol Nutr 1993; 17: 247-54.
-
(1993)
J Pediatr Gastroenterol Nutr
, vol.17
, pp. 247-254
-
-
Gurbindo, C.1
Sabbah, S.2
Menezes, J.3
-
87
-
-
0030225555
-
Lamina propria mononuclear cells express and respond to interleukin-2 differently in Crohn's disease and ulcerative colitis
-
Shinoda M, Haruta J, Tanimoto M, et al. Lamina propria mononuclear cells express and respond to interleukin-2 differently in Crohn's disease and ulcerative colitis. Intern Med 1996; 35: 679-85.
-
(1996)
Intern Med
, vol.35
, pp. 679-685
-
-
Shinoda, M.1
Haruta, J.2
Tanimoto, M.3
-
88
-
-
0027419329
-
Symptomatic exacerbation of Crohn disease after treatment with high-dose interleukin-2
-
Sparano JA, Brandt LJ, Dutcher JP, et al. Symptomatic exacerbation of Crohn disease after treatment with high-dose interleukin-2. Ann Intern Med 1993; 118: 617-8.
-
(1993)
Ann Intern Med
, vol.118
, pp. 617-618
-
-
Sparano, J.A.1
Brandt, L.J.2
Dutcher, J.P.3
-
89
-
-
10744232542
-
Basiliximab (anti- CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
-
Creed TJ, Norman MR, Probert CS, et al. Basiliximab (anti- CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis. Aliment Pharmacol Ther 2003; 18: 65-75.
-
(2003)
Aliment Pharmacol Ther
, vol.18
, pp. 65-75
-
-
Creed, T.J.1
Norman, M.R.2
Probert, C.S.3
-
90
-
-
33646232018
-
Basiliximab for the treatment of steroid-resistant ulcerative colitis: further Cytokines and Chemokines in Mucosal Homeostasis 149 experience in moderate and severe disease
-
Creed TJ, Probert CS, Norman MN, et al. Basiliximab for the treatment of steroid-resistant ulcerative colitis: further Cytokines and Chemokines in Mucosal Homeostasis 149 experience in moderate and severe disease. Aliment Pharmacol Ther 2006; 23: 1435-42.
-
(2006)
Aliment Pharmacol Ther
, vol.23
, pp. 1435-1442
-
-
Creed, T.J.1
Probert, C.S.2
Norman, M.N.3
-
91
-
-
33750343050
-
Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial
-
Van Assche G, Sandborn WJ, Feagan BG,, et al. Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial. Gut 2006; 55: 1568-74.
-
(2006)
Gut
, vol.55
, pp. 1568-1574
-
-
Van Assche, G.1
Sandborn, W.J.2
Feagan, B.G.3
-
92
-
-
18644374105
-
Blocking IL-1 in systemic inflammation
-
Dinarello CA. Blocking IL-1 in systemic inflammation. J Exp Med 2005; 201: 1355-9.
-
(2005)
J Exp Med
, vol.201
, pp. 1355-1359
-
-
Dinarello, C.A.1
-
93
-
-
2542457495
-
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases
-
Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117: 561-74.
-
(2004)
Cell
, vol.117
, pp. 561-574
-
-
Martinon, F.1
Tschopp, J.2
-
94
-
-
0032576359
-
Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease
-
Binion DG, West GA, Volk EE, et al. Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease. Lancet 1998; 352: 1742-6.
-
(1998)
Lancet
, vol.352
, pp. 1742-1746
-
-
Binion, D.G.1
West, G.A.2
Volk, E.E.3
-
95
-
-
0025167803
-
Interleukin 1 (IL-1) gene expression, synthesis and effect of specific IL-1 receptor blockade in rabbit immune complex colitis
-
Cominelli F, Nast CC, Clark BD, et al. Interleukin 1 (IL-1) gene expression, synthesis and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. J Clin Invest 1990; 86: 972-80.
-
(1990)
J Clin Invest
, vol.86
, pp. 972-980
-
-
Cominelli, F.1
Nast, C.C.2
Clark, B.D.3
-
96
-
-
0030908361
-
Role of cytokines in the early stages of chronic colitis in TCR alpha-mutant mice
-
Mizoguchi E, Mizoguchi A, Bhan AK. Role of cytokines in the early stages of chronic colitis in TCR alpha-mutant mice. Lab Invest 1997; 76: 385-97.
-
(1997)
Lab Invest
, vol.76
, pp. 385-397
-
-
Mizoguchi, E.1
Mizoguchi, A.2
Bhan, A.K.3
-
97
-
-
26444588087
-
Interleukin- 1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis
-
Kwon KH, Murakami A, Hayashi R, Ohigashi H. Interleukin- 1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis. Biochem Biophys Res Commun 2005; 337: 647-54.
-
(2005)
Biochem Biophys Res Commun
, vol.337
, pp. 647-654
-
-
Kwon, K.H.1
Murakami, A.2
Hayashi, R.3
Ohigashi, H.4
-
98
-
-
0032408502
-
Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice
-
Arai Y, Takanashi H, Kitagawa H, Okayasu I. Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice. Cytokine 1998; 10: 890-6.
-
(1998)
Cytokine
, vol.10
, pp. 890-896
-
-
Arai, Y.1
Takanashi, H.2
Kitagawa, H.3
Okayasu, I.4
-
100
-
-
34249913692
-
The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6mice and suppresses IP-10 mRNA but not TNFalpha mRNA expression
-
Bauer C, Loher F, DauerMet al. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6mice and suppresses IP-10 mRNA but not TNFalpha mRNA expression. Dig Dis Sci 2007; 52: 1642-52.
-
(2007)
Dig Dis Sci
, vol.52
, pp. 1642-1652
-
-
Bauer, C.1
Loher, F.2
Dauer, M.3
-
101
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008; 456: 264-8.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
-
102
-
-
13244277880
-
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
-
Maeda S, Hsu LC, Liu H, et al. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 2005; 307: 734-8.
-
(2005)
Science
, vol.307
, pp. 734-738
-
-
Maeda, S.1
Hsu, L.C.2
Liu, H.3
-
104
-
-
8144230706
-
Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
-
LudwiczekO, Vannier E, Borggraefe I, et al. Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease. Clin Exp Immunol 2004; 138: 323-9.
-
(2004)
Clin Exp Immunol
, vol.138
, pp. 323-329
-
-
Ludwiczek, O.1
Vannier, E.2
Borggraefe, I.3
-
105
-
-
0029889689
-
Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis andCrohn'sdisease
-
Reimund JM,Wittersheim C, Dumont S, et al. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis andCrohn'sdisease. JClin Immunol 1996; 16: 144-50.
-
(1996)
JClin Immunol
, vol.16
, pp. 144-150
-
-
Reimund, J.M.1
Wittersheim, C.2
Dumont, S.3
-
106
-
-
0027409322
-
Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells
-
Youngman KR, Simon PL, West GA, et al. Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells. Gastroenterology 1993; 104: 749-58.
-
(1993)
Gastroenterology
, vol.104
, pp. 749-758
-
-
Youngman, K.R.1
Simon, P.L.2
West, G.A.3
-
107
-
-
0031921472
-
Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease
-
McAlindon ME, Hawkey CJ, Mahida YR. Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease. Gut 1998; 42: 214-9.
-
(1998)
Gut
, vol.42
, pp. 214-219
-
-
McAlindon, M.E.1
Hawkey, C.J.2
Mahida, Y.R.3
-
108
-
-
0026590363
-
Peripheral blood monocyte cytokine production and acute phase response in inflammatory bowel disease
-
Mazlam MZ, Hodgson HJ. Peripheral blood monocyte cytokine production and acute phase response in inflammatory bowel disease. Gut 1992; 33: 773-8.
-
(1992)
Gut
, vol.33
, pp. 773-778
-
-
Mazlam, M.Z.1
Hodgson, H.J.2
-
109
-
-
0027935291
-
Characterization of circulating interleukin-1 receptor antagonist expression in children with inflammatory bowel disease
-
Hyams JS, Fitzgerald JE,WyzgaNet al. Characterization of circulating interleukin-1 receptor antagonist expression in children with inflammatory bowel disease. Dig Dis Sci 1994; 39: 1893-9.
-
(1994)
Dig Dis Sci
, vol.39
, pp. 1893-1899
-
-
Hyams, J.S.1
Fitzgerald, J.E.2
Wyzga, N.3
-
110
-
-
0033528272
-
Tumour necrosis factor alpha and interleukin 1beta in relapse of Crohn's disease
-
Schreiber S, Nikolaus S, Hampe J, et al. Tumour necrosis factor alpha and interleukin 1beta in relapse of Crohn's disease. Lancet 1999; 353: 459-61.
-
(1999)
Lancet
, vol.353
, pp. 459-461
-
-
Schreiber, S.1
Nikolaus, S.2
Hampe, J.3
-
113
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441: 235-8.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
114
-
-
33646560950
-
Transforming growth factor-beta induces development of the T(H)17 lineage
-
Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441: 231-4.
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O'Quinn, D.B.3
-
115
-
-
34548125305
-
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
-
Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8: 942-9.
-
(2007)
Nat Immunol
, vol.8
, pp. 942-949
-
-
Acosta-Rodriguez, E.V.1
Napolitani, G.2
Lanzavecchia, A.3
Sallusto, F.4
-
116
-
-
0036694589
-
IL-6 in autoimmune disease and chronic inflammatory proliferative disease
-
Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002; 13: 357-68.
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 357-368
-
-
Ishihara, K.1
Hirano, T.2
-
117
-
-
0030891228
-
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
-
Romano M, Sironi M, Toniatti C, et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 1997; 6: 315-25.
-
(1997)
Immunity
, vol.6
, pp. 315-325
-
-
Romano, M.1
Sironi, M.2
Toniatti, C.3
-
118
-
-
0032518415
-
IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
-
Xing Z, Gauldie J, Cox G, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998; 101: 311-20.
-
(1998)
J Clin Invest
, vol.101
, pp. 311-320
-
-
Xing, Z.1
Gauldie, J.2
Cox, G.3
-
120
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
Suzuki A, Hanada T, Mitsuyama K, et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001; 193: 471-81.
-
(2001)
J Exp Med
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
Hanada, T.2
Mitsuyama, K.3
-
121
-
-
0034193039
-
IL-6 is required for the development of Th1 cell-mediated murine colitis
-
Yamamoto M, Yoshizaki K, Kishimoto T, ItoH. IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 2000; 164: 4878-82.
-
(2000)
J Immunol
, vol.164
, pp. 4878-4882
-
-
Yamamoto, M.1
Yoshizaki, K.2
Kishimoto, T.3
Ito, H.4
-
122
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med 2000; 6: 583-8.
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
-
123
-
-
0036142256
-
Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
-
Mizoguchi E, Mizoguchi A, Takedatsu H,, et al. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology 2002; 122: 134-44.
-
(2002)
Gastroenterology
, vol.122
, pp. 134-144
-
-
Mizoguchi, E.1
Mizoguchi, A.2
Takedatsu, H.3
-
124
-
-
0033034365
-
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
-
Takeda K, Clausen BE, Kaisho T, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999; 10: 39-49.
