Blockade of CXCL12/CXCR4 axis ameliorates murine experimental colitis

Journal of Pharmacology and Experimental Therapeutics

Volumn 327, Issue 2, 2008, Pages 383-392

  Mikami, Sakae ^a   Nakase, Hiroshi ^a   Yamamoto, Shuji ^a   Takeda, Yasuhiro ^a   Yoshino, Takuya ^a   Kasahara, Katushiro ^a   Ueno, Satoru ^a   Uza, Norimitsu ^a   Oishi, Shinya ^a   Fujii, Nobutaka ^a   Nagasawa, Takashi ^b   Chiba, Tsutomu ^a  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; DEXTRAN SULFATE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR ALPHA; TF 14016; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL MIGRATION; COLITIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; ENTERITIS; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LEUKOCYTE MIGRATION INHIBITION; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; ULCERATIVE COLITIS; WEIGHT CHANGE;

ANIMALS; CELL MOVEMENT; CHEMOKINE CXCL12; COLITIS; COLON; DEXTRAN SULFATE; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INFLAMMATORY BOWEL DISEASES; INTERLEUKIN-10; LEUKOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CXCR4; T-LYMPHOCYTES, REGULATORY;

EID: 54349085334     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.141085     Document Type: Article

References (40)

1. Ajuebor MN, Kunkel SL, and Hogaboam CM (2004) The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis. Eur J Pharmacol 497:343-349.
2. + lymphocyte-associated Th2-type immune response in the intestine. J Immunol 164:6303-6312.
3. Annunziato F, Cosmi L, Galli G, Beltrame C, Romagnani P, Manetti R, Romagnani S, and Maggi E (1999) Assessment of chemokine receptor expression by human Th1 and Th2 cells in vitro and in vivo. J Leukoc Biol 65:691-699.
4. Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, and Springer TA (1996) The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-833.
5. Blumberg RS, Saubermann LJ, and Strober W (1999) Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr Opin Immunol 11:648-656.
6. Buckley CD, Amft N, Bradfield PF, Pilling D, Ross E, Arenzana-Seisdedos F, Amara A, Curnow SJ, Lord JM, Scheel-Toellner D, et al. (2000) Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium. J Immunol 165:3423-3429.
7. Cooper HS, Murthy SN, Shah RS, and Sedergran DJ (1993) Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest 69:238-249.
8. Curnow SJ, Wloka K, Faint JM, Amft N, Cheung CM, Savant V, Lord J, Akbar AN, Buckley CD, Murray PI, et al. (2004) Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor of patients with uveitis. J Immunol 172:7154-7161.
9. Dieleman LA, Ridwan BU, Tennyson GS, Beagley KW, Bucy RP, and Elson CO (1994) Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 107:1643-1652.
10. Fiocchi C (1998) Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115:182-205.
11. + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 157:1261-1270.
12. Gijsbers K, Geboes K, and Van Damme J (2006) Chemokines in gastrointestinal disorders. Curr Drug Targets 7:47-64.
13. Haas CS, Martinez RJ, Attia N, Haines GK 3rd, Campbell PL, and Koch AE (2005) Chemokine receptor expression in rat adjuvant-induced arthritis. Arthritis Rheum 52:3718-3730.
14. Homey B, Alenius H, Muller A, Soto H, Bowman EP, Yuan W, McEvoy L, Lauerma AI, Assmann T, Bünemann E, et al. (2002) CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med 8:157-165.
15. Imai K, Kobayashi M, Wang J, Ohiro Y, Hamada J, Cho Y, Imamura M, Musashi M, Kondo T, Hosokawa M, et al. (1999a) Selective transendothelial migration of hematopoietic progenitor cells: a role in homing of progenitor cells. Blood 93:149-156.
16. Imai K, Kobayashi M, Wang J, Shinobu N, Yoshida H, Hamada J, Shindo M, Higashino F, Tanaka J, Asaka M, et al. (1999b) Selective secretion of chemoattractants for hematopoietic progenitor cells by bone marrow endothelial cells: a possible role in homing of hematopoietic progenitor cells to bone marrow. Br J Haematol 106:905-911.
17. Jourdan P, Abbal C, Noraz N, Hori T, Uchiyama T, Vendrell JP, Bousquet J, Taylor N, Pene J, and Yssel H (1998) IL-4 induces functional cell-surface expression of CXCR4 on human T cells. J Immunol 160:4153-4157.
