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Volumn , Issue , 2010, Pages 119-156

Cytokines and Chemokines in Mucosal Homeostasis

Author keywords

Anti inflammatory cytokines; Chemokines cytokines directing recruitment and migration of circulating leukocytes; Cytokines and chemokines in mucosal homeostasis; Pro inflammatory cytokines; Unclassified cytokines Interleukin 21, Interleukin 27, Interleukin 32

Indexed keywords


EID: 84885994368     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444318418.ch10     Document Type: Chapter
Times cited : (7)

References (354)
  • 1
    • 9644291539 scopus 로고    scopus 로고
    • IL-12 and IL-23: master regulators of innate and adaptive immunity
    • Langrish CL, McKenzie BS, Wilson NJ, et al. IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol Rev 2004; 202: 96-105.
    • (2004) Immunol Rev , vol.202 , pp. 96-105
    • Langrish, C.L.1    McKenzie, B.S.2    Wilson, N.J.3
  • 2
    • 0035827347 scopus 로고    scopus 로고
    • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
    • Mullen AC, High FA, Hutchins AS, et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 2001; 292: 1907-10.
    • (2001) Science , vol.292 , pp. 1907-1910
    • Mullen, A.C.1    High, F.A.2    Hutchins, A.S.3
  • 3
    • 0034056441 scopus 로고    scopus 로고
    • Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice
    • Hans W, Scholmerich J, Gross V, Falk W. Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice. Eur Cytokine Netw 2000; 11: 67-74.
    • (2000) Eur Cytokine Netw , vol.11 , pp. 67-74
    • Hans, W.1    Scholmerich, J.2    Gross, V.3    Falk, W.4
  • 4
    • 0031066597 scopus 로고    scopus 로고
    • G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines
    • Hornquist CE, Lu X, Rogers-FaniPMet al. G(alpha)i2-deficient mice with colitis exhibit a local increase in memory CD4+ T cells and proinflammatory Th1-type cytokines. J Immunol 1997; 158: 1068-77.
    • (1997) J Immunol , vol.158 , pp. 1068-1077
    • Hornquist, C.E.1    Lu, X.2    Rogers-Fani, P.M.3
  • 5
    • 0031568001 scopus 로고    scopus 로고
    • Induction and prevention of colonic inflammation in IL-2-deficient mice
    • Ehrhardt RO, Ludviksson BR, Gray B, et al. Induction and prevention of colonic inflammation in IL-2-deficient mice. J Immunol 1997; 158: 566-73.
    • (1997) J Immunol , vol.158 , pp. 566-573
    • Ehrhardt, R.O.1    Ludviksson, B.R.2    Gray, B.3
  • 6
    • 0037121941 scopus 로고    scopus 로고
    • Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumornecrosis factor-induced Crohn's-like inflammatory bowel disease
    • Kontoyiannis D, Boulougouris G,ManoloukosMet al. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumornecrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 2002; 196: 1563-74.
    • (2002) J Exp Med , vol.196 , pp. 1563-1574
    • Kontoyiannis, D.1    Boulougouris, G.2    Manoloukos, M.3
  • 7
    • 0036142235 scopus 로고    scopus 로고
    • Distinct inflammatory mechanisms mediate early versus late colitis in mice
    • Spencer DM, Veldman GM, Banerjee S, et al. Distinct inflammatory mechanisms mediate early versus late colitis in mice. Gastroenterology 2002; 122: 94-105.
    • (2002) Gastroenterology , vol.122 , pp. 94-105
    • Spencer, D.M.1    Veldman, G.M.2    Banerjee, S.3
  • 8
    • 0032425062 scopus 로고    scopus 로고
    • Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism
    • Kullberg MC, Ward JM, Gorelick PL, et al. Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun 1998; 66: 5157-66.
    • (1998) Infect Immun , vol.66 , pp. 5157-5166
    • Kullberg, M.C.1    Ward, J.M.2    Gorelick, P.L.3
  • 9
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells
    • Simpson SJ, Shah S, ComiskeyMet al. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med 1998; 187: 1225-34.
    • (1998) J Exp Med , vol.187 , pp. 1225-1234
    • Simpson, S.J.1    Shah, S.2    Comiskey, M.3
  • 10
    • 15844396183 scopus 로고    scopus 로고
    • Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    • Thierfelder WE, van Deursen JM, Yamamoto K, et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 1996; 382: 171-4.
    • (1996) Nature , vol.382 , pp. 171-174
    • Thierfelder, W.E.1    van Deursen, J.M.2    Yamamoto, K.3
  • 11
    • 9644257195 scopus 로고    scopus 로고
    • Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4
    • Watford WT, Hissong BD, Bream JH, et al. Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4. Immunol Rev 2004; 202: 139-56.
    • (2004) Immunol Rev , vol.202 , pp. 139-156
    • Watford, W.T.1    Hissong, B.D.2    Bream, J.H.3
  • 12
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin-12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • Monteleone G, Biancone L, Marasco R, et al. Interleukin-12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997; 112: 1169-78.
    • (1997) Gastroenterology , vol.112 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3
  • 13
    • 8344284998 scopus 로고    scopus 로고
    • Anti-interleukin-12 antibody for active Crohn's disease
    • Mannon PJ, Fuss IJ,Mayer L, et al. Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 2004; 351: 2069-79.
    • (2004) N Engl J Med , vol.351 , pp. 2069-2079
    • Mannon, P.J.1    Fuss, I.J.2    Mayer, L.3
  • 14
    • 53049091561 scopus 로고    scopus 로고
    • A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patientswith moderate-to-severeCrohn's disease
    • Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patientswith moderate-to-severeCrohn's disease. Gastroenterology 2008; 135: 1130-41.
    • (2008) Gastroenterology , vol.135 , pp. 1130-1141
    • Sandborn, W.J.1    Feagan, B.G.2    Fedorak, R.N.3
  • 15
    • 47249089097 scopus 로고    scopus 로고
    • IL-1, IL-18 and IL-33 families of cytokines
    • Arend WP, Palmer G, Gabay C. IL-1, IL-18 and IL-33 families of cytokines. Immunol Rev 2008; 223: 20-38.
    • (2008) Immunol Rev , vol.223 , pp. 20-38
    • Arend, W.P.1    Palmer, G.2    Gabay, C.3
  • 16
    • 0032193770 scopus 로고    scopus 로고
    • IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells and B cells: synergism with IL-18 for IFN-gamma production
    • Yoshimoto T, Takeda K, Tanaka T, et al. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells and B cells: synergism with IL-18 for IFN-gamma production. J Immunol 1998; 161: 3400-7.
    • (1998) J Immunol , vol.161 , pp. 3400-3407
    • Yoshimoto, T.1    Takeda, K.2    Tanaka, T.3
  • 18
    • 0030933144 scopus 로고    scopus 로고
    • Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells
    • Yoshimoto T, Okamura H, Tagawa YI, et al. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-gamma production from activated B cells. Proc Natl Acad Sci USA 1997; 94: 3948-53.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3948-3953
    • Yoshimoto, T.1    Okamura, H.2    Tagawa, Y.I.3
  • 19
    • 0036135586 scopus 로고    scopus 로고
    • Treatment of T celldependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA
    • Wirtz S, Becker C, Blumberg R, et al. Treatment of T celldependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA. J Immunol 2002; 168: 411-20.
    • (2002) J Immunol , vol.168 , pp. 411-420
    • Wirtz, S.1    Becker, C.2    Blumberg, R.3
  • 20
    • 0034800289 scopus 로고    scopus 로고
    • Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease
    • Kanai T, Watanabe M, Okazawa A, et al. Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease. Gastroenterology 2001; 121: 875-88.
    • (2001) Gastroenterology , vol.121 , pp. 875-888
    • Kanai, T.1    Watanabe, M.2    Okazawa, A.3
  • 21
    • 0036103112 scopus 로고    scopus 로고
    • Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage
    • Sivakumar PV, Westrich GM, Kanaly S, et al. Interleukin 18 is a primary mediator of the inflammation associated with dextran sulphate sodium induced colitis: blocking interleukin 18 attenuates intestinal damage. Gut 2002; 50: 812-20.
    • (2002) Gut , vol.50 , pp. 812-820
    • Sivakumar, P.V.1    Westrich, G.M.2    Kanaly, S.3
  • 22
    • 0034653432 scopus 로고    scopus 로고
    • IFN-gamma-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12
    • Nakamura S, Otani T, Ijiri Y, et al. IFN-gamma-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL-18 and IL-12. J Immunol 2000; 164: 3330-6.
    • (2000) J Immunol , vol.164 , pp. 3330-3336
    • Nakamura, S.1    Otani, T.2    Ijiri, Y.3
  • 23
    • 0033152023 scopus 로고    scopus 로고
    • IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Cytokines and Chemokines in Mucosal Homeostasis 147 expression and localization in intestinal mucosal cells
    • Pizarro TT, Michie MH, Bentz M, et al. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Cytokines and Chemokines in Mucosal Homeostasis 147 expression and localization in intestinal mucosal cells. J Immunol 1999; 162: 6829-35.
    • (1999) J Immunol , vol.162 , pp. 6829-6835
    • Pizarro, T.T.1    Michie, M.H.2    Bentz, M.3
  • 24
    • 0033168120 scopus 로고    scopus 로고
    • Bioactive IL-18 expression is up-regulated in Crohn's disease
    • Monteleone G, Trapasso F, Parrello T, et al. Bioactive IL-18 expression is up-regulated in Crohn's disease. J Immunol 1999; 163: 143-7.
    • (1999) J Immunol , vol.163 , pp. 143-147
    • Monteleone, G.1    Trapasso, F.2    Parrello, T.3
  • 25
    • 57249089060 scopus 로고    scopus 로고
    • The role of interferon gamma in regulation of CD4+ T-cells and its clinical implications
    • Chen J, Liu X. The role of interferon gamma in regulation of CD4+ T-cells and its clinical implications. Cell Immunol 2009; 254: 85-90.
    • (2009) Cell Immunol , vol.254 , pp. 85-90
    • Chen, J.1    Liu, X.2
  • 26
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo SJ, Kim ST, Costa GL, et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000; 100: 655-69.
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3
  • 27
    • 0141519112 scopus 로고    scopus 로고
    • IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells
    • Hibbert L, Pflanz S, De Waal Malefyt R, Kastelein RA. IL-27 and IFN-alpha signal via Stat1 and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res 2003; 23: 513-22.
    • (2003) J Interferon Cytokine Res , vol.23 , pp. 513-522
    • Hibbert, L.1    Pflanz, S.2    De Waal Malefyt, R.3    Kastelein, R.A.4
  • 28
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 2005; 307: 430-3.
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 29
    • 34848841804 scopus 로고    scopus 로고
    • Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient inWiskott-Aldrich syndrome protein
    • Nguyen DD, Maillard MH, Cotta-de-Almeida V, et al. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient inWiskott-Aldrich syndrome protein. Gastroenterology 2007; 133: 1188-97.
    • (2007) Gastroenterology , vol.133 , pp. 1188-1197
    • Nguyen, D.D.1    Maillard, M.H.2    Cotta-de-Almeida, V.3
  • 30
    • 0029975876 scopus 로고    scopus 로고
    • Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease
    • Mizoguchi A, Mizoguchi E, Chiba C, et al. Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease. J Exp Med 1996; 183: 847-56.
    • (1996) J Exp Med , vol.183 , pp. 847-856
    • Mizoguchi, A.1    Mizoguchi, E.2    Chiba, C.3
  • 31
    • 0031736096 scopus 로고    scopus 로고
    • Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines
    • Dieleman LA, Palmen MJ, Akol H, et al. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol 1998; 114: 385-91.
    • (1998) Clin Exp Immunol , vol.114 , pp. 385-391
    • Dieleman, L.A.1    Palmen, M.J.2    Akol, H.3
  • 32
    • 0028179230 scopus 로고
    • Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • Powrie F, Correa-Oliveira R, Mauze S, Coffman RL. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994; 179: 589-600.
    • (1994) J Exp Med , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 33
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    • BergDJ, DavidsonN, KuhnRet al. Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 1996; 98: 1010-20.
    • (1996) J Clin Invest , vol.98 , pp. 1010-1020
    • Berg, D.J.1    Davidson, N.2    Kuhn, R.3
  • 34
    • 33747089041 scopus 로고    scopus 로고
    • Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology
    • Uhlig HH, McKenzie BS,Hue S, et al. Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 2006; 25: 309-18.
    • (2006) Immunity , vol.25 , pp. 309-318
    • Uhlig, H.H.1    McKenzie, B.S.2    Hue, S.3
  • 35
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath MF, Fuss I, Kelsall BL, et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995; 182: 1281-90.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3
  • 36
    • 0032707491 scopus 로고    scopus 로고
    • In vitro activated CD4+ T cells from interferon-gamma (IFN-gamma)- deficient mice induce intestinal inflammation in immunodeficient hosts
    • Bregenholt S, Brimnes J, Nissen MH, Claesson MH. In vitro activated CD4+ T cells from interferon-gamma (IFN-gamma)- deficient mice induce intestinal inflammation in immunodeficient hosts. Clin Exp Immunol 1999; 118: 228-34.
    • (1999) Clin Exp Immunol , vol.118 , pp. 228-234
    • Bregenholt, S.1    Brimnes, J.2    Nissen, M.H.3    Claesson, M.H.4
  • 37
    • 0025333699 scopus 로고
    • Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine
    • MacDonald TT, Hutchings P, Choy MY, et al. Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine. Clin Exp Immunol 1990; 81: 301-5.
    • (1990) Clin Exp Immunol , vol.81 , pp. 301-305
    • MacDonald, T.T.1    Hutchings, P.2    Choy, M.Y.3
  • 39
    • 0027441514 scopus 로고
    • Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa
    • Breese E, Braegger CP, Corrigan CJ, et al. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993; 78: 127-31.
    • (1993) Immunology , vol.78 , pp. 127-131
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3
  • 40
    • 0028787818 scopus 로고
    • Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease
    • Noguchi M, Hiwatashi N, Liu Z, Toyota T. Enhanced interferon-gamma production and B7-2 expression in isolated intestinal mononuclear cells from patients with Crohn's disease. J Gastroenterol 1995; 30 Suppl 8: 52-5.
    • (1995) J Gastroenterol , vol.30 , Issue.SUUPL 8 , pp. 52-55
    • Noguchi, M.1    Hiwatashi, N.2    Liu, Z.3    Toyota, T.4
  • 41
    • 0034164544 scopus 로고    scopus 로고
    • Interleukin-10 expression in intestine of Crohn disease
    • Akagi S,Hiyama E, Imamura Y, Takesue Y, et al. Interleukin-10 expression in intestine of Crohn disease. Int J MolMed 2000; 5: 389-95.
    • (2000) Int J MolMed , vol.5 , pp. 389-395
    • Akagi, S.1    Hiyama, E.2    Imamura, Y.3    Takesue, Y.4
  • 42
    • 0028576989 scopus 로고
    • Interferon expression in Crohn's disease patients: increased interferon-gamma and -alpha mRNA in the intestinal lamina propria mononuclear cells
    • Fais S, Capobianchi MR, SilvestriMet al. Interferon expression in Crohn's disease patients: increased interferon-gamma and -alpha mRNA in the intestinal lamina propria mononuclear cells. J Interferon Res 1994; 14: 235-8.
    • (1994) J Interferon Res , vol.14 , pp. 235-238
    • Fais, S.1    Capobianchi, M.R.2    Silvestri, M.3
  • 43
    • 0028853750 scopus 로고
    • The role of proinflammatory and immunoregulatory cytokines in the pathogenesis of ulcerative colitis
    • Murata Y, Ishiguro Y, Itoh J,, et al. The role of proinflammatory and immunoregulatory cytokines in the pathogenesis of ulcerative colitis. J Gastroenterol 1995; 30 Suppl 8: 56-60.