-
(1999)
Immunity
, vol.10
, pp. 39-49
-
-
Takeda, K.1
Clausen, B.E.2
Kaisho, T.3
-
125
-
-
1642619154
-
Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis
-
Alonzi T, Newton IP, Bryce PJ, et al. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 2004; 26: 45-56.
-
(2004)
Cytokine
, vol.26
, pp. 45-56
-
-
Alonzi, T.1
Newton, I.P.2
Bryce, P.J.3
-
126
-
-
33847206969
-
IL-17 family cytokines and the expanding diversity of effector T cell lineages
-
Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007; 25: 821-52.
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 821-852
-
-
Weaver, C.T.1
Hatton, R.D.2
Mangan, P.R.3
Harrington, L.E.4
-
127
-
-
0026689516
-
Tumor necrosis factoralpha, interleukin-1 beta and interleukin-6 expression in inflammatory bowel disease
-
Stevens C, Walz G, Singaram C, et al. Tumor necrosis factoralpha, interleukin-1 beta and interleukin-6 expression in inflammatory bowel disease. Dig Dis Sci 1992; 37: 818-26.
-
(1992)
Dig Dis Sci
, vol.37
, pp. 818-826
-
-
Stevens, C.1
Walz, G.2
Singaram, C.3
-
128
-
-
0026336617
-
Colonic mucosal interleukin-6 in inflammatory bowel disease
-
Mitsuyama K, Sasaki E, Toyonaga A, et al. Colonic mucosal interleukin-6 in inflammatory bowel disease. Digestion 1991; 50: 104-11.
-
(1991)
Digestion
, vol.50
, pp. 104-111
-
-
Mitsuyama, K.1
Sasaki, E.2
Toyonaga, A.3
-
129
-
-
0025746614
-
High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis
-
Mahida YR, Kurlac L, Gallagher A, Hawkey CJ. High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis. Gut 1991; 32: 1531-4.
-
(1991)
Gut
, vol.32
, pp. 1531-1534
-
-
Mahida, Y.R.1
Kurlac, L.2
Gallagher, A.3
Hawkey, C.J.4
-
130
-
-
0026607022
-
Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
-
Gross V, Andus T, Caesar I, et al. Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. Gastroenterology 1992; 102: 514-9.
-
(1992)
Gastroenterology
, vol.102
, pp. 514-519
-
-
Gross, V.1
Andus, T.2
Caesar, I.3
-
131
-
-
0033179725
-
Clinical relevance of serum interleukin-6 in Crohn's disease: single point measurements, therapy monitoring and prediction of clinical relapse
-
Reinisch W, Gasche C, Tillinger W, et al. Clinical relevance of serum interleukin-6 in Crohn's disease: single point measurements, therapy monitoring and prediction of clinical relapse. Am J Gastroenterol 1999; 94: 2156-64.
-
(1999)
Am J Gastroenterol
, vol.94
, pp. 2156-2164
-
-
Reinisch, W.1
Gasche, C.2
Tillinger, W.3
-
132
-
-
33644818803
-
A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory bowel disease
-
Mitsuyama K, Tomiyasu N, Suzuki A, et al. A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory bowel disease. Clin Exp Immunol 2006; 143: 125-31.
-
(2006)
Clin Exp Immunol
, vol.143
, pp. 125-131
-
-
Mitsuyama, K.1
Tomiyasu, N.2
Suzuki, A.3
-
133
-
-
11144358366
-
A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
-
Ito H, Takazoe M, Fukuda Y, et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004; 126: 989-96. discussion 947.
-
(2004)
Gastroenterology
, vol.126
, pp. 989-996
-
-
Ito, H.1
Takazoe, M.2
Fukuda, Y.3
-
134
-
-
18344385475
-
TL1A is a TNFlike ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator
-
Migone TS, Zhang J, Luo X, et al. TL1A is a TNFlike ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 2002; 16: 479-92.
-
(2002)
Immunity
, vol.16
, pp. 479-492
-
-
Migone, T.S.1
Zhang, J.2
Luo, X.3
-
135
-
-
33744791820
-
Role of TL1A and its receptor DR3 in twomodels of chronic murine ileitis
-
Bamias G, Mishina M, Nyce M, et al. Role of TL1A and its receptor DR3 in twomodels of chronic murine ileitis. Proc Natl Acad Sci USA 2006; 103: 8441-6.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 8441-8446
-
-
Bamias, G.1
Mishina, M.2
Nyce, M.3
-
136
-
-
33947637808
-
The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells
-
Prehn JL, Thomas LS, Landers CJ, et al. The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol 2007; 178: 4033-8.
-
(2007)
J Immunol
, vol.178
, pp. 4033-4038
-
-
Prehn, J.L.1
Thomas, L.S.2
Landers, C.J.3
-
137
-
-
2442689136
-
TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells
-
Papadakis KA, Prehn JL, Landers C, et al. TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. J Immunol 2004; 172: 7002-7.
-
(2004)
J Immunol
, vol.172
, pp. 7002-7007
-
-
Papadakis, K.A.1
Prehn, J.L.2
Landers, C.3
-
138
-
-
17044413324
-
Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes
-
Papadakis KA, Zhu D, Prehn JL, et al. Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. J Immunol 2005; 174: 4985-90.
-
(2005)
J Immunol
, vol.174
, pp. 4985-4990
-
-
Papadakis, K.A.1
Zhu, D.2
Prehn, J.L.3
-
139
-
-
48549106477
-
TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation
-
Takedatsu H, Michelsen KS, Wei B, et al. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 2008; 135: 552-67.
-
(2008)
Gastroenterology
, vol.135
, pp. 552-567
-
-
Takedatsu, H.1
Michelsen, K.S.2
Wei, B.3
-
140
-
-
51249119001
-
Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro- D-glucose and positron emission tomography
-
Brewer S, McPherson M, Fujiwara D, et al. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro- D-glucose and positron emission tomography. Gastroenterology 2008; 135: 744-55.
-
(2008)
Gastroenterology
, vol.135
, pp. 744-755
-
-
Brewer, S.1
McPherson, M.2
Fujiwara, D.3
-
141
-
-
10744225786
-
Expression, localization and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease
-
Bamias G, Martin C 3rd, Marini M, et al. Expression, localization and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J Immunol 2003; 171: 4868-74.
-
(2003)
J Immunol
, vol.171
, pp. 4868-4874
-
-
Bamias, G.1
Martin III, C.2
Marini, M.3
-
142
-
-
2942652655
-
Potential role for TL1A, the new TNFfamily member and potent costimulator of IFN-gamma, in mucosal inflammation
-
Prehn JL, Mehdizadeh S, Landers CJ, et al. Potential role for TL1A, the new TNFfamily member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin Immunol 2004; 112: 66-77.
-
(2004)
Clin Immunol
, vol.112
, pp. 66-77
-
-
Prehn, J.L.1
Mehdizadeh, S.2
Landers, C.J.3
-
143
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13: 715-25.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
-
144
-
-
0037449737
-
Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
-
Aggarwal S, Ghilardi N, XieMHet al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003; 278: 1910-4.
-
(2003)
J Biol Chem
, vol.278
, pp. 1910-1914
-
-
Aggarwal, S.1
Ghilardi, N.2
Xie, M.H.3
-
145
-
-
27544490377
-
Interleukin 17- producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
-
Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17- producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6: 1123-32.
-
(2005)
Nat Immunol
, vol.6
, pp. 1123-1132
-
-
Harrington, L.E.1
Hatton, R.D.2
Mangan, P.R.3
-
146
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M, HockingRJ, Atkins CJ, et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24: 179-89.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
-
147
-
-
60749107176
-
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
-
McGeachy MJ, Chen Y, Tato CM, et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 2009; 10: 314-24.
-
(2009)
Nat Immunol
, vol.10
, pp. 314-324
-
-
McGeachy, M.J.1
Chen, Y.2
Tato, C.M.3
-
148
-
-
34247523141
-
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation
-
Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 2007; 25: 221-42.
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 221-242
-
-
Kastelein, R.A.1
Hunter, C.A.2
Cua, D.J.3
-
149
-
-
0035877257
-
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility and premature death
-
Wiekowski MT, Leach MW, Evans EW, et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility and premature death. J Immunol 2001; 166: 7563-70.
-
(2001)
J Immunol
, vol.166
, pp. 7563-7570
-
-
Wiekowski, M.T.1
Leach, M.W.2
Evans, E.W.3
-
150
-
-
0141835046
-
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
-
Becker C,Wirtz S, Blessing M, et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 2003; 112: 693-706.
-
(2003)
J Clin Invest
, vol.112
, pp. 693-706
-
-
Becker, C.1
Wirtz, S.2
Blessing, M.3
-
151
-
-
25144515561
-
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
-
Happel KI, Dubin PJ, Zheng M, et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 2005; 202: 761-9.
-
(2005)
J Exp Med
, vol.202
, pp. 761-769
-
-
Happel, K.I.1
Dubin, P.J.2
Zheng, M.3
-
152
-
-
33750505009
-
Interleukin-23 drives innate and T cell-mediated intestinal inflammation
-
Hue S, Ahern P, Buonocore S, et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med 2006; 203: 2473-83.
-
(2006)
J Exp Med
, vol.203
, pp. 2473-2483
-
-
Hue, S.1
Ahern, P.2
Buonocore, S.3
-
153
-
-
33646397611
-
IL-23 is essential for T cellmediated colitis and promotes inflammation via IL-17 and IL-6
-
Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cellmediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 2006; 116: 1310-6.
-
(2006)
J Clin Invest
, vol.116
, pp. 1310-1316
-
-
Yen, D.1
Cheung, J.2
Scheerens, H.3
-
154
-
-
34250026960
-
Monoclonal antiinterleukin 23 reverses active colitis in a T cell-mediated model in mice
-
Elson CO, Cong Y, Weaver CT, et al. Monoclonal antiinterleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 2007; 132: 2359-70.
-
(2007)
Gastroenterology
, vol.132
, pp. 2359-2370
-
-
Elson, C.O.1
Cong, Y.2
Weaver, C.T.3
-
155
-
-
29744450121
-
Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are downregulated by treatment with anti-IL-12 p40 monoclonal antibody
-
Fuss IJ, Becker C, Yang Z, et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are downregulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 2006; 12: 9-15.
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 9-15
-
-
Fuss, I.J.1
Becker, C.2
Yang, Z.3
-
156
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314: 1461-3.
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
Taylor, K.D.2
Brant, S.R.3
-
157
-
-
44349124113
-
The genetics and immunopathogenesis of inflammatory bowel disease
-
Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008; 8: 458-66.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 458-466
-
-
Cho, J.H.1
-
158
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126: 1121-33.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
-
159
-
-
0842324613
-
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
-
Ogawa A, Andoh A, Araki Y, et al. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol 2004; 110: 55-62.
-
(2004)
Clin Immunol
, vol.110
, pp. 55-62
-
-
Ogawa, A.1
Andoh, A.2
Araki, Y.3
-
160
-
-
0034128634
-
Claudins regulate the intestinal barrier in response to immune mediators
-
Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 2000; 118: 1001-11.
-
(2000)
Gastroenterology
, vol.118
, pp. 1001-1011
-
-
Kinugasa, T.1
Sakaguchi, T.2
Gu, X.3
Reinecker, H.C.4
-
161
-
-
34547734621
-
Phenotypic and functional features of human Th17 cells
-
Annunziato F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007; 204: 1849-61.
