Interleukin-18 regulates both Th1 and Th2 responses

Annual Review of Immunology

Volumn 19, Issue , 2001, Pages 423-474

  Nakanishi, K ^a   Yoshimoto, T ^a   Tsutsui, H ^a   Okamura, H ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Host defense; Pathogenesis; Th1 mediated immune responses; Th2 mediated immune responses

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 4; LIPOPOLYSACCHARIDE BINDING PROTEIN; MESSENGER RNA; TOLL LIKE RECEPTOR;

ALLERGY; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BACTERIAL INFECTION; CYTOKINE PRODUCTION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; MYCOSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTOZOAL INFECTION; REVIEW; TH1 CELL; TH2 CELL; TUMOR REGRESSION; VIRUS INFECTION;

ANIMALS; AUTOIMMUNE DISEASES; B-LYMPHOCYTES; CELL DIFFERENTIATION; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; HYPERSENSITIVITY; INFECTION; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-18; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; MACROPHAGES; MICE; MODELS, IMMUNOLOGICAL; MULTIGENE FAMILY; ORGAN SPECIFICITY; PROTEIN PRECURSORS; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-18; SIGNAL TRANSDUCTION; TH1 CELLS; TH2 CELLS;

EID: 0035059368     PISSN: 07320582     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.immunol.19.1.423     Document Type: Review

References (291)