    • (1995) J Gastroenterol , vol.30 , Issue.SUUPL 8 , pp. 56-60
    • Murata, Y.1    Ishiguro, Y.2    Itoh, J.3
  • 44
    • 0031057872 scopus 로고    scopus 로고
    • Type 1 Thelper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
    • Parronchi P, Romagnani P, Annunziato F, et al. Type 1 Thelper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am J Pathol 1997; 150: 823-32.
    • (1997) Am J Pathol , vol.150 , pp. 823-832
    • Parronchi, P.1    Romagnani, P.2    Annunziato, F.3
  • 45
    • 18744425752 scopus 로고    scopus 로고
    • Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease
    • Desreumaux P, Brandt E, Gambiez L, et al. Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease. Gastroenterology 1997; 113: 118-26.
    • (1997) Gastroenterology , vol.113 , pp. 118-126
    • Desreumaux, P.1    Brandt, E.2    Gambiez, L.3
  • 46
    • 0021907183 scopus 로고
    • Molecular cloning of the complementary DNA for human tumor necrosis factor
    • Wang AM, Creasey AA, Ladner MB, et al. Molecular cloning of the complementary DNA for human tumor necrosis factor. Science 1985; 228: 149-54.
    • (1985) Science , vol.228 , pp. 149-154
    • Wang, A.M.1    Creasey, A.A.2    Ladner, M.B.3
  • 47
    • 44749088915 scopus 로고    scopus 로고
    • Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models
    • Kruglov AA, Kuchmiy A, Grivennikov SI, et al. Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models. Cytokine Growth Factor Rev 2008; 19: 231-44.
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 231-244
    • Kruglov, A.A.1    Kuchmiy, A.2    Grivennikov, S.I.3
  • 48
    • 0024405827 scopus 로고
    • The biology of cachectin/TNF-a primary mediator of the host response
    • Beutler B, Cerami A. The biology of cachectin/TNF-a primary mediator of the host response. Annu Rev Immunol 1989; 7: 625-55.
    • (1989) Annu Rev Immunol , vol.7 , pp. 625-655
    • Beutler, B.1    Cerami, A.2
  • 49
    • 18944375672 scopus 로고    scopus 로고
    • Long-term exposure of the HT-29 human intestinal epithelial cell line to TNF causes sustained upregulation of the polymeric Ig receptor and proinflammatory genes through transcriptional and posttranscriptional mechanisms
    • Bruno ME, Kaetzel CS. Long-term exposure of the HT-29 human intestinal epithelial cell line to TNF causes sustained upregulation of the polymeric Ig receptor and proinflammatory genes through transcriptional and posttranscriptional mechanisms. J Immunol 2005; 174: 7278-84.
    • (2005) J Immunol , vol.174 , pp. 7278-7284
    • Bruno, M.E.1    Kaetzel, C.S.2
  • 50
    • 0041885346 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide
    • Loncar MB, Al-azzeh ED, Sommer PS, et al. Tumour necrosis factor alpha and nuclear factor kappaB inhibit transcription of human TFF3 encoding a gastrointestinal healing peptide. Gut 2003; 52: 1297-303.
    • (2003) Gut , vol.52 , pp. 1297-1303
    • Loncar, M.B.1    Al-azzeh, E.D.2    Sommer, P.S.3
  • 51
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    • Kontoyiannis D, Pasparakis M, Pizarro TT, et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999; 10: 387-98.
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3
  • 52
    • 0035106502 scopus 로고    scopus 로고
    • Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
    • Kosiewicz MM, Nast CC, Krishnan A, et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest 2001; 107: 695-702.
    • (2001) J Clin Invest , vol.107 , pp. 695-702
    • Kosiewicz, M.M.1    Nast, C.C.2    Krishnan, A.3
  • 53
    • 0036896960 scopus 로고    scopus 로고
    • T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
    • Musch MW, Clarke LL, Mamah D, et al. T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase. J Clin Invest 2002; 110: 1739-47.
    • (2002) J Clin Invest , vol.110 , pp. 1739-1747
    • Musch, M.W.1    Clarke, L.L.2    Mamah, D.3
  • 54
    • 38649106435 scopus 로고    scopus 로고
    • TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality
    • Mizoguchi E, Hachiya Y, Kawada M, et al. TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality. Gastroenterology 2008; 134: 470-80.
    • (2008) Gastroenterology , vol.134 , pp. 470-480
    • Mizoguchi, E.1    Hachiya, Y.2    Kawada, M.3
  • 55
    • 0027451455 scopus 로고
    • Enhanced secretion of tumour necrosis factor-alpha, IL-6 and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease
    • Reinecker HC, Steffen M, Witthoeft T, et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6 and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol 1993; 94: 174-81.
    • (1993) Clin Exp Immunol , vol.94 , pp. 174-181
    • Reinecker, H.C.1    Steffen, M.2    Witthoeft, T.3
  • 56
    • 0030842468 scopus 로고    scopus 로고
    • Quantitative PCR analysis of TNFalpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies
    • Dionne S, Hiscott J, D'Agata I, et al. Quantitative PCR analysis of TNFalpha and IL-1 beta mRNA levels in pediatric IBD mucosal biopsies. Dig Dis Sci 1997; 42: 1557-66.
    • (1997) Dig Dis Sci , vol.42 , pp. 1557-1566
    • Dionne, S.1    Hiscott, J.2    D'Agata, I.3
  • 57
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease
    • Targan SR, Hanauer SB, van Deventer SJ, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor alpha for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997; 337: 1029-35.
    • (1997) Crohn's Disease cA2 Study Group. N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1    Hanauer, S.B.2    van Deventer, S.J.3
  • 58
    • 0033529049 scopus 로고    scopus 로고
    • Infliximab for the treatment of fistulas in patients with Crohn's disease
    • Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999; 340: 1398-405.
    • (1999) N Engl J Med , vol.340 , pp. 1398-1405
    • Present, D.H.1    Rutgeerts, P.2    Targan, S.3
  • 59
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial
    • Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541-9.
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 60
    • 10744221312 scopus 로고    scopus 로고
    • Infliximab maintenance therapy for fistulizing Crohn's disease
    • Sands BE, Anderson FH, Bernstein CN, et al. Infliximab maintenance therapy for fistulizing Crohn's disease. N Engl J Med 2004; 350: 876-85.
    • (2004) N Engl J Med , vol.350 , pp. 876-885
    • Sands, B.E.1    Anderson, F.H.2    Bernstein, C.N.3
  • 61
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. NEngl J Med 2005; 353: 2462-76.
    • (2005) NEngl J Med , vol.353 , pp. 2462-2476
    • Rutgeerts, P.1    Sandborn, W.J.2    Feagan, B.G.3
  • 62
    • 32044451548 scopus 로고    scopus 로고
    • Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial.
    • Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human antitumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology 2006; 130: 323-33. quiz 591.
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 63
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial
    • Colombel JF, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 2007; 132: 52-65.
    • (2007) Gastroenterology , vol.132 , pp. 52-65
    • Colombel, J.F.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 64
    • 34447515607 scopus 로고    scopus 로고
    • Maintenance therapy with certolizumab pegol for Crohn's disease
    • Schreiber S,Khaliq-KareemiM,Lawrance IC, et al. Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med 2007; 357: 239-50.
    • (2007) N Engl J Med , vol.357 , pp. 239-250
    • Schreiber, S.1    Khaliq-Kareemi, M.2    Lawrance, I.C.3
  • 65
    • 34447523749 scopus 로고    scopus 로고
    • Certolizumab pegol for the treatment of Crohn's disease
    • Sandborn WJ, Feagan BG, Stoinov S, et al. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med 2007; 357: 228-38.
    • (2007) N Engl J Med , vol.357 , pp. 228-238
    • Sandborn, W.J.1    Feagan, B.G.2    Stoinov, S.3
  • 66
    • 34248136340 scopus 로고    scopus 로고
    • Inflammatory bowel disease: clinical aspects and established and evolving therapies
    • Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 2007; 369: 1641-57.
    • (2007) Lancet , vol.369 , pp. 1641-1657
    • Baumgart, D.C.1    Sandborn, W.J.2
  • 67
    • 2442560241 scopus 로고    scopus 로고
    • Optimizing anti- TNF treatment in inflammatory bowel disease
    • Rutgeerts P, Van Assche G, Vermeire S. Optimizing anti- TNF treatment in inflammatory bowel disease. Gastroenterology 2004; 126: 1593-610.
    • (2004) Gastroenterology , vol.126 , pp. 1593-1610
    • Rutgeerts, P.1    Van Assche, G.2    Vermeire, S.3
  • 68
    • 41949097030 scopus 로고    scopus 로고
    • The biology of interleukin-2
    • Malek TR. The biology of interleukin-2. Annu Rev Immunol 2008; 26: 453-79.
    • (2008) Annu Rev Immunol , vol.26 , pp. 453-479
    • Malek, T.R.1
  • 69
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Saddlack B, Merz H, Scholrle H, et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993; 75: 253-61.
    • (1993) Cell , vol.75 , pp. 253-261
    • Saddlack, B.1    Merz, H.2    Scholrle, H.3
  • 70
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, et al. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995; 3: 521-30.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3
  • 71
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    • Suzuki H, Kundig TM, Furlonger C, et al. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995; 268: 1472-6.
    • (1995) Science , vol.268 , pp. 1472-1476
    • Suzuki, H.1    Kundig, T.M.2    Furlonger, C.3
  • 72
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-61.
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 73
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    • Fontenot JD, Rasmussen JP, Williams LM, et al. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005; 22: 329-41.
    • (2005) Immunity , vol.22 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3
  • 74
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot JD, Rasmussen JP, GavinMA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005; 6: 1142-51.
    • (2005) Nat Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 75
    • 2442637772 scopus 로고    scopus 로고
    • Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function
    • Thornton AM, Donovan EE, Piccirillo CA, Shevach EM. Cutting edge: IL-2 is critically required for the in vitro activation of CD4+CD25+ T cell suppressor function. J Immunol 2004; 172: 6519-23.
    • (2004) J Immunol , vol.172 , pp. 6519-6523
    • Thornton, A.M.1    Donovan, E.E.2    Piccirillo, C.A.3    Shevach, E.M.4
  • 77
    • 0031451918 scopus 로고    scopus 로고
    • Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation
    • Autenrieth IB, Bucheler N, Bohn E, et al. Cytokine mRNA expression in intestinal tissue of interleukin-2 deficient mice with bowel inflammation. Gut 1997; 41: 793-800.
    • (1997) Gut , vol.41 , pp. 793-800
    • Autenrieth, I.B.1    Bucheler, N.2    Bohn, E.3
  • 78
    • 0031954425 scopus 로고    scopus 로고
    • Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice
    • MeijssenMA, Brandwein SL, Reinecker HC, et al. Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice. Am J Physiol 1998; 274: G472-9.
    • (1998) Am J Physiol , vol.274
    • Meijssen, M.A.1    Brandwein, S.L.2    Reinecker, H.C.3
  • 79
    • 0029156966 scopus 로고
    • Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2- deficient colitis
    • Simpson SJ, Mizoguchi E, Allen D, et al. Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2- deficient colitis. Eur J Immunol 1995; 25: 2618-25.
    • (1995) Eur J Immunol , vol.25 , pp. 2618-2625
    • Simpson, S.J.1    Mizoguchi, E.2    Allen, D.3
  • 80
    • 38649118188 scopus 로고    scopus 로고
    • Protein kinase C theta plays a fundamental role in different types of chronic colitis
    • Nagahama K, Ogawa A, Shirane K, et al. Protein kinase C theta plays a fundamental role in different types of chronic colitis. Gastroenterology 2008; 134: 459-69.
    • (2008) Gastroenterology , vol.134 , pp. 459-469
    • Nagahama, K.1    Ogawa, A.2    Shirane, K.3
  • 81
    • 0033000343 scopus 로고    scopus 로고
    • IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation
    • Schultz M, Tonkonogy SL, Sellon RK, et al. IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am J Physiol 1999; 276: G1461-72.
    • (1999) Am J Physiol , vol.276
    • Schultz, M.1    Tonkonogy, S.L.2    Sellon, R.K.3
  • 82
    • 33747114270 scopus 로고    scopus 로고
    • Role of toll-like receptors in spontaneous commensal-dependent colitis
    • Rakoff-Nahoum S, Hao L, Medzhitov R. Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity 2006; 25: 319-29.
    • (2006) Immunity , vol.25 , pp. 319-329
    • Rakoff-Nahoum, S.1    Hao, L.2    Medzhitov, R.3
  • 83
    • 0026514203 scopus 로고
    • Increased concentrations of interleukin 1 beta, interleukin-2 and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease
    • Brynskov J, Tvede N, Andersen CB, Vilien M. Increased concentrations of interleukin 1 beta, interleukin-2 and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease. Gut 1992; 33: 55-8.
    • (1992) Gut , vol.33 , pp. 55-58
    • Brynskov, J.1    Tvede, N.2    Andersen, C.B.3    Vilien, M.4
  • 84
    • 0026552488 scopus 로고
    • Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis
    • Mullin GE, Lazenby AJ, HarrisML, et al. Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. Gastroenterology 1992; 102: 1620-7.
    • (1992) Gastroenterology , vol.102 , pp. 1620-1627
    • Mullin, G.E.1    Lazenby, A.J.2    Harris, M.L.3
  • 85
    • 0029130042 scopus 로고
    • Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)
    • NiessnerM, Volk BA. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 1995; 101: 428-35.
    • (1995) Clin Exp Immunol , vol.101 , pp. 428-435
    • Niessner, M.1    Volk, B.A.2
  • 86
    • 0027434948 scopus 로고
    • Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis
    • Gurbindo C, Sabbah S, Menezes J, et al. Interleukin-2 production in pediatric inflammatory bowel disease: evidence for dissimilar mononuclear cell function in Crohn's disease and ulcerative colitis. J Pediatr Gastroenterol Nutr 1993; 17: 247-54.
    • (1993) J Pediatr Gastroenterol Nutr , vol.17 , pp. 247-254
    • Gurbindo, C.1    Sabbah, S.2    Menezes, J.3
  • 87
    • 0030225555 scopus 로고    scopus 로고
    • Lamina propria mononuclear cells express and respond to interleukin-2 differently in Crohn's disease and ulcerative colitis
    • Shinoda M, Haruta J, Tanimoto M, et al. Lamina propria mononuclear cells express and respond to interleukin-2 differently in Crohn's disease and ulcerative colitis. Intern Med 1996; 35: 679-85.
    • (1996) Intern Med , vol.35 , pp. 679-685
    • Shinoda, M.1    Haruta, J.2    Tanimoto, M.3
  • 88
    • 0027419329 scopus 로고
    • Symptomatic exacerbation of Crohn disease after treatment with high-dose interleukin-2
    • Sparano JA, Brandt LJ, Dutcher JP, et al. Symptomatic exacerbation of Crohn disease after treatment with high-dose interleukin-2. Ann Intern Med 1993; 118: 617-8.
    • (1993) Ann Intern Med , vol.118 , pp. 617-618
    • Sparano, J.A.1    Brandt, L.J.2    Dutcher, J.P.3
  • 89
    • 10744232542 scopus 로고    scopus 로고
    • Basiliximab (anti- CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis
    • Creed TJ, Norman MR, Probert CS, et al. Basiliximab (anti- CD25) in combination with steroids may be an effective new treatment for steroid-resistant ulcerative colitis. Aliment Pharmacol Ther 2003; 18: 65-75.
