메뉴 건너뛰기




Volumn 6, Issue 11, 2005, Pages 1123-1132

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN RECEPTOR; STAT1 PROTEIN; STAT4 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 27544490377     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1254     Document Type: Article
Times cited : (4016)

References (51)
  • 1
    • 0024353079 scopus 로고
    • Th1 and Th2 cells: Different patterns of lymphokine secretion leads to different functional properties
    • Mosmann, T. & Coffman, R. Th1 and Th2 cells: Different patterns of lymphokine secretion leads to different functional properties. Annu. Rev. Immunol. 7, 145-173 (1989).
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.1    Coffman, R.2
  • 3
    • 0036885067 scopus 로고    scopus 로고
    • The lineage decisions of helper T cells
    • Murphy, K.M. & Reiner, S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2, 933-944 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 933-944
    • Murphy, K.M.1    Reiner, S.L.2
  • 4
    • 0036065808 scopus 로고    scopus 로고
    • Further checkpoints in Th1 development
    • Robinson, D.S. & O'Garra, A. Further checkpoints in Th1 development. Immunity 16, 755-758 (2002).
    • (2002) Immunity , vol.16 , pp. 755-758
    • Robinson, D.S.1    O'Garra, A.2
  • 6
    • 0038638583 scopus 로고    scopus 로고
    • An epigenetic view of helper T cell differentiation
    • Ansel, K.M., Lee, D.U. & Rao, A. An epigenetic view of helper T cell differentiation. Nat. Immunol. 4, 616-623 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 616-623
    • Ansel, K.M.1    Lee, D.U.2    Rao, A.3
  • 7
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo, S.J., Dighe, A.S., Gubler, U. & Murphy, K.M. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817-824 (1997).
    • (1997) J. Exp. Med. , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 8
    • 0032212793 scopus 로고    scopus 로고
    • Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
    • Ouyang, W. et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity 9, 745-755 (1998).
    • (1998) Immunity , vol.9 , pp. 745-755
    • Ouyang, W.1
  • 9
    • 18444385868 scopus 로고    scopus 로고
    • + T cells
    • + T cells. Immunity 16, 779-790 (2002).
    • (2002) Immunity , vol.16 , pp. 779-790
    • Pflanz, S.1
  • 10
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng, W. & Flavell, R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89, 587-596 (1997).
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 11
    • 0033973582 scopus 로고    scopus 로고
    • Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
    • Ouyang, W. et al. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12, 27-37 (2000).
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1
  • 12
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 233-240
    • Langrish, C.L.1
  • 13
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua, D.J. et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003).
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1
  • 14
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy, C.A. et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198, 1951-1957 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 1951-1957
    • Murphy, C.A.1
  • 15
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal, S., Ghilardi, N., Xie, M.H., de Sauvage, F.J. & Gurney, A.L. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278, 1910-1914 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3    de Sauvage, F.J.4    Gurney, A.L.5
  • 16
    • 0037114150 scopus 로고    scopus 로고
    • IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination
    • Gran, B. et al. IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: Evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination. J. Immunol. 169, 7104-7110 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 7104-7110
    • Gran, B.1
  • 17
    • 13244290058 scopus 로고    scopus 로고
    • IL-12- and IL-23-induced T helper cell subsets: Birds of the same feather flock together
    • Bettelli, E. & Kuchroo, V.K. IL-12- and IL-23-induced T helper cell subsets: Birds of the same feather flock together. J. Exp. Med. 201, 169-171 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 169-171
    • Bettelli, E.1    Kuchroo, V.K.2
  • 18
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • Oppmann, B. et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725 (2000).
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1
  • 19
    • 0036604306 scopus 로고    scopus 로고
    • A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
    • Parham, C. et al. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168. 5699-5708 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 5699-5708
    • Parham, C.1
  • 20
    • 9644291539 scopus 로고    scopus 로고
    • IL-12 and IL-23: Master regulators of innate and adaptive immunity
    • Langrish, C.L. et al. IL-12 and IL-23: Master regulators of innate and adaptive immunity. Immunol. Rev. 202, 96-105 (2004).