1. Cloning of a new cytokine that induces IFN-γ production by T cells
2. A novel costimulatory factor for gamma interferon induction found in the liver of mice causes endotoxic shock
3. Interleukin-18: A novel cytokine that augments both innate and acquired immunity
4. Regulation of interferon-γ production by IL-12 and IL-18
5. Overview of interleukin-18: More than an interferon-gamma inducing factor
6. Interleukin-18 and interleukin-1β: Two cytokine substrates for ICE (caspase-1)
7. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist
8. IL-18: A Th1-inducing, proinflammatory cytokine and new member of the IL-1 family
9. Interleukin-18
10. Pathophysiological roles of interleukin-18 for inflammatory liver diseases
11. The role of IL-18 in innate immunity
12. Potentiality of interleukin-18 as a useful reagent for the treatment of infectious diseases
13. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu
14. Activation of interferon-γ, inducing factor mediated by interleukin-1β converting enzyme
15. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
16. Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice
17. Biologic basis for interleukin-1 in disease
18. Caspase-1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand
19. Purification and characterization of the human interleukin-18 receptor
20. Generation of IL-18 receptor-deficient mice: Evidence for IL-1 receptor-related protein as an essential IL-18 binding receptor
21. Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells
22. IL-18 receptor
23. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling
24. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants
25. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
26. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
27. Unresponsiveness of MyD88-deficient mice to endotoxin
28. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
29. Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades
30. Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice
31. IL-1 Receptor-associated kinase modulates host responsiveness to endotoxin
32. The IL-1 receptor/toll-like receptor superfamily: Crucial receptors for inflammation and host defense
33. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon-γ production from activated B cells
34. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: Synergism with IL-18 for IFN-γ production
35. Interleukin 18
36. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-γ production by dendritic cells
37. IL-18 is a potent coinducer of IL- 13 in NK and T cells: A new potential role for IL-18 in modulating the immune response
38. + T cells, IL-4 and STAT6
39. IL-18, although anti-allergic when administered with IL-12, stimulates IL-4 and histamine release by basophils
40. The molecular cell biology of interferon-γ and its receptor
41. Cellular mechanisms in vivo production of gamma interferon induced by lipopolysaccharide in mice infected with Mycobacterium boris BCG
42. High serum IL-6 level reflects susceptible status of the host to endotoxin and IL-1/tumor necrosis factor
43. Importance of direct hepatocytolysis by liver macrophages in experimental fulminant hepatitis
44. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific and adaptive immunity
45. Cloning of the cDNA for human IFN-γ-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein
46. A newly defined interleukin-1?
47. + T cells but induces type I T cells in the liver by induction of IL-12 and IL-18 production from Kupffer cells
48. IL-18 accounts for both TNF-α- and Fas ligand-mediated hepatotoxic pathways in endotoxin-induced liver injury in mice
49. Regulation of IL-18 (IFN-γ-inducing factor) gene expression
50. Roles of IFN consensus sequence binding protein and PU.1 in regulating IL-18 gene expression
51. Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation
52. Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA
53. Interleukin-12; a cytokine at the interface of inflammation and immunity
54. Differential requirement of IFN consensus sequence binding protein for the production of IL-12 and induction of Th1-type cells in response to IFN-γ
55. Cell-specific expression of the macrophage scavenger receptor gene is dependent on PU.1 and a composite AP-1/ets motif
56. Repression of I-Aβ gene expression by the transcription factor PU.1
57. IFN-γ and lipopolysaccharide induce DNA binding of transcription factor PU.1 in murine tissue macrophages
58. Control of messenger RNA stability
59. The human interleukin 18 gene IL-18 maps to 11q22.2-q22.3 closely linked to the DRD2 gene locus and distinct from mapped IDDM loci
60. Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2
61. Interleukin-18 regulation of interferon-γ, production and cell proliferation as shown in interleukin-1β-converting enzyme (caspase-1)-deficient mice
62. IL-18 (IFN-γ-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice
63. Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFNγ -inducing factors but enhances NK cell production of IFN-γ
64. Interferon-γ-dependent expression of inducible nitric oxide synthase, interleukin-12, and interferon-γ-inducing factor in macrophages elicited by allografted tumor cells
65. Cultures of astrocytes and microglia express interleukin 18
66. Murine microglial cells produce and respond to interleukin-18
67. Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1β are differentially regulated in human blood mononuclear cells and mouse spleen cells
68. Production of functional IL-18 by different subtypes of murine and human dendritic cells (DC): DC-derived IL-18 enhances IL- 12-dependent Th1 development
69. Production of IL-18 (IFN-γ-inducing factor) messenger RNA and functional protein by murine keratinocytes
70. Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) β
71. Immunohistochemical and immuno-electron-microscopic detection of interferon-γ-inducing factor (interleukin-18) in mouse intestinal epithelial cells
72. Airway epithelium expresses interleukin-18
73. Interleukin-18 (interferon-γ-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-γ to inhibit osteoclast formation
74. Induction of interferon-γ inducing factor in the adrenal cortex
75. Modulation of IL-18 production in the adrenal cortex following acute ACTH or chronic corticosterone treatment
76. Detection of the interleukin 18 family in rat brain by RT-PCR
77. Skin-specific caspase-1 transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18
78. Molecular cloning of the interleukin-1β converting enzyme