18. Katsuta T, Lim C, Shimoda K, Shibuta K, Mitra P, Banner BF, Mori M, and Barnard GF (2000) Interleukin-8 and SDF1-alpha mRNA expression in colonic biopsies from patients with inflammatory bowel disease. Am J Gastroenterol 95:3157-3164.
19. Matsuura M, Okazaki K, Nishio A, Nakase H, Tamaki H, Uchida K, Nishi T, Asada M, Kawasaki K, Fukui T, et al. (2005) Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis. Gastroenterology 128:975-986.
20. Melgar S, Drmotova M, Rehnström E, Jansson L, and Michaëlsson E (2006) Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis. Cytokine 35:275-283.
21. Murano M, Maemura K, Hirata I, Toshina K, Nishikawa T, Hamamoto N, Sasaki S, Saitoh O, and Katsu K (2000) Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis. Clin Exp Immunol 120:51-58.
22. Nagasawa T, Nakajima T, Tachibana K, Iizasa H, Bleul CC, Yoshie O, Matsushima K, Yoshida N, Springer TA, and Kishimoto T (1996a) Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin. Proc Natl Acad Sci U S A 93:14726-14729.
23. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, and Kishimoto T (1996b) Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nature 382:635-638.
24. + T cell accumulation in rheumatoid arthritis synovium. J Immunol 165:6590-6598.
25. Ogawa H, Iimura M, Eckmann L, and Kagnoff MF (2004) Regulated production of the chemokine CCL28 in human colon epithelium. Am J Physiol Gastrointest Liver Physiol 287:G1062-G1069.
26. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, and Nakaya R (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 98:694-702.
27. + cells on vascular endothelium under shear flow. J Clin Invest 104:1199-1211.
28. Peled A, Petit I, Kollet O, Magid M, Ponomaryov T, Byk T, Nagler A, Ben-Hur H, Many A, Shultz L, et al. (1999b) Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4. Science 283:845-848.
29. Phillips RJ, Burdick MD, Hong K, Lutz MA, Murray LA, Xue YY, Belperio JA, Keane MP, and Strieter RM (2004) Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 114:438-446.
30. Ponomaryov T, Peled A, Petit I, Taichman RS, Habler L, Sandbank J, Arenzana-Seisdedos F, Magerus A, Caruz A, Fujii N, et al. (2000) Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function. J Clin Invest 106:1331-1339.
31. Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, Travers S, Rachmilewitz D, Hanauer SB, Lichtenstein GR, et al. (2005) Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 8:2462-2476.
32. Sartor RB (1995) Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterol Clin North Am 24:475-507.
33. Tachibana K, Hirota S, Iizasa H, Yoshida H, Kawabata K, Kataoka Y, Kitamura Y, Matsushima K, Yoshida N, Nishikawa S, et al. (1998) The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393:591-594.
34. Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent JO, Wang Z, et al. (2003) Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org Biomol Chem 1:3663-3669.
35. Tamamura H, Fujisawa M, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, and Fujii N (2004) Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent. FEBS Lett 569:99-104.
36. Terada R, Yamamoto K, Hakoda T, Shimada N, Okano N, Baba N, Ninomiya Y, Gershwin ME, and Shiratori Y (2003) Stromal cell-derived factor-1 from biliary epithelial cells recruits CXCR4-positive cells: implications for inflammatory liver diseases. Lab Invest 83:665-672.
37. Tokoyoda K, Egawa T, Sugiyama T, Choi BI, and Nagasawa T (2004) Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20:707-718.
38. Wald O, Pappo O, Safdi R, Dagan-Berger M, Beider K, Wald H, Franitza S, Weiss I, Avniel S, Boaz P, et al. (2004) Involvement of the CXCL12/CXCR4 pathway in the advanced liver disease that is associated with hepatitis C virus or hepatitis B virus. Eur J Immunol 34:1164-1174.
39. Williams KL, Fuller CR, Dieleman LA, DaCosta CM, Haldeman KM, Sartor RB, and Lund PK (2001) Enhanced survival and mucosal repair after dextran sodium sulfate-induced colitis in transgenic mice that overexpress growth hormone. Gastroenterology 120:925-937.
40. Zou YR, Kottmann AH, Kuroda M, Taniuchi I, and Littman DR (1998) Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393:595-599.