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 65-75
    • Creed, T.J.1    Norman, M.R.2    Probert, C.S.3
  • 90
    • 33646232018 scopus 로고    scopus 로고
    • Basiliximab for the treatment of steroid-resistant ulcerative colitis: further Cytokines and Chemokines in Mucosal Homeostasis 149 experience in moderate and severe disease
    • Creed TJ, Probert CS, Norman MN, et al. Basiliximab for the treatment of steroid-resistant ulcerative colitis: further Cytokines and Chemokines in Mucosal Homeostasis 149 experience in moderate and severe disease. Aliment Pharmacol Ther 2006; 23: 1435-42.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1435-1442
    • Creed, T.J.1    Probert, C.S.2    Norman, M.N.3
  • 91
    • 33750343050 scopus 로고    scopus 로고
    • Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial
    • Van Assche G, Sandborn WJ, Feagan BG,, et al. Daclizumab, a humanised monoclonal antibody to the interleukin 2 receptor (CD25), for the treatment of moderately to severely active ulcerative colitis: a randomised, double blind, placebo controlled, dose ranging trial. Gut 2006; 55: 1568-74.
    • (2006) Gut , vol.55 , pp. 1568-1574
    • Van Assche, G.1    Sandborn, W.J.2    Feagan, B.G.3
  • 92
    • 18644374105 scopus 로고    scopus 로고
    • Blocking IL-1 in systemic inflammation
    • Dinarello CA. Blocking IL-1 in systemic inflammation. J Exp Med 2005; 201: 1355-9.
    • (2005) J Exp Med , vol.201 , pp. 1355-1359
    • Dinarello, C.A.1
  • 93
    • 2542457495 scopus 로고    scopus 로고
    • Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases
    • Martinon F, Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases. Cell 2004; 117: 561-74.
    • (2004) Cell , vol.117 , pp. 561-574
    • Martinon, F.1    Tschopp, J.2
  • 94
    • 0032576359 scopus 로고    scopus 로고
    • Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease
    • Binion DG, West GA, Volk EE, et al. Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease. Lancet 1998; 352: 1742-6.
    • (1998) Lancet , vol.352 , pp. 1742-1746
    • Binion, D.G.1    West, G.A.2    Volk, E.E.3
  • 95
    • 0025167803 scopus 로고
    • Interleukin 1 (IL-1) gene expression, synthesis and effect of specific IL-1 receptor blockade in rabbit immune complex colitis
    • Cominelli F, Nast CC, Clark BD, et al. Interleukin 1 (IL-1) gene expression, synthesis and effect of specific IL-1 receptor blockade in rabbit immune complex colitis. J Clin Invest 1990; 86: 972-80.
    • (1990) J Clin Invest , vol.86 , pp. 972-980
    • Cominelli, F.1    Nast, C.C.2    Clark, B.D.3
  • 96
    • 0030908361 scopus 로고    scopus 로고
    • Role of cytokines in the early stages of chronic colitis in TCR alpha-mutant mice
    • Mizoguchi E, Mizoguchi A, Bhan AK. Role of cytokines in the early stages of chronic colitis in TCR alpha-mutant mice. Lab Invest 1997; 76: 385-97.
    • (1997) Lab Invest , vol.76 , pp. 385-397
    • Mizoguchi, E.1    Mizoguchi, A.2    Bhan, A.K.3
  • 97
    • 26444588087 scopus 로고    scopus 로고
    • Interleukin- 1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis
    • Kwon KH, Murakami A, Hayashi R, Ohigashi H. Interleukin- 1beta targets interleukin-6 in progressing dextran sulfate sodium-induced experimental colitis. Biochem Biophys Res Commun 2005; 337: 647-54.
    • (2005) Biochem Biophys Res Commun , vol.337 , pp. 647-654
    • Kwon, K.H.1    Murakami, A.2    Hayashi, R.3    Ohigashi, H.4
  • 98
    • 0032408502 scopus 로고    scopus 로고
    • Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice
    • Arai Y, Takanashi H, Kitagawa H, Okayasu I. Involvement of interleukin-1 in the development of ulcerative colitis induced by dextran sulfate sodium in mice. Cytokine 1998; 10: 890-6.
    • (1998) Cytokine , vol.10 , pp. 890-896
    • Arai, Y.1    Takanashi, H.2    Kitagawa, H.3    Okayasu, I.4
  • 100
    • 34249913692 scopus 로고    scopus 로고
    • The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6mice and suppresses IP-10 mRNA but not TNFalpha mRNA expression
    • Bauer C, Loher F, DauerMet al. The ICE inhibitor pralnacasan prevents DSS-induced colitis in C57BL/6mice and suppresses IP-10 mRNA but not TNFalpha mRNA expression. Dig Dis Sci 2007; 52: 1642-52.
    • (2007) Dig Dis Sci , vol.52 , pp. 1642-1652
    • Bauer, C.1    Loher, F.2    Dauer, M.3
  • 101
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008; 456: 264-8.
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1    Fujita, N.2    Jang, M.H.3
  • 102
    • 13244277880 scopus 로고    scopus 로고
    • Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    • Maeda S, Hsu LC, Liu H, et al. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 2005; 307: 734-8.
    • (2005) Science , vol.307 , pp. 734-738
    • Maeda, S.1    Hsu, L.C.2    Liu, H.3
  • 104
    • 8144230706 scopus 로고    scopus 로고
    • Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease
    • LudwiczekO, Vannier E, Borggraefe I, et al. Imbalance between interleukin-1 agonists and antagonists: relationship to severity of inflammatory bowel disease. Clin Exp Immunol 2004; 138: 323-9.
    • (2004) Clin Exp Immunol , vol.138 , pp. 323-329
    • Ludwiczek, O.1    Vannier, E.2    Borggraefe, I.3
  • 105
    • 0029889689 scopus 로고    scopus 로고
    • Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis andCrohn'sdisease
    • Reimund JM,Wittersheim C, Dumont S, et al. Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis andCrohn'sdisease. JClin Immunol 1996; 16: 144-50.
    • (1996) JClin Immunol , vol.16 , pp. 144-150
    • Reimund, J.M.1    Wittersheim, C.2    Dumont, S.3
  • 106
    • 0027409322 scopus 로고
    • Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells
    • Youngman KR, Simon PL, West GA, et al. Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells. Gastroenterology 1993; 104: 749-58.
    • (1993) Gastroenterology , vol.104 , pp. 749-758
    • Youngman, K.R.1    Simon, P.L.2    West, G.A.3
  • 107
    • 0031921472 scopus 로고    scopus 로고
    • Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease
    • McAlindon ME, Hawkey CJ, Mahida YR. Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease. Gut 1998; 42: 214-9.
    • (1998) Gut , vol.42 , pp. 214-219
    • McAlindon, M.E.1    Hawkey, C.J.2    Mahida, Y.R.3
  • 108
    • 0026590363 scopus 로고
    • Peripheral blood monocyte cytokine production and acute phase response in inflammatory bowel disease
    • Mazlam MZ, Hodgson HJ. Peripheral blood monocyte cytokine production and acute phase response in inflammatory bowel disease. Gut 1992; 33: 773-8.
    • (1992) Gut , vol.33 , pp. 773-778
    • Mazlam, M.Z.1    Hodgson, H.J.2
  • 109
    • 0027935291 scopus 로고
    • Characterization of circulating interleukin-1 receptor antagonist expression in children with inflammatory bowel disease
    • Hyams JS, Fitzgerald JE,WyzgaNet al. Characterization of circulating interleukin-1 receptor antagonist expression in children with inflammatory bowel disease. Dig Dis Sci 1994; 39: 1893-9.
    • (1994) Dig Dis Sci , vol.39 , pp. 1893-1899
    • Hyams, J.S.1    Fitzgerald, J.E.2    Wyzga, N.3
  • 110
    • 0033528272 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha and interleukin 1beta in relapse of Crohn's disease
    • Schreiber S, Nikolaus S, Hampe J, et al. Tumour necrosis factor alpha and interleukin 1beta in relapse of Crohn's disease. Lancet 1999; 353: 459-61.
    • (1999) Lancet , vol.353 , pp. 459-461
    • Schreiber, S.1    Nikolaus, S.2    Hampe, J.3
  • 111
  • 112
  • 113
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E, Carrier Y, Gao W, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441: 235-8.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3
  • 114
    • 33646560950 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces development of the T(H)17 lineage
    • Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441: 231-4.
    • (2006) Nature , vol.441 , pp. 231-234
    • Mangan, P.R.1    Harrington, L.E.2    O'Quinn, D.B.3
  • 115
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8: 942-9.
    • (2007) Nat Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 116
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K, Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 2002; 13: 357-68.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 117
    • 0030891228 scopus 로고    scopus 로고
    • Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
    • Romano M, Sironi M, Toniatti C, et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 1997; 6: 315-25.
    • (1997) Immunity , vol.6 , pp. 315-325
    • Romano, M.1    Sironi, M.2    Toniatti, C.3
  • 118
    • 0032518415 scopus 로고    scopus 로고
    • IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses
    • Xing Z, Gauldie J, Cox G, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998; 101: 311-20.
    • (1998) J Clin Invest , vol.101 , pp. 311-320
    • Xing, Z.1    Gauldie, J.2    Cox, G.3
  • 120
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    • Suzuki A, Hanada T, Mitsuyama K, et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 2001; 193: 471-81.
    • (2001) J Exp Med , vol.193 , pp. 471-481
    • Suzuki, A.1    Hanada, T.2    Mitsuyama, K.3
  • 121
    • 0034193039 scopus 로고    scopus 로고
    • IL-6 is required for the development of Th1 cell-mediated murine colitis
    • Yamamoto M, Yoshizaki K, Kishimoto T, ItoH. IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol 2000; 164: 4878-82.
    • (2000) J Immunol , vol.164 , pp. 4878-4882
    • Yamamoto, M.1    Yoshizaki, K.2    Kishimoto, T.3    Ito, H.4
  • 122
    • 18344410191 scopus 로고    scopus 로고
    • Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo
    • Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med 2000; 6: 583-8.
    • (2000) Nat Med , vol.6 , pp. 583-588
    • Atreya, R.1    Mudter, J.2    Finotto, S.3
  • 123
    • 0036142256 scopus 로고    scopus 로고
    • Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
    • Mizoguchi E, Mizoguchi A, Takedatsu H,, et al. Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice. Gastroenterology 2002; 122: 134-44.
    • (2002) Gastroenterology , vol.122 , pp. 134-144
    • Mizoguchi, E.1    Mizoguchi, A.2    Takedatsu, H.3
  • 124
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda K, Clausen BE, Kaisho T, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999; 10: 39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3
  • 125
    • 1642619154 scopus 로고    scopus 로고
    • Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis
    • Alonzi T, Newton IP, Bryce PJ, et al. Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine 2004; 26: 45-56.
    • (2004) Cytokine , vol.26 , pp. 45-56
    • Alonzi, T.1    Newton, I.P.2    Bryce, P.J.3
  • 126
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007; 25: 821-52.
    • (2007) Annu Rev Immunol , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 127
    • 0026689516 scopus 로고
    • Tumor necrosis factoralpha, interleukin-1 beta and interleukin-6 expression in inflammatory bowel disease
    • Stevens C, Walz G, Singaram C, et al. Tumor necrosis factoralpha, interleukin-1 beta and interleukin-6 expression in inflammatory bowel disease. Dig Dis Sci 1992; 37: 818-26.
    • (1992) Dig Dis Sci , vol.37 , pp. 818-826
    • Stevens, C.1    Walz, G.2    Singaram, C.3
  • 128
    • 0026336617 scopus 로고
    • Colonic mucosal interleukin-6 in inflammatory bowel disease
    • Mitsuyama K, Sasaki E, Toyonaga A, et al. Colonic mucosal interleukin-6 in inflammatory bowel disease. Digestion 1991; 50: 104-11.
    • (1991) Digestion , vol.50 , pp. 104-111
    • Mitsuyama, K.1    Sasaki, E.2    Toyonaga, A.3
  • 129
    • 0025746614 scopus 로고
    • High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis
    • Mahida YR, Kurlac L, Gallagher A, Hawkey CJ. High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis. Gut 1991; 32: 1531-4.
    • (1991) Gut , vol.32 , pp. 1531-1534
    • Mahida, Y.R.1    Kurlac, L.2    Gallagher, A.3    Hawkey, C.J.4
  • 130
    • 0026607022 scopus 로고
    • Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
    • Gross V, Andus T, Caesar I, et al. Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. Gastroenterology 1992; 102: 514-9.
    • (1992) Gastroenterology , vol.102 , pp. 514-519
    • Gross, V.1    Andus, T.2    Caesar, I.3
  • 131
    • 0033179725 scopus 로고    scopus 로고
    • Clinical relevance of serum interleukin-6 in Crohn's disease: single point measurements, therapy monitoring and prediction of clinical relapse
    • Reinisch W, Gasche C, Tillinger W, et al. Clinical relevance of serum interleukin-6 in Crohn's disease: single point measurements, therapy monitoring and prediction of clinical relapse. Am J Gastroenterol 1999; 94: 2156-64.
    • (1999) Am J Gastroenterol , vol.94 , pp. 2156-2164
    • Reinisch, W.1    Gasche, C.2    Tillinger, W.3
  • 132
    • 33644818803 scopus 로고    scopus 로고
    • A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory bowel disease
    • Mitsuyama K, Tomiyasu N, Suzuki A, et al. A form of circulating interleukin-6 receptor component soluble gp130 as a potential interleukin-6 inhibitor in inflammatory bowel disease. Clin Exp Immunol 2006; 143: 125-31.
    • (2006) Clin Exp Immunol , vol.143 , pp. 125-131
    • Mitsuyama, K.1    Tomiyasu, N.2    Suzuki, A.3
  • 133
    • 11144358366 scopus 로고    scopus 로고
    • A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease
    • Ito H, Takazoe M, Fukuda Y, et al. A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease. Gastroenterology 2004; 126: 989-96. discussion 947.
    • (2004) Gastroenterology , vol.126 , pp. 989-996
    • Ito, H.1    Takazoe, M.2    Fukuda, Y.3
  • 134
    • 18344385475 scopus 로고    scopus 로고
    • TL1A is a TNFlike ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator
    • Migone TS, Zhang J, Luo X, et al. TL1A is a TNFlike ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity 2002; 16: 479-92.
    • (2002) Immunity , vol.16 , pp. 479-492
    • Migone, T.S.1    Zhang, J.2    Luo, X.3
  • 135
    • 33744791820 scopus 로고    scopus 로고
    • Role of TL1A and its receptor DR3 in twomodels of chronic murine ileitis
    • Bamias G, Mishina M, Nyce M, et al. Role of TL1A and its receptor DR3 in twomodels of chronic murine ileitis. Proc Natl Acad Sci USA 2006; 103: 8441-6.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8441-8446
    • Bamias, G.1    Mishina, M.2    Nyce, M.3
  • 136
    • 33947637808 scopus 로고    scopus 로고
    • The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells
    • Prehn JL, Thomas LS, Landers CJ, et al. The T cell costimulator TL1A is induced by FcgammaR signaling in human monocytes and dendritic cells. J Immunol 2007; 178: 4033-8.
    • (2007) J Immunol , vol.178 , pp. 4033-4038
    • Prehn, J.L.1    Thomas, L.S.2    Landers, C.J.3
  • 137
    • 2442689136 scopus 로고    scopus 로고
    • TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells
    • Papadakis KA, Prehn JL, Landers C, et al. TL1A synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells. J Immunol 2004; 172: 7002-7.