-
(2007)
J Exp Med
, vol.204
, pp. 1849-1861
-
-
Annunziato, F.1
Cosmi, L.2
Santarlasci, V.3
-
162
-
-
0037216498
-
Increased expression of interleukin 17 in inflammatory bowel disease
-
Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003; 52: 65-70.
-
(2003)
Gut
, vol.52
, pp. 65-70
-
-
Fujino, S.1
Andoh, A.2
Bamba, S.3
-
163
-
-
0037299902
-
Upregulation of interleukin-12 and -17 in active inflammatory bowel disease
-
Nielsen OH, Kirman I, Rudiger N, et al. Upregulation of interleukin-12 and -17 in active inflammatory bowel disease. Scand J Gastroenterol 2003; 38: 180-5.
-
(2003)
Scand J Gastroenterol
, vol.38
, pp. 180-185
-
-
Nielsen, O.H.1
Kirman, I.2
Rudiger, N.3
-
164
-
-
42449084096
-
Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD
-
Seiderer J, Elben I, Diegelmann J, et al. Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm Bowel Dis 2008; 14: 437-45.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 437-445
-
-
Seiderer, J.1
Elben, I.2
Diegelmann, J.3
-
165
-
-
33744481749
-
Origins of the T(H)1-T(H)2 model: a personal perspective
-
Coffman RL. Origins of the T(H)1-T(H)2 model: a personal perspective. Nat Immunol 2006; 7: 539-41.
-
(2006)
Nat Immunol
, vol.7
, pp. 539-541
-
-
Coffman, R.L.1
-
166
-
-
52649167708
-
CD4 T cells: fates, functions and faults
-
Zhu J, Paul WE. CD4 T cells: fates, functions and faults. Blood 2008; 112: 1557-69.
-
(2008)
Blood
, vol.112
, pp. 1557-1569
-
-
Zhu, J.1
Paul, W.E.2
-
167
-
-
0029876629
-
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
-
Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996; 4: 313-9.
-
(1996)
Immunity
, vol.4
, pp. 313-319
-
-
Kaplan, M.H.1
Schindler, U.2
Smiley, S.T.3
Grusby, M.J.4
-
168
-
-
0030810155
-
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
-
Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89: 587-96.
-
(1997)
Cell
, vol.89
, pp. 587-596
-
-
Zheng, W.1
Flavell, R.A.2
-
169
-
-
0032538915
-
Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
-
Boirivant M, Fuss IJ, Chu A, Strober W. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 1998; 188: 1929-39.
-
(1998)
J Exp Med
, vol.188
, pp. 1929-1939
-
-
Boirivant, M.1
Fuss, I.J.2
Chu, A.3
Strober, W.4
-
170
-
-
0032901919
-
The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice
-
Mizoguchi A, Mizoguchi E, Bhan AK. The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice. Gastroenterology 1999; 116: 320-6.
-
(1999)
Gastroenterology
, vol.116
, pp. 320-326
-
-
Mizoguchi, A.1
Mizoguchi, E.2
Bhan, A.K.3
-
171
-
-
0037736679
-
Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features and outcome in a single-center cohort of 55 patients
-
Dupuis-Girod S, Medioni J, Haddad E, et al. Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features and outcome in a single-center cohort of 55 patients. Pediatrics 2003; 111: e622-7.
-
(2003)
Pediatrics
, vol.111
-
-
Dupuis-Girod, S.1
Medioni, J.2
Haddad, E.3
-
172
-
-
0033583477
-
Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses
-
Dohi T, Fujihashi K, Rennert PD, et al. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med 1999; 189: 1169-80.
-
(1999)
J Exp Med
, vol.189
, pp. 1169-1180
-
-
Dohi, T.1
Fujihashi, K.2
Rennert, P.D.3
-
173
-
-
0029744262
-
Involvement of interleukin-4 and -10 in inflammatory bowel disease
-
Nielsen OH, Koppen T, Rudiger N, et al. Involvement of interleukin-4 and -10 in inflammatory bowel disease. Dig Dis Sci 1996; 41: 1786-93.
-
(1996)
Dig Dis Sci
, vol.41
, pp. 1786-1793
-
-
Nielsen, O.H.1
Koppen, T.2
Rudiger, N.3
-
174
-
-
85047690640
-
Nonclassical CD1drestricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
-
Fuss IJ, Heller F, Boirivant M, et al. Nonclassical CD1drestricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 2004; 113: 1490-7.
-
(2004)
J Clin Invest
, vol.113
, pp. 1490-1497
-
-
Fuss, I.J.1
Heller, F.2
Boirivant, M.3
-
175
-
-
3242717983
-
Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice
-
Takedatsu H, Mitsuyama K, Matsumoto S, et al. Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice. Eur J Immunol 2004; 34: 1561-9.
-
(2004)
Eur J Immunol
, vol.34
, pp. 1561-1569
-
-
Takedatsu, H.1
Mitsuyama, K.2
Matsumoto, S.3
-
176
-
-
58749091674
-
Untangling the complex web of IL-4- and IL-13-mediated signaling pathways
-
Wills-Karp M, Finkelman FD. Untangling the complex web of IL-4- and IL-13-mediated signaling pathways. Sci Signal 2008; 1: pe55.
-
(2008)
Sci Signal
, vol.1
-
-
Wills-Karp, M.1
Finkelman, F.D.2
-
177
-
-
0036850908
-
Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK T cells
-
Heller F, Fuss IJ, Nieuwenhuis EE, et al. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK T cells. Immunity 2002; 17: 629-38.
-
(2002)
Immunity
, vol.17
, pp. 629-638
-
-
Heller, F.1
Fuss, I.J.2
Nieuwenhuis, E.E.3
-
178
-
-
34247586091
-
Induction of IL-13 triggers TGFbeta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis
-
Fichtner-Feigl S, Fuss IJ, Young CA, et al. Induction of IL-13 triggers TGFbeta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J Immunol 2007; 178: 5859-70.
-
(2007)
J Immunol
, vol.178
, pp. 5859-5870
-
-
Fichtner-Feigl, S.1
Fuss, I.J.2
Young, C.A.3
-
179
-
-
18244405108
-
IL-25 induces IL-4, IL-5 and IL-13 and Th2-associated pathologies in vivo
-
Fort MM, Cheung J, Yen D, et al. IL-25 induces IL-4, IL-5 and IL-13 and Th2-associated pathologies in vivo. Immunity 2001; 15: 985-95.
-
(2001)
Immunity
, vol.15
, pp. 985-995
-
-
Fort, M.M.1
Cheung, J.2
Yen, D.3
-
180
-
-
33645888708
-
Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5 and IL-13 at the onset of helminth expulsion
-
Fallon PG, Ballantyne SJ, Mangan NE, et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5 and IL-13 at the onset of helminth expulsion. J Exp Med 2006; 203: 1105-16.
-
(2006)
J Exp Med
, vol.203
, pp. 1105-1116
-
-
Fallon, P.G.1
Ballantyne, S.J.2
Mangan, N.E.3
-
181
-
-
33645896155
-
Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
-
Owyang AM, Zaph C, Wilson EH, et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med 2006; 203: 843-9.
-
(2006)
J Exp Med
, vol.203
, pp. 843-849
-
-
Owyang, A.M.1
Zaph, C.2
Wilson, E.H.3
-
183
-
-
0030018186
-
T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
-
Davidson NJ, Leach MW, Fort MM, et al. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 1996; 184: 241-51.
-
(1996)
J Exp Med
, vol.184
, pp. 241-251
-
-
Davidson, N.J.1
Leach, M.W.2
Fort, M.M.3
-
184
-
-
0030704726
-
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
-
Groux H, O'Garra A, Bigler M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389: 737-42.
-
(1997)
Nature
, vol.389
, pp. 737-742
-
-
Groux, H.1
O'Garra, A.2
Bigler, M.3
-
185
-
-
0028519015
-
Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
-
Powrie F, LeachMW, Mauze S, et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994; 1: 553-62.
-
(1994)
Immunity
, vol.1
, pp. 553-562
-
-
Powrie, F.1
Leach, M.W.2
Mauze, S.3
-
186
-
-
0030942666
-
Altered immune responses in interleukin 10 transgenic mice
-
Hagenbaugh A, Sharma S, Dubinett SMet al. Altered immune responses in interleukin 10 transgenic mice. J Exp Med 1997; 185: 2101-10.
-
(1997)
J Exp Med
, vol.185
, pp. 2101-2110
-
-
Hagenbaugh, A.1
Sharma, S.2
Dubinett, S.M.3
-
187
-
-
0033523607
-
An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
-
Asseman C, Mauze S, Leach MW, et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999; 190: 995-1004.
-
(1999)
J Exp Med
, vol.190
, pp. 995-1004
-
-
Asseman, C.1
Mauze, S.2
Leach, M.W.3
-
189
-
-
33645029163
-
TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice
-
Kanai T, Kawamura T, Dohi T, et al. TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice. Inflamm Bowel Dis 2006; 12: 89-99.
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 89-99
-
-
Kanai, T.1
Kawamura, T.2
Dohi, T.3
-
190
-
-
33845453812
-
Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
-
Kamanaka M, Kim ST,Wan YY, et al. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 2006; 25: 941-52.
-
(2006)
Immunity
, vol.25
, pp. 941-952
-
-
Kamanaka, M.1
Kim, S.T.2
Wan, Y.Y.3
-
191
-
-
34548131112
-
Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3-precursor cells in the absence of interleukin 10
-
Maynard CL, Harrington LE, Janowski KM, et al. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3-precursor cells in the absence of interleukin 10. Nat Immunol 2007; 8: 931-41.
-
(2007)
Nat Immunol
, vol.8
, pp. 931-941
-
-
Maynard, C.L.1
Harrington, L.E.2
Janowski, K.M.3
-
192
-
-
0036197923
-
Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
-
Mizoguchi A, Mizoguchi E, Takedatsu H, et al. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002; 16: 219-30.
-
(2002)
Immunity
, vol.16
, pp. 219-230
-
-
Mizoguchi, A.1
Mizoguchi, E.2
Takedatsu, H.3
-
193
-
-
0036953455
-
IL-10 gene therapy prevents TNBS-induced colitis
-
Lindsay J,Van MontfransC, Brennan F, et al. IL-10 gene therapy prevents TNBS-induced colitis. Gene Ther 2002; 9: 1715-21.
-
(2002)
Gene Ther
, vol.9
, pp. 1715-1721
-
-
Lindsay, J.1
Van Montfrans, C.2
Brennan, F.3
-
194
-
-
0034714188
-
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
-
Steidler L, HansW, Schotte L, et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 2000; 289: 1352-5.
-
(2000)
Science
, vol.289
, pp. 1352-1355
-
-
Steidler, L.1
Hans, W.2
Schotte, L.3
-
195
-
-
0141650591
-
Over-expression of interleukin in mucosal T 2 cells of patients with active ulcerative colitis
-
Melgar S, Yeung MM, Bas A, et al. Over-expression of interleukin in mucosal T 2 cells of patients with active ulcerative colitis. Clin Exp Immunol 2003; 134: 127-37.