    • (2004) Immunol. Rev. , vol.202 , pp. 96-105
    • Langrish, C.L.1
  • 22
    • 0141519112 scopus 로고    scopus 로고
    • IL-27 and IFN-α signal via Stat1 and Stat3 and induce T-Bet and IL-12Rβ2 in naive Tcells
    • Hibbert, L., Pflanz, S., De Waal Malefyt, R. & Kastelein, R.A. IL-27 and IFN-α signal via Stat1 and Stat3 and induce T-Bet and IL-12Rβ2 in naive Tcells. J. Interferon Cytokine Res. 23, 513-522 (2003).
    • (2003) J. Interferon Cytokine Res. , vol.23 , pp. 513-522
    • Hibbert, L.1    Pflanz, S.2    De Waal Malefyt, R.3    Kastelein, R.A.4
  • 23
    • 0029671318 scopus 로고    scopus 로고
    • Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE)
    • Ferber, I.A. et al. Mice with a disrupted IFN-γ gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J. Immunol. 156, 5-7 (1996).
    • (1996) J. Immunol. , vol.156 , pp. 5-7
    • Ferber, I.A.1
  • 24
    • 0030587910 scopus 로고    scopus 로고
    • IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-incluced autoimmune encephalomyelitis
    • Willenborg, D.O., Fordham, S., Bernard, C.C., Cowden, W.B. & Ramshaw, I.A. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-incluced autoimmune encephalomyelitis. J. Immunol. 157, 3223-3227 (1996).
    • (1996) J. Immunol. , vol.157 , pp. 3223-3227
    • Willenborg, D.O.1    Fordham, S.2    Bernard, C.C.3    Cowden, W.B.4    Ramshaw, I.A.5
  • 25
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls, J.K. & Linden, A. Interleukin-17 family members and inflammation. Immunity 21, 467-476 (2004).
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 26
    • 0027464928 scopus 로고
    • Immune response in mice that lack the interferon-γ receptor
    • Huang, S. et al. Immune response in mice that lack the interferon-γ receptor. Science 259, 1742-1745 (1993).
    • (1993) Science , vol.259 , pp. 1742-1745
    • Huang, S.1
  • 27
    • 0027400726 scopus 로고
    • Multiple defects of immune cell function in mice with disrupted interferon-γ genes
    • Dalton, D.K. et al. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259, 1739-1742 (1993).
    • (1993) Science , vol.259 , pp. 1739-1742
    • Dalton, D.K.1
  • 28
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo, S.J. et al. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100, 655-669 (2000).
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1
  • 29
    • 0035910037 scopus 로고    scopus 로고
    • T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
    • Lighvani, A.A. et al. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells. Proc. Natl. Acad. Sci. USA 98, 15137-15142 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 15137-15142
    • Lighvani, A.A.1
  • 30
    • 0035827347 scopus 로고    scopus 로고
    • H1 cells before IL-12-dependent selection
    • H1 cells before IL-12-dependent selection. Science 292, 1907-1910 (2001).
    • (2001) Science , vol.292 , pp. 1907-1910
    • Mullen, A.C.1
  • 32
    • 0141506101 scopus 로고    scopus 로고
    • Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter
    • Cho, J.Y., Grigura, V., Murphy, T.L. & Murphy, K. Identification of cooperative monomeric Brachyury sites conferring T-bet responsiveness to the proximal IFN-gamma promoter. Int. Immunol. 15, 1149-1160 (2003).
    • (2003) Int. Immunol. , vol.15 , pp. 1149-1160
    • Cho, J.Y.1    Grigura, V.2    Murphy, T.L.3    Murphy, K.4
  • 33
    • 0037059462 scopus 로고    scopus 로고
    • H1 lineage commitment and IFN-γ production in CD4 and CD8 T cells
    • H1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295, 338-342 (2002).
    • (2002) Science , vol.295 , pp. 338-342
    • Szabo, S.J.1
  • 34
    • 0029965236 scopus 로고    scopus 로고
    • Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
    • Murphy, E. et al. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. J. Exp. Med. 183, 901-913 (1996).