    • (2004) J Immunol , vol.172 , pp. 7002-7007
    • Papadakis, K.A.1    Prehn, J.L.2    Landers, C.3
  • 138
    • 17044413324 scopus 로고    scopus 로고
    • Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes
    • Papadakis KA, Zhu D, Prehn JL, et al. Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes. J Immunol 2005; 174: 4985-90.
    • (2005) J Immunol , vol.174 , pp. 4985-4990
    • Papadakis, K.A.1    Zhu, D.2    Prehn, J.L.3
  • 139
    • 48549106477 scopus 로고    scopus 로고
    • TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation
    • Takedatsu H, Michelsen KS, Wei B, et al. TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation. Gastroenterology 2008; 135: 552-67.
    • (2008) Gastroenterology , vol.135 , pp. 552-567
    • Takedatsu, H.1    Michelsen, K.S.2    Wei, B.3
  • 140
    • 51249119001 scopus 로고    scopus 로고
    • Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro- D-glucose and positron emission tomography
    • Brewer S, McPherson M, Fujiwara D, et al. Molecular imaging of murine intestinal inflammation with 2-deoxy-2-[18F]fluoro- D-glucose and positron emission tomography. Gastroenterology 2008; 135: 744-55.
    • (2008) Gastroenterology , vol.135 , pp. 744-755
    • Brewer, S.1    McPherson, M.2    Fujiwara, D.3
  • 141
    • 10744225786 scopus 로고    scopus 로고
    • Expression, localization and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease
    • Bamias G, Martin C 3rd, Marini M, et al. Expression, localization and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease. J Immunol 2003; 171: 4868-74.
    • (2003) J Immunol , vol.171 , pp. 4868-4874
    • Bamias, G.1    Martin III, C.2    Marini, M.3
  • 142
    • 2942652655 scopus 로고    scopus 로고
    • Potential role for TL1A, the new TNFfamily member and potent costimulator of IFN-gamma, in mucosal inflammation
    • Prehn JL, Mehdizadeh S, Landers CJ, et al. Potential role for TL1A, the new TNFfamily member and potent costimulator of IFN-gamma, in mucosal inflammation. Clin Immunol 2004; 112: 66-77.
    • (2004) Clin Immunol , vol.112 , pp. 66-77
    • Prehn, J.L.1    Mehdizadeh, S.2    Landers, C.J.3
  • 143
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 2000; 13: 715-25.
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 144
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal S, Ghilardi N, XieMHet al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003; 278: 1910-4.
    • (2003) J Biol Chem , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3
  • 145
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17- producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17- producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 2005; 6: 1123-32.
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 146
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M, HockingRJ, Atkins CJ, et al. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006; 24: 179-89.
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3
  • 147
    • 60749107176 scopus 로고    scopus 로고
    • The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    • McGeachy MJ, Chen Y, Tato CM, et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 2009; 10: 314-24.
    • (2009) Nat Immunol , vol.10 , pp. 314-324
    • McGeachy, M.J.1    Chen, Y.2    Tato, C.M.3
  • 148
    • 34247523141 scopus 로고    scopus 로고
    • Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation
    • Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol 2007; 25: 221-42.
    • (2007) Annu Rev Immunol , vol.25 , pp. 221-242
    • Kastelein, R.A.1    Hunter, C.A.2    Cua, D.J.3
  • 149
    • 0035877257 scopus 로고    scopus 로고
    • Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility and premature death
    • Wiekowski MT, Leach MW, Evans EW, et al. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility and premature death. J Immunol 2001; 166: 7563-70.
    • (2001) J Immunol , vol.166 , pp. 7563-7570
    • Wiekowski, M.T.1    Leach, M.W.2    Evans, E.W.3
  • 150
    • 0141835046 scopus 로고    scopus 로고
    • Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    • Becker C,Wirtz S, Blessing M, et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 2003; 112: 693-706.
    • (2003) J Clin Invest , vol.112 , pp. 693-706
    • Becker, C.1    Wirtz, S.2    Blessing, M.3
  • 151
    • 25144515561 scopus 로고    scopus 로고
    • Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
    • Happel KI, Dubin PJ, Zheng M, et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 2005; 202: 761-9.
    • (2005) J Exp Med , vol.202 , pp. 761-769
    • Happel, K.I.1    Dubin, P.J.2    Zheng, M.3
  • 152
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    • Hue S, Ahern P, Buonocore S, et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med 2006; 203: 2473-83.
    • (2006) J Exp Med , vol.203 , pp. 2473-2483
    • Hue, S.1    Ahern, P.2    Buonocore, S.3
  • 153
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cellmediated colitis and promotes inflammation via IL-17 and IL-6
    • Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cellmediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Invest 2006; 116: 1310-6.
    • (2006) J Clin Invest , vol.116 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 154
    • 34250026960 scopus 로고    scopus 로고
    • Monoclonal antiinterleukin 23 reverses active colitis in a T cell-mediated model in mice
    • Elson CO, Cong Y, Weaver CT, et al. Monoclonal antiinterleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 2007; 132: 2359-70.
    • (2007) Gastroenterology , vol.132 , pp. 2359-2370
    • Elson, C.O.1    Cong, Y.2    Weaver, C.T.3
  • 155
    • 29744450121 scopus 로고    scopus 로고
    • Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are downregulated by treatment with anti-IL-12 p40 monoclonal antibody
    • Fuss IJ, Becker C, Yang Z, et al. Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are downregulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 2006; 12: 9-15.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 9-15
    • Fuss, I.J.1    Becker, C.2    Yang, Z.3
  • 156
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314: 1461-3.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 157
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol 2008; 8: 458-66.
    • (2008) Nat Rev Immunol , vol.8 , pp. 458-466
    • Cho, J.H.1
  • 158
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov II, McKenzie BS, Zhou L, et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 2006; 126: 1121-33.
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3
  • 159
    • 0842324613 scopus 로고    scopus 로고
    • Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    • Ogawa A, Andoh A, Araki Y, et al. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol 2004; 110: 55-62.
    • (2004) Clin Immunol , vol.110 , pp. 55-62
    • Ogawa, A.1    Andoh, A.2    Araki, Y.3
  • 160
    • 0034128634 scopus 로고    scopus 로고
    • Claudins regulate the intestinal barrier in response to immune mediators
    • Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 2000; 118: 1001-11.
    • (2000) Gastroenterology , vol.118 , pp. 1001-1011
    • Kinugasa, T.1    Sakaguchi, T.2    Gu, X.3    Reinecker, H.C.4
  • 161
    • 34547734621 scopus 로고    scopus 로고
    • Phenotypic and functional features of human Th17 cells
    • Annunziato F, Cosmi L, Santarlasci V, et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007; 204: 1849-61.
    • (2007) J Exp Med , vol.204 , pp. 1849-1861
    • Annunziato, F.1    Cosmi, L.2    Santarlasci, V.3
  • 162
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003; 52: 65-70.
    • (2003) Gut , vol.52 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3
  • 163
    • 0037299902 scopus 로고    scopus 로고
    • Upregulation of interleukin-12 and -17 in active inflammatory bowel disease
    • Nielsen OH, Kirman I, Rudiger N, et al. Upregulation of interleukin-12 and -17 in active inflammatory bowel disease. Scand J Gastroenterol 2003; 38: 180-5.
    • (2003) Scand J Gastroenterol , vol.38 , pp. 180-185
    • Nielsen, O.H.1    Kirman, I.2    Rudiger, N.3
  • 164
    • 42449084096 scopus 로고    scopus 로고
    • Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD
    • Seiderer J, Elben I, Diegelmann J, et al. Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm Bowel Dis 2008; 14: 437-45.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 437-445
    • Seiderer, J.1    Elben, I.2    Diegelmann, J.3
  • 165
    • 33744481749 scopus 로고    scopus 로고
    • Origins of the T(H)1-T(H)2 model: a personal perspective
    • Coffman RL. Origins of the T(H)1-T(H)2 model: a personal perspective. Nat Immunol 2006; 7: 539-41.
    • (2006) Nat Immunol , vol.7 , pp. 539-541
    • Coffman, R.L.1
  • 166
    • 52649167708 scopus 로고    scopus 로고
    • CD4 T cells: fates, functions and faults
    • Zhu J, Paul WE. CD4 T cells: fates, functions and faults. Blood 2008; 112: 1557-69.
    • (2008) Blood , vol.112 , pp. 1557-1569
    • Zhu, J.1    Paul, W.E.2
  • 167
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996; 4: 313-9.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 168
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89: 587-96.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 169
    • 0032538915 scopus 로고    scopus 로고
    • Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
    • Boirivant M, Fuss IJ, Chu A, Strober W. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 1998; 188: 1929-39.
    • (1998) J Exp Med , vol.188 , pp. 1929-1939
    • Boirivant, M.1    Fuss, I.J.2    Chu, A.3    Strober, W.4
  • 170
    • 0032901919 scopus 로고    scopus 로고
    • The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice
    • Mizoguchi A, Mizoguchi E, Bhan AK. The critical role of interleukin 4 but not interferon gamma in the pathogenesis of colitis in T-cell receptor alpha mutant mice. Gastroenterology 1999; 116: 320-6.
    • (1999) Gastroenterology , vol.116 , pp. 320-326
    • Mizoguchi, A.1    Mizoguchi, E.2    Bhan, A.K.3
  • 171
    • 0037736679 scopus 로고    scopus 로고
    • Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features and outcome in a single-center cohort of 55 patients
    • Dupuis-Girod S, Medioni J, Haddad E, et al. Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features and outcome in a single-center cohort of 55 patients. Pediatrics 2003; 111: e622-7.
    • (2003) Pediatrics , vol.111
    • Dupuis-Girod, S.1    Medioni, J.2    Haddad, E.3
  • 172
    • 0033583477 scopus 로고    scopus 로고
    • Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses
    • Dohi T, Fujihashi K, Rennert PD, et al. Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses. J Exp Med 1999; 189: 1169-80.
    • (1999) J Exp Med , vol.189 , pp. 1169-1180
    • Dohi, T.1    Fujihashi, K.2    Rennert, P.D.3
  • 173
    • 0029744262 scopus 로고    scopus 로고
    • Involvement of interleukin-4 and -10 in inflammatory bowel disease
    • Nielsen OH, Koppen T, Rudiger N, et al. Involvement of interleukin-4 and -10 in inflammatory bowel disease. Dig Dis Sci 1996; 41: 1786-93.
    • (1996) Dig Dis Sci , vol.41 , pp. 1786-1793
    • Nielsen, O.H.1    Koppen, T.2    Rudiger, N.3
  • 174
    • 85047690640 scopus 로고    scopus 로고
    • Nonclassical CD1drestricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis
    • Fuss IJ, Heller F, Boirivant M, et al. Nonclassical CD1drestricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest 2004; 113: 1490-7.
    • (2004) J Clin Invest , vol.113 , pp. 1490-1497
    • Fuss, I.J.1    Heller, F.2    Boirivant, M.3
  • 175
    • 3242717983 scopus 로고    scopus 로고
    • Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice
    • Takedatsu H, Mitsuyama K, Matsumoto S, et al. Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit mice. Eur J Immunol 2004; 34: 1561-9.
    • (2004) Eur J Immunol , vol.34 , pp. 1561-1569
    • Takedatsu, H.1    Mitsuyama, K.2    Matsumoto, S.3
  • 176
    • 58749091674 scopus 로고    scopus 로고
    • Untangling the complex web of IL-4- and IL-13-mediated signaling pathways
    • Wills-Karp M, Finkelman FD. Untangling the complex web of IL-4- and IL-13-mediated signaling pathways. Sci Signal 2008; 1: pe55.
    • (2008) Sci Signal , vol.1
    • Wills-Karp, M.1    Finkelman, F.D.2
  • 177
    • 0036850908 scopus 로고    scopus 로고
    • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK T cells
    • Heller F, Fuss IJ, Nieuwenhuis EE, et al. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK T cells. Immunity 2002; 17: 629-38.
    • (2002) Immunity , vol.17 , pp. 629-638
    • Heller, F.1    Fuss, I.J.2    Nieuwenhuis, E.E.3
  • 178
    • 34247586091 scopus 로고    scopus 로고
    • Induction of IL-13 triggers TGFbeta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis
    • Fichtner-Feigl S, Fuss IJ, Young CA, et al. Induction of IL-13 triggers TGFbeta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis. J Immunol 2007; 178: 5859-70.
    • (2007) J Immunol , vol.178 , pp. 5859-5870
    • Fichtner-Feigl, S.1    Fuss, I.J.2    Young, C.A.3
  • 179
    • 18244405108 scopus 로고    scopus 로고
    • IL-25 induces IL-4, IL-5 and IL-13 and Th2-associated pathologies in vivo
    • Fort MM, Cheung J, Yen D, et al. IL-25 induces IL-4, IL-5 and IL-13 and Th2-associated pathologies in vivo. Immunity 2001; 15: 985-95.
    • (2001) Immunity , vol.15 , pp. 985-995
    • Fort, M.M.1    Cheung, J.2    Yen, D.3
  • 180
    • 33645888708 scopus 로고    scopus 로고
    • Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5 and IL-13 at the onset of helminth expulsion
    • Fallon PG, Ballantyne SJ, Mangan NE, et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5 and IL-13 at the onset of helminth expulsion. J Exp Med 2006; 203: 1105-16.
    • (2006) J Exp Med , vol.203 , pp. 1105-1116
    • Fallon, P.G.1    Ballantyne, S.J.2    Mangan, N.E.3
  • 181
    • 33645896155 scopus 로고    scopus 로고
    • Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
    • Owyang AM, Zaph C, Wilson EH, et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med 2006; 203: 843-9.
    • (2006) J Exp Med , vol.203 , pp. 843-849
    • Owyang, A.M.1    Zaph, C.2    Wilson, E.H.3
  • 183
    • 0030018186 scopus 로고    scopus 로고
    • T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    • Davidson NJ, Leach MW, Fort MM, et al. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 1996; 184: 241-51.
    • (1996) J Exp Med , vol.184 , pp. 241-251
    • Davidson, N.J.1    Leach, M.W.2    Fort, M.M.3
  • 184
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • Groux H, O'Garra A, Bigler M, et al. A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997; 389: 737-42.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3
  • 185
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • Powrie F, LeachMW, Mauze S, et al. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994; 1: 553-62.
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3
  • 186
    • 0030942666 scopus 로고    scopus 로고
    • Altered immune responses in interleukin 10 transgenic mice
    • Hagenbaugh A, Sharma S, Dubinett SMet al. Altered immune responses in interleukin 10 transgenic mice. J Exp Med 1997; 185: 2101-10.
    • (1997) J Exp Med , vol.185 , pp. 2101-2110
    • Hagenbaugh, A.1    Sharma, S.2    Dubinett, S.M.3
  • 187
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman C, Mauze S, Leach MW, et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999; 190: 995-1004.
    • (1999) J Exp Med , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3
  • 188
  • 189
    • 33645029163 scopus 로고    scopus 로고
    • TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice
    • Kanai T, Kawamura T, Dohi T, et al. TH1/TH2-mediated colitis induced by adoptive transfer of CD4+CD45RBhigh T lymphocytes into nude mice. Inflamm Bowel Dis 2006; 12: 89-99.
    • (2006) Inflamm Bowel Dis , vol.12 , pp. 89-99
    • Kanai, T.1    Kawamura, T.2    Dohi, T.3
  • 190
    • 33845453812 scopus 로고    scopus 로고
    • Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse
    • Kamanaka M, Kim ST,Wan YY, et al. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Immunity 2006; 25: 941-52.
