Involvement of CCL25 (TECK) in the generation of the murine small-intestinal CD8αα+CD3+ intraepithelial lymphocyte compartment

European Journal of Immunology

Volumn 32, Issue 12, 2002, Pages 3488-3497

  Marsal, Jan ^a   Svensson, Marcus ^a   Ericsson, Anna ^a   Iranpour, Amir H ^a   Carramolino, Laura ^b   Márquez, Gabriel ^b   Agace, William W ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Chemokine; Intraepithelial lymphocyte; Mucosa

Indexed keywords

BETA CHEMOKINE; BETA CHEMOKINE CCL25; CD3 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR9; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; UNCLASSIFIED DRUG;

AGE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL ISOLATION; CELL MATURATION; CONTROLLED STUDY; EPITHELIUM CELL; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MIGRATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRE T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SMALL INTESTINE; STEM CELL; T LYMPHOCYTE; THYMUS; WILD TYPE;

ANIMALS; ANTIGENS, CD3; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; EPITHELIAL CELLS; GENES, RAG-1; INTESTINE, SMALL; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS;

EID: 0036910773     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200212)32:12<3488::AID-IMMU3488>3.0.CO;2-E     Document Type: Article

References (39)

1. Lefrancois, L., Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 1991. 147: 1746-1751.
2. Arstila, T., Arstila, T. P., Calbo, S., Selz, F., Malassis-Seris, M., Vassalli, P., Kourilsky, P. and Guy-Grand, D., Identical T cell clones are located within the mouse gut epithelium and lamina propia and circulate in the thoracic duct lymph. J. Exp. Med. 2000. 191: 823-834.
3. Guy-Grand, D., Cerf-Bensussan, N., Malissen, B., Malassis-Seris, M., Briottet, C. and Vassalli, P., Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J. Exp. Med. 1991. 173: 471-481.
4. Rocha, B., Vassalli, P. and Guy-Grand, D., Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice. J. Exp. Med. 1994. 180: 681-686.
5. Lefrancois, L. and Olson, S., Reconstitution of the extrathymic intestinal T cell compartment in the absence of irradiation. J. Immunol. 1997. 159: 538-541.
6. Guy-Grand, D., Vanden Broecke, C., Briottet, C., Malassis-Seris, M., Selz, F. and Vassalli, P., Different expression of the recombination activity gene RAG-1 in various populations of thymocytes, peripheral T cells and gut thymus- independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement. Eur. J. Immunol. 1992. 22: 505-510.
7. Lin, T., Matsuzaki, G., Yoshida, H., Kobayashi, N., Kenai, H., Omoto, K. and Nomoto, K., CD3-CD8+ intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL. Eur. J. Immunol. 1994. 24: 1080-1087.
8. Oida, T., Suzuki, K., Nanno, M., Kanamori, Y., Saito, H., Kubota, E., Kato, S., Itoh, M., Kaminogawa, S. and Ishikawa, H., Role of gut cryptopatches in early extrathymic maturation of intestinal intraepithelial T cells. J. Immunol. 2000. 164: 3616-3626.
9. Bruno, L., Rocha, B., Rolink, A., von Boehmer, H. and Rodeweld, H. R., Intra- and extra-thymic expression of the pre-T cell receptor alpha gene. Eur. J. Immunol. 1995. 25: 1877-1882.
10. Page, S. T., Bogatzki, L. Y., Hamerman, J. A., Sweenie, C. H., Hogarth, P. J., Malissen, M., Perlmutter, R. M. and Pullen, A. M., Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor alpha beta lineage. Proc. Natl. Acad. Sci. USA 1998. 95: 9459-9464.
11. Saito, H., Kanamori, Y., Takemori, T., Nariuchi, H., Kubota, E., Takahashi-Iwanaga, H., Iwanaga, T. and Ishikawa, H., Generation of intestinal T cells from progenitors residing in gut cryptopatches. Science 1998. 280: 275-278.
12. Suzuki, K., Oida, T., Hamada, H., Hitotsumatsu, O., Watanabe, M., Hibi, T., Yamamoto, H., Kubota, E., Kaminogawa, S. and Ishikawa, H., Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis. Immunity 2000. 13: 691-702.
13. Lambolez, F., Azogui, O., Joret, A. M., Garcia, C., von Boehmer, H., Di Santo, J., Ezine, S. and Roche, B., Characterization of T cell differentiation in the murine gut. J. Exp. Med. 2002. 195: 437-449.
14. Lefrancois, L. and Olson, S., A novel pathway of thymus-directed T lymphocyte maturation. J. Immunol. 1994. 153: 987-995.
15. Lin, T., Matsuzaki, G., Kenai, H. and Nomoto, K., Progenies of fetal thymocytes are the major source of CD4-CD8+ alpha alpha intestinal intraepithelial lymphocytes early in ontogeny. Eur. J. Immunol. 1994. 24: 1785-1791.
16. Vicari, A. P., Figueroa, D. J., Hedrick, J. A., Foster, J. S., Singh, K. P., Marion, S., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Bacon, K. B. and Zlotnik, A., TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity 1997. 7: 291-301.
