CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance

Science

Volumn 307, Issue 5707, 2005, Pages 254-258

  Niess, Jan Hendrik ^a   Brand, Stephan ^a   Gu, Xiubin ^a   Landsman, Limor ^b   Jung, Steffen ^b,c   McCormick, Beth A ^a   Vyas, Jatin M ^a   Boes, Marianne ^d   Ploegh, Hidde L ^d   Fox, James G ^e   Littman, Dan R ^c   Reinecker, Hans Christian ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BACTERIA; IMMUNOLOGY; PATHOLOGY;

DENDRITIC CELLS (DC); MACROPHAGES; PATHOGENIC BACTERIA; PATHOGENS;

CELLS;

ANTIGEN; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE (C X3 C MOTIF) LIGAND 1; CHEMOKINE (C-X3-C MOTIF) LIGAND 1; CHEMOKINE RECEPTOR; CX3C CHEMOKINE; CX3CR1 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN;

BACTERIUM; IMMUNITY;

ARTICLE; BACTERIAL IMMUNITY; BONE MARROW CELL; DENDRITIC CELL; IMMUNOLOGICAL TOLERANCE; INFLAMMATION; INTESTINE FLORA; LAMINA PROPRIA; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE; ANIMAL; ANIMAL SALMONELLOSIS; CYTOLOGY; ESCHERICHIA COLI; GENE DELETION; GENETICS; ILEUM; IMMUNOLOGY; INTESTINE MUCOSA; ISOLATION AND PURIFICATION; LYMPHOID TISSUE; METABOLISM; MICROBIOLOGY; MUCOSAL IMMUNITY; PEYER PATCH; PHAGOCYTOSIS; PHYSIOLOGY; SALMONELLA TYPHIMURIUM; TRANSGENIC MOUSE;

BACTERIA (MICROORGANISMS); MICROBIOTA;

ANIMALS; CHEMOKINES, CX3C; DENDRITIC CELLS; ESCHERICHIA COLI; GENE DELETION; GREEN FLUORESCENT PROTEINS; ILEUM; IMMUNITY, MUCOSAL; INTESTINAL MUCOSA; INTESTINE, SMALL; LYMPHOID TISSUE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PEYER'S PATCHES; PHAGOCYTOSIS; RECEPTORS, CHEMOKINE; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM;

EID: 12244297799     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1102901     Document Type: Article

References (21)

1. H. H. Uhlig, F. Powrie, J. Clin. Invest. 112, 648 (2003).
2. B. L. Kelsall, C. A. Biron, O. Sharma, P. M. Kaye, Nature Immunol. 3, 699 (2002).
3. M. R. Neutra, A. Frey, J. P. Kraehenbuhl, Cell 86, 345 (1996).
4. I. Mellman, R. M. Steinman, Cell 106, 255 (2001).
5. J. Banchereau et al., Ann. N.Y. Acad. Sci. 987, 180 (2003).
6. A. Iwasaki, B. L. Kelsall, J. Exp. Med. 190, 229 (1999).
7. M. H. Jang et al., Proc. Natl. Acad. Sci. U.S.A. 101, 6110 (2004).
8. F. P. Huang, C. F. Farquhar, N. A. Mabbott, M. E. Bruce, G. G. MacPherson, J. Gen. Virol. 83, 267 (2002).
9. A. J. Macpherson, T. Uhr, Science 303, 1662 (2004).
10. I. Maric, P. G. Holt, M. H. Perdue, J. Bienenstock, J. Immunol. 156, 1408 (1996).
11. M. Rescigno et al., Nature Immunol. 2, 361 (2001).
12. Materials and methods are available as supporting material on Science Online.
13. S. Jung et al., Mol. Cell. Biol. 20, 4106 (2000).
14. A. Muehlhoefer et al., J. Immunol. 164, 3368 (2000).
15. A. D. Lucas et al., Am. J. Pathol. 158, 855 (2001).
16. F. Geissmann, S. Jung, D. R. Littman, Immunity 19, 71 (2003).
17. J. H. Niess et al., data not shown.
18. A. Iwasaki, B. L. Kelsall, J. Exp. Med. 191, 1381 (2000).
19. D. N. Cook et al., Immunity 12, 495 (2000).
20. X. Zhao et al., J. Immunol. 171, 2797 (2003).
21. Supported by grants DK54427, DK43351, and DK33506 (H.C.R.) and AI33856 (D.R.L). J.H.N. was supported by the Deutsche Forschungsgemeinschaft (Ni575/2-1) and a Research Fellowship Award from the Crohn's and Colitis Foundation of America. D.R.L. is an investigator of the Howard Hughes Medical Institute. S.J. is an incumbent of the Pauline Recanati Career Development Chair and Scholar of the Benoziyo Center for Molecular Medicine.