    • (2006) Immunity , vol.25 , pp. 941-952
    • Kamanaka, M.1    Kim, S.T.2    Wan, Y.Y.3
  • 191
    • 34548131112 scopus 로고    scopus 로고
    • Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3-precursor cells in the absence of interleukin 10
    • Maynard CL, Harrington LE, Janowski KM, et al. Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3-precursor cells in the absence of interleukin 10. Nat Immunol 2007; 8: 931-41.
    • (2007) Nat Immunol , vol.8 , pp. 931-941
    • Maynard, C.L.1    Harrington, L.E.2    Janowski, K.M.3
  • 192
    • 0036197923 scopus 로고    scopus 로고
    • Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation
    • Mizoguchi A, Mizoguchi E, Takedatsu H, et al. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002; 16: 219-30.
    • (2002) Immunity , vol.16 , pp. 219-230
    • Mizoguchi, A.1    Mizoguchi, E.2    Takedatsu, H.3
  • 193
    • 0036953455 scopus 로고    scopus 로고
    • IL-10 gene therapy prevents TNBS-induced colitis
    • Lindsay J,Van MontfransC, Brennan F, et al. IL-10 gene therapy prevents TNBS-induced colitis. Gene Ther 2002; 9: 1715-21.
    • (2002) Gene Ther , vol.9 , pp. 1715-1721
    • Lindsay, J.1    Van Montfrans, C.2    Brennan, F.3
  • 194
    • 0034714188 scopus 로고    scopus 로고
    • Treatment of murine colitis by Lactococcus lactis secreting interleukin-10
    • Steidler L, HansW, Schotte L, et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science 2000; 289: 1352-5.
    • (2000) Science , vol.289 , pp. 1352-1355
    • Steidler, L.1    Hans, W.2    Schotte, L.3
  • 195
    • 0141650591 scopus 로고    scopus 로고
    • Over-expression of interleukin in mucosal T 2 cells of patients with active ulcerative colitis
    • Melgar S, Yeung MM, Bas A, et al. Over-expression of interleukin in mucosal T 2 cells of patients with active ulcerative colitis. Clin Exp Immunol 2003; 134: 127-37.
    • (2003) Clin Exp Immunol , vol.134 , pp. 127-137
    • Melgar, S.1    Yeung, M.M.2    Bas, A.3
  • 196
    • 33744933432 scopus 로고    scopus 로고
    • A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease
    • Braat H, Rottiers P, Hommes DW, et al. A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol 2006; 4: 754-9.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 754-759
    • Braat, H.1    Rottiers, P.2    Hommes, D.W.3
  • 197
    • 33846086980 scopus 로고    scopus 로고
    • Transforming growth factor-beta: innately bipolar
    • Wahl SM. Transforming growth factor-beta: innately bipolar. Curr Opin Immunol 2007; 19: 55-62.
    • (2007) Curr Opin Immunol , vol.19 , pp. 55-62
    • Wahl, S.M.1
  • 198
    • 33646164362 scopus 로고    scopus 로고
    • Transforming growth factorbeta regulation of immune responses
    • Li MO, Wan YY, Sanjabi S, et al. Transforming growth factorbeta regulation of immune responses. Annu Rev Immunol 2006; 24: 99-146.
    • (2006) Annu Rev Immunol , vol.24 , pp. 99-146
    • Li, M.O.1    Wan, Y.Y.2    Sanjabi, S.3
  • 199
    • 0027532076 scopus 로고
    • Regulation of intestinal epithelial proliferation: a few answers, many questions
    • Podolsky DK. Regulation of intestinal epithelial proliferation: a few answers, many questions. Am J Physiol 1993; 264: G179-86.
    • (1993) Am J Physiol , vol.264
    • Podolsky, D.K.1
  • 200
    • 0025222530 scopus 로고
    • Transforming growth factor beta 1 increases IgA isotype switching at the clonal level
    • Kim PH, Kagnoff MF. Transforming growth factor beta 1 increases IgA isotype switching at the clonal level. J Immunol 1990; 145: 3773-8.
    • (1990) J Immunol , vol.145 , pp. 3773-3778
    • Kim, P.H.1    Kagnoff, M.F.2
  • 201
    • 0026542168 scopus 로고
    • Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering
    • Miller A, Lider O, Roberts AB, et al. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci USA 1992; 89: 421-5.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 421-425
    • Miller, A.1    Lider, O.2    Roberts, A.B.3
  • 202
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis
    • Chen Y, Kuchroo VK, Inobe J, et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994; 265: 1237-40.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3
  • 203
    • 0037013930 scopus 로고    scopus 로고
    • Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation
    • Gorelik L, Constant S, Flavell RA. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med 2002; 195: 1499-505.
    • (2002) J Exp Med , vol.195 , pp. 1499-1505
    • Gorelik, L.1    Constant, S.2    Flavell, R.A.3
  • 204
    • 0031253731 scopus 로고    scopus 로고
    • TGFbeta production regulates the development of the 2,4,6-trinitrophenolconjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice
    • Ludviksson BR, Ehrhardt RO, Strober W. TGFbeta production regulates the development of the 2,4,6-trinitrophenolconjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice. J Immunol 1997; 159: 3622-8.
    • (1997) J Immunol , vol.159 , pp. 3622-3628
    • Ludviksson, B.R.1    Ehrhardt, R.O.2    Strober, W.3
  • 205
    • 1642577126 scopus 로고    scopus 로고
    • TGFbeta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    • Nakamura K, Kitani A, Fuss I, et al. TGFbeta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol 2004; 172: 834-42.
    • (2004) J Immunol , vol.172 , pp. 834-842
    • Nakamura, K.1    Kitani, A.2    Fuss, I.3
  • 206
    • 0029956024 scopus 로고    scopus 로고
    • A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells
    • Powrie F, Carlino J, Leach MW, et al. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med 1996; 183: 2669-74.
    • (1996) J Exp Med , vol.183 , pp. 2669-2674
    • Powrie, F.1    Carlino, J.2    Leach, M.W.3
  • 207
    • 0037099613 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    • Piccirillo CA, Letterio JJ, Thornton AM, et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med 2002; 196: 237-46.
    • (2002) J Exp Med , vol.196 , pp. 237-246
    • Piccirillo, C.A.1    Letterio, J.J.2    Thornton, A.M.3
  • 208
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot JD, Dooley JL, Farr AG, Rudensky AY. Developmental regulation of Foxp3 expression during ontogeny. J Exp Med 2005; 202: 901-6.
    • (2005) J Exp Med , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 209
    • 15444363794 scopus 로고    scopus 로고
    • T cells that cannot respond to TGFbeta escape control by CD4(+)CD25(+) regulatory T cells
    • Fahlen L, Read S, Gorelik L, et al. T cells that cannot respond to TGFbeta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med 2005; 201: 737-46.
    • (2005) J Exp Med , vol.201 , pp. 737-746
    • Fahlen, L.1    Read, S.2    Gorelik, L.3
  • 210
    • 34547788180 scopus 로고    scopus 로고
    • Afunctionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGFbeta and retinoic acid-dependent mechanism
    • Coombes JL, Siddiqui KR, Arancibia-CarcamoCV, et al. Afunctionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGFbeta and retinoic acid-dependent mechanism. J Exp Med 2007; 204: 1757-64.
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3
  • 211
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun CM, Hall JA, Blank RB, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007; 204: 1775-85.
    • (2007) J Exp Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3
  • 212
    • 5644300399 scopus 로고    scopus 로고
    • Retinoic acid imprints gut-homing specificity on T cells
    • IwataM, Hirakiyama A, Eshima Y, et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004; 21: 527-38.
    • (2004) Immunity , vol.21 , pp. 527-538
    • Iwata, M.1    Hirakiyama, A.2    Eshima, Y.3
  • 213
    • 34547769253 scopus 로고    scopus 로고
    • All-transretinoic acid mediates enhanced T reg cell growth, differentiation and gut homing in the face of high levels of co-stimulation
    • Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-transretinoic acid mediates enhanced T reg cell growth, differentiation and gut homing in the face of high levels of co-stimulation. J Exp Med 2007; 204: 1765-74.
    • (2007) J Exp Med , vol.204 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3    Noelle, R.J.4
  • 214
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D, Park Y, KimGet al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007; 317: 256-60.
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3
  • 215
    • 0029913624 scopus 로고    scopus 로고
    • Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease
    • BabyatskyMW, Rossiter G, Podolsky DK. Expression of transforming growth factors alpha and beta in colonic mucosa in inflammatory bowel disease. Gastroenterology 1996; 110: 975-84.
    • (1996) Gastroenterology , vol.110 , pp. 975-984
    • Babyatsky, M.W.1    Rossiter, G.2    Podolsky, D.K.3
  • 216
    • 0033497296 scopus 로고    scopus 로고
    • Transforming growth factor-betas and their signaling receptors are coexpressed in Crohn's disease
    • di Mola FF, Friess H, Scheuren A, et al. Transforming growth factor-betas and their signaling receptors are coexpressed in Crohn's disease. Ann Surg 1999; 229: 67-75.
    • (1999) Ann Surg , vol.229 , pp. 67-75
    • di Mola, F.F.1    Friess, H.2    Scheuren, A.3
  • 217
    • 0141762545 scopus 로고    scopus 로고
    • TGFbeta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis
    • Del Zotto B, Mumolo G, PronioAMet al. TGFbeta1 production in inflammatory bowel disease: differing production patterns in Crohn's disease and ulcerative colitis. Clin Exp Immunol 2003; 134: 120-6.
    • (2003) Clin Exp Immunol , vol.134 , pp. 120-126
    • Del Zotto, B.1    Mumolo, G.2    Pronio, A.M.3
  • 218
    • 0032776134 scopus 로고    scopus 로고
    • Site-specific changes in transforming growth factor-alpha and -beta1 expression in colonic mucosa of adolescents with inflammatory bowel disease
    • Xian CJ, Xu X, Mardell CE, et al. Site-specific changes in transforming growth factor-alpha and -beta1 expression in colonic mucosa of adolescents with inflammatory bowel disease. Scand J Gastroenterol 1999; 34: 591-600.
    • (1999) Scand J Gastroenterol , vol.34 , pp. 591-600
    • Xian, C.J.1    Xu, X.2    Mardell, C.E.3
  • 219
    • 0028838414 scopus 로고
    • Immunohistochemical localization of transforming growth factor-beta receptors I and II in inflammatory bowel disease
    • Ohtani H, Kagaya H, Nagura H. Immunohistochemical localization of transforming growth factor-beta receptors I and II in inflammatory bowel disease. J Gastroenterol 1995; 30 Suppl 8: 76-7.
    • (1995) J Gastroenterol , vol.30 , Issue.SUUPL 8 , pp. 76-77
    • Ohtani, H.1    Kagaya, H.2    Nagura, H.3
  • 220
    • 54349125596 scopus 로고    scopus 로고
    • Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease
    • Burke JP, Ferrante M, Dejaegher K, et al. Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease. Inflamm Bowel Dis 2008; 14: 1197-204.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 1197-1204
    • Burke, J.P.1    Ferrante, M.2    Dejaegher, K.3
  • 221
    • 30044449492 scopus 로고    scopus 로고
    • IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGFbeta1 production and fibrosis
    • Fichtner-Feigl S, StroberW, Kawakami K, et al. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGFbeta1 production and fibrosis. Nat Med 2006; 12: 99-106.
    • (2006) Nat Med , vol.12 , pp. 99-106
    • Fichtner-Feigl, S.1    Strober, W.2    Kawakami, K.3
  • 223
    • 0034894059 scopus 로고    scopus 로고
    • Blocking Smad7 restores TGFbeta1 signaling in chronic inflammatory bowel disease
    • Monteleone G, Kumberova A, CroftNMet al. Blocking Smad7 restores TGFbeta1 signaling in chronic inflammatory bowel disease. J Clin Invest 2001; 108: 601-9.
    • (2001) J Clin Invest , vol.108 , pp. 601-609
    • Monteleone, G.1    Kumberova, A.2    Croft, N.M.3
  • 224
    • 33846906224 scopus 로고    scopus 로고
    • Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
    • Zheng Y, Danilenko DM, Valdez P, et al. Interleukin-22, a T(H)17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 2007; 445: 648-51.
    • (2007) Nature , vol.445 , pp. 648-651
    • Zheng, Y.1    Danilenko, D.M.2    Valdez, P.3
  • 225
    • 0036604122 scopus 로고    scopus 로고
    • Cutting edge: immune cells as sources and targets of the IL-10 family members
    • Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 2002; 168: 5397-402.
    • (2002) J Immunol , vol.168 , pp. 5397-5402
    • Wolk, K.1    Kunz, S.2    Asadullah, K.3    Sabat, R.4
  • 226
    • 4143095716 scopus 로고    scopus 로고
    • IL-22 increases the innate immunity of tissues
    • Wolk K, Kunz S,Witte E, et al. IL-22 increases the innate immunity of tissues. Immunity 2004; 21: 241-54.
    • (2004) Immunity , vol.21 , pp. 241-254
    • Wolk, K.1    Kunz, S.2    Witte, E.3
  • 227
    • 33749983749 scopus 로고    scopus 로고
    • Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells
    • Wolk K, Sabat R. Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells. Cytokine Growth Factor Rev 2006; 17: 367-80.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 367-380
    • Wolk, K.1    Sabat, R.2
  • 228
    • 24144477540 scopus 로고    scopus 로고
    • Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts
    • Andoh A, Zhang Z, Inatomi O, et al. Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts. Gastroenterology 2005; 129: 969-84.
    • (2005) Gastroenterology , vol.129 , pp. 969-984
    • Andoh, A.1    Zhang, Z.2    Inatomi, O.3
  • 229
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
    • Sugimoto K, Ogawa A, Mizoguchi E, et al. IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 2008; 118: 534-44.
    • (2008) J Clin Invest , vol.118 , pp. 534-544
    • Sugimoto, K.1    Ogawa, A.2    Mizoguchi, E.3
  • 230
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
    • Zenewicz LA, Yancopoulos GD, Valenzuela DM, et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008; 29: 947-57.
    • (2008) Immunity , vol.29 , pp. 947-957
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3
  • 231
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva S, Sun R, Pan HN, et al. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 2004; 39: 1332-42.
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3
  • 232
    • 39649121919 scopus 로고    scopus 로고
    • Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate Cytokines and Chemokines in Mucosal Homeostasis 153 with disease activity and IL23R genotype status
    • Schmechel S, Konrad A, Diegelmann J, et al. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate Cytokines and Chemokines in Mucosal Homeostasis 153 with disease activity and IL23R genotype status. Inflamm Bowel Dis 2008; 14: 204-12.
    • (2008) Inflamm Bowel Dis , vol.14 , pp. 204-212
    • Schmechel, S.1    Konrad, A.2    Diegelmann, J.3
  • 233
    • 0029100038 scopus 로고
    • Preclinical biology of interleukin 11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity
    • Goldman SJ. Preclinical biology of interleukin 11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity. Stem Cells 1995; 13: 462-71.
    • (1995) Stem Cells , vol.13 , pp. 462-471
    • Goldman, S.J.1
  • 234
    • 0031229726 scopus 로고    scopus 로고
    • Interleukin-11 inhibits macrophage interleukin-12 production
    • Leng SX, Elias JA. Interleukin-11 inhibits macrophage interleukin-12 production. J Immunol 1997; 159: 2161-8.
    • (1997) J Immunol , vol.159 , pp. 2161-2168
    • Leng, S.X.1    Elias, J.A.2
  • 235
    • 0032823806 scopus 로고    scopus 로고
    • Hematopoietic, immunomodulatory and epithelial effects of interleukin-11
    • Schwertschlag US, Trepicchio WL, Dykstra KH, et al. Hematopoietic, immunomodulatory and epithelial effects of interleukin-11. Leukemia 1999; 13: 1307-15.