-
(2003)
Clin Exp Immunol
, vol.134
, pp. 127-137
-
-
Melgar, S.1
Yeung, M.M.2
Bas, A.3
-
196
-
-
33744933432
-
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease
-
Braat H, Rottiers P, Hommes DW, et al. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol 2006; 4: 754-9.
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 754-759
-
-
Braat, H.1
Rottiers, P.2
Hommes, D.W.3
-
197
-
-
33846086980
-
Transforming growth factor-beta: innately bipolar
-
Wahl SM. Transforming growth factor-beta: innately bipolar. Curr Opin Immunol 2007; 19: 55-62.
-
(2007)
Curr Opin Immunol
, vol.19
, pp. 55-62
-
-
Wahl, S.M.1
-
198
-
-
33646164362
-
Transforming growth factorbeta regulation of immune responses
-
Li MO, Wan YY, Sanjabi S, et al. Transforming growth factorbeta regulation of immune responses. Annu Rev Immunol 2006; 24: 99-146.
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 99-146
-
-
Li, M.O.1
Wan, Y.Y.2
Sanjabi, S.3
-
199
-
-
0027532076
-
Regulation of intestinal epithelial proliferation: a few answers, many questions
-
Podolsky DK. Regulation of intestinal epithelial proliferation: a few answers, many questions. Am J Physiol 1993; 264: G179-86.
-
(1993)
Am J Physiol
, vol.264
-
-
Podolsky, D.K.1
-
200
-
-
0025222530
-
Transforming growth factor beta 1 increases IgA isotype switching at the clonal level
-
Kim PH, Kagnoff MF. Transforming growth factor beta 1 increases IgA isotype switching at the clonal level. J Immunol 1990; 145: 3773-8.
-
(1990)
J Immunol
, vol.145
, pp. 3773-3778
-
-
Kim, P.H.1
Kagnoff, M.F.2
-
201
-
-
0026542168
-
Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering
-
Miller A, Lider O, Roberts AB, et al. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci USA 1992; 89: 421-5.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 421-425
-
-
Miller, A.1
Lider, O.2
Roberts, A.B.3
-
202
-
-
0028037782
-
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis
-
Chen Y, Kuchroo VK, Inobe J, et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237-40.
-
(1994)
Science
, vol.265
, pp. 1237-1240
-
-
Chen, Y.1
Kuchroo, V.K.2
Inobe, J.3
-
203
-
-
0037013930
-
Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
-
Gorelik L, Constant S, Flavell RA. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med 2002; 195: 1499-505.
-
(2002)
J Exp Med
, vol.195
, pp. 1499-1505
-
-
Gorelik, L.1
Constant, S.2
Flavell, R.A.3
-
204
-
-
0031253731
-
TGFbeta production regulates the development of the 2,4,6-trinitrophenolconjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice
-
Ludviksson BR, Ehrhardt RO, Strober W. TGFbeta production regulates the development of the 2,4,6-trinitrophenolconjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice. J Immunol 1997; 159: 3622-8.
-
(1997)
J Immunol
, vol.159
, pp. 3622-3628
-
-
Ludviksson, B.R.1
Ehrhardt, R.O.2
Strober, W.3
-
205
-
-
1642577126
-
TGFbeta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
-
Nakamura K, Kitani A, Fuss I, et al. TGFbeta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 2004; 172: 834-42.
-
(2004)
J Immunol
, vol.172
, pp. 834-842
-
-
Nakamura, K.1
Kitani, A.2
Fuss, I.3
-
206
-
-
0029956024
-
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
-
Powrie F, Carlino J, Leach MW, et al. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996; 183: 2669-74.
-
(1996)
J Exp Med
, vol.183
, pp. 2669-2674
-
-
Powrie, F.1
Carlino, J.2
Leach, M.W.3
-
207
-
-
0037099613
-
CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
-
Piccirillo CA, Letterio JJ, Thornton AM, et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 2002; 196: 237-46.
-
(2002)
J Exp Med
, vol.196
, pp. 237-246
-
-
Piccirillo, C.A.1
Letterio, J.J.2
Thornton, A.M.3
-
209
-
-
15444363794
-
T cells that cannot respond to TGFbeta escape control by CD4(+)CD25(+) regulatory T cells
-
Fahlen L, Read S, Gorelik L, et al. T cells that cannot respond to TGFbeta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med 2005; 201: 737-46.
-
(2005)
J Exp Med
, vol.201
, pp. 737-746
-
-
Fahlen, L.1
Read, S.2
Gorelik, L.3
-
210
-
-
34547788180
-
Afunctionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGFbeta and retinoic acid-dependent mechanism
-
Coombes JL, Siddiqui KR, Arancibia-CarcamoCV, et al. Afunctionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGFbeta and retinoic acid-dependent mechanism. J Exp Med 2007; 204: 1757-64.
-
(2007)
J Exp Med
, vol.204
, pp. 1757-1764
-
-
Coombes, J.L.1
Siddiqui, K.R.2
Arancibia-Carcamo, C.V.3
-
211
-
-
34547757390
-
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
-
Sun CM, Hall JA, Blank RB, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007; 204: 1775-85.
-
(2007)
J Exp Med
, vol.204
, pp. 1775-1785
-
-
Sun, C.M.1
Hall, J.A.2
Blank, R.B.3
-
212
-
-
5644300399
-
Retinoic acid imprints gut-homing specificity on T cells
-
IwataM, Hirakiyama A, Eshima Y, et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004; 21: 527-38.
-
(2004)
Immunity
, vol.21
, pp. 527-538
-
-
Iwata, M.1
Hirakiyama, A.2
Eshima, Y.3
-
213
-
-
34547769253
-
All-transretinoic acid mediates enhanced T reg cell growth, differentiation and gut homing in the face of high levels of co-stimulation
-
Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-transretinoic acid mediates enhanced T reg cell growth, differentiation and gut homing in the face of high levels of co-stimulation. J Exp Med 2007; 204: 1765-74.
-
(2007)
J Exp Med
, vol.204
, pp. 1765-1774
-
-
Benson, M.J.1
Pino-Lagos, K.2
Rosemblatt, M.3
Noelle, R.J.4
-
214
-
-
34447503805
-
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
-
Mucida D, Park Y, KimGet al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007; 317: 256-60.
-
(2007)
Science
, vol.317
, pp. 256-260
-
-
Mucida, D.1
Park, Y.2
Kim, G.3
-
215
-
-
0029913624
-
Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease
-
BabyatskyMW, Rossiter G, Podolsky DK. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996; 110: 975-84.
-
(1996)
Gastroenterology
, vol.110
, pp. 975-984
-
-
Babyatsky, M.W.1
Rossiter, G.2
Podolsky, D.K.3
-
216
-
-
0033497296
-
Transforming growth factor-betas and their signaling receptors are coexpressed in Crohn's disease
-
di Mola FF, Friess H, Scheuren A, et al. Transforming growth factor-betas and their signaling receptors are coexpressed in Crohn's disease. Ann Surg 1999; 229: 67-75.
-
(1999)
Ann Surg
, vol.229
, pp. 67-75
-
-
di Mola, F.F.1
Friess, H.2
Scheuren, A.3
-
217
-
-
0141762545
-
TGFbeta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis
-
Del Zotto B, Mumolo G, PronioAMet al. TGFbeta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis. Clin Exp Immunol 2003; 134: 120-6.
-
(2003)
Clin Exp Immunol
, vol.134
, pp. 120-126
-
-
Del Zotto, B.1
Mumolo, G.2
Pronio, A.M.3
-
218
-
-
0032776134
-
Site-specific changes in transforming growth factor-alpha and -beta1 expression in colonic mucosa of adolescents with inflammatory bowel disease
-
Xian CJ, Xu X, Mardell CE, et al. Site-specific changes in transforming growth factor-alpha and -beta1 expression in colonic mucosa of adolescents with inflammatory bowel disease. Scand J Gastroenterol 1999; 34: 591-600.
-
(1999)
Scand J Gastroenterol
, vol.34
, pp. 591-600
-
-
Xian, C.J.1
Xu, X.2
Mardell, C.E.3
-
219
-
-
0028838414
-
Immunohistochemical localization of transforming growth factor-beta receptors I and II in inflammatory bowel disease
-
Ohtani H, Kagaya H, Nagura H. Immunohistochemical localization of transforming growth factor-beta receptors I and II in inflammatory bowel disease. J Gastroenterol 1995; 30 Suppl 8: 76-7.
-
(1995)
J Gastroenterol
, vol.30
, Issue.SUUPL 8
, pp. 76-77
-
-
Ohtani, H.1
Kagaya, H.2
Nagura, H.3
-
220
-
-
54349125596
-
Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease
-
Burke JP, Ferrante M, Dejaegher K, et al. Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease. Inflamm Bowel Dis 2008; 14: 1197-204.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 1197-1204
-
-
Burke, J.P.1
Ferrante, M.2
Dejaegher, K.3
-
221
-
-
30044449492
-
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGFbeta1 production and fibrosis
-
Fichtner-Feigl S, StroberW, Kawakami K, et al. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGFbeta1 production and fibrosis. Nat Med 2006; 12: 99-106.
-
(2006)
Nat Med
, vol.12
, pp. 99-106
-
-
Fichtner-Feigl, S.1
Strober, W.2
Kawakami, K.3
-
223
-
-
0034894059
-
Blocking Smad7 restores TGFbeta1 signaling in chronic inflammatory bowel disease
-
Monteleone G, Kumberova A, CroftNMet al. Blocking Smad7 restores TGFbeta1 signaling in chronic inflammatory bowel disease. J Clin Invest 2001; 108: 601-9.
-
(2001)
J Clin Invest
, vol.108
, pp. 601-609
-
-
Monteleone, G.1
Kumberova, A.2
Croft, N.M.3
-
224
-
-
33846906224
-
Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
-
Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007; 445: 648-51.
-
(2007)
Nature
, vol.445
, pp. 648-651
-
-
Zheng, Y.1
Danilenko, D.M.2
Valdez, P.3
-
225
-
-
0036604122
-
Cutting edge: immune cells as sources and targets of the IL-10 family members
-
Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 2002; 168: 5397-402.
-
(2002)
J Immunol
, vol.168
, pp. 5397-5402
-
-
Wolk, K.1
Kunz, S.2
Asadullah, K.3
Sabat, R.4
-
226
-
-
4143095716
-
IL-22 increases the innate immunity of tissues
-
Wolk K, Kunz S,Witte E, et al. IL-22 increases the innate immunity of tissues. Immunity 2004; 21: 241-54.
-
(2004)
Immunity
, vol.21
, pp. 241-254
-
-
Wolk, K.1
Kunz, S.2
Witte, E.3
-
227
-
-
33749983749
-
Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
-
Wolk K, Sabat R. Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells. Cytokine Growth Factor Rev 2006; 17: 367-80.
-
(2006)
Cytokine Growth Factor Rev
, vol.17
, pp. 367-380
-
-
Wolk, K.1
Sabat, R.2
-
228
-
-
24144477540
-
Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
-
Andoh A, Zhang Z, Inatomi O, et al. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 2005; 129: 969-84.
