Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid

Science

Volumn 317, Issue 5835, 2007, Pages 256-260

  Mucida, Daniel ^a   Park, Yunji ^a   Kim, Gisen ^a   Turovskaya, Olga ^a   Scott, Iain ^a   Kronenberg, Mitchell ^a   Cheroutre, Hilde ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 17; INTERLEUKIN 6; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA; DIBENZAZEPINE DERIVATIVE; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; INTERLEUKIN 2; LE 540; UNCLASSIFIED DRUG;

IMMUNE RESPONSE; IMMUNITY; METABOLITE; ORGANIC ACID; VITAMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; IMMUNE RESPONSE; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; COLITIS; CYTOLOGY; DENDRITIC CELL; HELPER CELL; IMMUNOLOGY; INTESTINE MUCOSA; LISTERIOSIS; LYMPHOCYTE ACTIVATION; METABOLISM; PHYSIOLOGY; SPLEEN; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COLITIS; DENDRITIC CELLS; DIBENZAZEPINES; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-17; INTERLEUKIN-2; INTERLEUKIN-6; INTESTINAL MUCOSA; LISTERIA INFECTIONS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SPLEEN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; TRETINOIN;

EID: 34447503805     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1145697     Document Type: Article

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19. We thank M. Steinberg, Y. Kinjo, and E. Tupin for helpful discussions; X. Zhang for providing the LE135 inhibitor; Y. Wang-Zhu for providing C57BL/6 mice; C. Lena for help in intraepithelial lymphocyte preparations; S. Feau and Y. Huang for help with Listeria infection; and M. Cheroutre for her contribution. This work was supported by NIH grant RO1 AI050265-06 and The Crohn's and Colitis Foundation of America fellowship (Y.P.).