Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells

Immunity

Volumn 4, Issue 3, 1996, Pages 313-319

  Kaplan, Mark H ^a   Schindler, Ulrike ^b   Smiley, Stephen T ^a   Grusby, Michael J ^a,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b AMGEN INC   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; STAT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; HELPER CELL; LYMPHOCYTE DIFFERENTIATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0029876629     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80439-2     Document Type: Article

References (42)

1. Coffman, R.L., Ohara, J., Bond, M.W., Carty, J., Zlotnik, A., and Paul, W.E. (1986). B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide activated B cells. J. Immunol. 136, 4538-4541.
2. Conrad, D.H., Waldschmidt, T., Lee, W.T., Rao, M., Keegan, A.D., Noelle, R.J., Lynch, R.G., and Kehry, M.R. (1987). Effect of B cell stimulatory factor-1 (Interleukin-4) on Fc∈ and Fcγ receptor expression on murlne B lymphocytes and B cell lines. J. Immunol. 139, 2290-2296.
3. Conrad, D.H., Ben-Sasson, S.Z., Le Gros, G., Finkelman, F.D., and Paul, W.E. (1990). Infection with Nippostrongylus brasiliensis or injection of anti-lgD antibodies markedly enhances Fc-receptor mediated interleukin 4 production by non-B, non-T cells. J. Exp. Med. 171, 1497-1508.
4. Danial, N.N., Pernis, A., and Rothman, P.B. (1995). Jak-Stat signaling induced by the v-abloncogene. Science 269, 1875-1877.
5. Dignam, J.D., Lebovitz, R.M., and Roeder, R.G. (1983). Accurate transcription initiation by RNA polymerase II in a soluble extract isolated from mammalian nuclei. Nucl. Acids Res. 11, 1475-1489.
6. Finkelman, F.D., Svetic, A., Gresser, I., Snapper, C., Holmes, J., Trotta, P.P., Katona, I.M., and Gause, W.C. (1991). Regulation by interferon γ of immunoglobulin isotype selection and lymphokine production in mice. J. Exp. Med. 174, 1179-1188.
7. Giri, J.G., Ahdieh, M., Eisenman, J., Shanebeck, K., Grabstein, K., Kumaki, S., Namen, A., Park, L.S., Cosman, D., and Anderson, D. (1994). Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13, 2822-2830.
8. Hilton, D.J., Zhang, J.-G., Metcalf, D., Alexander, W.S., Nicola, N.A., and Wilson, T.A. (1996). Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor. Proc. Natl. Acad. Sci. USA 93, 497-501.
9. Hou, J., Schindler, U., Henzel, W.J., Ho., T.C., Brasseur, M., and McKnight, S.L. (1994). An interleukin-4-induced transcription factor: IL-4 Stat. Science 265, 1701-1706.
10. Howard, M., Farrar, J., Hilfiker, M., Johnson, B., Takatsu, K., Hamaoka, T., and Paul, W.E. (1982). Identification of a T cell derived B cell growth factor distinct from interleukin 2. J. Exp. Med. 155, 914-923.
11. Ichiki, T., Takahashi, W., and Watanabe, T. (1993). Regulation of the expression of human C∈ germline transcript: identification of a novel IL-4 responsive element. J. Immunol. 150, 5408-5417.
12. Ihle, J.N. (1995). Cytokine receptor signaling. Nature 377, 591-594.
13. Johnston, J.A., Kawamura, M., Kirken, R.A., Chen, Y.-Q., Blake, T.B., Shibuya, K., Ortaldo, J.R., McVicar, D.W., and O'Shea, J.J. (1994). Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370, 151-153.
14. Keegan, A.D., Nelms, K., White, M., Wang, L-M., Pierce, J.H., and Paul, W.E. (1994). An IL-4 receptor region containing an insulin receptor motif is important for IL-4 mediated IRS-1 phosphorylation and cell growth. Cell 76, 811-820.
15. Kondo, M., Takeshita, T., Higuchi, M., Nakamura, M., Sudo, T., Nishikawa, S.-I., and Sugamura, K. (1994). Functional participation of the IL-2 receptor γ chain in IL-7 receptor complexes. Science 263, 1453-1454.
16. Kopf, M., Le Gros, G., Bachmann, M., Lamers, M.C., Bluethmann, H., and Kohler, G. (1993). Disrupton of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362, 245-248.
17. Kotanides, H., and Reich, N.C. (1993). Requirement of tyrosine phosphorylation for rapid activation of a DNA binding factor by IL-4. Science 262, 1265-1267.
18. Kuchroo, V.K., Das, M.P., Brown, J.A., Ranger, A.M., Zamvil, S.S., Sobel, R.A., Weiner, H.L., Nabavi, N., and Glimcher, L.H. (1995). B7-1 and B7-2 costimulatory molecules activate differentially the Th1/ Th2 developmental pathways: application to autoimmune disease therapy. Cell 80, 707-718.
19. Kuhn, R., Rajewsky, K., and Muller, W. (1991). Generation and analysis of interleukin-4 deficient mice. Science 254, 707-710.