-
(2005)
Gastroenterology
, vol.129
, pp. 969-984
-
-
Andoh, A.1
Zhang, Z.2
Inatomi, O.3
-
229
-
-
38849141814
-
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto K, Ogawa A, Mizoguchi E, et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 2008; 118: 534-44.
-
(2008)
J Clin Invest
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
Ogawa, A.2
Mizoguchi, E.3
-
230
-
-
57449090428
-
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
-
Zenewicz LA, Yancopoulos GD, Valenzuela DM, et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008; 29: 947-57.
-
(2008)
Immunity
, vol.29
, pp. 947-957
-
-
Zenewicz, L.A.1
Yancopoulos, G.D.2
Valenzuela, D.M.3
-
231
-
-
2342462460
-
Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
-
Radaeva S, Sun R, Pan HN, et al. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 2004; 39: 1332-42.
-
(2004)
Hepatology
, vol.39
, pp. 1332-1342
-
-
Radaeva, S.1
Sun, R.2
Pan, H.N.3
-
232
-
-
39649121919
-
Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate Cytokines and Chemokines in Mucosal Homeostasis 153 with disease activity and IL23R genotype status
-
Schmechel S, Konrad A, Diegelmann J, et al. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate Cytokines and Chemokines in Mucosal Homeostasis 153 with disease activity and IL23R genotype status. Inflamm Bowel Dis 2008; 14: 204-12.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 204-212
-
-
Schmechel, S.1
Konrad, A.2
Diegelmann, J.3
-
233
-
-
0029100038
-
Preclinical biology of interleukin 11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity
-
Goldman SJ. Preclinical biology of interleukin 11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity. Stem Cells 1995; 13: 462-71.
-
(1995)
Stem Cells
, vol.13
, pp. 462-471
-
-
Goldman, S.J.1
-
234
-
-
0031229726
-
Interleukin-11 inhibits macrophage interleukin-12 production
-
Leng SX, Elias JA. Interleukin-11 inhibits macrophage interleukin-12 production. J Immunol 1997; 159: 2161-8.
-
(1997)
J Immunol
, vol.159
, pp. 2161-2168
-
-
Leng, S.X.1
Elias, J.A.2
-
235
-
-
0032823806
-
Hematopoietic, immunomodulatory and epithelial effects of interleukin-11
-
Schwertschlag US, Trepicchio WL, Dykstra KH, et al. Hematopoietic, immunomodulatory and epithelial effects of interleukin-11. Leukemia 1999; 13: 1307-15.
-
(1999)
Leukemia
, vol.13
, pp. 1307-1315
-
-
Schwertschlag, U.S.1
Trepicchio, W.L.2
Dykstra, K.H.3
-
236
-
-
0032742184
-
Interleukin-11 reduces T-celldependent experimental liver injury in mice
-
Bozza M, Bliss JL, Maylor R, et al. Interleukin-11 reduces T-celldependent experimental liver injury in mice. Hepatology 1999; 30: 1441-7.
-
(1999)
Hepatology
, vol.30
, pp. 1441-1447
-
-
Bozza, M.1
Bliss, J.L.2
Maylor, R.3
-
237
-
-
33746375044
-
Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer
-
Deutscher N, Bataille F, Hausmann M, et al. Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer. Int J Colorectal Dis 2006; 21: 573-81.
-
(2006)
Int J Colorectal Dis
, vol.21
, pp. 573-581
-
-
Deutscher, N.1
Bataille, F.2
Hausmann, M.3
-
238
-
-
0029747033
-
Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation
-
Peterson RL, Bozza MM, Dorner AJ. Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation.AmJ Pathol 1996; 149: 895-902.
-
(1996)
AmJ Pathol
, vol.149
, pp. 895-902
-
-
Peterson, R.L.1
Bozza, M.M.2
Dorner, A.J.3
-
239
-
-
0029835760
-
Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats
-
Qiu BS, Pfeiffer CJ, Keith JC Jr. Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats. Dig Dis Sci 1996; 41: 1625-30.
-
(1996)
Dig Dis Sci
, vol.41
, pp. 1625-1630
-
-
Qiu, B.S.1
Pfeiffer, C.J.2
Keith Jr., J.C.3
-
240
-
-
0033886814
-
Recombinant human interleukin-11 modulates ion transport and mucosal inflammation in the small intestine and colon
-
Greenwood-Van Meerveld B, Tyler K, Keith JC Jr. Recombinant human interleukin-11 modulates ion transport and mucosal inflammation in the small intestine and colon. Lab Invest 2000; 80: 1269-80.
-
(2000)
Lab Invest
, vol.80
, pp. 1269-1280
-
-
Greenwood-Van Meerveld, B.1
Tyler, K.2
Keith Jr., J.C.3
-
241
-
-
0032407805
-
Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease
-
Peterson RL, Wang L, Albert L, et al. Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease. Lab Invest 1998; 78: 1503-12.
-
(1998)
Lab Invest
, vol.78
, pp. 1503-1512
-
-
Peterson, R.L.1
Wang, L.2
Albert, L.3
-
242
-
-
0033404492
-
Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions
-
Trepicchio WL, OzawaM,Walters IB, et al. Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions. J Clin Invest 1999; 104: 1527-37.
-
(1999)
J Clin Invest
, vol.104
, pp. 1527-1537
-
-
Trepicchio, W.L.1
Ozawa, M.2
Walters, I.B.3
-
243
-
-
0036186051
-
Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease
-
Sands BE, Winston BD, Salzberg B, et al. Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease. Aliment Pharmacol Ther 2002; 16: 399-406.
-
(2002)
Aliment Pharmacol Ther
, vol.16
, pp. 399-406
-
-
Sands, B.E.1
Winston, B.D.2
Salzberg, B.3
-
244
-
-
33645455612
-
Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease
-
Herrlinger KR,Witthoeft T, Raedler A, et al. Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease. Am J Gastroenterol 2006; 101: 793-7.
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 793-797
-
-
Herrlinger, K.R.1
Witthoeft, T.2
Raedler, A.3
-
245
-
-
36549030784
-
The inhibitory cytokine IL-35 contributes to regulatory T-cell function
-
Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007; 450: 566-9.
-
(2007)
Nature
, vol.450
, pp. 566-569
-
-
Collison, L.W.1
Workman, C.J.2
Kuo, T.T.3
-
246
-
-
35848958662
-
New players in the cytokine orchestra of inflammatory bowel disease
-
Fantini MC, Monteleone G, Macdonald TT. New players in the cytokine orchestra of inflammatory bowel disease. Inflamm Bowel Dis 2007; 13: 1419-23.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 1419-1423
-
-
Fantini, M.C.1
Monteleone, G.2
Macdonald, T.T.3
-
247
-
-
41349121555
-
Regulation of gut inflammation and th17 cell response by interleukin-21
-
Fina D, Sarra M, FantiniMC, et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 2008; 134: 1038-48.
-
(2008)
Gastroenterology
, vol.134
, pp. 1038-1048
-
-
Fina, D.1
Sarra, M.2
Fantini, M.C.3
-
248
-
-
15744390341
-
Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
-
Monteleone G, Monteleone I, Fina D, et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 2005; 128: 687-94.
-
(2005)
Gastroenterology
, vol.128
, pp. 687-694
-
-
Monteleone, G.1
Monteleone, I.2
Fina, D.3
-
249
-
-
9644279571
-
The role of IL-27 in the development of T-cell responses during parasitic infections
-
Hunter CA,Villarino A, Artis D, Scott P. The role of IL-27 in the development of T-cell responses during parasitic infections. Immunol Rev 2004; 202: 106-14.
-
(2004)
Immunol Rev
, vol.202
, pp. 106-114
-
-
Hunter, C.A.1
Villarino, A.2
Artis, D.3
Scott, P.4
-
250
-
-
33747588291
-
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
-
Batten M, Li J, Yi S, et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006; 7: 929-36.
-
(2006)
Nat Immunol
, vol.7
, pp. 929-936
-
-
Batten, M.1
Li, J.2
Yi, S.3
-
251
-
-
0037168543
-
Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice
-
Nieuwenhuis EE, Neurath MF, Corazza N, et al. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad SciUSA 2002; 99: 16951-6.
-
(2002)
Proc Natl Acad SciUSA
, vol.99
, pp. 16951-6
-
-
Nieuwenhuis, E.E.1
Neurath, M.F.2
Corazza, N.3
-
252
-
-
44849096815
-
IL-27R deficiency delays the onset of colitis and protects fromhelminth-induced pathology in a model of chronic IBD
-
Villarino AV, Artis D, Bezbradica JS, et al. IL-27R deficiency delays the onset of colitis and protects fromhelminth-induced pathology in a model of chronic IBD. Int Immunol 2008; 20: 739-52.
-
(2008)
Int Immunol
, vol.20
, pp. 739-752
-
-
Villarino, A.V.1
Artis, D.2
Bezbradica, J.S.3
-
253
-
-
27944495565
-
T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis
-
Honda K, Nakamura K, Matsui N, et al. T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Inflamm Bowel Dis 2005; 11: 1044-52.
-
(2005)
Inflamm Bowel Dis
, vol.11
, pp. 1044-1052
-
-
Honda, K.1
Nakamura, K.2
Matsui, N.3
-
254
-
-
12444304581
-
Interleukin-32: a cytokine and inducer of TNFalpha
-
Kim SH, Han SY, Azam T, et al. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity 2005; 22: 131-42.
-
(2005)
Immunity
, vol.22
, pp. 131-142
-
-
Kim, S.H.1
Han, S.Y.2
Azam, T.3
-
255
-
-
56149122501
-
A human dendritic cell subset receptive to the Venezuelan equine encephalitis virusderived replicon particle constitutively expresses IL-32
-
Nishimoto KP, Laust AK, Nelson EL. A human dendritic cell subset receptive to the Venezuelan equine encephalitis virusderived replicon particle constitutively expresses IL-32. J Immunol 2008; 181: 4010-8.
-
(2008)
J Immunol
, vol.181
, pp. 4010-4018
-
-
Nishimoto, K.P.1
Laust, A.K.2
Nelson, E.L.3
-
256
-
-
34547887644
-
Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease
-
Shioya M, Nishida A, Yagi Y, et al. Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin Exp Immunol 2007; 149: 480-6.
-
(2007)
Clin Exp Immunol
, vol.149
, pp. 480-486
-
-
Shioya, M.1
Nishida, A.2
Yagi, Y.3
-
257
-
-
28044453314
-
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1- dependent mechanism
-
Netea MG, Azam T, Ferwerda G, et al. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1- dependent mechanism. Proc Natl Acad Sci USA 2005; 102: 16309-14.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 16309-14
-
-
Netea, M.G.1
Azam, T.2
Ferwerda, G.3
-
258
-
-
70350510213
-
Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases
-
ShodaH, Fujio K,YamaguchiYet al. Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases. Arthritis Res Ther 2006; 8: R166.
-
(2006)
Arthritis Res Ther
, vol.8
-
-
Shoda, H.1
Fujio, K.2
Yamaguchi, Y.3
-
259
-
-
46249090513
-
Colony-stimulating factors in inflammation and autoimmunity
-
Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 2008; 8: 533-44.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 533-544
-
-
Hamilton, J.A.1
-
260
-
-
0031020373
-
Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis
-
Rasmussen SJ, Eckmann L, Quayle AJ, et al. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest 1997; 99: 77-87.