    • (1999) Leukemia , vol.13 , pp. 1307-1315
    • Schwertschlag, U.S.1    Trepicchio, W.L.2    Dykstra, K.H.3
  • 236
    • 0032742184 scopus 로고    scopus 로고
    • Interleukin-11 reduces T-celldependent experimental liver injury in mice
    • Bozza M, Bliss JL, Maylor R, et al. Interleukin-11 reduces T-celldependent experimental liver injury in mice. Hepatology 1999; 30: 1441-7.
    • (1999) Hepatology , vol.30 , pp. 1441-1447
    • Bozza, M.1    Bliss, J.L.2    Maylor, R.3
  • 237
    • 33746375044 scopus 로고    scopus 로고
    • Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer
    • Deutscher N, Bataille F, Hausmann M, et al. Functional expression of the interleukin-11 receptor alpha-chain in normal colonic epithelium and colon cancer. Int J Colorectal Dis 2006; 21: 573-81.
    • (2006) Int J Colorectal Dis , vol.21 , pp. 573-581
    • Deutscher, N.1    Bataille, F.2    Hausmann, M.3
  • 238
    • 0029747033 scopus 로고    scopus 로고
    • Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation
    • Peterson RL, Bozza MM, Dorner AJ. Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation.AmJ Pathol 1996; 149: 895-902.
    • (1996) AmJ Pathol , vol.149 , pp. 895-902
    • Peterson, R.L.1    Bozza, M.M.2    Dorner, A.J.3
  • 239
    • 0029835760 scopus 로고    scopus 로고
    • Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats
    • Qiu BS, Pfeiffer CJ, Keith JC Jr. Protection by recombinant human interleukin-11 against experimental TNB-induced colitis in rats. Dig Dis Sci 1996; 41: 1625-30.
    • (1996) Dig Dis Sci , vol.41 , pp. 1625-1630
    • Qiu, B.S.1    Pfeiffer, C.J.2    Keith Jr., J.C.3
  • 240
    • 0033886814 scopus 로고    scopus 로고
    • Recombinant human interleukin-11 modulates ion transport and mucosal inflammation in the small intestine and colon
    • Greenwood-Van Meerveld B, Tyler K, Keith JC Jr. Recombinant human interleukin-11 modulates ion transport and mucosal inflammation in the small intestine and colon. Lab Invest 2000; 80: 1269-80.
    • (2000) Lab Invest , vol.80 , pp. 1269-1280
    • Greenwood-Van Meerveld, B.1    Tyler, K.2    Keith Jr., J.C.3
  • 241
    • 0032407805 scopus 로고    scopus 로고
    • Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease
    • Peterson RL, Wang L, Albert L, et al. Molecular effects of recombinant human interleukin-11 in the HLA-B27 rat model of inflammatory bowel disease. Lab Invest 1998; 78: 1503-12.
    • (1998) Lab Invest , vol.78 , pp. 1503-1512
    • Peterson, R.L.1    Wang, L.2    Albert, L.3
  • 242
    • 0033404492 scopus 로고    scopus 로고
    • Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions
    • Trepicchio WL, OzawaM,Walters IB, et al. Interleukin-11 therapy selectively downregulates type I cytokine proinflammatory pathways in psoriasis lesions. J Clin Invest 1999; 104: 1527-37.
    • (1999) J Clin Invest , vol.104 , pp. 1527-1537
    • Trepicchio, W.L.1    Ozawa, M.2    Walters, I.B.3
  • 243
    • 0036186051 scopus 로고    scopus 로고
    • Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease
    • Sands BE, Winston BD, Salzberg B, et al. Randomized, controlled trial of recombinant human interleukin-11 in patients with active Crohn's disease. Aliment Pharmacol Ther 2002; 16: 399-406.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 399-406
    • Sands, B.E.1    Winston, B.D.2    Salzberg, B.3
  • 244
    • 33645455612 scopus 로고    scopus 로고
    • Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease
    • Herrlinger KR,Witthoeft T, Raedler A, et al. Randomized, double blind controlled trial of subcutaneous recombinant human interleukin-11 versus prednisolone in active Crohn's disease. Am J Gastroenterol 2006; 101: 793-7.
    • (2006) Am J Gastroenterol , vol.101 , pp. 793-797
    • Herrlinger, K.R.1    Witthoeft, T.2    Raedler, A.3
  • 245
    • 36549030784 scopus 로고    scopus 로고
    • The inhibitory cytokine IL-35 contributes to regulatory T-cell function
    • Collison LW, Workman CJ, Kuo TT, et al. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007; 450: 566-9.
    • (2007) Nature , vol.450 , pp. 566-569
    • Collison, L.W.1    Workman, C.J.2    Kuo, T.T.3
  • 246
    • 35848958662 scopus 로고    scopus 로고
    • New players in the cytokine orchestra of inflammatory bowel disease
    • Fantini MC, Monteleone G, Macdonald TT. New players in the cytokine orchestra of inflammatory bowel disease. Inflamm Bowel Dis 2007; 13: 1419-23.
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 1419-1423
    • Fantini, M.C.1    Monteleone, G.2    Macdonald, T.T.3
  • 247
    • 41349121555 scopus 로고    scopus 로고
    • Regulation of gut inflammation and th17 cell response by interleukin-21
    • Fina D, Sarra M, FantiniMC, et al. Regulation of gut inflammation and th17 cell response by interleukin-21. Gastroenterology 2008; 134: 1038-48.
    • (2008) Gastroenterology , vol.134 , pp. 1038-1048
    • Fina, D.1    Sarra, M.2    Fantini, M.C.3
  • 248
    • 15744390341 scopus 로고    scopus 로고
    • Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease
    • Monteleone G, Monteleone I, Fina D, et al. Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease. Gastroenterology 2005; 128: 687-94.
    • (2005) Gastroenterology , vol.128 , pp. 687-694
    • Monteleone, G.1    Monteleone, I.2    Fina, D.3
  • 249
    • 9644279571 scopus 로고    scopus 로고
    • The role of IL-27 in the development of T-cell responses during parasitic infections
    • Hunter CA,Villarino A, Artis D, Scott P. The role of IL-27 in the development of T-cell responses during parasitic infections. Immunol Rev 2004; 202: 106-14.
    • (2004) Immunol Rev , vol.202 , pp. 106-114
    • Hunter, C.A.1    Villarino, A.2    Artis, D.3    Scott, P.4
  • 250
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten M, Li J, Yi S, et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006; 7: 929-36.
    • (2006) Nat Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3
  • 251
    • 0037168543 scopus 로고    scopus 로고
    • Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice
    • Nieuwenhuis EE, Neurath MF, Corazza N, et al. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad SciUSA 2002; 99: 16951-6.
    • (2002) Proc Natl Acad SciUSA , vol.99 , pp. 16951-6
    • Nieuwenhuis, E.E.1    Neurath, M.F.2    Corazza, N.3
  • 252
    • 44849096815 scopus 로고    scopus 로고
    • IL-27R deficiency delays the onset of colitis and protects fromhelminth-induced pathology in a model of chronic IBD
    • Villarino AV, Artis D, Bezbradica JS, et al. IL-27R deficiency delays the onset of colitis and protects fromhelminth-induced pathology in a model of chronic IBD. Int Immunol 2008; 20: 739-52.
    • (2008) Int Immunol , vol.20 , pp. 739-752
    • Villarino, A.V.1    Artis, D.2    Bezbradica, J.S.3
  • 253
    • 27944495565 scopus 로고    scopus 로고
    • T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis
    • Honda K, Nakamura K, Matsui N, et al. T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Inflamm Bowel Dis 2005; 11: 1044-52.
    • (2005) Inflamm Bowel Dis , vol.11 , pp. 1044-1052
    • Honda, K.1    Nakamura, K.2    Matsui, N.3
  • 254
    • 12444304581 scopus 로고    scopus 로고
    • Interleukin-32: a cytokine and inducer of TNFalpha
    • Kim SH, Han SY, Azam T, et al. Interleukin-32: a cytokine and inducer of TNFalpha. Immunity 2005; 22: 131-42.
    • (2005) Immunity , vol.22 , pp. 131-142
    • Kim, S.H.1    Han, S.Y.2    Azam, T.3
  • 255
    • 56149122501 scopus 로고    scopus 로고
    • A human dendritic cell subset receptive to the Venezuelan equine encephalitis virusderived replicon particle constitutively expresses IL-32
    • Nishimoto KP, Laust AK, Nelson EL. A human dendritic cell subset receptive to the Venezuelan equine encephalitis virusderived replicon particle constitutively expresses IL-32. J Immunol 2008; 181: 4010-8.
    • (2008) J Immunol , vol.181 , pp. 4010-4018
    • Nishimoto, K.P.1    Laust, A.K.2    Nelson, E.L.3
  • 256
    • 34547887644 scopus 로고    scopus 로고
    • Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease
    • Shioya M, Nishida A, Yagi Y, et al. Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease. Clin Exp Immunol 2007; 149: 480-6.
    • (2007) Clin Exp Immunol , vol.149 , pp. 480-486
    • Shioya, M.1    Nishida, A.2    Yagi, Y.3
  • 257
    • 28044453314 scopus 로고    scopus 로고
    • IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1- dependent mechanism
    • Netea MG, Azam T, Ferwerda G, et al. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1- dependent mechanism. Proc Natl Acad Sci USA 2005; 102: 16309-14.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16309-14
    • Netea, M.G.1    Azam, T.2    Ferwerda, G.3
  • 258
    • 70350510213 scopus 로고    scopus 로고
    • Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases
    • ShodaH, Fujio K,YamaguchiYet al. Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases. Arthritis Res Ther 2006; 8: R166.
    • (2006) Arthritis Res Ther , vol.8
    • Shoda, H.1    Fujio, K.2    Yamaguchi, Y.3
  • 259
    • 46249090513 scopus 로고    scopus 로고
    • Colony-stimulating factors in inflammation and autoimmunity
    • Hamilton JA. Colony-stimulating factors in inflammation and autoimmunity. Nat Rev Immunol 2008; 8: 533-44.
    • (2008) Nat Rev Immunol , vol.8 , pp. 533-544
    • Hamilton, J.A.1
  • 260
    • 0031020373 scopus 로고    scopus 로고
    • Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis
    • Rasmussen SJ, Eckmann L, Quayle AJ, et al. Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis. J Clin Invest 1997; 99: 77-87.
    • (1997) J Clin Invest , vol.99 , pp. 77-87
    • Rasmussen, S.J.1    Eckmann, L.2    Quayle, A.J.3
  • 261
    • 38849170507 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor ameliorates DSSinduced experimental colitis
    • Sainathan SK, Hanna EM, Gong Q, et al. Granulocyte macrophage colony-stimulating factor ameliorates DSSinduced experimental colitis. Inflamm BowelDis 2008; 14: 88-99.
    • (2008) Inflamm BowelDis , vol.14 , pp. 88-99
    • Sainathan, S.K.1    Hanna, E.M.2    Gong, Q.3
  • 262
    • 57049185731 scopus 로고    scopus 로고
    • The role of granulocyte macrophagecolony- stimulating factor in acute intestinal inflammation
    • Xu Y, Hunt NH, Bao S. The role of granulocyte macrophagecolony- stimulating factor in acute intestinal inflammation. Cell Res 2008; 18: 1220-9.
    • (2008) Cell Res , vol.18 , pp. 1220-1229
    • Xu, Y.1    Hunt, N.H.2    Bao, S.3
  • 263
    • 0037048904 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor
    • Dieckgraefe BK, Korzenik JR. Treatment of active Crohn's disease with recombinant human granulocyte-macrophage colony-stimulating factor. Lancet 2002; 360: 1478-80.
    • (2002) Lancet , vol.360 , pp. 1478-1480
    • Dieckgraefe, B.K.1    Korzenik, J.R.2
  • 265
    • 14644404938 scopus 로고    scopus 로고
    • An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease
    • Korzenik JR, Dieckgraefe BK. An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease. Aliment Pharmacol Ther 2005; 21: 391-400.
    • (2005) Aliment Pharmacol Ther , vol.21 , pp. 391-400
    • Korzenik, J.R.1    Dieckgraefe, B.K.2
  • 266
    • 0035135221 scopus 로고    scopus 로고
    • Increased secretion of granulocyte-macrophage colony-stimulating factor in mucosal lesions of inflammatory bowel disease
    • Noguchi M, Hiwatashi N, Liu ZX, Toyota T. Increased secretion of granulocyte-macrophage colony-stimulating factor in mucosal lesions of inflammatory bowel disease. Digestion 2001; 63 Suppl 1: 32-6.
    • (2001) Digestion , vol.63 , Issue.SUUPL 1 , pp. 32-36
    • Noguchi, M.1    Hiwatashi, N.2    Liu, Z.X.3    Toyota, T.4
  • 267
    • 3142588819 scopus 로고    scopus 로고
    • Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease -a possible target for infliximab treatment
    • Agnholt J, Kelsen J, Brandsborg B, et al. Increased production of granulocyte-macrophage colony-stimulating factor in Crohn's disease -a possible target for infliximab treatment. Eur J Gastroenterol Hepatol 2004; 16: 649-55.
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 649-655
    • Agnholt, J.1    Kelsen, J.2    Brandsborg, B.3
  • 268
    • 18944379196 scopus 로고    scopus 로고
    • The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance
    • Fry TJ, Mackall CL. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J Immunol 2005; 174: 6571-6.
    • (2005) J Immunol , vol.174 , pp. 6571-6576
    • Fry, T.J.1    Mackall, C.L.2
  • 269
    • 0033744745 scopus 로고    scopus 로고
    • Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammacdependent cytokines IL-2, IL-7 and IL-15
    • Porter BO, Malek TR. Thymic and intestinal intraepithelial T lymphocyte development are each regulated by the gammacdependent cytokines IL-2, IL-7 and IL-15. Semin Immunol 2000; 12: 465-74.
    • (2000) Semin Immunol , vol.12 , pp. 465-474
    • Porter, B.O.1    Malek, T.R.2
  • 270
    • 0343183279 scopus 로고    scopus 로고
    • Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches
    • Laky K, Lefrancois L, Lingenheld EG, et al. Enterocyte expression of interleukin 7 induces development of gammadelta T cells and Peyer's patches. J Exp Med 2000; 191: 1569-80.
    • (2000) J Exp Med , vol.191 , pp. 1569-1580
    • Laky, K.1    Lefrancois, L.2    Lingenheld, E.G.3
  • 271
    • 0032472838 scopus 로고    scopus 로고
    • Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa
    • Watanabe M, Ueno Y, Yajima T, et al. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med 1998; 187: 389-402.
    • (1998) J Exp Med , vol.187 , pp. 389-402
    • Watanabe, M.1    Ueno, Y.2    Yajima, T.3
  • 272
    • 0032533480 scopus 로고    scopus 로고
    • IL-7 deficiency prevents development of a non-T cell non-B cell-mediated colitis
    • von Freeden-Jeffry U, Davidson N,Wiler R, et al. IL-7 deficiency prevents development of a non-T cell non-B cell-mediated colitis. J Immunol 1998; 161: 5673-80.
    • (1998) J Immunol , vol.161 , pp. 5673-5680
    • von Freeden-Jeffry, U.1    Davidson, N.2    Wiler, R.3
  • 273
    • 34247157433 scopus 로고    scopus 로고
    • IL-7 Is essential for the development and the persistence of chronic colitis
    • Totsuka T, Kanai T, Nemoto Y, et al. IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol 2007; 178: 4737-48.