17. Wurbel, M. A., Philippe, J. M., Nguyen, C., Victorero, G., Freeman, T., Wooding, P., Miazek, A., Mattei, M. G., Malissen, M., Jordan, B. R., Malissen, B., Carrier, A. and Naquet, P., The chemokine TECK is expressed by thymic and intestinal epithelial cells and attracts double- and single-positive thymocytes expressing the TECK receptor CCR9. Eur. J. Immunol. 2000. 30: 262-271.
18. Kunkel, E. J., Campbell, J. J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A. I., Ebert, E. C., Vierra, M. A., Goodman, S. B., Genovese, M. C., Wardlaw, A. J., Greenberg, H. B., Parker, C. M., Butcher, E. C., Andrew, D. P. and Agace, W. W., Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. J. Exp. Med. 2000. 192: 761-768.
19. Zabel, B. A., Agace, W. W., Campbell, J. J., Heath, H. M., Parent, D., Roberts, A. I., Ebert, E. C., Kassam, N., Qin, S., Zovko, M., LaRosa, G. J., Yang, L. L., Soler, D., Butcher, E. C., Ponath, P. D., Parker, C. M. and Andrew, D. P., Human G Protein-coupled Receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required, for thymus-expressed chemokine-mediated chemotaxis. J. Exp. Med. 1999. 190: 1241-1256.
20. Carramolino, L., Zaballos, A., Kremer, L., Villares, R., Martin, P., Ardavin, C., Martinez, A. C. and Marquez, G., Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8(+) T cells from secondary lymphoid organs. Blood 2001. 97: 850-857.
21. + gut intraepithelial lymphocytes. Blood 2001. 98: 2626-2632.
22. Uehera, S., Grinberg, A., Farber, J. M. and Love, P. E., A Role for CCR9 in T lymphocyte development and migration. J. Immunol. 2002. 168: 2811-2819.
23. Gosling, J., Dairaghi, D. J., Wang, Y., Hanley, M., Talbot, D., Miao, Z. and Schall, T. J., Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J. Immunol. 2000. 164: 2851-2856.
24. Poussier, P., Edouard, P., Lee, C., Binnie, M. and Julius, M., Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes. J. Exp. Med. 1992. 176: 187-199.
25. Suzuki, S., Sugahara, S., Shimizu, T., Tada, T., Minagawa, M., Maruyama, S., Watanabe, H., Saito, H., Ishikawa, H., Hatakeyama, K. and Abo, T., Low level of mixing of partner cells seen in extrathymic T cells in the liver and intestine of parabiotic mice: its biological implication. Eur. J. Immunol. 1998. 28: 3719-3729.
26. + lymphocyte localization to the small intestinal mucosa. J. Clin. Invest. 2002. 110: 1113-1121.
27. Youn, B. S., Kim, Y. J., Mantel, C., Yu, K. Y. and Broxmeyer, H. E., Blocking of c-FLIP(L)-independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9/TECK interaction. Blood 2001. 98: 925-933.
28. Brunner, T., Arnold, D., Wasem, C., Herren, S. and Frutschi, C., Regulation of cell death and survival in intestinal intraepithelial lymphocytes. Cell Death Differ. 2001. 8: 706-714.
29. Woodward, J. and Jenkinson, E., Identification and characterization of lymphoid precursors in the murine intestinal epithelium. Eur. J. Immunol. 2001. 31: 3329-3338.
30. Shinkai, Y. and Alt, F. W., CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression. Int. Immunol. 1994. 6: 995-1001.
31. Jacobs, H., Vandeputte, D., Tolkamp, L., de Vries, E., Borst, J. and Berns, A., CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur. J. Immunol. 1994. 24: 934-939.
32. Norment, A. M., Bogatzki, L. Y., Gantner, B. N. and Bevan, M. J., Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling. J. Immunol. 2000. 164: 639-648.
33. Campbell, J. J., Pan, J. and Butcher, E. C., Cutting edge: developmental switches in chemokine responses during T cell maturation. J. Immunol. 1999. 163: 2353-2357.
34. Page, S. T., Bogatzki, L. Y., Hamerman, J. A., Malissen, M., Perlmutter, R. M. and Pullen, A. M., Differential effects of manipulating signaling in early T cell development in intestinal intraepithelial lymphocytes and thymocytes. Int. Immunol. 1999. 11: 169-177.
35. Page, S. T., van Oers, N. S., Perlmutter, R. M., Weiss, A. and Pullen, A. M., Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development. Eur. J. Immunol. 1997. 27: 554-562.
36. She, J., Simpson, S. J., Gupta, A., Hollander, G., Levelt, C., Liu, C. P., Allen, D., van Houten, N., Wang, B. and Terhorst, C., CD16-expressing CD8 alpha alpha+ T lymphocytes in the intestinal epithelium: possible precursors of Fc gamma R-CD8 alpha alpha+ T cells. J. Immunol. 1997. 158: 4678-4687.
37. Penney, L., Kilshaw, P. J. and MacDonald, T. T., Regional variation in the proliferative rate and lifespan of alpha beta TCR+ and gamma delta TCR+ intraepithelial lymphocytes in the murine small intestine. Immunology 1995. 86: 212-218.
38. Laky, K., Lefrancois, L. and Puddington, L., Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine. J. Immunol. 1997. 158: 1417-1427.
39. Schon, M. P., Arya, A., Murphy, E. A., Adams, C. M., Strauch, U. G., Agace, W. W., Marsal, J., Donohue, J. P., Her, H., Beier, D. R., Olson, S., Lefrancois, L., Brenner, M. B., Grusby, M. J. and Parker, C. M., Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J. Immunol. 1999. 162: 6641-6649.