-
(1997)
J Clin Invest
, vol.99
, pp. 77-87
-
-
Rasmussen, S.J.1
Eckmann, L.2
Quayle, A.J.3
-
261
-
-
38849170507
-
Granulocyte macrophage colony-stimulating factor ameliorates DSSinduced experimental colitis
-
Sainathan SK, Hanna EM, Gong Q, et al. Granulocyte macrophage colony-stimulating factor ameliorates DSSinduced experimental colitis. Inflamm BowelDis 2008; 14: 88-99.
-
(2008)
Inflamm BowelDis
, vol.14
, pp. 88-99
-
-
Sainathan, S.K.1
Hanna, E.M.2
Gong, Q.3
-
262
-
-
57049185731
-
The role of granulocyte macrophagecolony- stimulating factor in acute intestinal inflammation
-
Xu Y, Hunt NH, Bao S. The role of granulocyte macrophagecolony- stimulating factor in acute intestinal inflammation. Cell Res 2008; 18: 1220-9.
-
(2008)
Cell Res
, vol.18
, pp. 1220-1229
-
-
Xu, Y.1
Hunt, N.H.2
Bao, S.3
-
263
-
-
0037048904
-
Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor
-
Dieckgraefe BK, Korzenik JR. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 2002; 360: 1478-80.
-
(2002)
Lancet
, vol.360
, pp. 1478-1480
-
-
Dieckgraefe, B.K.1
Korzenik, J.R.2
-
264
-
-
19444363154
-
Sargramostim for active Crohn's disease
-
Korzenik JR, Dieckgraefe BK, Valentine JF, Hausman DF, Gilbert MJ. Sargramostim for active Crohn's disease. N Engl J Med 2005; 352: 2193-201.
-
(2005)
N Engl J Med
, vol.352
, pp. 2193-2201
-
-
Korzenik, J.R.1
Dieckgraefe, B.K.2
Valentine, J.F.3
Hausman, D.F.4
Gilbert, M.J.5
-
265
-
-
14644404938
-
An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease
-
Korzenik JR, Dieckgraefe BK. An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease. Aliment Pharmacol Ther 2005; 21: 391-400.
-
(2005)
Aliment Pharmacol Ther
, vol.21
, pp. 391-400
-
-
Korzenik, J.R.1
Dieckgraefe, B.K.2
-
266
-
-
0035135221
-
Increased secretion of granulocyte-macrophage colony-stimulating factor in mucosal lesions of inflammatory bowel disease
-
Noguchi M, Hiwatashi N, Liu ZX, Toyota T. Increased secretion of granulocyte-macrophage colony-stimulating factor in mucosal lesions of inflammatory bowel disease. Digestion 2001; 63 Suppl 1: 32-6.
-
(2001)
Digestion
, vol.63
, Issue.SUUPL 1
, pp. 32-36
-
-
Noguchi, M.1
Hiwatashi, N.2
Liu, Z.X.3
Toyota, T.4
-
267
-
-
3142588819
-
Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease -a possible target for infliximab treatment
-
Agnholt J, Kelsen J, Brandsborg B, et al. Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease -a possible target for infliximab treatment. Eur J Gastroenterol Hepatol 2004; 16: 649-55.
-
(2004)
Eur J Gastroenterol Hepatol
, vol.16
, pp. 649-655
-
-
Agnholt, J.1
Kelsen, J.2
Brandsborg, B.3
-
268
-
-
18944379196
-
The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance
-
Fry TJ, Mackall CL. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol 2005; 174: 6571-6.
-
(2005)
J Immunol
, vol.174
, pp. 6571-6576
-
-
Fry, T.J.1
Mackall, C.L.2
-
269
-
-
0033744745
-
Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammacdependent cytokines IL-2, IL-7 and IL-15
-
Porter BO, Malek TR. Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammacdependent cytokines IL-2, IL-7 and IL-15. Semin Immunol 2000; 12: 465-74.
-
(2000)
Semin Immunol
, vol.12
, pp. 465-474
-
-
Porter, B.O.1
Malek, T.R.2
-
270
-
-
0343183279
-
Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches
-
Laky K, Lefrancois L, Lingenheld EG, et al. Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches. J Exp Med 2000; 191: 1569-80.
-
(2000)
J Exp Med
, vol.191
, pp. 1569-1580
-
-
Laky, K.1
Lefrancois, L.2
Lingenheld, E.G.3
-
271
-
-
0032472838
-
Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa
-
Watanabe M, Ueno Y, Yajima T, et al. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med 1998; 187: 389-402.
-
(1998)
J Exp Med
, vol.187
, pp. 389-402
-
-
Watanabe, M.1
Ueno, Y.2
Yajima, T.3
-
272
-
-
0032533480
-
IL-7 deficiency prevents development of a non-T cell non-B cell-mediated colitis
-
von Freeden-Jeffry U, Davidson N,Wiler R, et al. IL-7 deficiency prevents development of a non-T cell non-B cell-mediated colitis. J Immunol 1998; 161: 5673-80.
-
(1998)
J Immunol
, vol.161
, pp. 5673-5680
-
-
von Freeden-Jeffry, U.1
Davidson, N.2
Wiler, R.3
-
273
-
-
34247157433
-
IL-7 Is essential for the development and the persistence of chronic colitis
-
Totsuka T, Kanai T, Nemoto Y, et al. IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol 2007; 178: 4737-48.
-
(2007)
J Immunol
, vol.178
, pp. 4737-4748
-
-
Totsuka, T.1
Kanai, T.2
Nemoto, Y.3
-
274
-
-
20144376580
-
IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice
-
Okada E, YamazakiM, TanabeMet al. IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice. Am J Physiol Gastrointest Liver Physiol 2005; 288: G745-54.
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.288
-
-
Okada, E.1
Yamazaki, M.2
Tanabe, M.3
-
275
-
-
0041344313
-
Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis
-
Yamazaki M, Yajima T, Tanabe M, et al. Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J Immunol 2003; 171: 1556-63.
-
(2003)
J Immunol
, vol.171
, pp. 1556-1563
-
-
Yamazaki, M.1
Yajima, T.2
Tanabe, M.3
-
276
-
-
40449131153
-
Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis
-
Tomita T, Kanai T, Nemoto Y, et al. Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis. J Immunol 2008; 180: 383-90.
-
(2008)
J Immunol
, vol.180
, pp. 383-390
-
-
Tomita, T.1
Kanai, T.2
Nemoto, Y.3
-
277
-
-
46849091975
-
TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
-
Yamamoto S, Shimizu S, Kiyonaka S, et al. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. NatMed 2008; 14: 738-47.
-
(2008)
NatMed
, vol.14
, pp. 738-747
-
-
Yamamoto, S.1
Shimizu, S.2
Kiyonaka, S.3
-
278
-
-
2542428442
-
Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells
-
Rot A, von Andrian UH. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 2004; 22: 891-928.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 891-928
-
-
Rot, A.1
von Andrian, U.H.2
-
279
-
-
0035023806
-
Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/-mice and Rag- 2-/-mice reconstituted with CD4+CD45RBhigh T cells
-
Scheerens H, Hessel E, de Waal-Malefyt R, et al. Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/-mice and Rag- 2-/-mice reconstituted with CD4+CD45RBhigh T cells. Eur J Immunol 2001; 31: 1465-74.
-
(2001)
Eur J Immunol
, vol.31
, pp. 1465-1474
-
-
Scheerens, H.1
Hessel, E.2
de Waal-Malefyt, R.3
-
280
-
-
0036140612
-
The increased expression of an array of C-X-C and C-C chemokines in the colonic mucosa of patientswith ulcerative colitis: regulation by corticosteroids
-
Yang SK, Choi MS, Kim OH, et al. The increased expression of an array of C-X-C and C-C chemokines in the colonic mucosa of patientswith ulcerative colitis: regulation by corticosteroids. Am J Gastroenterol 2002; 97: 126-32.
-
(2002)
Am J Gastroenterol
, vol.97
, pp. 126-132
-
-
Yang, S.K.1
Choi, M.S.2
Kim, O.H.3
-
281
-
-
32144454172
-
The many roles of chemokines and chemokine receptors in inflammation
-
Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354: 610-21.
-
(2006)
N Engl J Med
, vol.354
, pp. 610-621
-
-
Charo, I.F.1
Ransohoff, R.M.2
-
282
-
-
34247855761
-
Chemokine: receptor structure, interactions and antagonism
-
Allen SJ, Crown SE, Handel TM. Chemokine: receptor structure, interactions and antagonism. Annu Rev Immunol 2007; 25: 787-820.
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 787-820
-
-
Allen, S.J.1
Crown, S.E.2
Handel, T.M.3
-
283
-
-
0031930615
-
IL-4, IL-10 and IL-13 down-regulatemonocyte-chemoattracting protein-1 (MCP- 1) production in activated intestinal epithelial cells
-
Kucharzik T, Lugering N, Pauels HG, et al. IL-4, IL-10 and IL-13 down-regulatemonocyte-chemoattracting protein-1 (MCP- 1) production in activated intestinal epithelial cells. Clin Exp Immunol 1998; 111: 152-7.
-
(1998)
Clin Exp Immunol
, vol.111
, pp. 152-157
-
-
Kucharzik, T.1
Lugering, N.2
Pauels, H.G.3
-
284
-
-
0031948889
-
Interferon gamma induces differential upregulation of alpha and beta chemokine secretion in colonic epithelial cell lines
-
Warhurst AC, Hopkins SJ, Warhurst G. Interferon gamma induces differential upregulation of alpha and beta chemokine secretion in colonic epithelial cell lines. Gut 1998; 42: 208-13.
-
(1998)
Gut
, vol.42
, pp. 208-213
-
-
Warhurst, A.C.1
Hopkins, S.J.2
Warhurst, G.3
-
285
-
-
33646270895
-
Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
-
Motomura Y, Khan WI, El-Sharkawy RT, et al. Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1. Gut 2006; 55: 662-70.
-
(2006)
Gut
, vol.55
, pp. 662-670
-
-
Motomura, Y.1
Khan, W.I.2
El-Sharkawy, R.T.3
-
286
-
-
33751071608
-
Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells
-
Khan WI, Motomura Y, Wang H, et al. Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells. Am J Physiol Gastrointest Liver Physiol 2006; 291: G803-11.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.291
-
-
Khan, W.I.1
Motomura, Y.2
Wang, H.3
-
287
-
-
0034659767
-
Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine
-
Andres PG, Beck PL, Mizoguchi E, et al. Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine. J Immunol 2000; 164: 6303-12.
-
(2000)
J Immunol
, vol.164
, pp. 6303-6312
-
-
Andres, P.G.1
Beck, P.L.2
Mizoguchi, E.3
-
288
-
-
23844499474
-
The simultaneous blockade of chemokine receptors CCR2, CCR5 andCXCR3 by a nonpeptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis
-
Tokuyama H, Ueha S, KurachiMet al. The simultaneous blockade of chemokine receptors CCR2, CCR5 andCXCR3 by a nonpeptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis. Int Immunol 2005; 17: 1023-34.
