IL-6 Rescues Resting Mouse T Cells From Apoptosis

Journal of Immunology

Volumn 158, Issue 12, 1997, Pages 5791-5796

  Teague, T Kent ^a   Marrack, Philippa ^a   Kappler, John W ^a   Vella, Anthony T ^a,b  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 6; PROTEIN BCL 2; RECOMBINANT PROTEIN;

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; CELL CULTURE; CELL SURVIVAL; CHEMISTRY; MOUSE; MOUSE STRAIN; PHYSIOLOGY; T LYMPHOCYTE; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD4; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; INTERLEUKIN-6; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; T-LYMPHOCYTES;

EID: 0031570453     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Le Douarin, N. M., F. Dieterlen-Lievre, and P. D. Oliver. 1984. Ontogeny of primary lymphoid organs and lymphoid stem cells. Am. J. Anat. 170:261.
2. Sprent, J., D. Lo, E.-K. Gao, and Y. Ron. 1988. T cell selection in the thymus. Immun. Rev. 101:173.
3. Gallatin, M., T. St. John, M. Siegleman, R. Reichart, E. Butcher, and I. Weissman. 1986. Lymphocyte homing receptors. Cell 44:673.
4. Butcher, E. C., and L. J. Picker. 1996. Lymphocyte homing and homeostasis. Science 272:60.
5. Tough, D. F., and J. Sprent. 1994. Turnover of naive- and memory-phenotype T cells. J. Exp. Med. 179:1127.
6. Tough, D. F., and J. Sprent. 1995. Life span of naive and memory T cells. Stem Cells 13:242.
7. McDonagh, M., and E. B. Bell. 1995. The survival and turnover of mature and immature CD8 T cells. Immunology 84:514.
8. Modigliani, Y., G. Coutinho, O. Burlen-Defranoux, A, Coutinho, and A. Bandeira. 1994. Differential contribution of thymic outputs and peripheral expansion in the development of peripheral T cell pools. Eur. J. Immunol. 24: 1223.
9. Vella, A. T., J. E. McCormack, P. S. Linsley, J. W. Kappler, and P. Marrack. 1995. Lipopolysaccharide interferes with the induction of peripheral T cell death. Immunity 2:261.
10. Radvanyi, L. G., Y. Shi, H. Vaziri, A. Sharma, R. Dhala, G. B. Mills, and R. G. Miller. 1996. CD28 costimulation inhibits TCR-induced apoptosis during primary T cell response. J. Immunol. 156:1788.
11. L. Immunity 3:87.
12. + murine splenic T cells. Transplantation 61:486.
13. Akhar, A. N., N. J. Borthwick, R. G. Wickremasinghe, P. Panayoitidis, D. Pilling, M. Bofill, S. Krajewski, J. C. Reed, and M. Salmon. 1996. Interleukin-2 receptor common gamma-chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: selective induction of anti-apoptotic (bcl-2, bcl-xL) but not pro-apoptotic (bax, bcl-xS) aene expression. Eur. J. Immunol. 26:294.
14. + helper T cells. A model for the long-term survival of memory cells. J. Immunol. 156:1764.
15. Boise, L. H., A. J. Minn, C. H. June, T. Lindsten, and C. B. Thompson. 1995. Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division. Proc. Natl. Acad. Sci. USA 92:5491.
16. Tanner, J. E., and G. Tosato. 1992. Regulation of B-cell growth and immunoglobulin gene transcription by interleukin-6. Blood 79:452.
17. Burdin, N., C. Van Kooten, L. Galibert, J. S. Abrams, J. Wijdenes, J. Banchereau, and F. Rousset. 1995. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J. Immunol. 154:2533.
18. Kishimoto, T. 1989. The biology of interleukin-6. Blood 74:17.
19. Panzer, S., M. Madden, and K. Matsuki. 1993. Interaction of IL-1 beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) in human T cells activated by murine antigens. Clin. Exp. Immunol. 93:471.
20. Watson, C., S. Whittaker, N. Smith, A. J. Vora, D. C. Dumonde, and K. A. Brown. 1996. IL-6 acts on endothelial cells to preferentially increase their adherence for lymphocytes. Clin. Exp. Immunol. 105:112.
21. + primary T helper cells: role of IL1 and IL6 in inducing IL2 secretion and subsequent proliferation. Int. Immunol. 3:327.