20. Le Gros, G., Ben-Sasson, S.Z., Seder, R., Finkelman, F.D., and Paul, W.E. (1990). Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J. Exp. Med. 172, 921-929.
21. Lee, F., Yokota, T., Otsuka, T., Meyerson, P., Villaret, D., Coffman, R., Mosmann, T., Rennick, D., Roehm, N., Smith, C., Zlotnik, A., and Arai, K.-I. (1986). Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T cell and mast cell stimulating activities. Proc. Natl. Acad. Sci. USA 83, 2061-2065.
22. Lin, J.-X., Migone, T.-S., Tsang, M., Friedman, M., Weatherbee, J.A., Zhou, L., Yamauchi, A., Bloom, E.T., Mietz, J., John, S., and Leonard, W.J. (1995). The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2, 331-339.
23. Markowitz, J.S., Rogers, P.R., Grusby, M.J., Parker, D.C., and Glimcher, L.H. (1993). B lymphocyte development and activation independent of MHC class II expression. J. Immunol. 150, 1223-1233.
24. Migone, T-S., Lin, J.-X., Cereseto, A., Mulloy, J.C., O'Shea, J.J., Franchini, G., and Leonard, W.J. (1995). Constitutivelyactivated JakStat pathway in T cells transformed with HTLV-I. Science 269, 79-81.
25. Noelle, R., Krammer, P.H., Ohara, J., Uhr, J.W., and Vitetta, E.S. (1984). Increased expression of la antigens on resting B cells: an additional role for B cell growth factor. Proc. Natl. Acad. Sci. USA 81, 6149-6153.
26. Noguchi, M., Nakamura, Y., Russell, S.M., Ziegler, S.F., Tsang, M., Cao, X., and Leonard, W.J. (1993). Interleukin-2 receptor γ chain: a functional component of the interleukin-7 receptor. Science 262, 1877-1880.
27. Ohara, J., and Paul, W.E. (1988). Upregulation of interleukin 4/B cell stimulatory factor 1 receptor expression. Proc. Natl. Acad. Sci. USA 85, 8221-8225.
28. Paul, W.E., and Ohara, J. (1987). B-cell stimulatory factor-1/interleukin 4. Annu. Rev. Immunol. 5, 429-459.
29. Quelle, F.W., Shimoda, K., Thierfelder, W., Fischer, C., Kim, A., Ruben, S.M., Cleveland, J.L., Pierce, J.H., Keegan, A.D., Nelms, K., Paul, W.E., and Ihle, J.N. (1995). Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15, 3336-3343.
30. Russell, S.M., Johnston, J.A., Noguchi, M., Kawamura, M., Bacon, C.M., Friedmann, M., Berg, M., McVicar, D.W., Witthuhn, B.A., Silvennoinen, O., Goldman, A.S., Schmalsteig, F.C., Ihle, J.N., O'Shea, J.J., and Leonard, W.J. (1994). Interaction of IL-2Rβ and γc chains with Jak1 and Jak 3: implications for XSCID and XCID. Science 266, 1042-1045.
31. + T cells secreting Th1 or Th2 cytokines. Immunity 2, 271-279.
32. Schindler, C., and Darnell, J.E., Jr. (1995). Transcriptional responses to polypeptide ligands: the Jak-Stat pathway. Annu. Rev. Biochem. 64, 621-651.
33. Schindler, C., Kashleva, H., Pernis, A., Pine, R., and Rothman, P. (1994). STF-IL-4: a novel IL-4 induced signal transducing factor. EMBO J. 13, 1350-1356.
34. Schindler, U., Wu, P., Rothe, M., Brasseur, M., and McKnight, S.L. (1995). Components of a Stat recognition code: evidence for two layers of molecular selectivity. Immunity 2, 689-697.
35. Sun, X.L., Wang, L.-M., Zhang, Y., Yenush, L., Myers, M.G., Jr., Glasheen, E., Lane, W.S., Pierce, J.H., and White, M.F. (1995). Role of IRS-2 in insulin and cytokine signalling. Nature 377, 173-177.
36. Swain, S.L., Weinberg, A.D., English, M., and Huston, G. (1990). IL-4 directs the development of Th2-like helper effectors. J. Immunol. 145, 3796-3806.
37. Takeshita, T., Asao, H., Ohtani, K., Ishii, N., Kumaki, S., Tanaka, N., Munakata, H., Nakamura, M., and Sugamura, K. (1992). Cloning of the γ chain of the human IL-2 receptor. Science 257, 379-382.
38. Vitetta, E.S., Ohara, J., Myers, C., Layton, J., Krammer, P.M., and Paul, W.E. (1985). Serological, biochemical and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1 J. Exp. Med. 162, 1726-1732.
39. Witthuhn, B.A., Silvennoinen, O., Miura, O., Lai, K.S., Cwik, C., Liu, E., and Ihle, J.N. (1994). Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370, 153-157.
40. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179, 1285-1295.
41. Yu, C.-L., Meyer, D.J., Campbell, G.S., Larner, A.C., Carter-Su, C., Schwartz, J., and Jove, R. (1995). Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. Science 269, 81-83.
42. Zurawski, S.M., Chomarat, P., Djossou, O., McKenzie, A.N.J., Miossec, P., Banchereau, J., and Zurawski, G. (1995). The primary binding subunit of the human interleukin-4 receptor is also a component of the interleukin-13 receptor. J. Biol. Chem. 270, 13869-13878.