79. The interleukin-1β-converting enzyme (ICE) is localized on the eternal cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy
80. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
81. Expression, refolding, and autocatalytic proteolytic processing of the interleukin-1β-converting enzyme precursor
82. Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells
83. Endotoxin opens the Toll gates to innate immunity
84. LPS induced IL-18 secretion from murine Kupffer cells independently of MyD88 that is critically involved in induction of production of IL-12 and IL-1β
85. Virus infection activates 1L-1β and IL-18 production in human macrophages by a caspase- 1-dependent pathway
86. Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells
87. Nitric oxide prevents IL-1β and IFN-γ-inducing factor (IL-18) release from macrophages by inhibiting caspase-1 (IL-1β-converting enzyme)
88. The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin-1β-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
89. Human endothelial cells express proteinase 3, the target antigen of anticytoplasmic antibodies in Wegener's granulomatosis
90. Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo
91. Release of neutrophil proteinase 4 (3) and leukocyte elastase during phagocytosis and their interaction with proteinase inhibitors
92. Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa
93. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a trans membrane protein
94. Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
95. The human toll signaling pathway: Divergence of NF-κB and JNK/SAPK activation upstream of tumor necrosis factor-associated factor 6 (TRAF6)
96. Innate immunity: The virtues of a nonclonal system of recognition
97. d/Ran of endotoxin-resistant C3H/HeJ. Mice is defective in mediating lipopolysaccharide endotoxin responses
98. IL-1RrP is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP
99. The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function
100. T1/ST2 is preferentially expressed on murine Th2 cells, independent of interleukin 4, interleukin 5, and interleukin 10, and important for Th2 effector function
101. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
102. The costimulatory effect of IL-18 on the induction of antigen-specific IFN-γ production by resting T cells is IL-12 dependent and is mediated by up-regulation of the IL-12 receptor β2 subunit
103. IL-18 up-regulates perforin-mediated NK activity without increasing perforin messenger RNA expression by binding to constitutively expressed IL-18 receptor
104. Expression and responsiveness of human interleukin-18 receptor (IL-18R) on hematopoietic cell lines
105. Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response
106. Cloning and expression of interleukin-18 binding protein
107. IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-γ
108. Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
109. IL-18 binding and inhibition of interferon γ induction by human poxvirus-encoded proteins
110. A poxvirus protein that binds to and in-activates IL-18, and inhibits NK cell response
111. Ectromelia, vaccinia and cowpox viruses encode secreted interleukin-18-binding proteins
112. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
113. IGIF does not drive Th1 development but synergizes with IL-12 for interferongamma production and activates IRAK and NF-κB
114. Interleukin-18 activates NF-κB in murine T helper type 1 cells
115. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
116. Interleukin-18 induces activation and association of p56 (lck) and MAPK in a murine TH1 clone
117. erk-21
118. + T cells
119. A mechanism underlying synergy between IL-12 and IFN-γ-inducing factor in enhanced production of IFN-γ
120. IL-12 synergizes with IL-18 or IL-1β for IFN-γ production from human T cells
121. + T cells: Evidence for two distinct pathways for promoter activation
122. - cells
123. Comparison of the effects of interleukin-1α, interleukin-1β and interferon-γ-inducing factor on the production of interferon γ by natural killer
124. Interferon-γ-inducing factor up-regulates Fas ligand-mediated cytotoxic activity of murine natural killer cell clones
125. IL-12-induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor
126. + T lymphocytes
127. A distinct IL-18-induced pathway to fully activate NK T lymphocytes independently from TCR engagement
128. Constitutive and induced IL-18 receptor expression by various peripheral blood cell subsets as determined by anti-hIL-18R monoclonal antibody
129. Interaction of NF-κB and NFAT with the interferon-γ promoter
130. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain
131. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
132. Binding of interleukin-18 to the interleukin-1 receptor homologous receptor IL-1RrP1 leads to activation of signaling pathways similar to those used by interleukin-1
133. Function and activation of NF-κB in the immune system
134. An essential role for NF-κB in IL-18-induced IFN-γ expression in KG-1 cells
135. Selective expression and functions of interleukin 18 receptor on T helper (Th) type 1 but not Th2 cells
136. Interferon-γ-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: Synergism with interleukin-12 for interferon-gamma production
137. IFN-γ-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12
138. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses
139. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
140. T lymphocyte differentiation in the periphery
141. Defective NK cell activity and Th1 response in IL-18-deficient mice
142. + effector T cells is differentially regulated by IL-18 and IL-12
143. Interferon-γ-inducing factor, a novel cytokine, enhances Fas ligand-mediated cytotoxicity of murine T helper 1 cells
144. IL-18 augments perforin-dependent cytotoxicity of liver NK-T cells
145. Expression and function of TNF-related apoptosis-inducing ligand (TRAIL) on murine activated NK cells
146. + T cell-mediated cytotoxicity
147. + cytotoxic T lymphocytes by interleukin-18
148. Identification and characterization of a new member of the TNF family that induces apoptosis
149. TRAIL: A molecule with multiple receptors and control mechanisms
150. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo
151. The Fas death factor
152. Apoptosis by death factor
153. + T cells
154. Murine macrophages secrete interferon γ upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation
155. Histamine is a potent inducer of IL-18 and IFN-γ in human peripheral blood mononuclear cells