22. Yanagida, M., H. Fukamachi, K. Ohgami, T. Kuwaki, H. Ishii, H. Uzumaki, K. Amano, T. Tokiwa, H. Mitsui, H. Saito, Y. Iikura, T. Ishizaka, and T. Nakahata. 1995. Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells. Blood 86:3705.
23. Chopra, H., S. E. G. Fligiel, J. S. Hatfield, K. K. Nelson, C. A. Diglio, J. D. Taylor, and K. V. Honn. 1990. An in vivo study of the role of the tumor cell cytoskeleton in tumor cell-platelet-endothelial cell interactions. Cancer Res. 50: 7686.
24. Julius, M. H., E. Simpson, and L. Herzenberg. 1973. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 3:645.
25. MacPhee, M. A., R. H. Wiltrout, K. L. McCormick, T. J. Sayers, and A. M. Pilaro. 1994. A method for obtaining and culturing large numbers of purified organ-derived murine endothelial cells. J. Leukoctye Biol. 55:467.
26. Albelda, S. M. 1991. Endothelial and epithelial cell adhesion molecules. Am. J. Respir. Cell Mol. Biol. 4:195.
27. Nakayama, K., K. Nakayama, I. Negishi, K. Kuida, Y. Shinkai, M. C. Louie, L. E. Fields, P. J. Lucas, V. Stewart, F. W. Alt, and D. Y. Loh. 1993. Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. Science 261:1584.
28. Boise, L. H., and C. B. Thompson. 1996. Hierarchical control of lymphocyte survival. Science 274:67.
29. + T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis. Blood 80:452.
30. Adkins, B., K. Chun, K. Hamilton, and M. Nassiri. 1996. Naive murine neonatal T cells undergo apoptosis in response to primary stimulation. J. Immunol. 157: 1343.
31. Yoshida, K., T. Taga, M. Saito, S. Suematsu, A. Kumanogoh, T. Tanaka, H. Fujiwara, M. Hirata, T. Yamagami, T. Nakahata, T. Hirabayashi, Y. Yoneda, K. Tanaka, W. Z. Wang, C. Mori, K. Shiota, N. Yoshida, and T. Kishimoto. 1996. Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders. Proc. Natl. Acad. Sci. USA 93:407.
32. + allergen-specific T-cell clones from programmed cell death. Allergy 50:677.
33. Koopman, G., R. M. Keehnen, E. Lindhout, W. Newman, Y. Shimizu, G. A. van Seventer, C. de Groot, and S. T. Pals. 1994. Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells. J. Immunol. 152:3760.
34. Fabry, Z., K. M. Fitzsimmons, J. A. Herlein, T. O. Moninger, M. B. Dobbs, and M. N. Hart. 1993. Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes. J. Neuroimmunol. 47:23.
35. Tosato, G., K. B. Seamon, N. D. Goldman, P. B. Sehgal, L. T. May, G. C. Washington, K. D. Jones, and S. E. Pike. 1988. Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6). Science 239:502.
36. Kruger-Krasagakes, S., A. Moller, G. Kolde, U. Lippert, M. Weber, and B. M. Henz. 1996. Production of inierleukin-6 by human mast cells and basophilic cells. J. Invest. Dermatol. 106:75.
37. Van Damme, J., S. Cayphas, J. Van Snick, R. Conings, W. Put, J. P. Lenaerts, R. J. Simpson, and A. Billiau. 1987. Purification and characterization of human fibroblast-derived hybridoma growth factor identical to T-cell-derived B-cell stimulatory factor-2 (interleukin-6). Eur. J. Biochem. 168:543.
38. Cory, S. 1995. Regulation of lymphocyte survival by the bcl-2 gene family. Annu. Rev. Immunol. 13:513.
39. Sentman, C. L., J. R. Shutter, D. Hochenbery, O. Kanagawa, and S. J. Korsmeyer 1991. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell 67:879.
40. Bhardwaj, N., U. Santhanam, L. L. Lau, S. B. Tatter, J. Ghrayeb, M. Rivelis, R. M. Steinman, P. B. Sehgal, and L. T. May. 1989. IL-6/IFN-β2 in synovial effusions of patients with rheumatoid arthritis and other arthritides: identification of several isoforms and studies of cellular sources. J. Immunol. 143:2153.
41. Hirano, T., T. Matsuda, M. Turner, N. Miyasaka, G. Buchan, B. Tang, K. Sato, M. Shimizu, R. Maini, M. Feldmann, and T. Kishimoto. 1988. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18:1797.
42. Firestein, G. S., M. Yeo, and N. J. Zvaifler. 1995. Apoptosis in rheumatoid arthritis synovium. J. Clin. Invest. 96:1631.