Nod2 mutation in Crohn's disease potentiates NF-κB activity and IL-1β processing

Science

Volumn 307, Issue 5710, 2005, Pages 734-738

  Maeda, Shin ^a   Hsu, Li Chung ^a   Liu, Hongjun ^a   Bankston, Laurie A ^a,c   Iimura, Mitsutoshi ^b   Kagnoff, Martin F ^b   Eckmann, Lars ^b   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; LIVING SYSTEMS STUDIES; PATHOLOGY; PHYSIOLOGY; PROTEINS;

ANTIBACTERIAL DEFENSES; CROHN DISEASE (CD); INTESTINES; MURAMYL DIPEPTIDE (MDP);

DISEASES;

CASPASE RECRUITMENT DOMAIN PROTEIN 15; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MURAMYL DIPEPTIDE;

DISEASE;

ANIMAL MODEL; ARTICLE; CROHN DISEASE; CYTOKINE RELEASE; DNA BINDING; ENTERITIS; GENE EXPRESSION; HOST SUSCEPTIBILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN VARIANT; SIGNAL TRANSDUCTION;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BACTERIA; CELLS, CULTURED; COLITIS; COLON; CROHN DISEASE; CYTOKINES; DEXTRAN SULFATE; INTERLEUKIN-1; INTESTINAL MUCOSA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; MUTATION; NF-KAPPA B; NOD2 SIGNALING ADAPTOR PROTEIN; PEPTIDOGLYCAN; SIGNAL TRANSDUCTION;

EID: 13244277880     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1103685     Document Type: Article

References (25)

1. S. E. Girardin, J. P. Hugot, P. J. Sansonetti, Trends Immunol. 24, 652 (2003).
2. C. Fiocchi, Gastroenterology 115, 182 (1998).
3. Y. Ogura et al., Nature 411, 603 (2001).
4. J. P. Hugot et al., Nature 411, 599 (2001).
5. Y. Ogura et al., J. Biol. Chem. 276, 4812 (2001).
6. N. Inohara et al., J. Biol. Chem. 278, 5509 (2003).
7. S. E. Girardin et al., J. Biol. Chem. 278, 8869 (2003).
8. D. K. Podolsky, N. Engl. J. Med. 347, 417 (2002).
9. C. Wahl, S. Liptay, G. Adler, R. M. Schmid, J. Clin. Invest. 101, 1163 (1998).
10. E. Kopp, R. Medzhitov, Curr. Opin. Immunol. 15, 396 (2003).
11. A. L. Pauleau, P. J. Murray, Mol. Cell. Biol. 23, 7531 (2003).
12. S. Maeda et al., unpublished observation.
13. W. Strober, I. J. Fuss, R. S. Blumberg, Annu. Rev. Immunol. 20, 495 (2002).
14. H. C. Rath et al., Infect. Immun. 69, 2277 (2001).
15. Y. Weinrauch, A. Zychlinsky, Annu. Rev. Microbiol. 53, 155 (1999).
16. R. A. Le Feuvre, D. Brough, Y. Iwakura, K. Takeda, N. J. Rothwell, J. Biol. Chem. 277, 3210 (2002).
17. N. A. Thornberry, Y. Lazebnik, Science 281, 1312 (1998).
18. F. Martinon, J. Tschopp, Cell 117, 561 (2004).
19. F. R. Greten et al., Cell 118, 285 (2004).
20. T. Watanabe, A. Kitani, P. J. Murray, W. Strober, Nature Immunol. 5, 800 (2004).
21. B. E. Sands et al., N. Engl. J. Med. 350, 876 (2004).
22. P. J. Barnes, M. Karin, N. Engl. J. Med. 336, 1066 (1997).
23. L-W. Chen et al., Nature Med. 9, 575 (2003).
24. S. Rakoff-Nahoum, J. Paglino, F. Eslami-Varzaneh, S. Edberg, R. Medzhitov, Cell 118, 229 (2004).
25. Research was supported by grants from the NIH (AI43477 to M.K.; DK35108 to M.K., M.F.K., and L.E.; and AI56075 to L.E.) and the Crohn's and Colitis Foundation of America (L.E.). S.M., L.-C.H., and L.A.B. were supported by postdoctoral fellowships from the Japan Society for the Promotion of Science, the Cancer Research Institute, and NIH training grant (DK07202), respectively. M.K. is an American Cancer Society research professor.