-
(2005)
Int Immunol
, vol.17
, pp. 1023-1034
-
-
Tokuyama, H.1
Ueha, S.2
Kurachi, M.3
-
289
-
-
0028813487
-
Monocytechemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa
-
Reinecker HC, Loh EY, Ringler DJ, et al. Monocytechemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology 1995; 108: 40-50.
-
(1995)
Gastroenterology
, vol.108
, pp. 40-50
-
-
Reinecker, H.C.1
Loh, E.Y.2
Ringler, D.J.3
-
290
-
-
0030041142
-
Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease
-
Mazzucchelli L, Hauser C, Zgraggen K, et al. Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease. J Pathol 1996; 178: 201-6.
-
(1996)
J Pathol
, vol.178
, pp. 201-206
-
-
Mazzucchelli, L.1
Hauser, C.2
Zgraggen, K.3
-
291
-
-
0029888133
-
Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa
-
Grimm MC, Elsbury SK, Pavli P, Doe WF. Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa. J Leukoc Biol 1996; 59: 804-12.
-
(1996)
J Leukoc Biol
, vol.59
, pp. 804-812
-
-
Grimm, M.C.1
Elsbury, S.K.2
Pavli, P.3
Doe, W.F.4
-
293
-
-
0034773576
-
Tissue cytokine and chemokine expression in inflammatory bowel disease
-
McCormack G, Moriarty D, O'Donoghue DP, et al. Tissue cytokine and chemokine expression in inflammatory bowel disease. Inflamm Res 2001; 50: 491-5.
-
(2001)
Inflamm Res
, vol.50
, pp. 491-495
-
-
McCormack, G.1
Moriarty, D.2
O'Donoghue, D.P.3
-
294
-
-
4344651209
-
CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease
-
Connor SJ, Paraskevopoulos N, Newman R, et al. CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease. Gut 2004; 53: 1287-94.
-
(2004)
Gut
, vol.53
, pp. 1287-1294
-
-
Connor, S.J.1
Paraskevopoulos, N.2
Newman, R.3
-
295
-
-
15844419153
-
Identification of a major coreceptor for primary isolates of HIV-1
-
Deng H, Liu R, Ellmeier W, et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature 1996; 381: 661-6.
-
(1996)
Nature
, vol.381
, pp. 661-666
-
-
Deng, H.1
Liu, R.2
Ellmeier, W.3
-
296
-
-
4444279141
-
The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis
-
Ajuebor MN, Kunkel SL, Hogaboam CM. The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis. Eur J Pharmacol 2004; 497: 343-9.
-
(2004)
Eur J Pharmacol
, vol.497
, pp. 343-349
-
-
Ajuebor, M.N.1
Kunkel, S.L.2
Hogaboam, C.M.3
-
297
-
-
22644431611
-
Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model
-
Pender SL, Chance V, Whiting CV, et al. Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model. Gut 2005; 54: 1114-20.
-
(2005)
Gut
, vol.54
, pp. 1114-1120
-
-
Pender, S.L.1
Chance, V.2
Whiting, C.V.3
-
298
-
-
0035168846
-
The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat
-
AjueborMN, Hogaboam CM, Kunkel SL, et al. The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat. J Immunol 2001; 166: 552-8.
-
(2001)
J Immunol
, vol.166
, pp. 552-558
-
-
Ajuebor, M.N.1
Hogaboam, C.M.2
Kunkel, S.L.3
-
299
-
-
38549166392
-
Expression profiles of cytokines and chemokines in murine MDR1a-/-colitis
-
Masunaga Y, Noto T, Suzuki K, et al. Expression profiles of cytokines and chemokines in murine MDR1a-/-colitis. Inflamm Res 2007; 56: 439-46.
-
(2007)
Inflamm Res
, vol.56
, pp. 439-446
-
-
Masunaga, Y.1
Noto, T.2
Suzuki, K.3
-
300
-
-
33750026738
-
Comparison of RANTES expression in Crohn's disease and ulcerative colitis: an aid in the differential diagnosis
-
Ansari N, Abdulla J, Zayyani N, et al. Comparison of RANTES expression in Crohn's disease and ulcerative colitis: an aid in the differential diagnosis? J Clin Pathol 2006; 59: 1066-72.
-
(2006)
J Clin Pathol
, vol.59
, pp. 1066-1072
-
-
Ansari, N.1
Abdulla, J.2
Zayyani, N.3
-
301
-
-
0032788099
-
Increased expression of IP-10, IL-8,MCP-1 andMCP-3 in ulcerative colitis
-
Uguccioni M, Gionchetti P, Robbiani DF, et al. Increased expression of IP-10, IL-8,MCP-1 andMCP-3 in ulcerative colitis. Am J Pathol 1999; 155: 331-6.
-
(1999)
Am J Pathol
, vol.155
, pp. 331-336
-
-
Uguccioni, M.1
Gionchetti, P.2
Robbiani, D.F.3
-
302
-
-
12344314536
-
Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response
-
Oki M, Ohtani H, Kinouchi Y, et al. Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response? Lab Invest 2005; 85: 137-45.
-
(2005)
Lab Invest
, vol.85
, pp. 137-145
-
-
Oki, M.1
Ohtani, H.2
Kinouchi, Y.3
-
303
-
-
0035013827
-
Regulated MIP- 3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity
-
Izadpanah A, Dwinell MB, Eckmann L, et al. Regulated MIP- 3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. Am J Physiol Gastrointest Liver Physiol 2001; 280: G710-9.
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.280
-
-
Izadpanah, A.1
Dwinell, M.B.2
Eckmann, L.3
-
304
-
-
0036895299
-
Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP- 3alpha) production in normal colon and inflammatory bowel disease
-
Kwon JH, Keates S, Bassani L, et al. Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP- 3alpha) production in normal colon and inflammatory bowel disease. Gut 2002; 51: 818-26.
-
(2002)
Gut
, vol.51
, pp. 818-826
-
-
Kwon, J.H.1
Keates, S.2
Bassani, L.3
-
305
-
-
0242303557
-
CCR6 has a non-redundant role in the development of inflammatory bowel disease
-
Varona R, Cadenas V, Flores J, et al. CCR6 has a non-redundant role in the development of inflammatory bowel disease. Eur J Immunol 2003; 33: 2937-46.
-
(2003)
Eur J Immunol
, vol.33
, pp. 2937-2946
-
-
Varona, R.1
Cadenas, V.2
Flores, J.3
-
306
-
-
34347397614
-
MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice
-
Katchar K, Kelly CP, Keates S, et al. MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice. AmJ Physiol Gastrointest Liver Physiol 2007; 292: G1263-71.
-
(2007)
Am J Physiol Gastrointest Liver Physiol
, vol.292
-
-
Katchar, K.1
Kelly, C.P.2
Keates, S.3
-
307
-
-
34548761490
-
The chemokine receptor CCR6 is an important component of the innate immune response
-
Wen H, Hogaboam CM, Lukacs NW, et al. The chemokine receptor CCR6 is an important component of the innate immune response. Eur J Immunol 2007; 37: 2487-98.
-
(2007)
Eur J Immunol
, vol.37
, pp. 2487-2498
-
-
Wen, H.1
Hogaboam, C.M.2
Lukacs, N.W.3
-
308
-
-
20044376669
-
Increased lymphocyte trafficking to colonicmicrovessels is dependent onMAdCAM- 1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis
-
Teramoto K, Miura S, Tsuzuki Y, et al. Increased lymphocyte trafficking to colonicmicrovessels is dependent onMAdCAM- 1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis. Clin Exp Immunol 2005; 139: 421-8.
-
(2005)
Clin Exp Immunol
, vol.139
, pp. 421-428
-
-
Teramoto, K.1
Miura, S.2
Tsuzuki, Y.3
-
309
-
-
33646566609
-
CCR6- mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches
-
Salazar-Gonzalez RM, Niess JH, Zammit DJ, et al. CCR6- mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity 2006; 24: 623-32.
-
(2006)
Immunity
, vol.24
, pp. 623-632
-
-
Salazar-Gonzalez, R.M.1
Niess, J.H.2
Zammit, D.J.3
-
310
-
-
58849152515
-
The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut
-
Wang C, Kang SG, Lee J, et al. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol 2009; 2 (2):173-83.
-
(2009)
Mucosal Immunol
, vol.2
, Issue.2
, pp. 173-183
-
-
Wang, C.1
Kang, S.G.2
Lee, J.3
-
311
-
-
0033986966
-
The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9
-
Wurbel MA, Philippe JM, Nguyen C, et al. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur J Immunol 2000; 30: 262-71.
-
(2000)
Eur J Immunol
, vol.30
, pp. 262-271
-
-
Wurbel, M.A.1
Philippe, J.M.2
Nguyen, C.3
-
312
-
-
1342300522
-
Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine
-
Pabst O, Ohl L, Wendland M, et al. Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med 2004; 199: 411-6.
-
(2004)
J Exp Med
, vol.199
, pp. 411-416
-
-
Pabst, O.1
Ohl, L.2
Wendland, M.3
-
313
-
-
0036802422
-
CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa
-
SvenssonM,Marsal J, Ericsson A, et al. CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa. J Clin Invest 2002; 110: 1113-21.
-
(2002)
J Clin Invest
, vol.110
, pp. 1113-1121
-
-
Svensson, M.1
Marsal, J.2
Ericsson, A.3
-
314
-
-
0036910773
-
Involvement of CCL25 (TECK) in the generation of the murine small-intestinal CD8alpha alpha+CD3+ intraepithelial lymphocyte compartment
-
Marsal J, Svensson M, Ericsson A, et al. Involvement of CCL25 (TECK) in the generation of the murine small-intestinal CD8alpha alpha+CD3+ intraepithelial lymphocyte compartment. Eur J Immunol 2002; 32: 3488-97.
-
(2002)
Eur J Immunol
, vol.32
, pp. 3488-3497
-
-
Marsal, J.1
Svensson, M.2
Ericsson, A.3
-
315
-
-
0141449950
-
Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant
-
Johansson-Lindbom B, Svensson M, Wurbel MA, et al. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med 2003; 198: 963-9.
-
(2003)
J Exp Med
, vol.198
, pp. 963-969
-
-
Johansson-Lindbom, B.1
Svensson, M.2
Wurbel, M.A.3
-
316
-
-
0038264036
-
Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
-
Mora JR, Bono MR, Manjunath N, et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 2003; 424: 88-93.
-
(2003)
Nature
, vol.424
, pp. 88-93
-
-
Mora, J.R.1
Bono, M.R.2
Manjunath, N.3
-
317
-
-
26844538936
-
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
-
Johansson-Lindbom B, Svensson M, Pabst O, et al. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med 2005; 202: 1063-73.
-
(2005)
J Exp Med
, vol.202
, pp. 1063-1073
-
-
Johansson-Lindbom, B.1
Svensson, M.2
Pabst, O.3
-
318
-
-
33645054315
-
Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells
-
Worbs T, Bode U, Yan S, et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 2006; 203: 519-27.
-
(2006)
J Exp Med
, vol.203
, pp. 519-527
-
-
Worbs, T.1
Bode, U.2
Yan, S.3
-
319
-
-
26844468978
-
Essential role for CD103 in the T cell-mediated regulation of experimental colitis
-
Annacker O, Coombes JL, Malmstrom V, et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med 2005; 202: 1051-61.