156. IFN-γ-inducing factor (IL-18) increases allergic sensitization, serum IgE, Th2 cytokines, and airway eosinophilia in a mouse model of allergic asthma
157. Human keratinocytes constitutively express interleukin-18 and secrete biologically active interleukin-18 after treatment with pro-inflammatory mediators and dinitrochlorobenzene
158. Decreased expression of cytokines that induce type 1 helper T cell/interferon-γ responses in genetically susceptible mice infected with Mycobacterium avium
159. Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice
160. Production of interleukin-18 in human tuberculosis
161. In vivo immunomodulation following intradermal injection with DNA encoding IL-18
162. Depressed interleukin-12 (IL-12), but not IL-18, production in response to a 30- or 32-kilodalton mycobacterial antigen in patients with active pulmonary tuberculosis
163. Increased levels of circulating interleukin-18 in patients with advanced tuberculosis
164. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
165. The possible role of interleukin (IL)-12 and interferon-gamma-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice
166. IL-18 promotes type 1 cytokine production from NK cells and T cells in human intracellular infection
167. Interleukin 18 contributes to host resistance and gamma interferon production in mice infected with virulent Salmonella typhimurium
168. Caspase-1 activation of IL-1β and IL-18 are essential for Shigella flexneri-induced inflammation
169. Chlamydia trachomatis infection of epithelial cells induces the activation of caspase-1 and release of mature IL-18
170. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells
171. Combined effects of IL-12 and IL-18 on the clinical course and local cytokine production in murine pulmonary infection with Cryptococcus neoformans
172. Role of TNF-α in the induction of fungicidal activity of mouse peritoneal exudate cells against Cryptococcus neoformans by IL-12 and IL-18
173. Human defenses against Cryptococcus neoformans: An update
174. IL-18 contributes to host resistance against infection with Cryptococcus neoformans in mice with defective IL-12 synthesis through induction of IFN-γ production by NK cells
175. Interleukin- 18 protects mice against acute herpes simplex virus type 1 infection
176. Influenza A virus-induced IFN-α/β and IL-18 synergistically enhance IFN-γ gene expression in human T cells
177. In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection
178. Interleukin-18 enhances lipopolysaccharide-induced interferonγ, production in human whole blood cultures
179. + human blood mononuclear cells
180. Retinoic acid mimics transforming growth factor in the regulation of human immunodeficiency virus expression in monocytic cells
181. Interleukin 18 stimulates HIV type 1 in monocytic cells
182. Impaired interleukin 12 production in human immunodeficiency virus-infected patients
183. Regulation of immunity to parasites by T cells and T cell-derived cytokines
184. + lymphocytes in vivo during healing and progression of murine leishmaniasis
185. Type 1 interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite
186. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice
187. Potentiality of interleukin-18 as a useful reagent for treatment and prevention of Leishmania major infection
188. Genetically resistant mice lacking IL-18 gene develop Th1 response and control cutaneous Leishmania major infection
189. LeIF: A recombinant Leishmania protein that induces an IL-12-mediated Th1 cytokine profile
190. Trypanosoma cruzi induces strong IL-12 and IL-18 gene expression in vivo: Correlation with interferon-gamma (IFN-γ) production
191. Tumor-associated macrophages as targets for cancer therapy
192. In vivo antitumor effects of murine interferon-γ-inducing factor/interleukin-18 in mice beating syngeneic Meth A sarcoma malignant ascites
193. Interleukin 18 induces the sequential activation of natural killer cells and cytotoxic T lymphocytes to protect syngeneic mice from transplantation with Meth A sarcoma
194. Potent antitumor effects mediated by local expression of the mature form of the interferonγ inducing factor, interleukin-18 (IL-18)
195. Neuroblastoma cells expressing mature IL-18, but not proIL-18, induce a strong and immediate antitumor immune response
196. Interleukin-18 and the costimulatory molecule B7-1 have a synergistic anti-tumor effect on murine melanoma; implication of combined immunotherapy for poorly immunogenic malignancy
197. Antitumor activity of interleukin-18 on mouse glioma cells
198. WN-γ-inducing factor/IL- 18 administration mediates WN-γ- and IL-12-independent antitumor effects
199. Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand and perforin-induced tumor apoptosis, respectively
200. Modulation of interleukin-18 expression in human colon carcinoma: Consequences for tumor immune surveillance
201. IL-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1
202. Endogenous interleukin-18 modulates immune escape of murine melanoma cells by regulating the expression of Fas ligand and reactive oxygen intermediates
203. Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis
204. Interleukin-18 acts as an angiogenesis and tumor suppresser
205. Synergistic antitumor effects of interleukin-12 gene transfer and systemic administration of interleukin-18 in a mouse bladder cancer model
206. Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1β converting enzyme cDNA
207. Role of IL-12 in the induction and potentiation of IFN-γ in response to Bacillus Calmette-Guerin
208. Antitumor effects on mouse melanoma elicited by local secretion of interleukin-12 and their enhancement by testament with interleukin-18
209. Effectiveness of cancer vaccine therapy using cells transduced with the interleukin-12 gene combined with systemic interleukin- 18 administration
210. Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper T cells
211. Interleukin-18: Perspectives on the newest interleukin
212. Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor
213. Interleukins in the control of osteoclast differentiation
214. Cloning of rat brain interleukin-18 cDNA
215. HLA class II transgenic mice as models of human diseases
216. The role of MHC class II molecules in susceptibility and resistance to autoimmunity
217. Genetics of autoimmune diabetes in animal models
218. Identification of HLA-class-II-restricted epitopes of autoantigens in transgenic mice
219. Pancreatic infiltration but not diabetes occurs in the relative absence of MHC class II-restricted CD4 T cells: Studies using NOD/CIITA-deficient mice
220. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes
221. Insulin-dependent diabetes mellitus and its animal models
222. Transgenes and knockout mutations in animal models of type 1 diabetes and multiple sclerosis
223. Interferon-γ, impacts at multiple points during the progression of autoimmune diabetes
224. In autoimmune diabetes transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor α
225. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Li mice by the influence of interleukin (IL)-4 and/or IL-10
226. +T cells in autoimmune diabetes through the use of TCR transgenic mice
227. Cellular and molecular changes accompanying the progression from insulitis to diabetes
228. IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis
229. Interleukin-13 prevents autoimmune diabetes in NOD mice
230. Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
231. Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-γ
232. High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient and anti-myelin basic protein T cell receptor transgenic mice
233. Neutralizing antibodies to IFNγ-inducing factor prevent experimental autoimmune encephalomyelitis
234. The critical role of IL-12 and the IL-12Rβ2 subunit in the generation of pathogenic autoreactive Th1 cells
235. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
236. + T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions
237. Peripheral levels of caspase- 1 mRNA correlate with disease activity in patients with multiple sclerosis; a preliminary study
238. Caspase-1 regulates the inflammatory process leading to autoimmune demyelination
239. Role of cytokines in rheumatoid arthritis
240. Interleukin-18, rheumatoid arthritis, and tissue destruction
241. A proinflammatory role for IL-18 in rheumatoid arthritis
242. Combined effects of IL-12 and IL-18 on the induction of collagen-induced arthritis
243. IL-18-deficient mice are resistant to endotoxin-induced liver injury but highly susceptible to endotoxin shock
244. Lethal effect of the anti-Fas antibody in mice
245. Fas ligand in human serum
246. Lethal effect of recombinant human Fas ligand in mice pretreated with Propionibacterium acnes
247. NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines
248. Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL-18
249. Increases in intrahepatic CD68 positive cells, MAC387 positive cells, and proinflammatory cytokines (particularly interleukin 18) in chronic hepatitis C infection
250. Elevation of serum interleukin-18 levels and activation of Kupffer cells in biliary atresia
251. Graft-versus-host disease and the Th1/Th2 paradigm
252. Neutralizing IL-12 during induction of murine acute graft-versus-host disease polarizes the cytokine profile toward a Th2-type alloimmune response and confers long term protection from disease
253. The p55 IFN-α receptor plays a critical role in T cell alloreactivity
254. Elevated interleukin (IL)-18 levels during acute graft-versushost disease after allogeneic bone marrow transplantation
255. Kinetics of interferon-gamma secretion and its regulatory factors in the early phase of acute graft-versus-host disease
256. Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-γ in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation
257. T-cell inter-actions in autoimmunity: Insights from a murine model of graft-versus-host disease
258. IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versushost disease
259. Inhibition of in vitro immunoglobulin production by IL-12 in murine chronic graft-vs-host disease: Synergism with IL-18
260. IL-18 prevents the development of chronic graft-versus,host disease in mice
261. + T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
262. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
263. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
264. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease
265. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: Expression and localization in intestinal mucosal cells
266. Bioactive IL-18 expression is up-regulated in Crohn's disease
267. The key role of macrophages in the immunopathogenesis of inflammatory bowel disease
268. Colitis in HLA-B27/β2 microglobulin transgenic rats
269. IFN-γ-dependent and -independent mechanisms in adverse effects caused by concomitant administration of IL- 18 and IL- 12
270. IL-18 and IL-12 induce intestinal inflammation and fatty liver in mice in an IFN-γ-dependent manner
271. Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-γ receptor-deficient mice
272. Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against Escherichia coli and Salmonella typhimurium endotoxemia
273. Role of interleukin-18 (IL-18) during lethal shock: Decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice
274. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
275. Th2-like bronchoalveolar T-lymphocyte population in atopic asthma
276. Prevention of Th2-like cell responses by coadministration of IL- 12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels
277. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesis in vitro
278. + T cells and IL-18
279. Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse
280. IL-18 deficiency selectively enhances allergen-induced eosinophilia in mice
281. Differential roles of IL-18 in allergic airway disease: Induction of eotaxin by resident cell populations exacerbates eosinophils accumulation
282. Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse airways
283. Interleukin 18 and 12 synergistically upregulate interferon-γ, production by murine dendritic epidermal T cells
284. IL-12: A key cytokine in immune regulation
285. Counterregulation of interleukin-18 mRNA and protein expression during cutaneous wound repair in mice
286. The influence of tissue cross-talking on OA progression: Role of nonsteroidal antiinflammatory drags
287. Interleukin- 1β-converting enzyme/caspase-1 in human osteoarthritic tissues: Localization and role in the maturation of interleukin-1β and interleukin-18
288. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses
289. Interleukin-18 and interleukin-12 synergize to stimulate the production of vascular permeability factor by T lymphocytes in normal subjects and in patients with minimal-change nephrotic syndrome
290. Differentiation between vascular permeability factor and IL-2 in lymphocyte supernatants from patients with minimal-change nephrotic syndrome
291. Expression of interleukin-18 in the lung after endotoxemia or hemorrhage-induced acute lung injury