    • (2007) J Immunol , vol.178 , pp. 4737-4748
    • Totsuka, T.1    Kanai, T.2    Nemoto, Y.3
  • 274
    • 20144376580 scopus 로고    scopus 로고
    • IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice
    • Okada E, YamazakiM, TanabeMet al. IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice. Am J Physiol Gastrointest Liver Physiol 2005; 288: G745-54.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Okada, E.1    Yamazaki, M.2    Tanabe, M.3
  • 275
    • 0041344313 scopus 로고    scopus 로고
    • Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis
    • Yamazaki M, Yajima T, Tanabe M, et al. Mucosal T cells expressing high levels of IL-7 receptor are potential targets for treatment of chronic colitis. J Immunol 2003; 171: 1556-63.
    • (2003) J Immunol , vol.171 , pp. 1556-1563
    • Yamazaki, M.1    Yajima, T.2    Tanabe, M.3
  • 276
    • 40449131153 scopus 로고    scopus 로고
    • Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis
    • Tomita T, Kanai T, Nemoto Y, et al. Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis. J Immunol 2008; 180: 383-90.
    • (2008) J Immunol , vol.180 , pp. 383-390
    • Tomita, T.1    Kanai, T.2    Nemoto, Y.3
  • 277
    • 46849091975 scopus 로고    scopus 로고
    • TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
    • Yamamoto S, Shimizu S, Kiyonaka S, et al. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. NatMed 2008; 14: 738-47.
    • (2008) NatMed , vol.14 , pp. 738-747
    • Yamamoto, S.1    Shimizu, S.2    Kiyonaka, S.3
  • 278
    • 2542428442 scopus 로고    scopus 로고
    • Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells
    • Rot A, von Andrian UH. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu Rev Immunol 2004; 22: 891-928.
    • (2004) Annu Rev Immunol , vol.22 , pp. 891-928
    • Rot, A.1    von Andrian, U.H.2
  • 279
    • 0035023806 scopus 로고    scopus 로고
    • Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/-mice and Rag- 2-/-mice reconstituted with CD4+CD45RBhigh T cells
    • Scheerens H, Hessel E, de Waal-Malefyt R, et al. Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10-/-mice and Rag- 2-/-mice reconstituted with CD4+CD45RBhigh T cells. Eur J Immunol 2001; 31: 1465-74.
    • (2001) Eur J Immunol , vol.31 , pp. 1465-1474
    • Scheerens, H.1    Hessel, E.2    de Waal-Malefyt, R.3
  • 280
    • 0036140612 scopus 로고    scopus 로고
    • The increased expression of an array of C-X-C and C-C chemokines in the colonic mucosa of patientswith ulcerative colitis: regulation by corticosteroids
    • Yang SK, Choi MS, Kim OH, et al. The increased expression of an array of C-X-C and C-C chemokines in the colonic mucosa of patientswith ulcerative colitis: regulation by corticosteroids. Am J Gastroenterol 2002; 97: 126-32.
    • (2002) Am J Gastroenterol , vol.97 , pp. 126-132
    • Yang, S.K.1    Choi, M.S.2    Kim, O.H.3
  • 281
    • 32144454172 scopus 로고    scopus 로고
    • The many roles of chemokines and chemokine receptors in inflammation
    • Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354: 610-21.
    • (2006) N Engl J Med , vol.354 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 282
    • 34247855761 scopus 로고    scopus 로고
    • Chemokine: receptor structure, interactions and antagonism
    • Allen SJ, Crown SE, Handel TM. Chemokine: receptor structure, interactions and antagonism. Annu Rev Immunol 2007; 25: 787-820.
    • (2007) Annu Rev Immunol , vol.25 , pp. 787-820
    • Allen, S.J.1    Crown, S.E.2    Handel, T.M.3
  • 283
    • 0031930615 scopus 로고    scopus 로고
    • IL-4, IL-10 and IL-13 down-regulatemonocyte-chemoattracting protein-1 (MCP- 1) production in activated intestinal epithelial cells
    • Kucharzik T, Lugering N, Pauels HG, et al. IL-4, IL-10 and IL-13 down-regulatemonocyte-chemoattracting protein-1 (MCP- 1) production in activated intestinal epithelial cells. Clin Exp Immunol 1998; 111: 152-7.
    • (1998) Clin Exp Immunol , vol.111 , pp. 152-157
    • Kucharzik, T.1    Lugering, N.2    Pauels, H.G.3
  • 284
    • 0031948889 scopus 로고    scopus 로고
    • Interferon gamma induces differential upregulation of alpha and beta chemokine secretion in colonic epithelial cell lines
    • Warhurst AC, Hopkins SJ, Warhurst G. Interferon gamma induces differential upregulation of alpha and beta chemokine secretion in colonic epithelial cell lines. Gut 1998; 42: 208-13.
    • (1998) Gut , vol.42 , pp. 208-213
    • Warhurst, A.C.1    Hopkins, S.J.2    Warhurst, G.3
  • 285
    • 33646270895 scopus 로고    scopus 로고
    • Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
    • Motomura Y, Khan WI, El-Sharkawy RT, et al. Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1. Gut 2006; 55: 662-70.
    • (2006) Gut , vol.55 , pp. 662-670
    • Motomura, Y.1    Khan, W.I.2    El-Sharkawy, R.T.3
  • 286
    • 33751071608 scopus 로고    scopus 로고
    • Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells
    • Khan WI, Motomura Y, Wang H, et al. Critical role of MCP-1 in the pathogenesis of experimental colitis in the context of immune and enterochromaffin cells. Am J Physiol Gastrointest Liver Physiol 2006; 291: G803-11.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291
    • Khan, W.I.1    Motomura, Y.2    Wang, H.3
  • 287
    • 0034659767 scopus 로고    scopus 로고
    • Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine
    • Andres PG, Beck PL, Mizoguchi E, et al. Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine. J Immunol 2000; 164: 6303-12.
    • (2000) J Immunol , vol.164 , pp. 6303-6312
    • Andres, P.G.1    Beck, P.L.2    Mizoguchi, E.3
  • 288
    • 23844499474 scopus 로고    scopus 로고
    • The simultaneous blockade of chemokine receptors CCR2, CCR5 andCXCR3 by a nonpeptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis
    • Tokuyama H, Ueha S, KurachiMet al. The simultaneous blockade of chemokine receptors CCR2, CCR5 andCXCR3 by a nonpeptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis. Int Immunol 2005; 17: 1023-34.
    • (2005) Int Immunol , vol.17 , pp. 1023-1034
    • Tokuyama, H.1    Ueha, S.2    Kurachi, M.3
  • 289
    • 0028813487 scopus 로고
    • Monocytechemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa
    • Reinecker HC, Loh EY, Ringler DJ, et al. Monocytechemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa. Gastroenterology 1995; 108: 40-50.
    • (1995) Gastroenterology , vol.108 , pp. 40-50
    • Reinecker, H.C.1    Loh, E.Y.2    Ringler, D.J.3
  • 290
    • 0030041142 scopus 로고    scopus 로고
    • Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease
    • Mazzucchelli L, Hauser C, Zgraggen K, et al. Differential in situ expression of the genes encoding the chemokines MCP-1 and RANTES in human inflammatory bowel disease. J Pathol 1996; 178: 201-6.
    • (1996) J Pathol , vol.178 , pp. 201-206
    • Mazzucchelli, L.1    Hauser, C.2    Zgraggen, K.3
  • 291
    • 0029888133 scopus 로고    scopus 로고
    • Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa
    • Grimm MC, Elsbury SK, Pavli P, Doe WF. Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa. J Leukoc Biol 1996; 59: 804-12.
    • (1996) J Leukoc Biol , vol.59 , pp. 804-812
    • Grimm, M.C.1    Elsbury, S.K.2    Pavli, P.3    Doe, W.F.4
  • 293
    • 0034773576 scopus 로고    scopus 로고
    • Tissue cytokine and chemokine expression in inflammatory bowel disease
    • McCormack G, Moriarty D, O'Donoghue DP, et al. Tissue cytokine and chemokine expression in inflammatory bowel disease. Inflamm Res 2001; 50: 491-5.
    • (2001) Inflamm Res , vol.50 , pp. 491-495
    • McCormack, G.1    Moriarty, D.2    O'Donoghue, D.P.3
  • 294
    • 4344651209 scopus 로고    scopus 로고
    • CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease
    • Connor SJ, Paraskevopoulos N, Newman R, et al. CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease. Gut 2004; 53: 1287-94.
    • (2004) Gut , vol.53 , pp. 1287-1294
    • Connor, S.J.1    Paraskevopoulos, N.2    Newman, R.3
  • 295
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major coreceptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W, et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature 1996; 381: 661-6.
    • (1996) Nature , vol.381 , pp. 661-666
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 296
    • 4444279141 scopus 로고    scopus 로고
    • The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis
    • Ajuebor MN, Kunkel SL, Hogaboam CM. The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis. Eur J Pharmacol 2004; 497: 343-9.
    • (2004) Eur J Pharmacol , vol.497 , pp. 343-349
    • Ajuebor, M.N.1    Kunkel, S.L.2    Hogaboam, C.M.3
  • 297
    • 22644431611 scopus 로고    scopus 로고
    • Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model
    • Pender SL, Chance V, Whiting CV, et al. Systemic administration of the chemokine macrophage inflammatory protein 1alpha exacerbates inflammatory bowel disease in a mouse model. Gut 2005; 54: 1114-20.
    • (2005) Gut , vol.54 , pp. 1114-1120
    • Pender, S.L.1    Chance, V.2    Whiting, C.V.3
  • 298
    • 0035168846 scopus 로고    scopus 로고
    • The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat
    • AjueborMN, Hogaboam CM, Kunkel SL, et al. The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat. J Immunol 2001; 166: 552-8.
    • (2001) J Immunol , vol.166 , pp. 552-558
    • Ajuebor, M.N.1    Hogaboam, C.M.2    Kunkel, S.L.3
  • 299
    • 38549166392 scopus 로고    scopus 로고
    • Expression profiles of cytokines and chemokines in murine MDR1a-/-colitis
    • Masunaga Y, Noto T, Suzuki K, et al. Expression profiles of cytokines and chemokines in murine MDR1a-/-colitis. Inflamm Res 2007; 56: 439-46.
    • (2007) Inflamm Res , vol.56 , pp. 439-446
    • Masunaga, Y.1    Noto, T.2    Suzuki, K.3
  • 300
    • 33750026738 scopus 로고    scopus 로고
    • Comparison of RANTES expression in Crohn's disease and ulcerative colitis: an aid in the differential diagnosis
    • Ansari N, Abdulla J, Zayyani N, et al. Comparison of RANTES expression in Crohn's disease and ulcerative colitis: an aid in the differential diagnosis? J Clin Pathol 2006; 59: 1066-72.
    • (2006) J Clin Pathol , vol.59 , pp. 1066-1072
    • Ansari, N.1    Abdulla, J.2    Zayyani, N.3
  • 301
    • 0032788099 scopus 로고    scopus 로고
    • Increased expression of IP-10, IL-8,MCP-1 andMCP-3 in ulcerative colitis
    • Uguccioni M, Gionchetti P, Robbiani DF, et al. Increased expression of IP-10, IL-8,MCP-1 andMCP-3 in ulcerative colitis. Am J Pathol 1999; 155: 331-6.
    • (1999) Am J Pathol , vol.155 , pp. 331-336
    • Uguccioni, M.1    Gionchetti, P.2    Robbiani, D.F.3
  • 302
    • 12344314536 scopus 로고    scopus 로고
    • Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response
    • Oki M, Ohtani H, Kinouchi Y, et al. Accumulation of CCR5+ T cells around RANTES+ granulomas in Crohn's disease: a pivotal site of Th1-shifted immune response? Lab Invest 2005; 85: 137-45.
    • (2005) Lab Invest , vol.85 , pp. 137-145
    • Oki, M.1    Ohtani, H.2    Kinouchi, Y.3
  • 303
    • 0035013827 scopus 로고    scopus 로고
    • Regulated MIP- 3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity
    • Izadpanah A, Dwinell MB, Eckmann L, et al. Regulated MIP- 3alpha/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity. Am J Physiol Gastrointest Liver Physiol 2001; 280: G710-9.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.280
    • Izadpanah, A.1    Dwinell, M.B.2    Eckmann, L.3
  • 304
    • 0036895299 scopus 로고    scopus 로고
    • Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP- 3alpha) production in normal colon and inflammatory bowel disease
    • Kwon JH, Keates S, Bassani L, et al. Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP- 3alpha) production in normal colon and inflammatory bowel disease. Gut 2002; 51: 818-26.
    • (2002) Gut , vol.51 , pp. 818-826
    • Kwon, J.H.1    Keates, S.2    Bassani, L.3
  • 305
    • 0242303557 scopus 로고    scopus 로고
    • CCR6 has a non-redundant role in the development of inflammatory bowel disease
    • Varona R, Cadenas V, Flores J, et al. CCR6 has a non-redundant role in the development of inflammatory bowel disease. Eur J Immunol 2003; 33: 2937-46.
    • (2003) Eur J Immunol , vol.33 , pp. 2937-2946
    • Varona, R.1    Cadenas, V.2    Flores, J.3
  • 306
    • 34347397614 scopus 로고    scopus 로고
    • MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice
    • Katchar K, Kelly CP, Keates S, et al. MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice. AmJ Physiol Gastrointest Liver Physiol 2007; 292: G1263-71.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292
    • Katchar, K.1    Kelly, C.P.2    Keates, S.3
  • 307
    • 34548761490 scopus 로고    scopus 로고
    • The chemokine receptor CCR6 is an important component of the innate immune response
    • Wen H, Hogaboam CM, Lukacs NW, et al. The chemokine receptor CCR6 is an important component of the innate immune response. Eur J Immunol 2007; 37: 2487-98.
    • (2007) Eur J Immunol , vol.37 , pp. 2487-2498
    • Wen, H.1    Hogaboam, C.M.2    Lukacs, N.W.3
  • 308
    • 20044376669 scopus 로고    scopus 로고
    • Increased lymphocyte trafficking to colonicmicrovessels is dependent onMAdCAM- 1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis
    • Teramoto K, Miura S, Tsuzuki Y, et al. Increased lymphocyte trafficking to colonicmicrovessels is dependent onMAdCAM- 1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis. Clin Exp Immunol 2005; 139: 421-8.
    • (2005) Clin Exp Immunol , vol.139 , pp. 421-428
    • Teramoto, K.1    Miura, S.2    Tsuzuki, Y.3
  • 309
    • 33646566609 scopus 로고    scopus 로고
    • CCR6- mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches
    • Salazar-Gonzalez RM, Niess JH, Zammit DJ, et al. CCR6- mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches. Immunity 2006; 24: 623-32.
    • (2006) Immunity , vol.24 , pp. 623-632
    • Salazar-Gonzalez, R.M.1    Niess, J.H.2    Zammit, D.J.3
  • 310
    • 58849152515 scopus 로고    scopus 로고
    • The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut
    • Wang C, Kang SG, Lee J, et al. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol 2009; 2 (2):173-83.
    • (2009) Mucosal Immunol , vol.2 , Issue.2 , pp. 173-183
    • Wang, C.1    Kang, S.G.2    Lee, J.3
  • 311
    • 0033986966 scopus 로고    scopus 로고
    • The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9
    • Wurbel MA, Philippe JM, Nguyen C, et al. The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur J Immunol 2000; 30: 262-71.
