Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo

Nature Medicine

Volumn 6, Issue 5, 2000, Pages 583-588

  Atreya, R ^a   Mudter, J ^a   Finotto, S ^a   Mullberg J ^a   Jostock, T ^a   Wirtz, S ^a   Schutz M ^a   Bartsch, B ^a   Holtmann, M ^a   Becker, C ^a   Strand, D ^a   Czaja, J ^a   Schlaak, J F ^a   Lehr, H A ^a   Autschbach, F ^c   Schurmann G ^d   Nishimoto, N ^b   Yoshizaki, K ^b   Ito, H ^b   Kishimoto, T ^b   Galle, P R ^a   Rose John, S ^a   Neurath, M F ^a   more..

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; NEUTRALIZING ANTIBODY; PROTEIN BCL 2; PROTEIN BCL X;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLITIS; CONTROLLED STUDY; CROHN DISEASE; HELPER CELL; HUMAN; HUMAN TISSUE; LAMINA PROPRIA; MOUSE; MUCOSA CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

ADULT; ANIMALS; ANTIGENS, CD; APOPTOSIS; BCL-X PROTEIN; COLITIS, ULCERATIVE; CROHN DISEASE; CYTOKINE RECEPTOR GP130; DNA-BINDING PROTEINS; FEMALE; HUMANS; INTERLEUKIN-6; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MIDDLE AGED; MODELS, IMMUNOLOGICAL; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES; TRANS-ACTIVATORS;

ANIMALIA;

EID: 18344410191     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/75068     Document Type: Article

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