-
(2005)
J Exp Med
, vol.202
, pp. 1051-1061
-
-
Annacker, O.1
Coombes, J.L.2
Malmstrom, V.3
-
320
-
-
0034899072
-
CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel fromcolonic Crohn's disease
-
Papadakis KA, Prehn J, Moreno ST, et al. CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel fromcolonic Crohn's disease. Gastroenterology 2001; 121: 246-54.
-
(2001)
Gastroenterology
, vol.121
, pp. 246-254
-
-
Papadakis, K.A.1
Prehn, J.2
Moreno, S.T.3
-
321
-
-
33847390444
-
Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease
-
Saruta M, Yu QT, Avanesyan A, et al. Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. J Immunol 2007; 178: 3293-300.
-
(2007)
J Immunol
, vol.178
, pp. 3293-3300
-
-
Saruta, M.1
Yu, Q.T.2
Avanesyan, A.3
-
322
-
-
0031569588
-
Neutrophil-activating protein ENA-78 and IL-8 exhibit different patterns of expression in lipopolysaccharide- and cytokine-stimulated human monocytes
-
Schnyder-Candrian S, Walz A. Neutrophil-activating protein ENA-78 and IL-8 exhibit different patterns of expression in lipopolysaccharide- and cytokine-stimulated human monocytes. J Immunol 1997; 158: 3888-94.
-
(1997)
J Immunol
, vol.158
, pp. 3888-3894
-
-
Schnyder-Candrian, S.1
Walz, A.2
-
323
-
-
0030860713
-
Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis
-
Keates S, Keates AC, Mizoguchi E, et al. Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol 1997; 273: G75-82.
-
(1997)
Am J Physiol
, vol.273
-
-
Keates, S.1
Keates, A.C.2
Mizoguchi, E.3
-
324
-
-
0030768826
-
The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease
-
Z'Graggen K, Walz A, Mazzucchelli L, et al. The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease. Gastroenterology 1997; 113: 808-16.
-
(1997)
Gastroenterology
, vol.113
, pp. 808-816
-
-
Z'Graggen, K.1
Walz, A.2
Mazzucchelli, L.3
-
325
-
-
0024421453
-
Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils
-
Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 1989; 84: 1045-9.
-
(1989)
J Clin Invest
, vol.84
, pp. 1045-1049
-
-
Baggiolini, M.1
Walz, A.2
Kunkel, S.L.3
-
326
-
-
4444332518
-
Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations
-
Li J, Moran T, Swanson E, et al. Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum Mol Genet 2004; 13: 1715-25.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 1715-1725
-
-
Li, J.1
Moran, T.2
Swanson, E.3
-
327
-
-
0028275028
-
Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation
-
Mazzucchelli L, Hauser C, Zgraggen K, et al. Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am J Pathol 1994; 144: 997-1007.
-
(1994)
Am J Pathol
, vol.144
, pp. 997-1007
-
-
Mazzucchelli, L.1
Hauser, C.2
Zgraggen, K.3
-
328
-
-
0028319023
-
IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease
-
Mitsuyama K, Toyonaga A, Sasaki E, et al. IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease. Clin Exp Immunol 1994; 96: 432-6.
-
(1994)
Clin Exp Immunol
, vol.96
, pp. 432-436
-
-
Mitsuyama, K.1
Toyonaga, A.2
Sasaki, E.3
-
329
-
-
0030067724
-
Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease
-
Daig R, Andus T,Aschenbrenner E, et al. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 1996; 38: 216-22.
-
(1996)
Gut
, vol.38
, pp. 216-222
-
-
Daig, R.1
Andus, T.2
Aschenbrenner, E.3
-
330
-
-
0030862103
-
Intestinal interleukin-8 concentration and gene expression in inflammatory bowel disease
-
Nielsen OH, Rudiger N, Gaustadnes M, Horn T. Intestinal interleukin-8 concentration and gene expression in inflammatory bowel disease. Scand J Gastroenterol 1997; 32: 1028-34.
-
(1997)
Scand J Gastroenterol
, vol.32
, pp. 1028-1034
-
-
Nielsen, O.H.1
Rudiger, N.2
Gaustadnes, M.3
Horn, T.4
-
331
-
-
0026785837
-
Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis
-
Izzo RS,Witkon K, Chen AI, et al. Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis. Am J Gastroenterol 1992; 87: 1447-52.
-
(1992)
Am J Gastroenterol
, vol.87
, pp. 1447-1452
-
-
Izzo, R.S.1
Witkon, K.2
Chen, A.I.3
-
332
-
-
0027226007
-
Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis
-
Raab Y, Gerdin B, Ahlstedt S, Hallgren R. Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis. Gut 1993; 34: 1203-6.
-
(1993)
Gut
, vol.34
, pp. 1203-1206
-
-
Raab, Y.1
Gerdin, B.2
Ahlstedt, S.3
Hallgren, R.4
-
333
-
-
3442897382
-
CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue
-
Gijsbers K, Van Assche G, Joossens S, et al. CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue. Eur J Immunol 2004; 34: 1992-2000.
-
(2004)
Eur J Immunol
, vol.34
, pp. 1992-2000
-
-
Gijsbers, K.1
Van Assche, G.2
Joossens, S.3
-
334
-
-
0029758113
-
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
-
Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996; 382: 635-8.
-
(1996)
Nature
, vol.382
, pp. 635-638
-
-
Nagasawa, T.1
Hirota, S.2
Tachibana, K.3
-
335
-
-
0032482926
-
Impaired B-lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficientmice
-
MaQ, JonesD, Borghesani PR, et al. Impaired B-lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficientmice. Proc Natl Acad Sci USA 1998; 95: 9448-53.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9448-9453
-
-
Ma, Q.1
Jones, D.2
Borghesani, P.R.3
-
336
-
-
54349085334
-
Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis
-
Mikami S, Nakase H, Yamamoto S, et al. Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis. J Pharmacol Exp Ther 2008; 327: 383-92.
-
(2008)
J Pharmacol Exp Ther
, vol.327
, pp. 383-392
-
-
Mikami, S.1
Nakase, H.2
Yamamoto, S.3
-
337
-
-
0034654535
-
Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa
-
Muehlhoefer A, Saubermann LJ, Gu X, et al. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol 2000; 164: 3368-76.
-
(2000)
J Immunol
, vol.164
, pp. 3368-3376
-
-
Muehlhoefer, A.1
Saubermann, L.J.2
Gu, X.3
-
338
-
-
12244297799
-
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
-
Niess JH, Brand S, Gu X, et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005; 307: 254-8.
-
(2005)
Science
, vol.307
, pp. 254-258
-
-
Niess, J.H.1
Brand, S.2
Gu, X.3
-
339
-
-
0035104518
-
The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo
-
Lucas AD, Chadwick N, Warren BF, et al. The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. Am J Pathol 2001; 158: 855-66.
-
(2001)
Am J Pathol
, vol.158
, pp. 855-866
-
-
Lucas, A.D.1
Chadwick, N.2
Warren, B.F.3
-
340
-
-
33846216007
-
Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease
-
Sans M, Danese S, de la Motte C, et al. Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease. Gastroenterology 2007; 132: 139-53.
-
(2007)
Gastroenterology
, vol.132
, pp. 139-153
-
-
Sans, M.1
Danese, S.2
de la Motte, C.3
-
341
-
-
13844312846
-
Toll-like receptormediated responses of primary intestinal epithelial cells during the development of colitis
-
Singh JC, Cruickshank SM, Newton DJ, et al. Toll-like receptormediated responses of primary intestinal epithelial cells during the development of colitis. Am J Physiol Gastrointest Liver Physiol 2005; 288: G514-24.
-
(2005)
Am J Physiol Gastrointest Liver Physiol
, vol.288
-
-
Singh, J.C.1
Cruickshank, S.M.2
Newton, D.J.3
-
342
-
-
0035818564
-
Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease
-
Cornet A, Savidge TC, Cabarrocas J, et al. Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease? Proc Natl Acad Sci USA 2001; 98: 13306-11.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13306-11
-
-
Cornet, A.1
Savidge, T.C.2
Cabarrocas, J.3
-
343
-
-
0035576394
-
Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation and tissue destruction
-
Shaikh RB, Santee S, Granger SWet al. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation and tissue destruction. J Immunol 2001; 167: 6330-7.
-
(2001)
J Immunol
, vol.167
, pp. 6330-6337
-
-
Shaikh, R.B.1
Santee, S.2
Granger, S.W.3
-
344
-
-
0033558364
-
Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF plus IFN-gammaproducing CD4+ T cells that respond to bacterial antigens
-
Wirtz S, Finotto S, Kanzler S, et al. Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF plus IFN-gammaproducing CD4+ T cells that respond to bacterial antigens. J Immunol 1999; 162: 1884-8.
-
(1999)
J Immunol
, vol.162
, pp. 1884-1888
-
-
Wirtz, S.1
Finotto, S.2
Kanzler, S.3
-
345
-
-
0032536827
-
CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease
-
Cong Y, Brandwein SL, McCabe RP, et al. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med 1998; 187: 855-64.
-
(1998)
J Exp Med
, vol.187
, pp. 855-864
-
-
Cong, Y.1
Brandwein, S.L.2
McCabe, R.P.3
-
346
-
-
0037033434
-
T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis
-
Iqbal N, Oliver JR, Wagner FH, et al. T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J Exp Med 2002; 195: 71-84.
-
(2002)
J Exp Med
, vol.195
, pp. 71-84
-
-
Iqbal, N.1
Oliver, J.R.2
Wagner, F.H.3
-
347
-
-
0028006855
-
Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice
-
Dieleman LA, Ridwan BU, Tennyson GS, et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 1994; 107: 1643-52.
-
(1994)
Gastroenterology
, vol.107
, pp. 1643-1652
-
-
Dieleman, L.A.1
Ridwan, B.U.2
Tennyson, G.S.3
-
348
-
-
0034600789
-
Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGFbeta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation
-
Kitani A, Fuss IJ, Nakamura K, et al. Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGFbeta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation. J Exp Med 2000; 192: 41-52.
-
(2000)
J Exp Med
, vol.192
, pp. 41-52
-
-
Kitani, A.1
Fuss, I.J.2
Nakamura, K.3
-
349
-
-
0034924028
-
Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
-
Hahm KB, Im YH, Parks TWet al. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001; 49: 190-8.
-
(2001)
Gut
, vol.49
, pp. 190-198
-
-
Hahm, K.B.1
Im, Y.H.2
Parks, T.W.3
-
350
-
-
44849128021
-
Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF dependent Crohn's disease
-
Apostolaki M, Manoloukos M, Roulis M, et al. Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF dependent Crohn's disease. Gastroenterology 2008; 134: 2025-35.
-
(2008)
Gastroenterology
, vol.134
, pp. 2025-2035
-
-
Apostolaki, M.1
Manoloukos, M.2
Roulis, M.3
-
351
-
-
33746176176
-
Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease
-
Hommes DW, Mikhajlova TL, Stoinov S, et al. Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Gut 2006; 55: 1131-7.
-
(2006)
Gut
, vol.55
, pp. 1131-1137
-
-
Hommes, D.W.1
Mikhajlova, T.L.2
Stoinov, S.3
|