    • (2000) Eur J Immunol , vol.30 , pp. 262-271
    • Wurbel, M.A.1    Philippe, J.M.2    Nguyen, C.3
  • 312
    • 1342300522 scopus 로고    scopus 로고
    • Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine
    • Pabst O, Ohl L, Wendland M, et al. Chemokine receptor CCR9 contributes to the localization of plasma cells to the small intestine. J Exp Med 2004; 199: 411-6.
    • (2004) J Exp Med , vol.199 , pp. 411-416
    • Pabst, O.1    Ohl, L.2    Wendland, M.3
  • 313
    • 0036802422 scopus 로고    scopus 로고
    • CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa
    • SvenssonM,Marsal J, Ericsson A, et al. CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa. J Clin Invest 2002; 110: 1113-21.
    • (2002) J Clin Invest , vol.110 , pp. 1113-1121
    • Svensson, M.1    Marsal, J.2    Ericsson, A.3
  • 314
    • 0036910773 scopus 로고    scopus 로고
    • Involvement of CCL25 (TECK) in the generation of the murine small-intestinal CD8alpha alpha+CD3+ intraepithelial lymphocyte compartment
    • Marsal J, Svensson M, Ericsson A, et al. Involvement of CCL25 (TECK) in the generation of the murine small-intestinal CD8alpha alpha+CD3+ intraepithelial lymphocyte compartment. Eur J Immunol 2002; 32: 3488-97.
    • (2002) Eur J Immunol , vol.32 , pp. 3488-3497
    • Marsal, J.1    Svensson, M.2    Ericsson, A.3
  • 315
    • 0141449950 scopus 로고    scopus 로고
    • Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant
    • Johansson-Lindbom B, Svensson M, Wurbel MA, et al. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med 2003; 198: 963-9.
    • (2003) J Exp Med , vol.198 , pp. 963-969
    • Johansson-Lindbom, B.1    Svensson, M.2    Wurbel, M.A.3
  • 316
    • 0038264036 scopus 로고    scopus 로고
    • Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells
    • Mora JR, Bono MR, Manjunath N, et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature 2003; 424: 88-93.
    • (2003) Nature , vol.424 , pp. 88-93
    • Mora, J.R.1    Bono, M.R.2    Manjunath, N.3
  • 317
    • 26844538936 scopus 로고    scopus 로고
    • Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
    • Johansson-Lindbom B, Svensson M, Pabst O, et al. Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing. J Exp Med 2005; 202: 1063-73.
    • (2005) J Exp Med , vol.202 , pp. 1063-1073
    • Johansson-Lindbom, B.1    Svensson, M.2    Pabst, O.3
  • 318
    • 33645054315 scopus 로고    scopus 로고
    • Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells
    • Worbs T, Bode U, Yan S, et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med 2006; 203: 519-27.
    • (2006) J Exp Med , vol.203 , pp. 519-527
    • Worbs, T.1    Bode, U.2    Yan, S.3
  • 319
    • 26844468978 scopus 로고    scopus 로고
    • Essential role for CD103 in the T cell-mediated regulation of experimental colitis
    • Annacker O, Coombes JL, Malmstrom V, et al. Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med 2005; 202: 1051-61.
    • (2005) J Exp Med , vol.202 , pp. 1051-1061
    • Annacker, O.1    Coombes, J.L.2    Malmstrom, V.3
  • 320
    • 0034899072 scopus 로고    scopus 로고
    • CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel fromcolonic Crohn's disease
    • Papadakis KA, Prehn J, Moreno ST, et al. CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel fromcolonic Crohn's disease. Gastroenterology 2001; 121: 246-54.
    • (2001) Gastroenterology , vol.121 , pp. 246-254
    • Papadakis, K.A.1    Prehn, J.2    Moreno, S.T.3
  • 321
    • 33847390444 scopus 로고    scopus 로고
    • Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease
    • Saruta M, Yu QT, Avanesyan A, et al. Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. J Immunol 2007; 178: 3293-300.
    • (2007) J Immunol , vol.178 , pp. 3293-3300
    • Saruta, M.1    Yu, Q.T.2    Avanesyan, A.3
  • 322
    • 0031569588 scopus 로고    scopus 로고
    • Neutrophil-activating protein ENA-78 and IL-8 exhibit different patterns of expression in lipopolysaccharide- and cytokine-stimulated human monocytes
    • Schnyder-Candrian S, Walz A. Neutrophil-activating protein ENA-78 and IL-8 exhibit different patterns of expression in lipopolysaccharide- and cytokine-stimulated human monocytes. J Immunol 1997; 158: 3888-94.
    • (1997) J Immunol , vol.158 , pp. 3888-3894
    • Schnyder-Candrian, S.1    Walz, A.2
  • 323
    • 0030860713 scopus 로고    scopus 로고
    • Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis
    • Keates S, Keates AC, Mizoguchi E, et al. Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol 1997; 273: G75-82.
    • (1997) Am J Physiol , vol.273
    • Keates, S.1    Keates, A.C.2    Mizoguchi, E.3
  • 324
    • 0030768826 scopus 로고    scopus 로고
    • The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease
    • Z'Graggen K, Walz A, Mazzucchelli L, et al. The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease. Gastroenterology 1997; 113: 808-16.
    • (1997) Gastroenterology , vol.113 , pp. 808-816
    • Z'Graggen, K.1    Walz, A.2    Mazzucchelli, L.3
  • 325
    • 0024421453 scopus 로고
    • Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils
    • Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 1989; 84: 1045-9.
    • (1989) J Clin Invest , vol.84 , pp. 1045-1049
    • Baggiolini, M.1    Walz, A.2    Kunkel, S.L.3
  • 326
    • 4444332518 scopus 로고    scopus 로고
    • Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations
    • Li J, Moran T, Swanson E, et al. Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum Mol Genet 2004; 13: 1715-25.
    • (2004) Hum Mol Genet , vol.13 , pp. 1715-1725
    • Li, J.1    Moran, T.2    Swanson, E.3
  • 327
    • 0028275028 scopus 로고
    • Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation
    • Mazzucchelli L, Hauser C, Zgraggen K, et al. Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am J Pathol 1994; 144: 997-1007.
    • (1994) Am J Pathol , vol.144 , pp. 997-1007
    • Mazzucchelli, L.1    Hauser, C.2    Zgraggen, K.3
  • 328
    • 0028319023 scopus 로고
    • IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease
    • Mitsuyama K, Toyonaga A, Sasaki E, et al. IL-8 as an important chemoattractant for neutrophils in ulcerative colitis and Crohn's disease. Clin Exp Immunol 1994; 96: 432-6.
    • (1994) Clin Exp Immunol , vol.96 , pp. 432-436
    • Mitsuyama, K.1    Toyonaga, A.2    Sasaki, E.3
  • 329
    • 0030067724 scopus 로고    scopus 로고
    • Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease
    • Daig R, Andus T,Aschenbrenner E, et al. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 1996; 38: 216-22.
    • (1996) Gut , vol.38 , pp. 216-222
    • Daig, R.1    Andus, T.2    Aschenbrenner, E.3
  • 330
    • 0030862103 scopus 로고    scopus 로고
    • Intestinal interleukin-8 concentration and gene expression in inflammatory bowel disease
    • Nielsen OH, Rudiger N, Gaustadnes M, Horn T. Intestinal interleukin-8 concentration and gene expression in inflammatory bowel disease. Scand J Gastroenterol 1997; 32: 1028-34.
    • (1997) Scand J Gastroenterol , vol.32 , pp. 1028-1034
    • Nielsen, O.H.1    Rudiger, N.2    Gaustadnes, M.3    Horn, T.4
  • 331
    • 0026785837 scopus 로고
    • Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis
    • Izzo RS,Witkon K, Chen AI, et al. Interleukin-8 and neutrophil markers in colonic mucosa from patients with ulcerative colitis. Am J Gastroenterol 1992; 87: 1447-52.
    • (1992) Am J Gastroenterol , vol.87 , pp. 1447-1452
    • Izzo, R.S.1    Witkon, K.2    Chen, A.I.3
  • 332
    • 0027226007 scopus 로고
    • Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis
    • Raab Y, Gerdin B, Ahlstedt S, Hallgren R. Neutrophil mucosal involvement is accompanied by enhanced local production of interleukin-8 in ulcerative colitis. Gut 1993; 34: 1203-6.
    • (1993) Gut , vol.34 , pp. 1203-1206
    • Raab, Y.1    Gerdin, B.2    Ahlstedt, S.3    Hallgren, R.4
  • 333
    • 3442897382 scopus 로고    scopus 로고
    • CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue
    • Gijsbers K, Van Assche G, Joossens S, et al. CXCR1-binding chemokines in inflammatory bowel diseases: down-regulated IL-8/CXCL8 production by leukocytes in Crohn's disease and selective GCP-2/CXCL6 expression in inflamed intestinal tissue. Eur J Immunol 2004; 34: 1992-2000.
    • (2004) Eur J Immunol , vol.34 , pp. 1992-2000
    • Gijsbers, K.1    Van Assche, G.2    Joossens, S.3
  • 334
    • 0029758113 scopus 로고    scopus 로고
    • Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    • Nagasawa T, Hirota S, Tachibana K, et al. Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 1996; 382: 635-8.
    • (1996) Nature , vol.382 , pp. 635-638
    • Nagasawa, T.1    Hirota, S.2    Tachibana, K.3
  • 335
    • 0032482926 scopus 로고    scopus 로고
    • Impaired B-lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficientmice
    • MaQ, JonesD, Borghesani PR, et al. Impaired B-lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficientmice. Proc Natl Acad Sci USA 1998; 95: 9448-53.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9448-9453
    • Ma, Q.1    Jones, D.2    Borghesani, P.R.3
  • 336
    • 54349085334 scopus 로고    scopus 로고
    • Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis
    • Mikami S, Nakase H, Yamamoto S, et al. Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis. J Pharmacol Exp Ther 2008; 327: 383-92.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 383-392
    • Mikami, S.1    Nakase, H.2    Yamamoto, S.3
  • 337
    • 0034654535 scopus 로고    scopus 로고
    • Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa
    • Muehlhoefer A, Saubermann LJ, Gu X, et al. Fractalkine is an epithelial and endothelial cell-derived chemoattractant for intraepithelial lymphocytes in the small intestinal mucosa. J Immunol 2000; 164: 3368-76.
    • (2000) J Immunol , vol.164 , pp. 3368-3376
    • Muehlhoefer, A.1    Saubermann, L.J.2    Gu, X.3
  • 338
    • 12244297799 scopus 로고    scopus 로고
    • CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • Niess JH, Brand S, Gu X, et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005; 307: 254-8.
    • (2005) Science , vol.307 , pp. 254-258
    • Niess, J.H.1    Brand, S.2    Gu, X.3
  • 339
    • 0035104518 scopus 로고    scopus 로고
    • The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo
    • Lucas AD, Chadwick N, Warren BF, et al. The transmembrane form of the CX3CL1 chemokine fractalkine is expressed predominantly by epithelial cells in vivo. Am J Pathol 2001; 158: 855-66.
    • (2001) Am J Pathol , vol.158 , pp. 855-866
    • Lucas, A.D.1    Chadwick, N.2    Warren, B.F.3
  • 340
    • 33846216007 scopus 로고    scopus 로고
    • Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease
    • Sans M, Danese S, de la Motte C, et al. Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease. Gastroenterology 2007; 132: 139-53.
    • (2007) Gastroenterology , vol.132 , pp. 139-153
    • Sans, M.1    Danese, S.2    de la Motte, C.3
  • 341
    • 13844312846 scopus 로고    scopus 로고
    • Toll-like receptormediated responses of primary intestinal epithelial cells during the development of colitis
    • Singh JC, Cruickshank SM, Newton DJ, et al. Toll-like receptormediated responses of primary intestinal epithelial cells during the development of colitis. Am J Physiol Gastrointest Liver Physiol 2005; 288: G514-24.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Singh, J.C.1    Cruickshank, S.M.2    Newton, D.J.3
  • 342
    • 0035818564 scopus 로고    scopus 로고
    • Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease
    • Cornet A, Savidge TC, Cabarrocas J, et al. Enterocolitis induced by autoimmune targeting of enteric glial cells: a possible mechanism in Crohn's disease? Proc Natl Acad Sci USA 2001; 98: 13306-11.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 13306-11
    • Cornet, A.1    Savidge, T.C.2    Cabarrocas, J.3
  • 343
    • 0035576394 scopus 로고    scopus 로고
    • Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation and tissue destruction
    • Shaikh RB, Santee S, Granger SWet al. Constitutive expression of LIGHT on T cells leads to lymphocyte activation, inflammation and tissue destruction. J Immunol 2001; 167: 6330-7.
    • (2001) J Immunol , vol.167 , pp. 6330-6337
    • Shaikh, R.B.1    Santee, S.2    Granger, S.W.3
  • 344
    • 0033558364 scopus 로고    scopus 로고
    • Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF plus IFN-gammaproducing CD4+ T cells that respond to bacterial antigens
    • Wirtz S, Finotto S, Kanzler S, et al. Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF plus IFN-gammaproducing CD4+ T cells that respond to bacterial antigens. J Immunol 1999; 162: 1884-8.
    • (1999) J Immunol , vol.162 , pp. 1884-1888
    • Wirtz, S.1    Finotto, S.2    Kanzler, S.3
  • 345
    • 0032536827 scopus 로고    scopus 로고
    • CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease
    • Cong Y, Brandwein SL, McCabe RP, et al. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med 1998; 187: 855-64.
    • (1998) J Exp Med , vol.187 , pp. 855-864
    • Cong, Y.1    Brandwein, S.L.2    McCabe, R.P.3
  • 346
    • 0037033434 scopus 로고    scopus 로고
    • T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis
    • Iqbal N, Oliver JR, Wagner FH, et al. T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J Exp Med 2002; 195: 71-84.
    • (2002) J Exp Med , vol.195 , pp. 71-84
    • Iqbal, N.1    Oliver, J.R.2    Wagner, F.H.3
  • 347
    • 0028006855 scopus 로고
    • Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice
    • Dieleman LA, Ridwan BU, Tennyson GS, et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 1994; 107: 1643-52.
    • (1994) Gastroenterology , vol.107 , pp. 1643-1652
    • Dieleman, L.A.1    Ridwan, B.U.2    Tennyson, G.S.3
  • 348
    • 0034600789 scopus 로고    scopus 로고
    • Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGFbeta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation
    • Kitani A, Fuss IJ, Nakamura K, et al. Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGFbeta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor beta2 chain downregulation. J Exp Med 2000; 192: 41-52.
    • (2000) J Exp Med , vol.192 , pp. 41-52
    • Kitani, A.1    Fuss, I.J.2    Nakamura, K.3
  • 349
    • 0034924028 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
    • Hahm KB, Im YH, Parks TWet al. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001; 49: 190-8.
    • (2001) Gut , vol.49 , pp. 190-198
    • Hahm, K.B.1    Im, Y.H.2    Parks, T.W.3
  • 350
    • 44849128021 scopus 로고    scopus 로고
    • Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF dependent Crohn's disease
    • Apostolaki M, Manoloukos M, Roulis M, et al. Role of beta7 integrin and the chemokine/chemokine receptor pair CCL25/CCR9 in modeled TNF dependent Crohn's disease. Gastroenterology 2008; 134: 2025-35.
    • (2008) Gastroenterology , vol.134 , pp. 2025-2035
    • Apostolaki, M.1    Manoloukos, M.2    Roulis, M.3
  • 351
    • 33746176176 scopus 로고    scopus 로고
    • Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease
    • Hommes DW, Mikhajlova TL, Stoinov S, et al. Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease. Gut 2006; 55: 1131-7.
    • (2006) Gut , vol.55 , pp. 1131-1137
    • Hommes, D.W.1    Mikhajlova, T.L.2    Stoinov, S.3


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