    • (1996) J. Exp. Med. , vol.183 , pp. 901-913
    • Murphy, E.1
  • 35
    • 9644295708 scopus 로고    scopus 로고
    • Issues in T-helper 1 development-resolved and unresolved
    • Berenson, L.S., Ota, N. & Murphy, K.M. Issues in T-helper 1 development-resolved and unresolved. Immunol. Rev. 202, 157-174 (2004).
    • (2004) Immunol. Rev. , vol.202 , pp. 157-174
    • Berenson, L.S.1    Ota, N.2    Murphy, K.M.3
  • 36
    • 1142287411 scopus 로고    scopus 로고
    • N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation
    • Ota, N., Brett, T.J., Murphy, T.L., Fremont, D.H. & Murphy, K.M. N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nat. Immunol. 5, 208-215 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 208-215
    • Ota, N.1    Brett, T.J.2    Murphy, T.L.3    Fremont, D.H.4    Murphy, K.M.5
  • 37
    • 3142724732 scopus 로고    scopus 로고
    • Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis
    • Bettelli, E. et al. Loss of T-bet, but not STAT1, prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 200, 79-87 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 79-87
    • Bettelli, E.1
  • 38
    • 0034789247 scopus 로고    scopus 로고
    • Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    • Chitnis, T. et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J. Clin. Invest. 108, 739-747 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 739-747
    • Chitnis, T.1
  • 39
    • 8444226727 scopus 로고    scopus 로고
    • Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes
    • Lovett-Racke, A.E. et al. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity 21, 719-731 (2004).
    • (2004) Immunity , vol.21 , pp. 719-731
    • Lovett-Racke, A.E.1
  • 40
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • Nakae, S. et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17, 375-387 (2002).
    • (2002) Immunity , vol.17 , pp. 375-387
    • Nakae, S.1
  • 41
    • 1342324752 scopus 로고    scopus 로고
    • Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice
    • Ghilardi, N. et al. Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J. Immunol. 172, 2827-2833 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 2827-2833
    • Ghilardi, N.1
  • 42
    • 0242584872 scopus 로고    scopus 로고
    • Cutting edge: Roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection
    • Happel, K.I. et al. Cutting edge: Roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J. Immunol, 170, 4432-4436 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 4432-4436
    • Happel, K.I.1
  • 43
    • 17944364849 scopus 로고    scopus 로고
    • Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense
    • Ye, P. et al. Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J. Exp. Med. 194, 519-527 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 519-527
    • Ye, P.1
  • 44
    • 2942720565 scopus 로고    scopus 로고
    • Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development
    • Smits, H.H. et al. Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development. Eur. J. Immunol. 34, 1371-1380 (2004).
    • (2004) Eur. J. Immunol. , vol.34 , pp. 1371-1380
    • Smits, H.H.1
  • 45
    • 0029813545 scopus 로고    scopus 로고
    • H1-like responses
    • H1-like responses. J. Clin. Invest. 98, 1010-1020 (1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 1010-1020
    • Berg, D.J.1
  • 46
    • 16044363695 scopus 로고    scopus 로고
    • IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses
    • Magram, J. et al. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4, 471-481 (1996).
    • (1996) Immunity , vol.4 , pp. 471-481
    • Magram, J.1
  • 47
    • 0027406812 scopus 로고
    • Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
    • Shinkai, Y. et al. Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259, 822-825 (1993).
    • (1993) Science , vol.259 , pp. 822-825
    • Shinkai, Y.1
  • 49
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz, M.A. et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84, 431-442 (1996).
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1
  • 50
    • 0032005477 scopus 로고    scopus 로고
    • Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
    • Murali-Krishna, K. et al. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection. Immunity 8, 177-187 (1998).
    • (1998) Immunity , vol.8 , pp. 177-187
    • Murali-Krishna, K.1
  • 51
    • 10344233176 scopus 로고    scopus 로고
    • Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells
    • Kubo, T. et al. Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells. J. Immunol. 173, 7249-7258 (2004).
    • (2004) J. Immunol. , vol.173 , pp. 7249-7258
    • Kubo, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.